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Enhanced cytotoxic effect on human lung carcinoma cell line(A549) by gold nanoparticles synthesized from Justicia adhatoda leaf extract

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Asian Pacific Journal of Tropical Biomedicine 2018年第11期8卷 540-547页

作者： D.Latha P.Prabu C.Arulvasu R.manikandan S.Sampurnam V.Narayanan Department of Inorganic Chemistry University of Madras Guindy Campus Department of Zoology Pachaiyappa's College for Men Kanchipuram Department of Zoology University of Madras Guindy Campus Chennai

Objective: To synthesize bio-inspired gold nanoparticles(AuNPs) using the leaf extract of Justicia adhatoda and evaluate the anti-cancer activity on human lung cancer cell line(A549).Methods: Synthesis of AuNPs was done using an aqueous leaf extract of Justicia adhatoda as a green route. The bio-synthesized AuNPs were confirmed and characterized by using various spectral studies such as UV-Vis spectrum, Scanning Electron Microscope with EDAX, Transmission Electron Microscope, Fourier Transmission Infrared Spectroscope analysis and Surface Enhanced Raman Spectroscopy. The cell viability was determined by MTT reduction assay. In addition, cytomorphology and the nuclear morphological study of A549 cell line was observed under fluorescence microscope. Results: UV-Vis spectrum showed surface plasmon resonance peak at 547 nm, scanning electron microscope and transmission electron microscope studies showed the monodispersed spherical shape and its average size in the range of 40.1 nm was noticed. Fourier Transmission Infrared Spectroscope analysis confirmed that the C=O group of amino acids of proteins had strong ability to bind with the surface of nanoparticle. Interestingly, our results also demonstrated inhibited proliferation of A549 cell line by MTT(IC50 value: 80 μg/mL). Cell morphology was observed and cell death was caused by apoptosis as revealed by propidium iodide staining. Conclusions: The current study proves the anticancer potential of bio-synthesized AuNPs. Thus, synthesized AuNPs can be used for the treatment of human lung cancer cell(A549) and it can be exploited for drug delivery in future.

关键词： Justicia adhatoda Leaf extract AuNPs Cytotoxicity A549 cell line

A Combinatorial Optimized Knapsack Linear Space for Information Retrieval

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Computers, Materials & Continua 2021年第3期66卷 2891-2903页

作者： Varghese S.Chooralil Vinodh P.Vijayan Biju Paul M.M.Anishin Raj B.Karthikeyan G.manikandan Rajagiri School of Engineering&Technology Kochi682039India Mangalam College of Engineering Kottayam686631India Department of CSE Viswajyothi College of Engineering&TechnologyVazhakulam686670India School of Computing SASTRA Deemed To Be UniversityThanjavur613401India

Key information extraction can reduce the dimensional effects while evaluating the correct preferences of users during semantic data ***,the classifiers are used to maximize the performance of web-page recommendation in terms of precision and *** recent method disambiguates contextual sentiment using conceptual prediction with robustness,however the conceptual prediction method is not able to yield the optimal ***-dependent terms are primarily evaluated by constructing linear space of context features,presuming that if the terms come together in certain consumerrelated reviews,they are semantically ***,the more frequently they coexist,the greater the semantic dependency ***,the influence of the terms that coexist with each other can be part of the frequency of the terms of their semantic dependence,as they are non-integrative and their individual meaning cannot be *** this work,we consider the strength of a term and the influence of a term as a combinatorial optimization,called Combinatorial Optimized Linear Space Knapsack for Information Retrieval(COLSK-IR).The COLSK-IR is considered as a knapsack problem with the total weight being the“term influence”or“influence of term”and the total value being the“term frequency”or“frequency of term”for semantic data *** method,by which the term influence and the term frequency are considered to identify the optimal solutions,is called combinatorial ***,we choose the knapsack for performing an integer programming problem and perform multiple experiments using the linear space through combinatorial optimization to identify the possible optimum *** is evident from our experimental results that the COLSK-IR provides better results than previous methods to detect strongly dependent snippets with minimum ambiguity that are related to inter-sentential context during semantic data analysis.

