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Spatial and Temporal Function of Biological Asymmetric Neural Network

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Spatial and Temporal Function of Biological Asymmetric Neura...

IJCNN International Joint Conference on Neural Networks

作者： Naohiro ishii Department of Intelligence and Computer Science Nagoya Institute of Technology Gokiso-cho Showa-kuNagoya 466Japan

＜正＞Asymmetrical neural networks are shown in the biological neural network as the catfish *** and bipolar cell responses are linearly related to the input modulation of light,while amacrine cells work linearly and nonlinearly in their *** cells make asymmetrical neural networks in the ***,we can find two types of asymmetrical neural networks;One is an asymmetrical neural network for spatial interaction of the moving object,the other is an asymmetrical neural network for temporal interaction of the hght intensity *** the asymmetric network contains a cell with quadratic nature,we applied Wiener nonlinear analysis to the *** analyzing the biological asymmetric neural network,it is shown that the asymmetric networks are excellent in the ability of spatial and temporal information processing.

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静水中较大气泡运动特性实验研究

核动力工程 2015年第1期36卷 161-164页

作者：李仲春宋小明姜胜耀俞冀阳 Mamoru ishii 清华大学北京100084 中国核动力研究设计院核反应堆系统设计技术重点实验室成都610041 中国核动力研究设计院成都610041 普渡大学美国47906

对较大气泡在静水中的水力学特性、气泡上升速度、气泡形状与曳力系数等进行研究。气泡的产生是通过将特定体积的气泡存放在倒置的球帽杯中,然后释放到静水中。气泡的运动特性通过高速摄像仪捕捉,气泡相关运动参数通过数字图像处理程序... 详细信息

对较大气泡在静水中的水力学特性、气泡上升速度、气泡形状与曳力系数等进行研究。气泡的产生是通过将特定体积的气泡存放在倒置的球帽杯中,然后释放到静水中。气泡的运动特性通过高速摄像仪捕捉,气泡相关运动参数通过数字图像处理程序得到。实验得到不同尺寸气泡在静水中上升的特性,并将实验结果与现有的曳力模型进行比较,表明Tomiyama等关系式对于曳力以及气泡最终上升的预测比ishii-Chawa模型好,较大气泡的形状具有一定的相似性。实验结果对存在较大气泡的两相流动特性以及相间交换特性有重要意义。

关键词：球帽型气泡运动特性曳力

The Role of Oxidative Stress from Mitochondria on Aging

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The Role of Oxidative Stress from Mitochondria on Aging

The 8th Asia/Oceania Regional Congress of Gerontology and Geriatrics

作者： Naoaki ishii Department of Molecular Life Science Tokai University School of Medicine IseharaKanagawa 259-1193Japan

A mutation in a subunit,cytochrome b large subunit(***:CYT-1;mouse and human:SDHC),of complex Ⅱ in electron transport system,results in increasing O- production and therefore lead to premature aging in *** patients with an inherited propensity for vascularized head and neck tumors(i.e., paragangliomas)have been found to have one of several mutations in this gene.

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Minimizing Mass Subject to Displacement and Restriction to Design Space in Shape Optimization

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Minimizing Mass Subject to Displacement and Restriction to D...

The First China-Japan-Korea Joint Symposium on Optimization of Structural and Mechanical Systems

作者： Keizo ishii Quint Corporation 1-14-1 Fuchu-choFuchu-shiTokyo183-0055Japan

＜正＞In this paper, we discuss two problems in shape optimization design based on the traction method. 1) An approach that minimizes mass subject to displacement, an inverse problem of min-max problem, is proposed based on the traction method. To avoid impossibility of differentiation of local measure of displacement, local constraint condition is transferred to global integral one using Kreisselmeier-Steinhauser function. Further, the multiple loading problem is also able to transferred to a single loading problem. 2) A numerical approach to control the amount of domain variation within an admissible design space is proposed through the introduction of nodal stiffness element to the speed analysis of traction method. In this method, the domain variation is controlled by changing the nodal stiffness according to a function relationship between the variation amount and the nodal stiffness which is established in the paper. Finally, the numerical results of 2D and 3D examples show the effectiveness and practical utility of the proposed approaches for shape optimization problem.

