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Assessment of Endometrial Carcinoma markers and Hormone Receptors Profile before and after Bariatric Surgery: A Clinico-Pathological-Immunohistochemical Study

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Open Journal of Obstetrics and Gynecology 2019年第7期9卷 1019-1031页

作者： Walid mohamed Elnagar Samah Said Elbasateeny mai mohamed Abdelwahab mahmoud Abdou Yassin Taha Abdelwahab Baiomy maha Abdelhamid Fathy Amin Dalia Abdallah El-shafei Department of Obstetrics and Gynecology Faculty of Medicine Zagazig University Zagazig Egypt Department of Pathology Faculty of Medicine (Rabigh Branch) King Abdul Aziz University Jeddah KSA Department of Pathology Faculty of Medicine Zagazig University Zagazig Egypt Department of General Surgery Faculty of Medicine Zagazig University Zagazig Egypt Department of Physiology Faculty of Medicine Zagazig University Zagazig Egypt Department of Community Environmental & Occupational Medicine Faculty of Medicine Zagazig University Zagazig Egypt

Background: Obesity is a major risk factor for endometrial carcinoma, and we aim to assess markers of carcinogenesis including PTEN and Ki-67 and hormone receptors profile including ER, PR and AR before and after bariatric surgery to find out its effects in reducing endometrial carcinoma risk in morbid obese females. Patients and methods: The study included 80 females with morbid obesity (BmI > 40 Kg/m2) who underwent bariatric surgery. All were sampled by Pipelle biopsy at baseline and 12 months after operation and examined histopathologically and immunohistochemically for Ki-67, PTEN, ER, PR and AR. Results: Sixty two out of 80 (62/80) females showed no pathological abnormalities;4 had polyps;7 had simple endometrial hyperplasia;4 had atypical endometrial hyperplasia and 3 had endometrial carcinoma. In total, 34 females underwent gastric bypass operation (42.5%) and 46 underwent a sleeve gastrectomy operation (57.5%). There was a statistically significant difference between baseline weight and BmI before and after surgery (p men with simple hyperplasia, resolution occurred in 5 within 7 months of surgery. Three of 4 females with atypical hyperplasia (AH) showed resolution after 9 months. mean Ki-67 score was lower at 12 months (p men with baseline endometrial abnormalities, of whom 5/15 regained glandular PTEN expression as their endometrial abnormalities resolved. There was a significant reduction in ER score after surgery (p males with morbid obesity have a higher risk of harboring endometrial abnormalities even if asymptomatic. However, the endometrial pathology and the high ER and PR expression can be normalized within one year without me

关键词： Bariatric Surgery Obesity Endometrial Cancer Hormone Receptors

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HER2免疫组织化学1＋浸润性乳腺癌的基因扩增状态和mRNA表达分析

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中华病理学杂志 2018年第7期47卷 522-526页

作者：武莎斐刘媛媛刘笑玎姜英罗玉凤崔全才梁智勇曾瑄中国医学科学院、分子病理研究中心、北京协和医院病理科 100730

目的探讨HER2免疫组织化学（IHC）1＋乳腺癌患者的基因扩增状态和原位HER2 mRNA表达情况，为精准检测HER2及相关临床策略的修订提供初步参考数据。方法抽取北京协和医院2011至2013年间手术获取的非特殊型浸润性乳腺癌HER2 IHC 1＋存档... 详细信息

目的探讨HER2免疫组织化学（IHC）1＋乳腺癌患者的基因扩增状态和原位HER2 mRNA表达情况，为精准检测HER2及相关临床策略的修订提供初步参考数据。方法抽取北京协和医院2011至2013年间手术获取的非特殊型浸润性乳腺癌HER2 IHC 1＋存档蜡块标本65例，制作组织芯片，分别采用荧光原位杂交（FISH）和RNAscope方法检测其HER2基因状态和原位mRNA表达水平。如原发灶HER2的FISH结果不确定或阴性但mRNA高表达，再以FISH复检其淋巴结转移灶的HER2基因状态。结果在65例标本中，FISH阳性4例（6.2%），其中2例为HER2/CEP17〉2且平均HER2基因拷贝数〉4，另2例为HER2/CEP17〈2但平均HER2基因拷贝数〉6；在此4例FISH阳性标本中，2例为mRNA高表达（RNAscope 3分），另2例为中度表达（RNAscope 2分）。另外，在全部标本中，3例HER2/CEP17〉2但平均HER2基因拷贝数〈4，其中2例mRNA高表达（RNAscope 3分和4分），另1例mRNA中度表达（RNAscope 2分）。未见HER2基因状态及mRNA表达与临床病理特征（肿瘤大小、分化程度、淋巴结转移、脉管癌栓）之间存在明显相关性（P均〉0.05）。结论在本组HER2 IHC 1＋乳腺癌中检出了部分FISH阳性的标本，其mRNA也有一定程度的表达，可判断为抗HER2治疗的潜在获益者。鉴于精准分子分型对于乳腺癌临床处理及相关诊疗策略制定具有重要意义，后续有必要进行大样本量的验证。

