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多目标最优化方法论入门(二)

运筹学学报(中英文) 1983年第1期 40-47页

作者： a.p.wierzbicki 钱愚

增广限度效用函数若某一决策者的表现在他不能达到某一目的时(一个消费者维持其最低限度的生活即是一例),显得不同于在他能达到所有目的而又须将多余的加以分配时,则他的效用函数应该把这种表现表达出来.在极大化的情形,给定一个限度或... 详细信息

增广限度效用函数若某一决策者的表现在他不能达到某一目的时(一个消费者维持其最低限度的生活即是一例),显得不同于在他能达到所有目的而又须将多余的加以分配时,则他的效用函数应该把这种表现表达出来.在极大化的情形,给定一个限度或者一个参考目标水平

关键词：线性效用函数余额概念惩罚函数交互作用过程风险不关心型效用函数思维形式最优化模型标量化函数类

KNOWLEDGE SCIENCES AND NANATSUDAKI： A NEW MODEL OF KNOWLEDGE CREATION pROCESSES

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Journal of Systems Science and Systems Engineering 2007年第1期16卷 2-21页

作者： Andrzej p. wierzbicki Yoshiteru NAKAMORI Center for Strategic Development of Science and Technology Japan Advanced Institute of Science and Technology Asahidai 1-1 Nomi Ishikawa 923-1292 Japan National Institute of Telecommunications Szachowa 11 04-894 Warsaw Poland School of Knowledge Science and Center for Strategic Development of Science and Technology Japan Advanced Institute of Science and Technology Asahidai 1-1 Nomi Ishikawa 923-1292 Japan

The paper starts from a discussion of the concepts of knowledge management versus technology management, and the emergence of knowledge sciences. This is followed be a summary of recent results in the theory of knowledge creation. Most of them concern diverse spirals of creative interplay between rational （explicit） and intuitive or emotional （tacit） aspects of knowledge. Some of them concentrate on organizational （market or purpose-oriented） knowledge creation, other describe academic （research-oriented） knowledge creation. The problem addressed in this paper is how to integrate diverse spirals of knowledge creation into a prescriptive or exemplar model that would help to overcome the differences between organizational （market-oriented） and normal academic knowledge creation. As such prescriptive approach, the JAIST Nanatsudaki Model of knowledge creation is proposed. It consists of seven spirals, known from other studies, but integrated in a sequence resulting from the experience of authors in practical management of research activities. Not all of these spirals have to be fully utilized, depending on a particular application, but all of them relate to some essential aspects of either academic or organizational knowledge creation. The paper presents Nanatsudaki Model in detail with comments on consecutive spirals. The results of a survey of opinions about creativity conditions at JAIST indicate the importance of many spirals constituting the Nanatsudaki Model. Directions of further testing the Nanatsudaki Model are indicated.

关键词： Knowledge creation descriptive and prescriptive models knowledge management

THE IMpORTANCE OF MULTIMEDIA pRINCIpLE AND EMERGENCE pRINCIpLE FOR THE KNOWLEDGE CIVILISATION AGE

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Journal of Systems Science and Systems Engineering 2008年第3期17卷 297-318页

作者： Andrzej p.wierzbicki Yoshiteru NAKAMORI Center for Strategic Development of Science and Technology Japan Advanced Institute of Science and Technology(JAIST) National Institute of Telecommunications Poland School of Knowledge Science JAIST

The paper discusses two basic principles derived from results of studies concerning foundations of micro-theories of knowledge creation; these are Multimedia principle and Emergence principle. Their epistemic, systemic and metaphysical importance is discussed, together with their relations to the episteme of technology treated as a separate cultural sphere. A spiral of evolutionary knowledge creation is presented, in which an extended Falsification principle plays the role of an objectifying feedback; this spiral is related to an episteme of Evolutionary Constructive Objectivism proposed earlier for the coming knowledge civilisation age.

关键词： Micro-theories of knowledge creation multimedia principle emergence principle episteme of technology evolutionary constructive objectivism theory of truth metaphysics evolutionary knowledge creation

KNOWLEDGE SYNTHESIS IN TECHNOLOGY DEVELOpMENT

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Journal of Systems Science and Systems Engineering 2009年第2期18卷 184-202页

作者： Yukihiro YAMASHITA Yoshiteru NAKAMORI Andrzej p.wierzbicki School of Knowledge Science Japan Advanced Institute of Science and Technology 1-1 AsahidaiNomiIshikawa 923-1292Japan National Institute of Telecommunications Szachowa IWarsaw 04-894Poland

This paper introduces a knowledge construction model called the i-System for knowledge integration and creation and its relation to the new concept of the Creative Space. The five ontological elements of the i-System are Intelligence, Involvement, Imagination, Intervention, and Integration corresponding to five diverse dimensions of the Creative Space. The paper discusses the meanings and functions of these dimensions in knowledge integration and creation, and presents applications of the i-System to technology roadmapping and archiving.

