检索结果-南通市图书馆

Journal of Thermal Science 2013年第6期22卷 555-564页

作者： a.marsan I.Trébinjac S.Coste G.Leroy Laboratoire de Mécanique des Fluides et d'Acoustique UMR CNRS 5509 cole Centrale de Lyon Turbomeca Safran group

The temporal behaviour of a flow separation in the hub-suction side comer of a transonic diffuser is studied thanks to unsteady numerical simulations based on the phase-lagged approach. The validity of the numerical re- sults is confn＇med by comparison with experimental unsteady pressure measurements. An analysis of the instan- taneous skin-friction pattern and particles trajectories is presented. It highlights the topology of the separation and its temporal behaviour. The major result is that, despite of a highly time-dependent core flow, the separation is found to be a ＂fixed unsteady separation＂ characterized by a fixed location of the main saddle of the separation but an extent of the stall region modulated by the pressure waves induced by the impeller-diffuser interaction.

关键词： Corner Separation Radial Vaned Diffuser Centrifugal Compressor Surge

Breed and adaptive response modulate bovine peripheral blood cells＇ transcriptome

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2017年第2期8卷 335-350页

作者： Nataliya Poscic Tommaso Montanari Mariasilvia D’Andrea Danilo Licastro Fabio Pilla Paolo Ajmone-marsan Andrea Minuti Sandy Sgorlon Department of Agriculture FoodEnvironment and Animal Science(DI4A)University of Udinevia delle Scienze 20633100 UdineItaly Department ofAgricultural Environmental and Food SciencesUniversity of Molisevia F.De Sanctis snc86100 CampobassoItaly. CBM S.c.r.I SS 14-km 163.5 AREAScience Park34149 BasovizzaTSitaly. Institute of Zootechnics Catholic University of the Sacred Heartvia Emilia Parmense 8429133 PiacenzaItaly.

Background： Adaptive response includes a variety of physiological modifications to face changes in external or internal conditions and adapt to a new situation. The acute phase proteins（APPs） are reactants synthesized against environmental stimuli like stress, infection, ***： To delineate the differences in molecular constituents of adaptive response to the environment we performed the whole-blood transcriptome analysis in Italian Holstein（IH） and Italian Simmental（IS） breeds. For this, 663 IH and IS cows from six commercial farms were clustered according to the blood level of APPs. Ten extreme individuals（five APP＋ and APP-variants） from each farm were selected for the RNA-seq using the Illumina sequencing technology. Differentially expressed（DE） genes were analyzed using dynamic impact approach（DIA）and DAVID annotation clustering. Milk production data were statistically elaborated to assess the association of APP＋ and APP-gene expression patterns with variations in milk ***： The overall de novo assembly of cDNA sequence data generated 13,665 genes expressed in bovine blood cells. Comparative genomic analysis revealed 1,152 DE genes in the comparison of all APP＋ vs. all APP-variants; 531 and 217 DE genes specific for IH and IS comparison respectively. In all comparisons overexpressed genes were more represented than underexpressed ones. DAVID analysis revealed 369 DE genes across breeds, 173 and 73 DE genes in IH and IS comparison respectively. Among the most impacted pathways for both breeds were vitamin B6 metabolism, folate biosynthesis, nitrogen metabolism and linoleic acid ***： Both DIA and DAVID approaches produced a high number of significantly impacted genes and pathways with a narrow connection to adaptive response in cows with high level of blood APPs. A similar variation in gene expression and impacted pathways between APP＋ and APP-variants was found between two studied breeds. Such similarity was also c

关键词： Acute phase proteins Adaptive response Dynamic impact approach(DIA) Hypothalamic-pituitaryadrenal(HPA) axis RNA-Seq Stress response Transcriptomics

Transcriptome‑wide mapping of milk somatic cells upon subclinical mastitis infection in dairy cattle

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2023年第6期14卷 2630-2648页

作者： Vittoria Bisutti Nuria Mach Diana Giannuzzi Alice Vanzin Emanuele Capra Riccardo Negrini Maria Elena Gelain Alessio Cecchinato Paolo Ajmone‑marsan Sara Pegolo DAFNAE University of PadovaViale Dell’Universita 16LegnaroPD 35020Italy. IHAP Universite de ToulouseINRAEENVT23 Chemin Des CapellesToulouse 31300France. IBBA National Research CouncilVia EinsteinLodi 26900Italy. DIANA Universita Cattolica del Sacro CuoreVia E.Parmense 84Piacenza 29122Italy. BCA University of PadovaViale Dell’Universita 16LegnaroPD 35020Italy.

