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A Multipathogen Bile Sample-based PCR Assay Can Guide Empirical Antimicrobial Strategies in Cholestatic Liver Diseases

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 788-795页

作者： Michael Jahn Mustafa KÖzçürümez Sebastian Dolff Hana Rohn Dominik Heider Alexander Dechêne Ali Canbay Peter M.Rath Antonios Katsounas Department of nephrology University Hospital EssenUniversity of Duisburg-EssenEssenGermany Department of Medicine Universitätsklinikum Knappschaftskrankenhaus BochumRuhr-University BochumBochumGermany Department of Infectious Diseases University Hospital EssenUniversity of Duisburg-EssenEssenGermany Department of Mathematics and Computer Science University of MarburgMarburgGermany Department for Internal Medicine Nuremberg Hospital NorthParacelsus Private Medical University NurembergNurembergGermany Institute of Medical Microbiology University Hospital EssenUniversity of Duisburg-EssenEssenGermany

Background and objectives:Polymerase chain reaction(PCR)techniques provide rapid detection of *** pilot study evaluated the diagnostic utility and clinical impact of multiplex real-time PCR(mRT-PCR,SeptiFast)*** microbial culture(CMC)in bile samples of patients with chronic cholestatic liver diseases(cCLDs),endoscopic retrograde cholangio-pancreatography(ERCP),and peri-interventional-antimicrobial-prophylaxis(pAP).Methods:We prospectively collected bile samples from 26 patients for microbiological analysis by CMC and *** of the results of both methods was determined by Krippendorff's alpha(α)for inter-rater reliability and the Jaccard index of ***:mRT-PCR_(bile)and CMC_(bile)results were concordant for only Candida albicans(α=0.8406;Jaccard index=0.8181).mRT-PCR_(bile)detected pathogens in 8/8 cases(100%),CMC_(bile)in 7/8(87.5%),and CMCblood in 5/8(62.5%)with clinical signs of ***_(bile),CMC_(bile),and CMCblood had identical detection results in 3/8(37.5%)with clinical signs of infection(two Klebsiella *** one Enterococcus faecium).The total pathogen count was significantly higher with mRT-PCR_(bile)than with CMC_(bile)(62 vs.31;χ^(2)=30.031,pnefit infection management in patients with cholestatic *** of mRT-PCR in a bile sample-based diagnostic routine can support more rapid and targeted use of antimicrobial agents in cCLD-patients undergoing ERCP and reduce the rate/length of unnecessary administration of broad-spectrum antibiotics.

关键词： ERCP PCR Antibiotic prophylaxis Cholestasis Cholangitis

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Dental pulp stem cells as a promising model to study imprinting diseases

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International Journal of Oral Science 2022年第2期14卷 174-181页

作者： Eloïse Giabicani Aurélie Pham Céline Sélénou Marie-Laure Sobrier Caroline Andrique Julie Lesieur Agnès Linglart Anne Poliard Catherine Chaussain Irène netchine Universitéde Paris URP2496Laboratoire Pathologiesimagerie et biothérapies oro-facialesMontrougeFrance INSERM UMRS_938 Centre de Recherche Saint AntoineParisFrance APHP Hôpital de BicêtreEndocrinologie et Diabétologie de l’EnfantCentre de Référence des Maladies Rares du Métabolisme du Calcium et du PhosphateLe Kremlin-BicêtreFrance APHP Hôpital BretonneauCentre de Référence des Maladies Rares du Métabolisme du Calcium et du Phosphate et FHU DDS-netParisFrance Sorbonne Université INSERMUMRS_938APHPHôpital Armand TrousseauExplorations Fonctionnelles EndocriniennesParisFrance

