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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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3D tomographic analysis of equatorial plasma bubble using GnSS-TEC data from Indonesian GnSS network

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Earth and Planetary Physics 2025年第1期9卷 127-136页

作者： Ihsan naufal Muafiry Prayitno Abadi Teguh n.Pratama Dyah R.Martiningrum Sri Ekawati Yuandhika GWismaya Febrylian FChabibi Gatot HPramono Research Center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia Dept.of Physics Faculty of ScienceUniversiti Teknologi MalaysiaJohor BahruMalaysia Dept.Earth Planet Sci. Hokkaido UniversitySapporoJapan School of Electrical Engineering Telkom UniversityBandungIndonesia

Equatorial Plasma Bubbles(EPBs)are ionospheric irregularities that take place near the magnetic *** most commonly occur after sunset during the equinox months,although they can also be observed during other *** phenomenon significantly disrupts radio wave signals essential to communication and navigation *** national network of Global navigation Satellite System(GnSS)receivers in Indonesia(>30°longitudinal range)provides an opportunity for detailed EPB *** explore this,we conducted preliminary 3D tomography of total electron content(TEC)data captured by GnSS receivers following a geomagnetic storm on December 3,2023,when at least four EPB clusters occurred in the Southeast Asian *** and extracted TEC depletion with a 120-minute running average were then used as inputs for a 3D tomography *** 2D spatial distribution consistently captured the four EPB clusters over *** tomography results were validated through a classical checkerboard test and comparisons with other ionospheric data sources,such as the Global Ionospheric Map(GIM)and International Reference Ionosphere(IRI)*** of the results demonstrates the capability of the Indonesian GnSS network to measure peak ionospheric *** findings highlight the potential for future three-dimensional research of plasma bubbles in low-latitude regions using existing GnSS networks,with extensive longitudinal coverage.

关键词： EPB Indonesian GnSS network 3D tomography

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Experimental study on microstructural and corrosion behaviors of friction stir processed steel with CoCrFeCuTi HEA reinforcement and effect of annealing

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Science China Technological Sciences 2025年第1期 233-250页

作者： S.Aravind KRISHnA n.RADHIKA Alokesh PRAMAnIK n.JEYAPRAKASH Department of Mechanical Engineering Amrita School of EngineeringAmrita Vishwa Vidyapeetham School of Civil and Mechanical Engineering Curtin University School of Mechanical and Electrical Engineering China University of Mining and Technology

The ability to perform against extreme corrosion environments in stainless steel depreciates under challenging conditions in industrial applications. This can be resolved by employing surface modification techniques to modify the surface with the required characteristics. The present study investigates the outcomes of friction stir processing of SS304 with CoCrFeCuTi high entropy alloy(HEA) as reinforcement and the property enhancements post-annealing. The synthesized CoCrFeCuTi HEA exhibited irregular fragments with 17 μm mean particle size and body centred cubic(BCC) phase. The microstructure of the processed surface revealed ultra-refined grains with a uniform distribution of HEA filler. The microstructures of the samples annealed at 400℃, 550℃, 700℃ and 850℃ for 2 h also showed significant grain growth and grain refinements. The processed sample with HEA reinforcement annealed at 700℃ exhibited enhanced microhardness and tensile strength by 63% and 0.88 times than that of the processed sample with HEA pre-annealing. The subsequent electrochemical corrosion test displayed better corrosion resistance for the HEA-processed and annealed sample. Hot corrosion tests at 900℃ showcased excellent resistance for the HEA processed and annealed samples by 14.92%, 12.75%, and 14.83% against the samples pre-annealed under three different salt mixtures, and the corroded surface was analyzed.