Background Subclinical intramammary infection(IMI)represents a significant problem in maintaining dairy cows’*** severity and extent depend on the interaction between the causative agent,environment,and *** investigate the molecular mechanisms behind the host immune response,we used RNA-Seq for the milk somatic cells(SC)transcriptome profiling in healthy cows(n=9),and cows naturally affected by subclinical IMI from Proto-theca spp.(n=11)and Streptococcus agalactiae(***;n=11).Data Integration Analysis for Biomarker discov-ery using Latent Components(DIABLO)was used to integrate transcriptomic data and host phenotypic traits related to milk composition,SC composition,and udder health to identify hub variables for subclinical IMI *** A total of 1,682 and 2,427 differentially expressed genes(DEGs)were identified when comparing Prototheca *** *** to healthy animals,***-specific pathway analyses evidenced that Proto-theca’s infection upregulated antigen processing and lymphocyte proliferation pathways while *** induced a reduction of energy-related pathways like the tricarboxylic acid cycle,and carbohydrate and lipid *** integrative analysis of commonly shared DEGs between the two pathogens(n=681)referred to the core-mastitis response genes,and phenotypic data evidenced a strong covariation between those genes and the flow cytometry immune cells(r2=0.72),followed by the udder health(r2=0.64)and milk quality parameters(r2=0.64).Variables with r≥0.90 were used to build a network in which the top 20 hub variables were identified with the Cytoscape cyto-hubba *** genes in common between DIABLO and cytohubba(n=10)were submitted to a ROC analysis which showed they had excellent predictive performances in terms of discriminating healthy and mastitis-affected animals(sensitivity>0.89,specificity>0.81,accuracy>0.87,and precision>0.69).Among these genes,CIITA could play a key role in re

关键词： Data integration Immune response Milk somatic cells RNA-sequencing Subclinical mastitis

在线全文

学校读者我要写书评

暂无评论

IPv6将迎来应用的雪崩浪潮

中国教育网络 2008年第5期 21-22页

作者： Carolyn Duffy marsan

在日本，所有的人都认为IPv4已经面临困境。日本的许多互联网服务供应商都在担心，如果他们还是紧抓住IPv4不放的话，其未来将何去何从。再过一年，他们就会把日本所有IPv4的地址分派完了。所以对他们来讲，时机真的已经到来了。——Kaz... 详细信息

在日本，所有的人都认为IPv4已经面临困境。日本的许多互联网服务供应商都在担心，如果他们还是紧抓住IPv4不放的话，其未来将何去何从。再过一年，他们就会把日本所有IPv4的地址分派完了。所以对他们来讲，时机真的已经到来了。——Kazuhiro

关键词： IPv6 雪崩应用 IPv4 互联网服务日本

Impact of age on transcatheter aortic valve implantation outcomes：a comparison of patients aged≤ 80 years versus patients ＆gt; 80 years

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2016年第1期13卷 31-36页

作者： Frank van der Kley Philippe J van Rosendael Spyridon Katsanos Vasileios Kamperidis Nina a.marsan Ioannis Karalis Arend de Weger Meindert Palmen Jeroen J Bax Martin J Schalij Victoria Delgado Heart Lung Center Leiden University Medical Center Leiden the Netherlands