Parental imprinting is an epigenetic process leading to monoallelic expression of certain genes depending on their parental *** diseases are characterized by growth and metabolic issues starting from birth to *** are mainly due to methylation defects in imprinting control region that drive the abnormal expression of imprinted *** currently lack relevant animal or cellular models to unravel the pathophysiology of growth failure in these *** aimed to characterize the methylation of imprinting regions in dental pulp stem cells and during their differentiation in osteogenic cells(involved in growth regulation)to assess the interest of this cells in modeling imprinting *** collected dental pulp stem cells from five controls and four patients(three with Silver-Russell syndrome and one with Beckwith-Wiedemann syndrome).Methylation analysis of imprinting control regions involved in these syndromes showed a normal profile in controls and the imprinting defect in *** results were maintained in dental pulp stem cells cultured under osteogenic ***,we confirmed the same pattern in six other loci involved in imprinting diseases in *** also confirmed monoallelic expression of H19(an imprinted gene)in controls and its biallelic expression in one *** imprinting control regions methylation analysis shows the strong potential of dental pulp stem cells in modeling imprinting diseases,in which imprinting regions are preserved in culture and during osteogenic *** will allow to perform in vitro functional and therapeutic tests in cells derived from dental pulp stem cells and generate other cell-types.

关键词： pulp maintained fir

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Stochastic Model for Multiple Classes and Subclasses Simple Documents Processing

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Intelligent Information Management 2021年第2期13卷 124-140页

作者： Pierre Moukeli Mbindzoukou Arsène Roland Moukoukou Marius Massala Laboratoire Africain d’Informatique et de Mathématique Appliquée (LAIMA) Institut Africain d’Informatique Libreville Gabon Département Informatique Institut Supérieur de Technologie (IST) Libreville Gabon Département Mathématique Université des Sciences et Techniques de MASUKU Franceville Gabon Département de Géographie Université Omar Bongo Libreville Gabon

The issue of document management has been raised for a long time, especially with the appearance of office automation in the 1980s, which led to dematerialization and Electronic Document Management (EDM). In the same period, workflow management has experienced significant development, but has become more focused on the industry. However, it seems to us that document workflows have not had the same interest for the scientific community. But nowadays, the emergence and supremacy of the Internet in electronic exchanges are leading to a massive dematerialization of documents;which requires a conceptual reconsideration of the organizational framework for the processing of said documents in both public and private administrations. This problem seems open to us and deserves the interest of the scientific community. Indeed, EDM has mainly focused on the storage (referencing) and circulation of documents (traceability). It paid little attention to the overall behavior of the system in processing documents. The purpose of our researches is to model document processing systems. In the previous works, we proposed a general model and its specialization in the case of small documents (any document processed by a single person at a time during its processing life cycle), which represent 70% of documents processed by administrations, according to our study. In this contribution, we extend the model for processing small documents to the case where they are managed in a system comprising document classes organized in subclasses;which is the case for most administrations. We have thus observed that this model is a Markovian ML×K/ML×K/1 queues network. We have analyzed the constraints of this model and deduced certain characteristics and metrics. In fine, the ultimate objective of our work is to design a document workflow management system, integrating a componen

关键词： Document Processing Workflow Hierarchic Chart Counting Processes Stochastic Models Waiting Lines Markov Processes Priority Queues Multiple Class and Subclass Queues

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Genome-wide association mapping in a sweet cherry germplasm collection(Prunus avium L.)reveals candidate genes for fruit quality traits

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Horticulture Research 2023年第10期10卷 227-249页

作者： Armel S.L.Donkpegan Anthony Bernard Teresa Barreneche José Quero-García Hélène Bonnet Mathieu Fouché Loïck Le Dantec Bénédicte Wenden Elisabeth Dirlewanger UMR BFP INRAEUniversity of Bordeaux71 Avenue Edouard BourlauxF-33882 Villenave d’OrnonFrance UMR BOA SYSAAFCentre INRAE Val de Loire37380 NouzillyFrance