关键词： min-max problem shape optimization domain variation nodal stiffness element

Challenges in Work-Family Balance and Support Needs of Japanese Parents with Nursery School-Aged Children

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Health 2023年第6期15卷 622-639页

作者： Yuko Shimoda Miyuki ishii Yuichi Hori Faculty of Nursing Kyoto Tachibana University Kyoto Japan College of Nursing Art and Science University of Hyogo Akashi Japan Graduate School of Health Sciences Kobe University Kobe Japan

We aimed to identify the challenges parents face raising preschool-aged children when trying to maintain a good work-family balance. We also highlight how public health nurses can support the community in this regard. Seven Japanese parents volunteered to participate, and individual in-depth interviews were conducted from May to October 2021. We analyzed the recorded interview data using qualitative descriptive methods. Three main themes concerning work-family balance challenges were extracted: 1) conflicts between parents’ childcare and work roles, 2) issues related to institutions and social systems, and 3) a lack of informal support. Factors contributing to the difficulties were a lack of time to spend with their children;an imbalance in the division of housework and childcare roles between married couples;the employment environment in Japan that makes it difficult to pursue a career while raising children;a lack of childcare services, including childcare for sick children;inadequate consultation systems;and an aging grandparents’ generation owing to late marriages. To solve this problem, we suggest that in addition to establishing a reliable system for providing childcare, local public health nurses should work with childcare workers to create an environment in which parents feel comfortable discussing work-family balance, considering the time constraints of parents during the childrearing period, and use nursery schools as a place for parent-child support.

关键词： Childrearing Parent Public Health Nurse Work-Family Balance

Numerical Study of Temperature Development of Slurry of Al-Si Alloy in Double-Axis-Electromagnetic Stirrer

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Journal of Iron and Steel Research International 2012年第S1期19卷 269-272页

作者： UENO Kazuyuki HOJO Keisuke ishii Hajimu SHIMASAKI Shin-ichi TANIGUCHI Shoji Graduate School of Engineering Tohoku University Graduate School of Environmental Studies Tohoku University

Flow and temperature fields of slurry of A1-Si alloy in the process of cup-cast method is numerically simulated. The simulation results agree with the experiment by Shimasaki et *** an estimated value of the overall h... 详细信息

关键词： electromagnetic stirrer numerical simulation semi-solid slurry cup-cast method

Formation of Gel-Like Shear-Induced Structure with Dosing of Dilute Surfactant Solution and Its Effect on Turbulent Channel Flow

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Open Journal of Fluid Dynamics 2022年第3期12卷 249-262页

作者： Shumpei Hara Kazuki ishii Yasuo Kawaguchi Department of Mechanical Engineering Doshisha University Kyoto Japan Department of Mechanical Engineering Tokyo University of Science Chiba Japan

A shear-induced structure (SIS) is formed under appropriate concentration and shear conditions in a surfactant micellar solution. In this study, we performed experiments of surfactant solution dosing in a fully developed two-dimensional turbulent channel flow from a sintered metallic wire mesh plate attached to a side wall. We investigated the behavior of the solution under the elongation during its passing through the wire mesh and under the strong shear due to the channel flow. It was confirmed that the dosed solution containing a laser dye was visualized by a laser sheet, and the accumulated gel from the wire mesh formed a layer and developed with time. Consequently, on dosing the dilute surfactant solution from the wire mesh, a gel-like SIS layer was formed, which majorly covered the wire mesh plate. The gel-like SIS layer on the wire mesh plate acted as a sticky solid and restricted the flow in the channel. This layer continued to grow while dosing, owing to which the pressure drop of the channel flow significantly increased. The gel-like SIS layer grew rapidly even in the turbulent flow and reached the equilibrium thickness. After the termination of the dosing, the gel layer collapsed gradually. In addition, the thickness of the gel-like SIS layer (indicating the strength indirectly) strongly depended on the surfactant concentration and the elongation rate in the wire mesh.

