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使用头部CT扫描的深度学习预测严重创伤性脑损伤病人的结果

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国际医学放射学杂志 2022年第5期 607-607页

作者： M.Pease D.Arefan J.Barber E.Yuh a.puccio K.Hochberger 武文婧

摘要严重创伤性脑损伤（sTBI）后，医生使用长期预测来指导急性临床护理，但难以预测昏迷病人的预后。目的开发和评估将头部CT扫描和临床信息结合的深度学习预后模

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Biotribology of artificial hip joints

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World Journal of Orthopedics 2015年第1期6卷 77-94页

作者： Francesca Di puccio Lorenza Mattei Department of Civil and Industrial Engineering University of Pisa

Hip arthroplasty can be considered one of the major successes of orthopedic surgery, with more than 350000 replacements performed every year in the United States with a constantly increasing rate. The main limitations to the lifespan of these devices are due to tribological aspects, in particular the wear of mating surfaces, which implies a loss of matter and modification of surface geometry. However, wear is a complex phenomenon, also involving lubrication and friction. The present paper deals with the tribological performance of hip implants and is organized in to three main sections. Firstly, the basic elements of tribology are presented, from contact mechanics of ball-in-socket joints to ultra high molecular weight polyethylene wear laws. Some fundamental equations are also reported, with the aim of providingthe reader with some simple tools for tribological investigations. In the second section, the focus moves to artificial hip joints, defining materials and geometrical properties and discussing their friction, lubrication and wear characteristics. In particular, the features of different couplings, from metal-on-plastic to metal-on-metal and ceramic-on-ceramic, are discussed as well as the role of the head radius and clearance. How friction, lubrication and wear are interconnected and most of all how they are specific for each loading and kinematic condition is highlighted. Thus, the significant differences in patients and their lifestyles account for the high dispersion of clinical data. Furthermore, such consideration has raised a new discussion on the most suitable in vitro tests for hip implants as simplified gait cycles can be too far from effective implant working conditions. In the third section, the trends of hip implants in the years from 2003 to 2012 provided by the National Joint Registry of England, Wales and Northern Ireland are summarized and commented on in a discussion.

关键词： Arthroplasty Replacement Hip Biotribology Wear Lubrication Friction

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Clinical Response with Sunitinib Therapy in the Treatment of Anaplastic Thyroid Cancer

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Journal of Cancer Therapy 2012年第2期3卷 132-136页

作者： Kenneth M. Wong Theodore Scott Nowicki Carmelo puccio Tauseef Ahmed Raj Tiwari Jan Geliebter Augustine Moscatello Department of Medical Oncology Westchester Medical Center Valhalla USA Department of Microbiology and Immunology New York Medical College Valhalla USA Department of Otolaryngology—Head and Neck Surgery New York Eye and Ear Infirmary New York USA Department of Otolaryngology—Head and Neck Surgery Westchester Medical Center Valhalla USA

Background: Anaplastic thyroid cancer (ATC), while rare, carries a uniformly poor prognosis. Current treatment includes surgery when possible, radiotherapy, and chemotherapy. Multiple chemotherapeutic agents are in the process of clinical testing, and promising agents include those in the tyrosine kinase inhibitor family. Our patient represents a novel case of ATC treated with sunitinib, one such tyrosine kinase inhibitor. Methods/Results: We utilized the experimental sunitinib in conjunction with radiation therapy to treat a patient with aggressive ATC in whom curative resection was unable to be achieved due to carotid sheath and tracheal involvement. The patient had marked clinical response and sustained stable disease for 8 months, which coincides with reported data regarding sunitinib to treat other thyroid malignancies. Conclusion: Our case illustrates the efficacy of sunitinib therapy as a possible adjunct in the treatment of ATC.

关键词： Sunitinib Anaplastic Thyroid Cancer Tyrosine Kinase Inhibitor Chemotherapy ATC

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从定期安全性更新报告过渡到定期受益-风险评价报告:初步经验和挑战

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中国药物警戒 2014年第4期11卷 210-215页

作者：张晓兰 Lester REICH 梁冰 Donald puccio Craig HAR TFORD 辉瑞有限公司全球研发中心全球安全和注册事务部上海201203

人用药品注册技术要求国际协调会议(ICH)提供了定期安全性更新报告指南(PSUR,ICH E2C(R1))和新的定期受益-风险评价报告指南(PBRER,ICH E2C(R2))。PBRER由PSUR演变而来,实现了从比较传统的获批后药物警戒定期总结报告到现代定期受益-风... 详细信息

人用药品注册技术要求国际协调会议(ICH)提供了定期安全性更新报告指南(PSUR,ICH E2C(R1))和新的定期受益-风险评价报告指南(PBRER,ICH E2C(R2))。PBRER由PSUR演变而来,实现了从比较传统的获批后药物警戒定期总结报告到现代定期受益-风险评价总结报告的转变,根据累积信息对批准上市产品做出最新的受益-风险评价。通过总结ICH E2C PSUR指南和PBRER指南的主要区别,介绍了某跨国制药公司在由编写PSUR改为编写PBRER的转变过程中所积累的初步经验及其遇到的挑战,讨论了中国在推进药物警戒系统的背景下实行PBRER的可能性。

关键词：人用药品注册技术要求国际协调会议定期安全性更新报告药物警戒药品上市后监测

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