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Switching angle optimization and fault analysis of a multistring-multilevel inverter for renewable-energy-source applications

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Clean Energy 2022年第6期6卷 907-930页

作者： Savitha m S.nagaraja Rao mS Ramaiah University of Applied Sciences Department of Electrical EngineeringBangaloreIndia

In this paper,a multistring-multilevel inverter(m-mLI)for renewable-energy-source applications has been proposed with reduced switch count and harmonics along with single-switch fault analysis for various *** requires only‘m+1’power switches for‘m’voltage *** proposed work achieves the fine-tuning of switching angles using a metaheuristic technique,*** teaching-learning-based optimization algorithm(TLBOA),to mitigate the total harmonic distortion(THD)of the ***,the proposed TLBOA has been compared with conventional modulation techniques such as equal phase(EP),half-equal phase(HEP),near-level control(NLC)and Newton-Raphson(NR)to verify the effectiveness of TLBOA for various voltage levels in terms of%voltage-THD(%V-THD),computational time and *** fine-tuning the switching angles,the%V-THD is improved significantly when compared with EP,HEP,NLC and NR modulation *** an 11-level single-phase m-mLI,the%V-THD using TLBOA at 0.91 modulation index(mI)is 5.051%.The lower-order harmonics,i.e.5,7,11 and 13,are eliminated to improve the power ***,mLIs are often prone to failure,resulting in waveform *** extreme reduction in power quality impacts the load and significant damage is *** location of the open-circuit fault to be identified becomes more tedious under the faulty conditions with increased switch counts and voltage levels since the mathematical modelling fails to address the scenario in less computational ***,the machine-learning approach,*** vector machine(SVm)with Bayesian optimization,has been discussed to locate the faulty ***,the proposed m-mLI configuration has been modelled,simulated and validated using mATLAB®and Simulink®.The results of the m-mLI configuration have been verified for 7,9 and 11 levels using TLBOA along with fault analysis using the SVm approach.

关键词： TLBO fault resilience multistring-multilevel inverters renewable-energy applications

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Reconstructing missing Hourly Real-Time Precipitation Data Using a Novel Intermittent Sliding Window Period Technique for Automatic Weather Station Data

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Journal of meteorological Research 2017年第4期31卷 774-790页

作者： nagaraja HEmA Krishna KANT Department of Computer Science and Engineering/Information Technology Jaypee Institute of Information Technology Noida 201307 India

Precipitation is the most discontinuous atmospheric parameter because of its temporal and spatial variability. Precipitation observations at automatic weather stations（AWSs） show different patterns over different time periods. This paper aims to reconstruct missing data by finding the time periods when precipitation patterns are similar, with a method called the intermittent sliding window period（ISWP） technique—a novel approach to reconstructing the majority of non-continuous missing real-time precipitation data. The ISWP technique is applied to a 1-yr precipitation dataset（January 2015 to January 2016）, with a temporal resolution of 1 h, collected at 11 AWSs run by the Indian meteorological Department in the capital region of Delhi. The acquired dataset has missing precipitation data amounting to 13.66%, of which 90.6% are reconstructed successfully. Furthermore, some traditional estimation algorithms are applied to the reconstructed dataset to estimate the remaining missing values on an hourly basis. The results show that the interpolation of the reconstructed dataset using the ISWP technique exhibits high quality compared with interpolation of the raw dataset. By adopting the ISWP technique, the root-mean-square errors（RmSEs）in the estimation of missing rainfall data—based on the arithmetic mean, multiple linear regression, linear regression,and moving average methods—are reduced by 4.2%, 55.47%, 19.44%, and 9.64%, respectively. However, adopting the ISWP technique with the inverse distance weighted method increases the RmSE by 0.07%, due to the fact that the reconstructed data add a more diverse relation to its neighboring AWSs.

关键词： automatic weather station intermittent sliding window period interpolation mean absolute error reconstruction of missing precipitation data

SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Evidence-based assessment of proton-pump inhibitors in Helicobacter pylori eradication: A systematic review

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World Journal of Gastroenterology 2014年第40期20卷 14527-14536页

作者： Vinayak nagaraja Guy D Eslick The Whiteley-martin Research Centre Discipline of Surgery The University of Sydney Nepean Hospital Penrith NSW 2751 Australia

Peptic ulcer disease continues to be issue especially due to its high prevalence in the developing *** pylori(***)infection associated duodenal ulcers should undergo eradication *** are many regimens offered for *** eradication which include triple,quadruple,or sequential therapy *** central aim of this systematic review is to evaluate the evidence for *** therapy from a meta-analytical *** consequence of the dose,type of proton-pump inhibitor,and the length of the treatment will be *** most important risk factor for eradication failure is resistance to clarithromycin and metronidazole.

关键词： Helicobacter pylori Peptic ulcer disease Systematic review Proton-pump inhibitors

Discrete Wavelet Transmission and modified PSO with ACO Based Feed Forward Neural Network model for Brain Tumour Detection

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Computers, materials & Continua 2020年第11期65卷 1081-1096页

作者： machiraju Jayalakshmi S.nagaraja Rao Department of Electrical&Computer Engineering JNTUA AnantapuramuAndhra PradeshIndia Department of ECE G.Pulla Reddy Engineering College(Autonomous)KurnoolAndhra PradeshIndia

In recent years,the development in the field of computer-aided diagnosis(CAD)has increased *** traditional machine learning algorithms have been proposed for identifying the pathological brain using magnetic resonance *** existing algorithms have drawbacks with respect to their accuracy,efficiency,and limited learning *** address these issues,we propose a pathological brain tumour detection method that utilizes the Weiner filter to improve the image contrast,2D-discrete wavelet transformation(2D-DWT)to extract the features,probabilistic principal component analysis(PPCA)and linear discriminant analysis(LDA)to normalize and reduce the features,and a feed-forward neural network(FNN)and modified particle swarm optimization(mPSO)with ant colony optimization(ACO)to improve the accuracy,stability,and overcome fitting issues in the classification of brain magnetic resonance *** proposed method achieves better results than other existing algorithms.

关键词： Discrete wavelet transformation ant colony optimization feed-forward neural network linear discriminant analysis

Irreversibility investigation of Casson fluid flow in an inclined channel subject to a Darcy-Forchheimer porous medium:a numerical study

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Applied mathematics and mechanics(English Edition) 2021年第1期42卷 95-108页

作者： A.ROJA B.J.GIREESHA B.nagaraja Department of PG Studies and Research in mathematics Kuvempu UniversityShankaraghattaShimoga 577451KarnatakaIndia

The heat transfer and entropy generation characteristics of the magnetohydrodynamic Casson fluid flow through an inclined microchannel with convective boundary conditions are ***,the effects of the viscous forces,Joule heating,heat source/sink,and radiation on the flow are taken into *** non-dimensional transformations are used to solve the governing ***,the reduced system is resolved by the fourth-fifth order Runge-Kutta-Fehlberg method along with the shooting *** effects of different physical parameters on the heat transfer and entropy generation are discussed in detail through *** the perspective of numerical results,it is recognized that the production of entropy can be improved with the Joule heating,viscous dissipation,and convective heating *** is concluded that the production of entropy is the maximum with increases in the Casson parameter,the angle of inclination,and the Hartmann *** the Reynolds number and the radiation parameter cause the dual impact on entropy generation.

关键词： inclined channel Casson fluid magnetism radiation entropy generation Bejan number