关键词： Turbulent Channel Flow Viscoelastic Fluid Gelation Scalar Transfer PIV/PLIF

Cell sheet technology for regeneration of esophageal mucosa

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World Journal of Gastroenterology 2012年第37期18卷 5145-5150页

作者： Ryo Takagi Masayuki Yamato Nobuo Kanai Daisuke Murakami Makoto Kondo Takaaki ishii Takeshi Ohki Hideo Namiki Masakazu Yamamoto Teruo Okano Institute of Advanced Biomedical Engineering and Science Tokyo Women's Medical University Department of Surgery Institute of GastroenterologyTokyo Women's Medical University Graduate School of Science and Engineering Waseda University

The progress of tissue-engineering technology has realized development of new therapies to treat various disorders by using cultured cells. Cell-and tissue-based therapies have been successfully applied to human patients, and several tissue-engineered products have been approved by the regulatory agencies and are commercially available. In the review article, we describe our experience of development and clinical application of cell sheet-based regenerative *** mucosal resection (EMR) and endoscopic submucosal dissection (ESD) have been shown to be useful for removal of gastrointestinal neoplasms with less invasiveness compared with open surgery, especially in esophageal surgery. However, postoperative inflammation and stenosis are major complications observed after intensive mucosal resection. Therefore, we have developed novel regenerative medicine to prevent such complications and promote wound healing of esophageal mucosa after EMR or ESD. Transplantable oral mucosal epithelial cell sheets were fabricated from patients' own oral mucosa. Immediately after EMR or ESD, fabricated autologous cell sheets were endoscopically transplanted to the ulcer sites. We performed a preclinical study with a canine model. In human clinical settings, cell culture and cell sheet fabrication were performed in clean rooms according to good manufacturing practice guidelines, and pharmaceutical drugs were used as supplements to culture medium in place of research regents used in animal study. We believe that cell-based regenerative medicine would be useful to improve quality of life of patients after EMR or ESD.

关键词： Cell sheet Endoscopic resection Esophagealstenosis Oral mucosa Good manufacturing practice

Twenty-four hour intra-arterial infusion of 5-fluorouracil,cisplatin,and leucovorin is more effective than 6-hour infusion for advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第2期13卷 280-284页

作者： Hidenari Nagai Masahiro Kanayama Katsuya Higami Kouichi Momiyama Akiko Ikoma Naoki Okano Katsuhiko Matsumaru Manabu Watanabe Koji ishii Yasukiyo Sumino Kazumasa Miki Division of Gastroenterology and Hepatology Toho University Medical Center Omori Hospital 6-11-1 Omorinishi Ota-ku Tokyo 143-8541 Japan

AIM. To evaluate the time dependence of intra-arterial 5-fluorouracil （5-FU） therapy for advanced hepatocellular carcinoma （aHCC）. METHODS： Thirty-seven adult Japanese patients who had aHCC and liver cirrhosis were treated with combined intra-arterial 5-FU, cisplatin （CDDP）, and leucovorin （LV）. The Japan Integrated Staging score （JIS score） of each patient was 3 or more. The patients were divided into two groups, alter which the 15 patients in group S were treated with 6-h infusion chemotherapy （LV at 12 mg/h, CDDP at 10 mg/h, and 5-FU at 250 mg/m^2 per 4 h） and the 22 patients in group L were treated with 24-h infusion chemotherapy （LV at 12 mg/h, CDDP at 10 mg/h, and 5-FU at 250 mg/m^2 per 22 h）. Continuous infusion chemotherapy was performed v/a the proper hepatic artery every 5 d for 4 wk using an implanted drug reservoir. RESULTS： The percentages of patients with a partial response after 4 wk of chemotherapy were 6.7% in group S and 31.8% in group L. The survival of group L was significantly better than that of group S, with the median survival time being 496 d in group L and 226 d in group S （P 〈 0.05）. CONCLUSION： Continuous 24-h intra-arterial infusion is more effective for aHCC and can markedly prolong survival time as compared to 6-h infusion.

关键词： 5-fluorouracil Cisplatin Advanced hepatocellular carcinoma Liver cirrhosis Intra-arterial chemotherapy