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Olfactory receptors in neural regeneration in the central nervous system

Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan serrano-Marín Rafael Rivas-Santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

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Plumbing System of Hunga Tonga Hunga Ha'apai Volcano

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Journal of Earth Science 2023年第3期34卷 706-716页

作者： román Alvarez Miguel Camacho Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas(IIMAS) Universidad Nacional Autónoma de MéxicoCoyoacán CDMX 04510Mexico Posgrado en Ciencias de la Tierra Universidad Nacional Autónoma de MéxicoCoyoacán CDMX 04510Mexico

The Hunga Tonga Hunga Ha’apai submarine volcano has experienced repeated eruptions in the latest *** recent one,in January 2022,released an enormous amount of energy inducing global perturbations,as tsunamis and atmospheric *** structure of the volcano is poorly understood,especially its internal ***-seated magmatic connections are difficult to define or *** use a high-resolution gravity data set obtained via satellite to calculate the Bouguer anomaly over its structure,to perform a preliminary exploration of its *** 3D gravity inversions,we find a complex plumbing system with various exhaust trajectories and multiple surface pockets of low-density material within the volcanic edifice;some appear to be associated with ring *** is in line with the report of the 2009 eruption,described as beginning from multiple *** found no signs of a magma chamber within 6 km depth,although several volcanic conduits are identified from such depth to the *** variations occur within a plumbing conduit or may vary from one conduit to another in the same *** models yield quantitative estimates for areas of magma-water interaction,constituting a baseline to compare with structural changes to be induced in future eruptions.

关键词： Hunga Tonga Hunga Ha'apai satellite gravity data 3D inversions volcano Tofua Island

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Verification and Validation for data marketplaces via a blockchain and smart contracts

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Blockchain(Research and Applications) 2022年第4期3卷 91-108页

作者： Will serrano The Bartlett University College London WC1E 6BTLondonUnited Kingdom

Actual challenges with data in physical infrastructure include:1)the adversity of its velocity based on access and retrieval,thus integration;2)its value as its intrinsic quality;3)its extensive volume with a limited variety in terms of systems;and finally,4)its veracity,as data can be modified to obtain an economical *** infrastructure design based on Agile project management and minimum viable products provides benefits against the traditional waterfall *** supports an early return on investment that promotes circular reinvesting while making the product more adaptable to variable social-economical ***,Agile also presents inherent issues due to its iterative ***,project information requires an efficient record of the aims,requirements,and governance not only for the investors,owners,or users but also to keep evidence in future health&safety and other statutory *** order to address these issues,this article presents a Validation and Verification(V&V)model for data marketplaces with a hierarchical process;each data V&V stage provides a layer of data abstraction,value-added services,and authenticity based on Artificial Intelligence(AI).In addition,this proposed solution applies Distributed Ledger Technology(DLT)for a decentralised approach where each user keeps and maintains the data within a *** presented model is validated in real data marketplace applications:1)live data for the Newcastle Urban Observatory Smart City Project,where data are collected from sensors embedded within the smart city via APIs;2)static data for University College London(UCL)—Real Estate—PEARL Project,where different project users and stakeholders introduce data into a Project Information Model(PIM).

关键词： Data marketplace Project information model Smart cities Smart buildings Real estate Distributed ledger technology Blockchain Smart contracts Artificial intelligence

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Participatory Risk Governance for Seoul,South Korea's Flood Risk Management

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International Journal of Disaster Risk Science 2024年第3期15卷 317-331页

作者： Bokjin ro Gregg Garfin School of Geography Development and EnvironmentThe University of ArizonaTucsonAZ85721USA Interdisciplinary Program for Disaster Crisis and Risk ManagementSungkyunkwan UniversitySuwonGyeonggi-do16419Republic of Korea School of Natural Resources and the Environment The University of ArizonaTucsonAZ85721USA

Risk governance is a widely used framework in natural and societal risk management *** from natural hazards in urban areas call for the establishment of rigorous and participatory urban risk *** this study,we examined participatory risk governance(PRG)of flood risk management(FRM)in Seoul,South *** conducted key informant interviews and implemented a survey with citizens,to explore perceptions of flood risks and risk management,and to examine prospects for improving PRG in *** found a gap between the perceptions of key informants and *** informants believed that citizens'low awareness of flood risks hinders *** our research found that citizens'risk awareness was not low,and risk awareness may not be the main barrier to participation in ***,we found that citizens lacked knowledge of FRM actions,and they assigned government bodies a high level of responsibility for FRM,compared to the level of responsibility that citizens assigned to ***,the actors involved in FRM tended not to trust each other,which implies a lack of mutual *** increase the eff ectiveness of PRG,we suggest a polycentric governance structure anchored by a leading actor group,and active promotion of the participation of actors at multiple levels of *** between government and citizen participants,designed to foster improved understanding and recognition of one another's roles and contributions to FRM,will enhance trust and improve the implementation of PRG in Seoul.

关键词： Citizen participation-Flood risk management Participatory risk governance Risk awareness South Korea:Urban flood risk

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Supercritical angle Raman microscopy: a surfacesensitive nanoscale technique without field enhancement

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Light(Science & Applications) 2017年第1期6卷 482-489页

作者： Diana serrano Stefan Seeger Department of Chemistry University of ZurichWintherthurerstrasse 190CH-8057 ZurichSwitzerland

Raman scattering microscopy is a versatile tool for label-free imaging and molecular fingerprint ***,we provide the first demonstration that the selective collection of scattered signals exceeding the critical angle for total internal reflection enables surface-confined spontaneous Raman investigations at nanometre *** high-axial selectivity leads to improved signal-to-background ratios,thus making this technique an excellent probe for surface-related molecular *** richness of the spectroscopic information obtained through the supercritical angle Raman(SAR)collection path was proven by comparing its output with that of a parallel far-field collection ***,we demonstrated that the proposed SAR technique is a versatile microscopy approach that can be used alone or in combination with amplified Raman modalities such as surfaceenhanced resonance Raman scattering.