关键词：乳腺肿瘤基因 erbB-2 免疫组织化学原位杂交 RNA 信使

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Checklist of the Birds of the Gaza Strip—Palestine

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Open Journal of Ecology 2023年第3期13卷 155-182页

作者： Abdel Fattah N. Abd Rabou Bashar S. Jarayseh Lara m. Sirdah mandy m. Sirdah Sinaa A. Ababsa Daoud I. Al-Hali Ayman W. Dardona Ashraf A. shafei Nedal A. Fayyad Abdallah S. Awad Wael I. Almeshal Samer S. Abuzerr Inas A. Abd Rabou Othman A. Abd Rabou mohammed A. Abd Rabou Sabah A. Abu Sharekh mohammed R. Al-Agha maged m. Yassin Abed Al Qader I. Hammad Norman A. Khalaf Walid F. mohamed Department of Biology Faculty of Science Islamic University of Gaza Gaza Strip Palestine Environmental Education Center Beit Jala West Bank Palestine Wildlife Documenter and Photographer Gaza Strip Palestine Wildlife Documenter and Photographer Kafr Kanna Galilee Palestine Qimmah Secondary School Jerusalem (Al-Quds) Palestine Environment Quality Authority Gaza Strip Palestine Center for Desert Agriculture King Abdullah University of Science and Technology Thuwal Kingdom of Saudi Arabia Doctoral School of Environmental Sciences E&#246tv&#246s Loránd University Budapest Hungary Department of medical Sciences University College of Science & Technology Gaza Strip Palestine Department of Nursing and Health Sciences University College of Applied Sciences Gaza Strip Palestine Department of Journalism and media Islamic University of Gaza Gaza Strip Palestine Department of GIS University College of Applied Sciences Gaza Strip Palestine Department of School Health Ministry of Education and Higher Education Gaza Strip Palestine Department of Environment and Earth Sciences Faculty of Science Islamic University of Gaza Gaza Palestine Faculty of medicine Islamic University of Gaza Gaza Strip Palestine Department of Geography Al-Aqsa University Gaza Strip Palestine Department of Environmental Research and media National Research Center Palestine Department of Biological and Geological Sciences Faculty of Education Ain Shams University Roxy Cairo Egypt

Bird fauna checklists are important tools in ecology, biology, and conservation planning for scientists, stakeholders, and decision-makers. Despite its small area, the Gaza Strip (365 km2) has a relatively large variety of resident and migratory bird fauna. Therefore, the current study aimed to provide an updated checklist of all bird fauna living in or inhabiting the Gaza Strip. Direct field observations using binoculars, continuous visits to zoos, pet stores and biology museums, discussion with bird hunters, follow-up of news and social networking sites, review of scientific publications and photography were the main tools to satisfy the purpose of the study. At least 250 bird species collected from different sources occur in the Gaza Strip and are included in the checklist. This list will not be static, but is inevitably subject to additions and changes in the face of times. The current 250 bird species of the Gaza Strip represent 45.4% of the 551 species of birds living in Palestine. The bird species were found to belong to 21 orders and 61 families. The Passeriformes (passerines) represented the largest order with 96 species of birds (38.4%), followed by the Charadriiformes 54 (21.6%), the Accipitriformes 18 (7.2%), Anseriformes 17 (6.8%) and Pelecaniformes 14 (5.6%), while the other orders represented the remaining percentage (20.4%). With regard to families, the Scolopacidae represented the largest family with 22 species of birds (8.8%), followed by the Anatidae and Accipitridae 17 for each (6.8%), the muscicapidae 16 (6.4%) and Chariidridae and Fringillidae 11 for each (4.4%), while the other families represented the remaining percentage (62.4%). According to the IUCN regional threat categories, 226 species (90.4%) were Least Concern (LC), 12 (4.8%) were Near Threatened (NT), 6 (2.4%) were Vulnerable (VU), 4 (1.6%) were Endangered (EN) and 2 (0.8%) were Critically Endangered (CR). In conclusion, the study recommends a sustainable control of bird h

关键词： Bird Fauna Checklist Bird Hunting Conservation IUCN Categories Gaza Strip

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An Inventory of Some Relatively Large marine mammals, Reptiles, and Fishes Sighted, Caught, By-Caught, or Stranded in the mediterranean Coast of the Gaza Strip-Palestine