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Green ionic metal-organic frameworks as nanocatalysts for CO_(2)fixation

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nano Research 2025年第1期18卷 260-269页

作者： nuria Martín Miguel Maireles-Porcar Julián Sánchez Velandia Belén Altava Francisco G.Cirujano Eduardo García-Verdugo Departamento de Química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(H_(2)dot)can be rapidly obtained under room temperature and aqueous conditions using either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TBAOH)as the base allows the green synthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR),scanning electron microscopy(SEM),thermo gravimetric analysis(TGA),H-nuclear magnetic resonance(nMR),elemental analysis,and X-ray photoelectron spectroscopy(XPS),and employed in the pressure,solvent,and additive-free CO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TOns of the confined tetrabutylammonium bromide(TBABr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis CO_(2)conversion

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Influence of temperature on tunneling-enhanced recombination in Si based p–i–n photodiodes

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Journal of Semiconductors 2014年第8期35卷 10-14页

作者： P.Dalapati n.B.Manik A.n.Basu Condensed Matter Physics Research Center Department of Physics Jadavpur University

We investigate the dominant dark current transport mechanism in Si based p-i-n photodiodes, namely, BPW 21R, SFH 205FA and BPX 61 photodiodes in the temperature range of 350 to 139 K. The forward current- voltage characteristics of these photodiodes are explained via the tunneling enhanced recombination model, which gives a quantitative description of the electronic mechanism in the p-i-n junction photodiodes. The observed tem- perature dependence of the saturation current and the diode ideality factor of these devices agree well with theo- retical predictions; the analysis also indicates the importance of doping for enhancement of tunneling. The present study will be helpful in applying the devices at low temperature ambience.

关键词： photodiode low temperature ideality factor reverse saturation current tunneling energy

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A new Method of Synthesis of Azo Schiff Base Ligands with Azo and Azomethine Donors： Synthesis of n-4-Methoxybenzylidene-2-（3-hydroxyphenylazo）-5-hydroxyaniline and Its nickel（Ⅱ） Complex

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Chinese Journal of Chemistry 2007年第6期25卷 869-871页

作者： OFORKA, n. C. MKPEnIE, V. n. Department of Pure and Industrial Chemistry University of Port Harcourt P. M. B. 5323 Port Harcourt Nigeria

A new method for the synthesis of azo Schiff an base ligand in which the azo and azomethine groups are coordination sites was developed through a Schiff base precursor. The precursor, n-4-methoxybenzylidene-3-hydroxyphenylamine （SB） derived from 3-aminophenol was regioselectively coupled with a diazonium ion para to the hydroxyl group of the amine component of the Schiff base. The para selectivity was controlled by the directing effect of the hydroxyl group. The ligand and its nickel（Ⅱ） complex were characterized by elemental analyses, IR and UV-Vis spectroscopy. The analytical and spectral data supported the mononuclear formulation of the complex with metal to ligand ratio （M ： L = 1 ： 2） and suggested a square planar geometry for the complex.

关键词： synthesis azo compound Schiff base ligand azo and azomethine donor

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Langmuir-Schaefer Film Investigation and Density Functional Theory Band Gap Calculations of Calix[n]arene-Para-Aminobenzoic Acid for Drug nanosensor Application

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1311-1318页

作者： WOnG Yeong Yi F L Supian A Radzwan M Musa n F n Abd Karim Department of Physics Sultan Idris Education UniversityTanjong Malim 35900Malaysia Department of Chemistry Sultan Idris Education UniversityTanjong Malim 35900Malaysia

Calix[n]arenes was utilized to detect PABA,the primary sunscreen *** study investigates the interaction of calix[4]arene(C4),calix[6]arene(C6),and PABA using the Langmuir method and first-principle density functional theory(DFT).Using the Langmuir-Schaefer(LS)technique,an ultrathin film composed of calix[n]arenes and their complexes with PABA was deposited on various *** on the Langmuir study,the PABA molecule was bonded to the lower rims of both C4 and C6 with the host-guest ratio of 1:*** of the LS films formed were then characterized by ultravioletvisible spectroscopy(UV-Vis),Fourier-transform infrared spectroscopy(FTIR)and carbon,hydrogen,nitrogen,sulfur elemental analyzer(CHnS).The band gap reduction obtained in the DFT study denotes the charge transfer interaction with promising reactivity between the calix[n]arenes and *** sensing of PABA by C4 and C6 is successful based on the formation of bonding between them due to the hosts’effective trapping *** outcomes of this study could be applied to drug delivery systems for future pharmaceutical and medical applications.