In sweet cherry(Prunus avium L.),large variability exists for various traits related to fruit *** is a need to discover the genetic architecture of these traits in order to enhance the efficiency of breeding strategies for consumer and producer *** this objective,a germplasm collection consisting of 116 sweet cherry accessions was evaluated for 23 agronomic fruit quality traits over 2-6 years,and characterized using a genotyping-by-sequencing *** SNP coverage collected was used to conduct a genome-wide association study using two multilocus models and three reference *** identified numerous SNP-trait associations for global fruit size(weight,width,and thickness),fruit cracking,fruit firmness,and stone size,and we pinpointed several candidate genes involved in phytohormone,calcium,and cell wall ***,we conducted a precise literature review focusing on the genetic architecture of fruit quality traits in sweet cherry to compare our results with potential colocalizations of marker-trait *** study brings new knowledge of the genetic control of important agronomic traits related to fruit quality,and to the development of marker-assisted selection strategies targeted towards the facilitation of breeding efforts.

关键词： breeding germplasm traits

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Evaluation of Quantitative and Qualitative Losses on Millet and White Rice in Storage Grains Caused by <i>Corcyra cephalonica</i>(Stainton) in Senegal

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Advances in Entomology 2021年第1期9卷 30-43页

作者： Mamadou LO Toffène Diome Cheikh Thiaw Mbacké Sembene Genetics and Population Management Team Department of Animal Biology Faculty of Science and Technology Cheikh Anta Diop University Dakar Senegal UFR Sciences and Techniques in Agronomy and Vegetable Production (STAPV) University of Sine Saloum El-Hadji Ibrahima Niass (USSEIN) Sing-Sing Kaolack Senegal

In Senegal, millet (Pennisetum glaucum (L.) R. Br.) and rice (Oryza sativa (L., 1753)) are the most widely consumed foods. This study is part of improving the conservation of these two cereals in Senegal by assessing the quantitative and qualitative losses caused by a lepidopteran, Corcyra cephalonica (Stainton) subservient to millet and rice stocks. For this purpose, samples of millet and rice from an area of the center of the groundnut basin (Diourbel) were collected, sterilized in the cold and infected with C. cephalonica eggs from the same locality. These infected samples were tracked during a development period of two successive generations. The samples were scrutinized before being infected and after a larval cycle of codling moth. The results showed that rice grains are richer in water (10.75% ± 0.4249%, on average) than millet (9.40% ± 0.3944%, on average) and the difference in rank is very significant (p-value = 0.0001 Moreover, the attack percentage on millet grains is three times higher (36.31% ± 25.18%) than rice (12.95% ± 6.69%) with a non-significant difference (p-value =

关键词： Millet Rice C. cephalonica Attack Percentage Loss Percentage

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Challenges for cysteamine stabilization,quantification,and biological effects improvement

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Journal of Pharmaceutical Analysis 2020年第6期10卷 499-516页

作者： Carla Atallah Catherine Charcosset Helene Greige-Gerges Bioactive Molecules Research Laboratory Doctoral School of Sciences and TechnologiesFaculty of SciencesLebanese UniversityLebanon Laboratory of Automatic Control Chemical and Pharmaceutical EngineeringClaude Bernard Lyon 1 UniversityFrance

The aminothiol cysteamine,derived from coenzyme A degradation in mammalian cells,presents several biological ***,the bitter taste and sickening odor,chemical instability,hygroscopicity,and poor pharmacokinetic profile of cysteamine limit its *** use of encapsulation systems is a good methodology to overcome these undesirable properties and improve the pharmacokinetic behavior of ***,the conjugation of cysteamine to the surface of nanoparticles is generally proposed to improve the intra-oral delivery of cyclodextrin-drug inclusion complexes,as well as to enhance the colorimetric detection of compounds by a gold nanoparticle aggregation *** the other hand,the detection and quantification of cysteamine is a challenging mission due to the lack of a chromophore in its structure and its susceptibility to oxidation before or during the *** agents are therefore applied for the quantification of this *** our knowledge,the derivatization techniques and the encapsulation systems used for cysteamine delivery were not reviewed ***,this review aims to compile all the data on these methods as well as to provide an overview of the various biological applications of cysteamine focusing on its skin application.

