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Clean air captures attention whereas pollution distracts:evidence from brain activities

Frontiers of Environmental Science & Engineering 2024年第4期18卷 5-15页

作者： Jianxun Yang Yunqi Liu Berry van den Berg Susie Wang Lele Chen Miaomiao Liu Jun Bi State Key Laboratory of Pollution Control and resource reuse School of the EnvironmentNanjing UniversityNanjing 210023China Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology(CICAEET) Nanjing University of Information Science&TechnologyNanjing 210044China Nanjing Foreign Language School Nanjing 210008China Department of Experimental Psychology University of GroningenGrote Kruisstraat 2/19712 TSGroningenThe Netherlands Department of Social Psychology University of GroningenGrote Kruisstraat 2/19712 TSGroningenThe Netherlands School of Education Science Nantong UniversityNantong 226019China

Awareness of the adverse impact of air pollution on attention-related performance such as learning and driving is rapidly ***,there is still little known about the underlying neurocognitive *** an adapted dot-probe task paradigm and event-related potential(ErP)technique,we investigated how visual stimuli of air pollution influence the attentional allocation *** were required to make responses to the onset of a target presented at the left or right visual *** probable location of the target was forewarned by a cue(pollution or clean air images),appearing at either the target location(attention-holding trials)or the opposite location(attention-shifting trials).Behavioral measures showed that when cued by pollution images,subjects had higher response accuracy in attention-shifting *** analysis results revealed that after the cue onset,pollution images evoked lower N300 amplitudes,indicating less attentioncapturing effects of dirty *** the target onset,pollution cues were correlated with the higher P300 amplitudes in attention-holding trials but lower amplitudes in attention-shifting *** indicates that after visual exposure to air pollution,people need more neurocognitive resources to maintain attention but less effort to shift attention *** findings provide the first neuroscientific evidence for the distracting effect of air *** conclude with several practical implications and suggest the ErP technique as a promising tool to understand human responses to environmental stressors.

关键词： Air pollution Attention Disengagement Performance Event-related potential

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Nanomaterial‑Based repurposing of Macrophage Metabolism and Its Applications

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Nano-Micro Letters 2024年第11期16卷 494-528页

作者： Tingting Meng Danfeng He Zhuolei Han rong Shi Yuhan Wang Bibo ren Cheng Zhang Zhengwei Mao Gaoxing Luo Jun den Institute of Burn research Southwest HospitalState Key Laboratory of Trauma and Chemical PoisoningArmy Medical UniversityChongqing 400038People’s Republic of China Department of Breast Surgery Gansu Provincial HospitalLanzhouGansu 730030People’s Republic of China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Macrophage immunotherapy represents an emerging therapeutic approach aimed at modulating the immune response to alleviate disease ***(NMs)have been engineered to monitor macrophage metabolism,enabling the evaluation of disease progression and the replication of intricate physiological signal *** achieve this either directly or by delivering regulatory signals,thereby mapping phenotype to effector functions through metabolic repurposing to customize macrophage fate for ***,a comprehensive summary regarding NM-mediated macrophage visualization and coordinated metabolic rewiring to maintain phenotypic equilibrium is currently *** review aims to address this gap by outlining recent advancements in NM-based metabolic *** initially explore the relationship between metabolism,polarization,and disease,before delving into recent NM innovations that visualize macrophage activity to elucidate disease onset and fine-tune its fate through metabolic remodeling for macrophage-centered ***,we discuss the prospects and challenges of NM-mediated metabolic immunotherapy,aiming to accelerate clinical *** anticipate that this review will serve as a valuable reference for researchers seeking to leverage novel metabolic intervention-matched immunomodulators in macrophages or other fields of immune engineering.

关键词： Immunomodulatory nanomaterial Macrophage polarization Macrophage metabolic reprogramming Immune engineering

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Cholesterol and Sericin as First Aid for Damaged Cells

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Journal of Biosciences and Medicines 2024年第4期12卷 79-88页

作者： denız Aksoy Doga Naz Turan Zeki Berkay Bayraktar Basak College Anatolian High School Aydin Turkey Bornova Anatolian High School Bornova Turkey Izmir Science High School Izmir Turkey