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Open Journal of Ecology 2023年第2期13卷 119-153页

作者： Abdel Fattah N. Abd Rabou Kamal E. Elkahlout Kamal J. Elnabris Adel J. Attallah Jehad Y. Salah mohammed A. Aboutair Waleed m. Thabit Sahar K. Serri Hassan G. Abu Hatab Sameeh m. Awadalah Wajdi m. Saqallah mokhles S. Alhawajri Tariq K. Al-Sammak Bashar S. Jarayseh Sinaa A. Ababsa Daoud I. Al-Hali Aysha A. Rafeea Doaa S. Ghattas Huda E. Abu Amra Israa m. Jaber Nedal A. Fayyad Ashraf A. shafei Inas A. Abd Rabou Othman A. Abd Rabou mohammed A. Abd Rabou mazen T. Abualtayef mohammed R. Al-Agha Yousif K. Ibrahim Rimel m. Benmessaoud mourad m. Cherif Hashem A. madkour Department of Biology and Biotechnology Faculty of Science Islamic University of Gaza Gaza Strip Palestine Department of marine Sciences Faculty of Science Islamic University of Gaza Gaza Strip Palestine Directorate General of Fisheries Ministry of Agriculture Gaza Strip Palestine Environmental Education Center Beit Jala Palestine Wildlife Documenter and Photographer Kafr Kanna Palestine Qimmah Secondary School Jerusalem Palestine Kamal Al-Ohood Primary School for Girls North Gaza Education Directorate Gaza Strip Palestine Department of Biology Faculty of Science Al-Aqsa University Gaza Strip Palestine Department of Nursing and Health Sciences University College of Applied Sciences Gaza Strip Palestine Department of Journalism and media Islamic University of Gaza Gaza Strip Palestine Department of GIS University College of Applied Sciences Gaza Strip Palestine Department of Environmental Engineering Faculty of Engineering Islamic University of Gaza Gaza Palestine Department of Environment and Earth Sciences Faculty of Science Islamic University of Gaza Gaza Palestine Water and Environment Quality Authority Gaza Strip Palestine National Institute of Agronomy of Tunisia Tunis Tunisia National Institute of marine Sciences and Technologies (INSTm) La Goulette Port Tunis Tunisia National Institute of Oceanography and Fisheries Hurghada Egypt

The mediterranean Sea is home to an interesting biodiversity. The current cumulative and descriptive study aims to enumerate some relatively large marine mammals, reptiles, and fishes that have been spotted, caught, by-caught, or stranded on the coast of the Gaza Strip, Palestine, which extends about 42 km along the mediterranean Sea. This 20-year study from 2003 to 2022 relied much on frequent field visits, meetings, and discussions with stakeholders, following local media sites and social media pages, and photography. The study recorded at least 26 giants or relatively large marine organisms on the mediterranean coast of the Gaza Strip, Palestine. Certainly, the coming years may bring other marine organisms of relatively large sizes. marine mammals included three species of cetaceans with the Fin Whale (Balaenoptera physalus) being the largest mammal and even the largest animal ever recorded in this study. marine reptiles included three species of sea turtles, the largest of which is the Leatherback Sea Turtle (Dermochelys coriacea), which is in fact the world’s largest sea turtle. The bony fishes were represented by ten species, the largest of which was the Ocean Sunfish (mola mola), which is the largest bony fish in the world. The cartilaginous fishes included ten species with the largest specimens encountered were the Shortfin Shark (Isurus oxyrinchus), Bluntnose Sixgill Shark (Hexanchus griseus), Scalloped Hammerhead Shark (Sphyrna lewini), and Giant Devil Ray (mobula mobular). Seabirds were not included in the study. The Alexandria Pompano (Alectis alexandrinus) and the Silver-Cheeked Toadfish (Lagocephalus sceleratus), which are bony fishes, appear to be the relatively smallest marine organisms recorded here. In conclusion, the role of the various parties must be coordinated to ensure the sustainability of human activities and their compatibility with the task of conserving local marine biota, including the gigantic or relatively large ones.