关键词： Key information extraction web-page context-dependent nonintegrative combinatorial optimization knapsack

纳米贵金属插入的粘土用于催化选择性加氢反应(英文)

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催化学报 2010年第10期31卷 1200-1208页

作者： manikandan DHANAGOPAL DURAISWAMI Divakar Rupa A.VALENTINE Mangalaraja RAMALINGA VISWANATHAN Sivakumar THIRIPURANTHAGAN Catalysis Laboratory Department of Chemical Engineering A.C. College of Technology Anna University Advanced Ceramic and Nanotechnology Laboratory Department of Materials Engineering Faculty of Engineering University of Concepcion Department of Chemical Engineering Faculty of Science and Technology University of Basque Country

The use of clay minerals in the synthesis of nanosized noble metal particles to give increased catalytic activity was investigated. Nanosized platinum and ruthenium catalysts intercalated in clay (montmorillonite/hectorite) were synthesised and their catalytic activity was evaluated for the selective hydrogenation of three different α,β-unsaturated aldehydes, namely, crotonaldehyde, cinnamaldehyde, and citral, in a gas phase microreactor. The metal nano-sol was prepared by the chemical reduction of its precursor by the micellar technique in the presence of cetyl trimethyl ammonium bromide (CTAB), and the micelle stabilized metal particles were intercalated in the clay mineral by ion exchange. TEM micrographs of the catalyst particles showed that the metal particles were in the nanometre range. The average diameters of the particles were 1-25 nm. The effects of temperature, metal loading, and hydrogen flow rate on the catalytic activity and selectivity for α,β- unsaturated alcohol were studied. The results were correlated with the structural properties of the catalysts. The products formed in each reaction over the different catalysts showed that the catalysts were very active for hydrogenation, and the selectivity for the desired product, namely, α,β-unsaturated alcohol, was good. The metal catalysts intercalated in montmorillonite showed better selectivity than that in hectorite because of its higher acidity. Increased selectivity for α,β-unsaturated alcohol was observed with increased flow rate of hydrogen.

关键词： selective hydrogenation nano-particle platinum ruthenium intercalated montmorillonite or hectorite vapor phase reaction

ODFF: Optimized Dual Fuzzy Flow Controller Based Voltage Sag Compensation for SMES-Based DVR in Power Quality Applications

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Circuits and Systems 2016年第10期7卷 2959-2974页

作者： M. manikandan A. Mahabub Basha Department of Electrical and Electronics Engineering Erode Sengunthar Engineering College Thudupathi India Department of Electronics and Communication Engineering K.S.R. College of Engineering Erode India

The booming electronics itself carries an impact on power quality. Superconducting Magnetic Energy Storage (SMES) is proposed to enhance power quality in three-phase systems under various loads. This paper aimed to compensate the voltage sags under various faults in the grid systems. The SMES is selected as an energy storage unit to improve the capability of voltage sag compensation. Optimized Dual Fuzzy Flow (ODFF) logic controller is designed to prevent the voltage sag time during excessive phase voltage variation. Hence the proposed controller strategy reduces the total harmonic distortion during various fault conditions. To regulate the contribution of active power, the least possible value is improved using ODFF. The depth of voltage sags compensation is achieved by the over modulation and an iterative loop is designed in the control block. While protecting sensitive loads from voltage disturbances, and sags initiated by the power system, the proposed configuration is advantageous for an industrial implementation. It is found that the proposed method can result in more than 50% additional sag support time when compared with the previous methods such as PI and PSO. Utilizing MATLAB Simulink, compensation of sag and minimization of THD is established, and the simulation tests are performed to evaluate the performance of the proposed control method.