Cells are surrounded by a double-layered phospholipid cell membrane responsible for the isolation of intracellular contents, active regulation of uptake from the extracellular environment, and intercellular connection and communication. These cell membranes must be intact and functionally active for cell survival and biological functioning. Compromised damage repair mechanisms usually result in impaired cellular homeostasis, leading to early or late problems. Chronic myopathies, certain myocardial diseases, aging, and acute or chronic neurodegenerative diseases (like Parkinson and Alzheimer) are directly related to cell membrane damage. This study examined the effect of a cholesterol-loaded nanoparticle (methyl-beta cyclodextrin) or the silk protein sericin on cell membrane and DNA integrity and cell viability in an in vitro cell damage model (frozen-thawed rabbit sperm cells). The cells were stored in liquid nitrogen (-196°C), thawed in small batches, and treated with cholesterol-loaded cyclodextrin or sericin before incubation at 35°C for 4 hours. Cell membrane integrity, DNA damage, and viability rates were assessed immediately after thawing and after the incubation period. The administration of sericin and cholesterol in a cell damage model increased cell survival and reduced DNA damage over a 4-hour post-thaw incubation period, suggesting their potential use as a “first aid” intervention at the cellular level.

关键词： Cell Membrane DNA Survival Damage Cholesterol Sericin Spermatozoa

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Systematic study of cluster radioactivity within the generalized liquid drop model

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Chinese Physics C 2024年第6期48卷 118-129页

作者：邓军刚程俊皓包小军张鸿飞 College of Science China Three Gorges UniversityYichang 443002China Center for Astronomy and Space Sciences China Three Gorges UniversityYichang 443002China Department of Physics National University of Defense TechnologyChangsha 410073China Department of Physics Collaborative Innovation Center for Quantum Effectsand Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of EducationHunan Normal UniversityChangsha 410081China School of Physics Xi'an Jiaotong UniversityXi'an 710049China

Cluster radioactivity is studied within the generalized liquid drop model(GLDM),in which the shell correction energy,pairing energy,and cluster preformation factor are *** calculations show significant improvements and can reproduce the experimental data within a factor of 8.04 after considering these physical *** addition,the systematic trend of the cluster preformation factors is discussed in terms of the N_(p)N_(n)scheme to study the influence of the valence proton-neutron interaction and shell effect on cluster *** is found that log10Pcis linearly related to N_(p)N_(n).This is in agreement with a recent study[*** et al.,***.C 108,014325(2023)],in which log10Pc,obtained using different theoretical models and treatment methods than those used in this study,also had a linear relationship with N_(p)N_(n).Combined with the work by Qi et al.,this study suggests that the linear relationship between log10Pcand N_(p)N_(n)is model-independent and both the shell effect and valence proton-neutron interaction play essential roles in cluster *** analytical formula is proposed to calculate the cluster preformation factor based on the N_(p)N_(n)*** addition,the cluster preformation factors and the cluster radioactivity half-lives of some heavy nuclei are predicted,which can provide a reference for future experiments.

关键词： cluster radioactivity cluster preformation factor shell effect generalized liquid drop model

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Supramolecular Polymerization of Hydrogen-Bonded Trimers in Bulk and Aqueous Medium

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CCS Chemistry 2024年第6期6卷 1458-1465页

作者： Freek V.de Graaf Stef A.H.Jansen Sandra M.C.Schoenmakers Bas van Genabeek Marle E.J.Vleugels Bart W.L.van den Bersselaar E.W.Meijer Ghislaine Vantomme Institute for Complex Molecular Systems Laboratory of Macromolecular and Organic ChemistryEindhoven University of Technology5600 MBEindhoven School of Chemistry and rNA Institute University of New South WalesSydneyNew South Wales 2052

Synthetic molecules that form functional noncovalent assemblies in water have received much attention for their potential applications as *** this work,we introduce a novel water-compatible monomer based on the phthalhydrazide moiety that assembles into hydrogen-bonded trimeric *** bulk,the material exhibits a cylindrical nanostructure in the liquid-crystalline phase at elevated temperatures,morphologically distinct from the crystalline lamellar *** water,these molecules effectively form cylinders in a one-dimensional fashion,yielding fibrous *** formation of these supramolecular polymers follows a cooperative mechanism,as evidenced by denaturation *** trimerized pattern represents a new category of aqueous su pramolecular polymers with future prospects for functional complex molecular systems.