关键词： calix[n]arenes band gap density functional theory Langmuir-Schaefer PABA sensor

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Interactive Effect of GA_3 ,n and P Ameliorate Growth, Seed and Fibre Yield by Enhancing Photosynthetic Capacity and Carbonic Anhydrase Activity of Linseed: A Dual Purpose Crop

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Journal of Integrative Agriculture 2013年第7期12卷 1183-1194页

作者： Mohammad n Khan Firoz Mohammad Department of Biology Faculty of Science University of Tabuk Plant Physiology Section Department of Botany Aligarh Muslim University

Linseed （Linum usitatissimum L.） is an important dual-purpose, industrial crop. Its seeds are used for the extraction of oil and stem for fibres. However, the production of linseed is not going parallel with the increasing demand of its products. The present work was carried out with an aim to find out whether exogenous application of gibberellic acid （GA3） with or without graded levels of nitrogen （n） and phosphorus （P） could improve the performance of three linseed genotypes Parvati, Shekhar and Shubhra together with minimizing the costly fertilizer input and losses. Four combinations of n and P, viz., 0 mg n＋0 mg P kg-1 soil （n0P0）, n13.4 P4.46 , n26.8P8.94 and n40.2P13.4 were constituted. Half dose of each combination was applied basally at the time of sowing and remaining half dose was given at 40 d after sowing （DAS） as foliar spray along with 10-6 mol L-1 GA3 . Prior to sowing, the seeds of each linseed genotype were grouped in to two, one group of seeds was soaked in 0 mol L-1 GA3 （control） and the other group was soaked in 10-6 M GA3 solution, each for 8 hours. Treatments were comprised of （i） 0 mol L-1 GA3＋n0P0 （T0 , control）, （ii） 10-6 mol L-1 GA3 ＋ n13.4P4.46 （T1）, （iii） 10-6 mol L-1 GA 3 ＋n 26.8 P 8.94 （T2） and （iv） 10-6 mol L-1 GA3＋n40.2P13.4 （T3）. The crop performance was assessed in terms of growth, physiological and biochemical parameters at 60 and 75 DAS and yield attributes at harvest （175 DAS）. The results showed a parallel increase in most of the parameters with increasing levels of n and P. However, application of 10-6 mol L-1 GA3 in association with n26.8P8.94 proved best, it enhanced seed yield, oil yield and fibre yield by 83.3, 97.3 and 78.7%, respectively accompanied with increase in net photosynthetic rate, carbonic anhydrase activity and dry matter accumulation. Among the genotypes tested, Shubhra performed best, while Parvati the least for most of the parameters studied. Thus, combined application of 10-6 mol L-1 GA3 plus n26.8P8.94 pro

关键词： gibberellin photosynthesis crbonic anhydrase linseed

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EFFECT　OF　RARE　EARTH　ELEMEnT　Er　On　STREnGTHEnInG　OF　InTERFACE　OF　Ti（C，n）　BASED　CERMETS

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中国有色金属学会会刊：英文版 1996年第3期6卷 136-139页

作者： Liu, n Cui, K Hu, ZH AnHUI InST TECHnOL DEPT MAT SCI & ENGNHEFEI 230069PEOPLES R CHINA HUAZHOnG UnIV SCI & TECHnOL WUHAN 430074PEOPLES R CHINA

ＥＦＦＥＣＴＯＦＲＡＲＥＥＡＲＴＨＥＬＥＭＥＮＴＥｒＯＮＳＴＲＥＮＧＴＨＥＮＩＮＧＯＦＩＮＴＥＲＦＡＣＥＯＦＴｉ（Ｃ，Ｎ）ＢＡＳＥＤＣＥＲＭＥＴＳ￥ＬｉｕＮｉｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎ... 详细信息

ＥＦＦＥＣＴＯＦＲＡＲＥＥＡＲＴＨＥＬＥＭＥＮＴＥｒＯＮＳＴＲＥＮＧＴＨＥＮＩＮＧＯＦＩＮＴＥＲＦＡＣＥＯＦＴｉ（Ｃ，Ｎ）ＢＡＳＥＤＣＥＲＭＥＴＳ￥ＬｉｕＮｉｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇｉｎｅｅｒｉｎｇ，...

关键词： rare earth element Er Ti(C n) based cermets bending strength hardness

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