关键词： near-field optics Raman scattering supercritical microscopy surface science

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Development of the modified k-ε turbulence model of power-law fluid for engineering applications

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Science China(Technological Sciences) 2012年第1期55卷 276-284页

作者： ro Kyoungchul RYOU HongSun Department of Mechanical Engineering Chung-Ang University

In the present study, a high Reynolds number version of a turbulence model was proposed by using drag reduction to analyze the turbulent flows of power-law fluid for engineering applications. In order to determine the model constants in the constitutive equation, numerical simulation was conducted under the same conditions that were applied to obtain the experiment re- suits and previous turbulence models. For validation of the modified turbulence model, numerical simulations were performed for power-law fluids of different viscosities. The results of the modified k-ε turbulence model showed better agreement with the experimental results than those of the standard k-ε turbulence model. In addition, computation time and computer resource of the modified k-ε turbulence model were reduced by about one third as compared to the low Reynolds number model for power-law fluids.

关键词： power-law fluid turbulent flow drag reduction turbulence model computational fluid dynamics(CFD)

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Molecular aspects of mammalian fertilization

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Asian Journal of Andrology 2001年第4期3卷 243-249页

作者： Hector serrano Dolores Garcia-Suarez Dept. Health Sciences Dept. Biology Universidad Autonoma Metropoliana-Iztapalapa Ave. Michoacan and Purisima Mexico City DF 09340 Mexico

Mammalian fertilization is a highly regulated process, much of which are not clearly understood. Here we presentsome information in order to elaborate a working hypothesis for this process, beginning with the sperm modifications inthe epidydimis up to sperm and egg plasmalemma interaction and fusion. We also discuss the still poorly understood ca-pacitation process, the phenomenon of sperm chemo-attraction that brings the capacitated sperm to interact with theoocyte vestments and certain aspects of the acrosome reaction. (Asian J Androl 2001 Dec; 3 : 243 - 249)

关键词： fertilization sperm maturation sperm capacitation sperm-ovum interactions membrane fusion

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Video learning based image classification method for object recognition

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Journal of Central South University 2013年第9期20卷 2399-2406页

作者： LEE Hong-ro SHIN Yong-ju Department of NTIS Center Korea Institute of Science & Technology Information

Automatic image classification is the first step toward semantic understanding of an object in the computer vision *** key challenge of problem for accurate object recognition is the ability to extract the robust features from various viewpoint images and rapidly calculate similarity between features in the image database or video *** order to solve these problems,an effective and rapid image classification method was presented for the object recognition based on the video learning *** optical-flow and RANSAC algorithm were used to acquire scene images from each video *** the selection of scene images,the local maximum points on comer of object around local area were found using the Harris comer detection algorithm and the several attributes from local block around each feature point were calculated by using scale invariant feature transform （SIFT） for extracting local ***,the extracted local descriptor was learned to the three-dimensional pyramid match *** results show that our method can extract features in various multi-viewpoint images from query video and calculate a similarity between a query image and images in the database.

关键词： image classification multi-viewpoint image feature extraction video learning

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Determination of coefficients of friction for laminated veneer lumber on steel under high pressure loads

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Friction 2021年第2期9卷 367-379页

作者： Michael DORN Karolína HABroVÁ Radek KOUBEK Erik serrano Department of Building Technology Linnaeus UniversityVäxjö35252Sweden Czech University of Life Sciences Prague-Department of Materials and Engineering Technology Prague 16521Czech Republic Daikin UK The HeightsBrooklandsWeybridgeKT130NYUnited Kingdom Division of Structural Mechanics Lund UniversityLund 22100Sweden

In this study,static coefficients of friction for laminated veneer lumber on steel surfaces were determined *** focus was on the frictional behaviors at different pressure levels,which were studied in combination with other influencing parameters:fiber orientation,moisture content,and surface *** of friction were obtained as 0.10–0.30 for a smooth steel surface and as high as 0.80 for a rough steel *** influenced the measured coefficients of friction,and lower normal pressures yielded higher *** influence of fiber angle was observed to be moderate,although clearly detectable,thereby resulting in a higher coefficient of friction when sliding perpendicular rather than parallel to the *** specimens contained higher coefficients of friction than oven-dry *** results provide realistic values for practical applications,particularly for use as input parameters of numerical simulations where the role of friction is often wrongfully considered.

关键词： laminated veneer lumber(LVL) wood static friction high pressure angle-to-grain moisture content

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Plants and heterotrimeric G proteins:Expect the unexpected

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Molecular Plant 2023年第3期16卷 506-508页

作者： Angel Ferrero-serrano David Chakravorty Biology Department Penn State University208 Mueller LaboratoryUniversity ParkPA 16802USA

The United Nations estimates that by 2050 the world population will reach 9.7 billion(United Nations Department of Economic and Social Affairs,Population Division,2022),which will increase food ***,predictions anticipate global crop yield declines of 5.6%–18.2%as a result of climate change(Zhao et al.,2017).Climate change will result in extreme weather events that are already occurring and that will become more frequent and variable in the ***,more than ever,we need plants that can cope with unpredictable weather events such as drought or heat ***,understanding and controlling plant stress responses is likely to be one of several fundamental advances crucial to meeting increased crop production *** is an urgent necessity to develop crops that tolerate multiple stresses without a deleterious reduction in fitness under optimal ***,efforts to release such varieties have often failed because of an unacceptable trade-off between growth and stress tolerance.

关键词： weather crops likely

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