关键词： noncovalent chemistry supramolecular polymers hydrogen bonding cooperativity nanostructure

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Genome-wide Studies reveal Genetic risk Factors for Hepatic Fat Content

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 57-68页

作者： Yanni Li Eline H.van den Berg Alexander Kurilshikov Dasha V.Zhernakova ranko Gacesa Shixian Hu Esteban A.Lopera-Maya Alexandra Zhernakova Lifelines Cohort Study Vincent E.de Meijer Serena Sanna robin P.F.Dullaart Hans Blokzijl Eleonora A.M.Festen Jingyuan Fu rinse K.Weersma Department of Gastroenterology and Hepatology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Genetics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Laboratory of Genomic Diversity Center for Computer TechnologiesITMO UniversitySaint Petersburg 199034Russia Institute of Precision Medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Surgery Section of Hepatobiliary Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Endocrinology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Pediatrics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands 不详

Genetic susceptibility to metabolic associated fatty liver disease(MAFLD)is complex and poorly *** characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk *** performed genome-wide association study(GWAS)on two noninvasive definitions of hepatic fat content:magnetic resonance imaging proton density fat fraction(MrI-PDFF)in 16,050 participants and fatty liver index(FLI)in 388,701 participants from the United Kingdom(UK)Biobank(UKBB).Heritability,genetic overlap,and similarity between hepatic fat content phenotypes were analyzed,and replicated in 10,398 participants from the University Medical Center Groningen(UMCG)Genetics Lifelines Initiative(UGLI).Meta-analysis of GWASs of MrI-PDFF in UKBB revealed five statistically significant loci,including two novel genomic loci harboring CrEB3L1(rs72910057-T,P=5.40E−09)and GCM1(rs1491489378-T,P=3.16E−09),respectively,as well as three previously reported loci:PNPLA3,TM6SF2,and *** of FLI in UKBB identified 196 genome-wide significant loci,of which 49 were replicated in UGLI,with top signals in ZPr1(P=3.35E−13)and FTO(P=2.11E−09).Statistically significant genetic correlation(rg)between MrI-PDFF(UKBB)and FLI(UGLI)GWAS results was found(rg=0.5276,P=1.45E−03).Novel MrI-PDFF genetic signals(CrEB3L1 and GCM1)were replicated in the FLI *** identified two novel genes for MrI-PDFF and 49 replicable loci for *** a difference in hepatic fat content assessment between MrI-PDFF and FLI,a substantial similar genetic architecture was *** is identified as an easy and reliable approach to study hepatic fat content at the population level.

关键词： Hepatic fat content MAFLD Genome-wide association study Fatty liver index Magnetic resonance imaging proton density fat fraction

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Experimental and Numerical Investigation of the Flow in rotating Diverging Channels

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Journal of Thermal Science 2010年第2期19卷 115-119页

作者： r.A.Van den Braembussche J.Prinsier A.Di Sante von Karman Institute for Fluid Dynamics Turbomachinery and Propulsion Department Waterloose steenweg presently at ALSTOM POWEr Steam Turbines R&D Brown Boveri Strasse 7

This paper reports on an experimental and numerical study at low reynolds number in order to evaluate the influence of the Coriolis forces on the flow in radial rotating channels. Operating conditions correspond to the flow in radial impellers for micro gasturbine applications. A comparison of detailed flow measurements with CFD resuits indicates that Navier Stokes solvers with standard k-ω and SST turbulence models predict the flow surprisingly well and that no extra corrections for Coriolis forces are required at these operating conditions

关键词： Coriolis forces turbulence models rotating channels boundary layers

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The reproductive biology of a Central American cichlid Neetroplus nematopus in Lake Xiloá ,Nicaragua

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Current Zoology 2010年第1期56卷 43-51页

作者： Kenneth r.McKAYE Jeremy HALE Eric P.van den BErGHE World Wide Fund for Nature Finland Universidad de Centroamericana Department of Mathematics Science and Technology Ave Maria University Latin American Campus