关键词： Knowledge construction creative space technology roadmapping technology archiving

ESTABLISH A CREATIVE ENVIRONMENT FOR ROADMAppING IN ACADEMY—FROM THE pERSpECTIVE OF I-SYSTEM METHODOLOGY

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Journal of Systems Science and Systems Engineering 2007年第4期16卷 469-488页

作者： Tieju MA Andrzej p. wierzbicki Yoshiteru NAKAMORI School of Knowledge Science Japan Advanced Institute of Science and Technology 1-1 Asahidai Nomi Ishikawa 923-1292 Japan 1nternational Institute for Applied Systems Analysis A-2361 Laxenburg Austria National Institute of Telecommunications Szachowa Str. 1 04-894 Warsaw Poland

Roadmapping, originated from industry as a strategic planning tool, is attracting increasing applications in academy. Based on the recognition that roadmapping is a knowledge creation process, this paper analyzes what kind of support is needed or helpful for establishing a creative environment for roadmapping in academy and reviews various types of such support from the perspective of i-system methodology. As case studies of such support, this paper further introduces roadmapping pratices in Janpan Advanced Institute of Science and Technology.

关键词： Creative environment,i-system methodology roadmapping

ELECTRONIC SUppORT FOR KNOWLEDGE CREATION IN A RESEARCH INSTITUTE

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Journal of Systems Science and Systems Engineering 2007年第2期16卷 235-253页

作者： Hongtao REN Jing TIAN Yoshiteru NAKAMORI Andrzej p. wierzbicki School of Knowledge Science Japan Advanced Institute of Science and Technology Ishikawa 923-1292 Japan National Institute of Telecommunications (NIT) Szachowa 1 04-894 Warsaw Poland International Institute for Applied Systems Analysis A-2361 Laxenburg Austria

This paper focuses on the question how to build an electronic support environment for knowledge creation in a research institute （JAIST）. In order to assess the importance of diverse conditions of scientific creativity, we performed a survey in JAIST, and extracted useful knowledge from the database of survey results. Following the analysis of the theory of academic processes of knowledge creation and the survey findings in JAIST, a computer-based integrated system is proposed. In the aspect of the system design, we postulate that an electronic support environment for academic creativity can be achieved through a seamless integration with Internet, Application Server, Middle Ware, Database and Data Warehouse. The paper addresses issues of knowledge representation in the Electronic Support System for academic research, testing and evaluation issues and conclusions.

关键词： Electronic support software system knowledge creation

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi pradeepkiran priyanka Rawat Arubala p.Reddy Erika Orlov pHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAp-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

Operando FT-IR study on basicity improvement of Ni(Mg,AI)O hydrotalcitederived catalysts promoted by glow plasma discharge

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plasma Science and Technology 2019年第4期21卷 123-136页

作者： R DEBEK D wierzbicki M MOTAK M E GALVEZ p DA COSTA F AZZOLINA-JURY Normandie Univ ENSICAEN.UNICAENCNRSLaboratoire Catalyse et SpectrochimieF-14000 CaenFrance AGH University of Scienee and Technology Faculty of Energy and FuelsDepartment of Fuels Technology30 A.Mickiewicza Av.30-059 KrakowPoland Sorbonne Universite Institut Jean Le Rond d'Alembert.CNRS UMR 71902 place de la gare de ceintureF-78210 Saint-Cyr-L'Ecole.France

CO2 adsorption on the surface of hydrotalcite-derived mixed oxide catalysts was investigated under low pressure glow discharge plasma in opercindo conditions via FT-IR *** catalysts were promoted with various transition metal species(Ce,Fe,La,Zr)to influence their physico-chemical *** and Zr species were successfully incorporated into hydrotalcite brucite *** calcination formed a single phase with Ni(Mg,A1)O mixed oxide,while La and Ce species formed separate *** had a consequence in the distribution of surface basic sites as well as in the affinity to CO produced upon CO2 dissociation in *** treatment activated the surface of prepared materials and changed their properties via the generation of strong basic sites associated with low coordinated surface oxygen ***,the CO2 adsorption capacity of prepared materials increased after plasma treatment.

关键词： plasma glow discharge basicity hydrotalcite carbon dioxide