关键词： Cysteamine Detection Encapsulation Skin Stability

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Regular Elements of B_X (D) Defined by the Class ∑₁(X,10)-Ⅱ

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Applied Mathematics 2016年第9期7卷 894-907页

作者： Yasha Diasamidze Nino Tsinaridze neşet Aydn Ali Erdoğan Shota Rustavelli University Batumi Georgia Ç anakkale Onsekiz Mart University &Ccedil anakkale Turkey Hacettepe University Ankara Turkey

This part of the paper is the continuotion of paper “Regular Elements of BX (D) Defined by the Class ∑1(X,10)-Ⅰ”.

关键词： Semilattice Semigroup Binary Relation

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Experimental Investigation of the Stability of the Performance Characteristics of a Photovoltaic Module in the Face of Environmental and Meteorological Factors

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Open Journal of Applied Sciences 2024年第2期14卷 589-608页

作者： Adingra Paul Arsène Kouassi Siaka Touré Diakaridja Traoré Laboratoire des Sciences de la Matière de l’Environnement et de l’Energie Solaire (LASMES) Unité de Formation et de Recherche des Sciences des Structures de la Matière et Technologie (UFR-SSMT) Université Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire

The explosive technological improvement of photovoltaic systems as well as the necessity of populations to come to less expensive energy sources, that have led to an implosion at the level of solar panel manufacturers. This causes a large flow of these equipments to developing countries where the need is high, without any quality control. That conducted an experimental investigation on the performance characteristics of a 250 wp monocrystalline silicon photovoltaic module in other to check the verification and quality control. Most of these PV panels which often have missing informations are manufactured and tested in places that are inadequate for our environmental and meteorological conditions. Also, their influences on the stability of internal parameters were evaluated in order to optimize their performance. The results obtained at maximum illumination (1000 w/m2) confirmed those produced by the manufacturer. The analysis of these characteristics showed that the illumination and the temperature (meteorological factors) influenced at most the stability of the internal characteristics of the module in the sense that the maximum power increased very rapidly beyond 750 w/m2 but a degradation of performance was accentuated for a temperature of the solar cells exceeding 50°C. The degradation coefficients were evaluated at -0.0864 V/°C for the voltage and at -1.6248 w/°C for the power. The 10° inclination angle of the solar panel proved to be ideal for optimizing overall efficiency in practical situations.

关键词： Renewables Energies Instruments Internal Parameters of Photovoltaic Panel Monocrystalline Photovoltaic Panel Solar Energy Production Energy Intermittence

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A Convective Thin Layer Drying Model with Shrinkage for Kent Mango Slices

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Advances in Chemical Engineering and Science 2016年第1期6卷 20-28页

作者： Alfa Oumar Dissa Hélène Desmorieux Jean Koulidiati Laboratoire de Physique et de Chimie de l’Environnement (LPCE) Unité de Formation et de Recherche en Sciences Exactes et Appliquée (UFR/SEA) Université de Ouagadougou Ouagadougou Burkina Faso Laboratoire d’Automatisme et de Génie des Procédés (LAGEP) UCBL1-CNRS UMR 5007-CPE Lyon Université Claude Bernard Lyon 1 Lyon France

In this work, a model of convective drying of mango slices was developed and validated by experiments. This model was established by considering slices shrinkage in the energy and the mass balances during the thin layer drying. The drying kinetics and the temperature curves of the product were simulated using the model at various drying temperatures. The simulated curves were then compared to the experimental curves obtained using a convective dryer controlled in temperature and moisture. The results showed that the drying curves were suitably fitted by the thin layer drying model with a correlation coefficient r2 = 0.997. Thus, taking shrinkage into account, it is possible to predict more effectively the thin layer drying kinetics of mango slices. This study therefore contributed to the mango drying modelling and to the mango dryer setting.