关键词： Optimized Dual Fuzzy Flow (ODFF) Superconducting Magnetic Energy Storage (SMES) Total Harmonic Distortion (THD) Voltage Sag Compensation Voltage Sag Depth

Modeling and Implementation of AC Electrical Capacitance Tomography

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Circuits and Systems 2016年第11期7卷 3818-3830页

作者： K. manikandan S. Sathiyamoorthy Department of Electronics and Instrumentation Engineering J.J. College of Engineering and Technology Anna University Chennai India

Electrical Capacitance Tomography (ECT) determines the dielectric permittivity of the interior object depending on the measurements of exterior capacitance. Generally, the electrodes are placed outside the PVC cylinder where the medium to be imaged is present;but in ECT using inter-electrode capacitance measurements can be achieved by placing inside of the dielectric medium. In the proposed ECT system, the ECT sensor is modeled using ANSYS software and the model is implemented in real ECT system. For each step of measurement, a stable AC signal is applied to a pair of electrodes that form a capacitor. The novel system is to measure the capacitance range variation in picofarad and the corresponding voltage ranges from 1 volt to 4 volts. The switching speed of all combinational electrodes is implemented using embedded system to achieve higher speed performance of AC ECT system which eliminates the drift and stray capacitance error. This is yielding the original image of unknown multiphase medium inside the electrodes using Lab VIEW. This paper investigates several advantages such as improved overall system performance;simple structure, avoids stray capacitance effect, reduces the drift problem and achieves high signal to noise ratio.

关键词： Electrical Capacitance Tomography ANSYS Lab VIEW Embedded System AC Signal

Applications of nanomaterials in mosquito vector control:A review

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Asian Pacific Journal of Tropical Medicine 2023年第11期16卷 479-489页

作者： Sahadiya Mandodan Aneha Kunnikuruvan Bhagyashree Bora Hemaladkshmi Padmanaban Abhisubesh Vijayakumar Kakhuangailiu Gangmei manikandan Sivaprakasam Jibi Lukose Mathivanan Ashokkumar Vijayalakshmi Krishnamoorthy Subbiah Poopathi Unit of Microbiology and Immunology ICMR-Vector Control Research CentreDepartment of Health ResearchMinistry of Health and Family WelfarePuducherry 605006India

The periodic outbreak of mosquito-borne diseases like dengue fever,zika fever,and yellow fever all over the world highlights the need for effective mosquito control methods targeting the biological *** to the lack of therapeutic measures,preventive treatments or vaccines against pathogens,insecticide resistance eventually lead the research focus towards novel technological applications in mosquito *** with ovicidal,larvicidal,adulticidal,and repellent properties for controlling mosquito vectors are under research.A literature search was carried out for advancements in nanomaterials,insecticides,and mosquito control in PubMed/MEDLINE,Scopus,Google Scholar,ScienceDirect,and Web of *** paper aims to provide insights into various nanomaterials relevant to mosquito-borne diseases,in vivo and in vitro toxicity evaluation against mosquito species,mode of action,effect on non-target organisms,and ecological *** and inorganic materials that provide controlled release,target delivery,less dosage,prolonged efficacy,a reduction in the use of organic solvents and emulsifiers,and minimum pollution to the environment have already been ***,further research on the ecological risk and economic feasibility of nanomaterials in mosquitocidal applications should be done prior to commercialization.

关键词： Nanomaterials Nanoformulation Nanopesticides Mosquito control

Mixed-phase composites derived from cobalt terephthalate as efficient battery-type electrodes for high-performance supercapattery

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Journal of Materials Science & Technology 2023年第26期157卷 220-233页

作者： Ramu manikandan Antonysamy Dennyson Savariraj Goli Nagaraju A.M.Kale J.Puigdollers Hyejin Park Hyun-Soo Kim Jae-Min Oh C.Justin Raj Byung Chul Kim Department of Energy and Materials Engineering Dongguk University-SeoulSeoul 04620Republic of Korea Advanced Functional Nanohybrid Material Laboratory Department of ChemistryDongguk University Seoul-CampusJung-guSeoul04620Republic of Korea Department of Materials Imperial College LondonLondon SW72AZUnited Kingdom Department of Advanced Components and Materials Engineering Sunchon National University255Jungang-roSuncheon-siJellanamdo57922Republic of Korea Department of Enginyeria Electrònica Universitat Politècnica CatalunyaBarcelona 08034Spain Next Generation Battery Research Center Korea Electrotechnology Research Institute(KERI)Changwon51543Republic of Korea Physics Division School of Advanced SciencesVellore Institute of Technology(VIT)Chennai CampusChennai600127Tamil NaduIndia

