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高血钾性周期性麻痹和持续性乏力:3 T mRI揭示细胞内23Na超载的初步结果

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国际医学放射学杂志 2012年第5期 475-476页

作者： E.Amarteifio a.m.nagel m.A.Weber K.Jurkat-Rott F.Lehmann-Horn 柯俊 Department of Diagnostic and Interventional Radiology University Hospital of HeidelbergIm Neuenheimer Feld 110D-69120 HeidelbergGermany

摘要目的通过3T23Na-mRI方法来评估高血钾性周期性麻痹病人肌浆内Na+离子是否增加,并评价药物治疗钠导致的肌肉水肿的疗效。方法此研究获得伦理委员会的批准,所有受试者签署知情同意书。12例高血钾性周期性麻痹病人[平均年龄(48±14)岁)... 详细信息

摘要目的通过3T23Na-mRI方法来评估高血钾性周期性麻痹病人肌浆内Na+离子是否增加,并评价药物治疗钠导致的肌肉水肿的疗效。方法此研究获得伦理委员会的批准,所有受试者签署知情同意书。12例高血钾性周期性麻痹病人[平均年龄(48±14)岁)]和12名健康志愿者[平均年龄(38±12)岁]分别在激发前和激发后(对一侧小腿降温)行小腿的1H和23Na的mR成像。23Na-mRI包括自旋-密度、T1加权及反转恢复序列。

关键词：周期性麻痹病人肌浆高血钾 T mRI Na

脑钠积累的分布与多发性硬化功能障碍的关系:23NamR横断面的成像研究

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国际医学放射学杂志 2012年第6期 582-583页

作者： W.Zaaraoui S.Konstandin B.Audoin a.m.nagel A.Rico I.malikova 卢平明郑晶晶 CRmBm no.7339Aix-Marseille UniversityCNRSMarseilleFrance

摘要目的通过23NamR成像,在复发-缓解型多发性硬化(RR mS)的不同阶段定量分析脑钠积累并首次描述钠异常的空间位置的特征。材料与方法该研究由当地伦理委员会批准,所有参与者均签署知情同意书

关键词：多发性硬化功能障碍 NamR

7.0 T mRI组织钠离子浓度定量作为乳腺癌化疗反应的早期标志物的可行性研究

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国际医学放射学杂志 2021年第3期44卷 356-356页

作者： O.Zaric A.Farr L.minarikova S.Lachner E.Asseryanis a.m.nagel 魏锋

摘要组织钠离子浓度（TSC）在乳腺癌病人中升高,并且可以确定化疗的反应。目的评价在7.0 T应用钠(23Na)mRI方案得到的TSC定量结果在预测乳腺癌新辅助化疗的早期

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7 T mRI 35Cl、23Na成像监测突变相关的肌肉周期性麻痹病人的肌肉水肿及脂肪中Na+及Cl-浓度的变化

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国际医学放射学杂志 2016年第6期 681-681页

作者： m.A.Weber a.m.nagel A.m.marschar P.Glemser K.Jurkat-Rott m.B.Wolf 张维涛 Clinic of Diagnostic and Interventional Radiology University Hospital Heidelberg

摘要目的探索是否可以用7 T mRI35Cl和23Na成像监测肌肉周期性麻痹中Na+及Cl-稳态的变化。方法本实验研究获得了相关伦理委员会的批准并且所有被试签订了知情

关键词：周期性麻痹 T mRI 病人水肿 Na Cl

3.0 T磁场强度下水负荷前后人体肾23Na-mR成像的定量和定性研究

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国际医学放射学杂志 2011年第6期 584-584页

作者： S.Haneder S.Konstandin J.N.morelli a.m.nagel F.G.Zoellner L.R.Schad 王焕军 Institute of Clinical Radiology and Nuclear medicine University Medical Centre MannheimMedical Faculty MannheimHeidelberg UniversityTheodor-Kutzer-Ufer 1-368167 MannheimGermany

目的采用3TmRI定性和定量评估水负荷前后人肾皮髓质对23Na的浓聚情况。材料与方法 14名健康志愿者(24～34岁,平均年龄28岁)被纳入此项研究。本研究经学术审查委员会批准,研究时间自2009年7月—12月。23Na-mR成像采用可依密度进行放射状... 详细信息

目的采用3TmRI定性和定量评估水负荷前后人肾皮髓质对23Na的浓聚情况。材料与方法 14名健康志愿者(24～34岁,平均年龄28岁)被纳入此项研究。本研究经学术审查委员会批准,研究时间自2009年7月—12月。23Na-mR成像采用可依密度进行放射状调整的3D梯度回

关键词： mR 皮髓质 Na-mR

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

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mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.ImRAN T.ASGHAR Z.ABBAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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