ObjectiveTo investigate the procedural outcomes and the long-term survival of patients undergoing transcatheter aortic valve implantation （TAVI） and compare study results of patients≤ 80 years and patients ＆gt; 80 years *** total of 240 patients treated with TAVI were divided into two groups according to age≤ 80 years （n = 105; 43.8%） and ＆gt; 80 years （n= 135; 56.2%）. The baseline characteristics and the pro-cedural outcomes were compared between these two groups of *** the exception of peripheral artery disease and hypercho-lesterolemia, which were more frequently observed in the older age group, baseline characteristics were comparable between groups. Complica-tion rates did not differ significantly between patients≤ 80 years and patients ＆gt; 80 years. There were no differences in 30-day mortality rates be-tween patients aged≤ 80 years and patients ＆gt; 80 years old （9.5%vs. 7.4%, respectively;P = 0.557）. After a median follow-up of 28 months （in-terquartile range： 16-42 months）, 50 （47.6%） patients aged≤ 80 years died compared to 57 （42%） deaths in the group of patients ＆gt; 80 years old （P= 0.404）.ConclusionThe results of the present single center study showed that age did not significantly impact the outcomes of TAVI.

关键词： Age Survival rate Transcatheter aortic valve implantation

在线全文

学校读者我要写书评

暂无评论

最大板间地震的长期前兆变化

世界地震译丛 2013年第2期44卷 18-23页

作者： M.Bouchon V.Durand D.marsan H.Karabulut J.Schmittbuhl 冯万鹏中国地震局地球物理研究所

很多地震会伴有前震(Jones and Molnar,1976,1979)。但是,对产生前震的机制和为什么有些地震有前震而其他却没有的原因,目前尚不清楚(Abercrombie and Mori,1996;Reasenberg,1999;Jones,1984;Doser,1990;Maeda,1999;McGuireetal,2005)。这里我们利用在北太平洋区域有最佳仪器记录地区的地震目录,来分析1999年到2011年间所有震级大于6.5、震源深度小于50km的地震的前震序列。所用数据包括了31例发生在板块边界的地震和31例板内地震。我们发现,与板内地震相比,板间地震的前震序列有显著不同的特点。北太平洋地区,发生在板块边界的最大地震在之前数月到数天时间内,会出现地震活动加速现象,并最终导致主震发生。相反,板内环境下前震出现的机会就非常少。我们认为,在板块边界地区大地震的破裂前,两个板块的分界面便开始了缓慢的滑动。这种相对长期的前兆性变化可能有助于减缓板块边界的地震灾害。

关键词：板间地震前兆前震序列板块边界板内地震太平洋区域太平洋地区 Mori

利用AFLP标记分析几个牛品种间的遗传距离

在线全文

学校读者我要写书评

暂无评论

中国畜牧兽医 2004年第6期31卷 U003-U003页

作者： P.Ajmone-marsan 高雪

利用扩增片断长度多态性 (AFL P)技术 ,检测意大利褐牛、玛列姆牛和经高度选择的荷斯坦 -弗里生牛品种间 (内 )AFL P多态性 ,并估计它们的相对遗传距离。利用一种等位基因置换程序来估算遗传距离间的方差。用 2 4 8个多态标记分析4 7头... 详细信息

利用扩增片断长度多态性 (AFL P)技术 ,检测意大利褐牛、玛列姆牛和经高度选择的荷斯坦 -弗里生牛品种间 (内 )AFL P多态性 ,并估计它们的相对遗传距离。利用一种等位基因置换程序来估算遗传距离间的方差。用 2 4 8个多态标记分析4 7头荷斯坦 -弗里生牛品种内遗传距离 ,结果表明种用公牛的平均遗传距离比母牛低。另外 ,用 10 6个多态标记比较了意大利褐牛、玛列姆牛和经高度选择的荷斯坦 -弗里生牛 ,结果在这3个品种间没有观察到特异性条带。品种内平均遗传距离的贡献值是品种间的 85 % ,但是其结果和根据品种来源的聚类结果是一致的。根据品种间的遗传距离分析 ,玛列姆牛处于相对分化的位置。然而 ,复等位基因标记表明。