关键词： mediterranean Sea marine Biodiversity marine mammals Sea Turtles Bony Fishes Cartilaginous Fishes Gaza Strip Palestine

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农药百菌清亚慢性吸入毒性研究

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湖南医学院学报 1987年第3期 255-258页

作者：钟赛贤王翔朴熊敏如罗莎菲陈本美湖南医学院劳动卫生职业病学教研室湖南医学院劳动卫生职业病学教研室湖南医学院劳动卫生职业病学教研室中山医科大学卫生系

百菌清13周亚慢性吸入毒性实验表明,高浓度组(5.31mg/m~8)动物呈轻度粘膜刺激,血清谷丙转氨酶明显下降,嗜伊红细胞、血清总蛋白均明显升高,肝、肾、肺出现出血、炎性坏死病灶。低浓度组(1.16mg/m~3)除部分动物嗜伊红细胞增多外,未见其... 详细信息

百菌清13周亚慢性吸入毒性实验表明,高浓度组(5.31mg/m~8)动物呈轻度粘膜刺激,血清谷丙转氨酶明显下降,嗜伊红细胞、血清总蛋白均明显升高,肝、肾、肺出现出血、炎性坏死病灶。低浓度组(1.16mg/m~3)除部分动物嗜伊红细胞增多外,未见其他异常。结果提示百菌清亚慢性吸入阈浓度为1.16mg/m~3。

关键词：百菌清杀虫剂,有机氯吸入中毒药效学控制和预防动物兔

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The Palestinian Terrestrial Vertebrate Fauna Preserved at the Biology Exhibitions of the Universities of the Gaza Strip

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Research in Ecology 2020年第4期2卷 9-21页

作者： Abdel Fattah N Abd Rabou Nour J musallam Eman J musallam Kamal E Elkahlout Kamal J Elnabris Tarek A El-Bashiti Ismail I Abdel Aziz Reham m Ishneiwra Eqbal S Radwan Hana S Saada Ashraf A shafei Nedal A Fayyad Saleh N mwafy Huda E Abu Amra Ramy A Abu Alajeen mohammed F Abu Owda Randa N Alfarra Haifaa A Hassouna Reem A Hassouna mohammed R Al-Agha mohammed A Abd Rabou Department of Biology and Biotechnology Islamic University of GazaGaza StripPalestine Department of English Islamic University of GazaGaza StripPalestine Department of Biology Al-Azhar UniversityGaza StripPalestine Department of Biology Al-Aqsa UniversityGaza StripPalestine Department of Geography Al-Aqsa UniversityGaza StripPalestine Department of Curricula and Teaching methods Islamic University of GazaGaza StripPalestine Department of Curricula and Teaching methods Ministry of EducationGaza StripPalestine Department of Pharmaceutical Sciences University of PalestineGaza StripPalestine Department of Environment and Earth Sciences Islamic University of GazaGaza StripPalestine Department of Information Technology University College of Applied SciencesGaza StripPalestine

The Gaza Strip(365 km^(2))of Palestine(27,000 km^(2))is home to a wealth of terrestrial vertebrate *** of these faunistic species find their ways to preservation at the local ***,the current study comes to document the Palestinian terrestrial vertebrate fauna acquired by the biology exhibitions(BEs)of Al-Azhar University,Islamic University of Gaza and Al-Aqsa University that are located at the Gaza City of the Gaza *** amphibians,reptiles,birds and mammals preserved at BEs of the universities in question were surveyed and scientifically classified during a three-month period extending from January to march,*** study showed that all BEs of local universities are underdeveloped,lacking attention and suffer from specimen scarcity and good *** BE at Al-Azhar University is the best in the arrangement and preservation of bird specimens.A total number of 200 specimens belonging to 54 terrestrial vertebrate fauna species,39 families and 17 orders was recorded at *** constituted 40.7%of the total species recorded,followed by birds(38.9%),mammals(14.8%)and amphibians(5.6%).The Islamic University of Gaza was considered the best in terms of the number of preserved species(39.8%),followed by Al-Azhar University(36.3%)and Al-Aqsa University(23.9%).The Common Toad(Bufo viridis)was the most preserved among the amphibian species *** was the biggest reptilian order,comprising 20 species(8 lizards and 12 snakes),with the Syrian Black Snake(Coluber jugularis asianus)was the *** Palestine Viper(Vipera palaestinae)is endemic to Palestine and most venomous and dangerous to human *** Great White Pelican(Pelecanus onocrotalus)was the largest Palestinian bird preserved at BE of Al-Azhar *** Egyptian mongoose(Herpestes ichneumon)and the Common Badger(meles meles)were the biggest mammalian specimens preserved,while the Palestine mole-rat(Spalax leucodon ehrenbergi)was the only Palestine endemic spe

关键词： Terrestrial vertebrate fauna Preservation Biology exhibitions Gaza universities Gaza Strip Palestine

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Checklist of the Birds of the Gaza Strip—Palestine

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Open Journal of Ecology（生态学期刊） 2023年第3期

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An Inventory of Some Relatively Large marine mammals, Reptiles, and Fishes Sighted,Caught, By-Caught, or Stranded in the mediterranean Coast of the Gaza Strip-Palestine

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Open Journal of Ecology（生态学期刊） 2023年第2期

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