Interfacial engineering of two-dimensional(2D)monometallic phosphides enables remarkable structural and electrochemical properties in energy storage ***,2D nanosheets(NSs)of FeP_(2)/Co_(2) P were grown on Ni-foam(FCP)using a solution-based and phosphorization approach to be used as freestanding for high-performance energy storage *** effective phosphorization strategy is successfully de-veloped to improve the overall crystalline phase,tailor the morphology,and boost the electrochemical performances of *** FCP NSs electrode exhibits a battery-type redox behavior with a maxi-mum high areal capacity of 1.96 C cm^(-2) at 4 mA cm^(-2) in 6 M KOH aqueous electrolyte compared to the other *** superior electrochemical performance was achieved by increasing the electroac-tive sites and high conductivity via surface tailoring and fast redox ***,a supercapattery was assembled utilizing FCP and activated carbon(AC)electrodes and it revealed maximum specific en-ergy(E_(s))and specific power(P_(s))of 41.2 Wh kg^(-1) and 7578 W kg^(-1) with good cycling stability of 91%after 10,000 cycles at 5 A g^(-1).Eventually,the supercapattery has been explored in practical applications by lighting up light-emitting diodes(LEDs),representing the real-time performance of superior energy storage devices.

关键词： 2D nanosheet Monometallic phosphide Battery-type material Supercapattery Energy storage

In vitro and comparative study on the extracellular enzyme activity of molds isolated from keratomycosis and soil

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 778-784页

作者： Arumugam Mythili Yendranbam Randhir Babu Singh Ravindran Priya Anamangadan Shafeeq Hassan Palanisamy manikandan Kanesan Panneerselvam Venkatapathy Narendran Coimbatore Subramanian Shobana Department of Microbiology Dr.G.R.Damodaran College of Science Department of Microbiology Aravind Eye Hospital and Post Graduate Institute of Ophthalmology Department of Microbiology M R Government Arts College

AIMTo isolate and identify the molds involved in mycotic keratitis; to isolate corresponding species from soil samples; to compare the extracellular enzyme activity indices of the molds isolated from keratitis cases a... 详细信息

关键词： mycotic keratitis extracellular enzymes enzyme activity index

Optimization Studies in Simultaneous Saccharification and Fermentation of Wheat Bran Flour into Ethanol

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Food and Nutrition Sciences 2022年第5期13卷 463-470页

作者： Kanagasabai manikandan Selvanarayanan Rengadurai Elango Babu Shanmugam Sothivanan Department of Chemical Engineering Annamalai University Annamalai Nagar India

The effects of process variables in Simultaneous Saccharification and Fermentation (SSF) of wheat bran flour were studied in bulk fermentation using a coculture of Aspergillus niger - Kluveromyces marxianus. The effect of substrate density, pH, temperature, and enzyme concentration on wheat bran was predicted by designing experiments in which a single parameter is varied keeping other variables at a constant level. The above parameters were optimized for a batch culture in a fermentor. Optimal values for substrate concentration, pH, temperature, and enzyme concentration during processing were 200 g/l, 5.5, 65°C, and 7.5 IU, respectively. In pre-treatment experiments, the concentration of enzymes and the pre-treatment temperature are highly correlated. The influence of pH, temperature, and substrate density on ethanol production was investigated. Temperature pH was determined as optimal, 32°C and 5.5, respectively. After 48 hours of fermentation at optimum pH, a solution of wheat bran containing a maximum of 6% starch produces a maximum of 22.9 g/l ethanol.

关键词： Simultaneous Saccharification and Fermentation (SSF) Co-Culture Fermentation Single Factor Optimization Ethanol