关键词： AFLP标记牛品种遗传距离遗传多样性

利用AFLP标记分析几个牛品种间的遗传距离

在线全文

学校读者我要写书评

暂无评论

中国畜牧兽医 2003年第3期30卷 52-52页

作者： P．Ajmone-marsan 高雪许尚忠

利用扩增片断长度多态性(AFLP)技术，检测意大利褐牛、玛列姆牛和经高度选择的荷斯坦-弗里生牛品种间(内)AFLP多态性，并估计它们的相对遗传距离。利用一种等位基因置换程序来估算遗传距离间的方差。用248个多态标记分析47头荷斯坦-弗... 详细信息

利用扩增片断长度多态性(AFLP)技术，检测意大利褐牛、玛列姆牛和经高度选择的荷斯坦-弗里生牛品种间(内)AFLP多态性，并估计它们的相对遗传距离。利用一种等位基因置换程序来估算遗传距离间的方差。用248个多态标记分析47头荷斯坦-弗里生牛品种内遗传距离，结果表明种用公牛的平均遗传距离比母牛低。另外，用106个多态标记比较了意大利褐牛、玛列姆牛和经高度选择的荷斯坦-弗里生牛，结果在这3个品种间没有观察到特异性条带。品种内平均遗传距离的贡献值是品种间的85％，但是其结果和根据品种来源的聚类结果是一致的。根据品种间的遗传距离分析，玛列姆牛处于相对分化的位置。然而，复等位基因标记表明，品种的形成过程对标记位点多样性的影响作用很小。

关键词：牛品种遗传距离 AFLP标记等位基因置换程序

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

四维定量血流MRI自动化心脏瓣膜跟踪技术

国际医学放射学杂志 2019年第2期42卷 228-228页

作者： V.P.Kamphuis A.W.Roest N.a.marsan P.J.van den Boogaard L.J.M.Kroft J.P.Aben 刘雯雯(译) 梁红琴(校) Department of Pediatrics Division of Pediatric CardiologyLeiden University Medical Center 不详

目的以后天获得性或先天性心脏病病人和健康志愿者为研究对象,对比分析四维血流MRI自动化心脏瓣膜跟踪技术与手动瓣膜跟踪技术。材料与方法在本回顾性研究中收集了114例病人和46名志愿者的数据,这些病人在2006—2017年期间接受了1.5 T或... 详细信息

目的以后天获得性或先天性心脏病病人和健康志愿者为研究对象,对比分析四维血流MRI自动化心脏瓣膜跟踪技术与手动瓣膜跟踪技术。材料与方法在本回顾性研究中收集了114例病人和46名志愿者的数据,这些病人在2006—2017年期间接受了1.5 T或3.0 T四维血流MRI。在114例病人中,女51例(45%),男63例(55%),其中33例患有后天获得性心脏病,81例患有先天性心脏病[中位年龄17岁,四分位距(IQR)13~49岁]。

关键词：跟踪技术 MRI 心脏瓣膜

二尖瓣和三尖瓣血流:应用回顾性瓣膜追踪3D速度编码MRI精确测量

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2009年第1期32卷 71-71页

作者： J.J. Westenberg S.D. Roes N. Ajmone marsan N.M. Binnendijk J. Doornbos J.J. Bax 周丽娜 Department of Radiology Leiden University Medical Center Albinusdreef 2 2333 ZA Leiden the Netherlands

目的验证回顾性瓣膜追踪3D3个方向速度编码MRI对血流量的评估，并在健康志愿者和瓣膜返流病人中与传统2D单向速度编码MRI结果相比较。材料与方法病人和志愿者均知情同意，研究获得当地医学伦理委员会的批准。病人的数据随机选自2006... 详细信息

目的验证回顾性瓣膜追踪3D3个方向速度编码MRI对血流量的评估，并在健康志愿者和瓣膜返流病人中与传统2D单向速度编码MRI结果相比较。材料与方法病人和志愿者均知情同意，研究获得当地医学伦理委员会的批准。病人的数据随机选自2006年7月—2007年7月的MR研究数据库，为回顾性资料。3D3个方向速度编码MRI首先在体外验证，并与2D单向速度编码MRI进行比较。

关键词：速度编码瓣膜返流 MRI 血流量追踪三尖瓣二尖瓣医学伦理委员会