关键词： Convective Drying Mango Modelling Thin Layer Kinetic

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Colorectal cancer fecal screening test completion after age 74,sources and outcomes in French program

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World Journal of Gastrointestinal Oncology 2019年第9期11卷 729-740页

作者： Akoi Koivogui Christian Balamou Raushan Rymzhanova Tu Letrung Hamou Ait Hadad Zahida Brixi Stéphane Cornelis Hélène Delattre-Massy Thomas Aparicio Robert Benamouzig Comité Départemental des Cancers(CDC-93) CRCDC-IDFSite de Seine-Saint-DenisBondy 93146France Office De Lutte contre les Cancers(ODLC-01) CRCDC-AURASite de l’AinBourg-en-Bresse 01000France Association pour le Depistage des Cancers(ADECA-FC) CRCDC-Bourgogne-Franche-ComteSite de Franche-ComteBesancon 25000France Prévention and Santé en Val-d’Oise(PSVO) Immeuble du CentaureCRCDCIDFSite de Val-d’OiseCergy Saint Christophe 95800France Association pour le Dépistage des Maladies Cancéreuses(ADMC91) CRCDC-IDFSite de l’EsonneCMC De BlignyBriis-sous-Forges 91640France Association de dépistage organisédes cancers(ADOC94) CRCDC-IDFSite de Val-de-MarneJoinville-le-Pont 94340France Association Icaunaise de Dépistage du Cancer(AIDEC) CRCDC-Bourgogne-Franche-ComtéSite de l’Yonne Saint-Georges-sur-Baulche 89000France Association pour le Dépistage Organisédes cancers(ADOC92) CRCDC-IDFSite des Hauts-de-SeineNanterre 92000France Service d'Hepato Gastro Enterologie Hopital Avicenne(AP-HP)Bobigny 93000France

BACKGROUND Elderly patients aged at least 75 years old(Elderly_75),represent 45%of colorectal cancer(CRC)*** others,the French Colorectal Cancer Screening Program(CRCSP)does not include Elderly_*** date,there is little evidence to justify stopping screening at 74 years of *** To describe CRC fecal screening test completion after age 74,source(CRCSP/Provider ordered)and outcomes of these *** The study concerned 18704 Elderly_75 residing in eleven French districts(Ain,Doubs,Essonne,Haute-Saone,Hauts-de-Seine,Jura,Seine-Saint-Denis,Territoire-de-Belfort,Val-de-Marne,Val-d'Oise,Yonne),having performed a CRC screening test between January 2008 and December *** tests performed in a circumstance of delayed response to a solicitation(DRS)from the local cancer screening managing center(Managing-Center)were distinguished from the tests non-solicited by the Managing-Center,performed after a recommendation by a General Practitioner(GP)or other provider ordered(RGP).DRS was any test realized by an Elderly_75 following an initial invitation from the ManagingCenter with a maximum 24 mo after this *** Non-DRS test was considered *** outcomes of these tests were described according to the circumstances of test *** Of 18995 screening-tests were performed at ages:75(83.5%),76-80(13.4%)and>80(3.1%)years ***_75 performed the screening test in a circumstance of DRS(71.9%)or RGP(28.1%).The proportion of the tests that could not be analyzed and not restarted was 13.2%.For these unanalyzed tests,the reason was age-related in 78.0%of cases,related to the laboratory's refusal to analyze the test of people aged≥*** colonoscopy completion rate was 81.3%.For those575 people with reported colonoscopy,no complication was listed.18.0%of the366 Elderly_75 with lesions had no anteriority in the *** neoplasia(124 Low-risk-polyps,159 High-risk-polyps,13 Unspecified-polyps and 70 CRCs)detection rate was 19.3/1000 Elderly_7

关键词： Colorectal cancer Fecal screening test Participation rate Colonoscopy completion rate Elderly

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