This study was conducted to provide a five-year database on the breeding seasonality and breeding biology of a Central American cichlid fish Neetroplus nematopus, a biparental substratum-spawning cichlid that cares for its eggs, wrigglers, and fry for up to six weeks. A total of 503 breeding pairs were monitored for breeding success. Breeding pairs of N. nematopus are sexually dimorphic in size, with females averaging 39% of male body mass. Fry emerged from 85% of nesting cavities. After three weeks, only 30% of the broods were present in the nesting cavity; these broods had a 30% survival rate, giving a 9% overall survival rate. Nineteen percent of the successful parents with three-week-old broods adopted foreign fry. A consistent unimodal breeding peak in December was observed for five years. This breeding peak differed dramatically from the bimodal breeding season 20 years found in the 1970s. The effects of extensive grenade fishing practices during the 1980s might have played a substantial role in the observed change. Grenade fishing stopped in 1991, and the number ofN. nematopus pairs increased by 136% from 1990 to 1995. With increased density of breeding fish, the breeding season for this species also expanded. The balance between divergent selection due to competition for breeding sites and stabilizing selection due to predation pressure on offspring is likely to mold the breeding season for N. nematopus and other cichlids of Lake Xilofi. We suggest that brood adoption and synchrony of breeding is a strategy to reduce predation on the parent＇s own young [Current Zoology 56 （1）： 43-51 2010].

关键词： Nicaragua Cichlids Breeding reproduction Synchrony Seasonality

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A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface

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International Journal of Oral Science 2024年第2期16卷 225-237页

作者： William Macalester Asme Boussahel rafael O.Moreno-Tortolero Mark r.Shannon Nicola West Darryl Hill Adam Perriman School of Cellular and Molecular Medicine Biomedical Sciences BuildingUniversity of BristolUniversity WalkBristolUnited Kingdom Bristol Centre for Functional Nanomaterials HH Wills Physics LaboratoryUniversity of BristolTyndall AvenueBristolUnited Kingdom Centre for Protolife research School of ChemistryUniversity of BristolCantocks CloseBristolUnited Kingdom Max Planck-Bristol Centre for Minimal Biology School of ChemistryUniversity of BristolBristolUnited Kingdom Periodontology Bristol Dental SchoolUniversity of BristolLower Maudlin StreetBristolUnited Kingdom

Emerging regenerative cell therapies for alveolar bone loss have begun to explore the use of cell laden hydrogels for minimally invasive surgery to treat small and spatially complex maxilla-oral ***,the oral cavity presents a unique and challenging environment for in vivo bone tissue engineering,exhibiting both hard and soft periodontal tissue as well as acting as key biocenosis for many distinct microbial communities that interact with both the external environment and internal body systems,which will impact on cell fate and subsequent treatment ***,we design and bioprint a facile 3D in vitro model of a human dentine interface to probe the effect of the dentine surface on human mesenchymal stem cells(hMSCs)encapsulated in a microporous hydrogel *** demonstrate that the dentine substrate induces osteogenic differentiation of encapsulated hMSCs,and that both dentine andβ-tricalcium phosphate substrates stimulate extracellular matrix production and maturation at the gel-media interface,which is distal to the gel-substrate *** findings demonstrate the potential for long-range effects on stem cells by mineralized surfaces during bone tissue engineering and provide a framework for the rapid development of 3D dentine-bone interface models.

关键词： interface den surface

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A Similitude Method and the Corresponding Blade Design of a Low-Speed Large-Scale Axial Compressor rotor

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Journal of Thermal Science 2014年第2期23卷 145-152页

作者： YU Chenghai MA Ning WANG Kai DU Juan Van den Braembussche r.A. LIN Feng Key Laboratory of Advanced Energy and Power Institute of Engineering ThermophysicsChinese Academy of Sciences Graduate School of Chinese Academy of Sciences von Karman Institute for Fluid Dynamics Turbomachinery and Propulsion DepartmentWaterloose steenweg721640 Sint-Genesius-RodeBelgium

A similitude method to model the tip clearance flow in a high-speed compressor with a low-speed model is presented in this *** first step of this method is the derivation of similarity criteria for tip clearance flow,on the basis of an inviscid model of tip clearance *** aerodynamic parameters needed for the model design are then obtained from a numerical simulation of the target high-speed compressor *** to the aerodynamic and geometric parameters of the target compressor rotor,a large-scale low-speed rotor blade is designed with an inverse blade design *** order to validate the similitude method,the features of tip clearance flow in the low-speed model compressor are compared with the ones in the high-speed compressor at both design and small flow rate *** is found that not only the trajectory of the tip leakage vortex but also the interface between the tip leakage flow and the incoming main flow in the high-speed compressor match well with that of its low speed *** results validate the effectiveness of the similitude method for the tip clearance flow proposed in this paper.

关键词： Similitude method Low-speed model Tip clearance flow TLF/MF interface

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