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measurement of circulating levels of VEGF-A,-C,and -D and their receptors,VEGFR-1 and -2 in gastric adenocarcinoma

World Journal of Gastroenterology 2008年第24期14卷 3879-3883页

作者： mansour S Al-moundhri A Al-Shukaili m Al-Nabhani B Al-Bahrani ia Burney A Rizivi SS Ganguly medical Oncology Unit Department of MedicineCollege of Medicine and Health SciencesSultan Qaboos University Department of microbiology and Immunology (SQU) National Cancer Institute Royal Hospital Department of Epidemiology and medical Statistics (SQU)

AIm: To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A,-C,and -D,and their receptors,VEGFR-1 and -2 in gastric adenocarcinomas. mETHODS: The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. RESULTS: The serum levels of VEGF-A and its receptor,VEGFR-1,were signifi cantly higher in patients with gastric cancer than in healthy donors (t = 2.3,P = 0.02 and t = 4.2,P m levels of VEGF-D were signif icantly higher in control subjects than in patients (t = 2.9,P = 0.004). There was no significant difference in serum levels of VEGF-C and VEGFR-2 between patients and controls. VEGF-C was associated with advanced tumor stage and presence of metastasis. VEGFR-1 was associated with metastasis,advanced overall stage,tumor differentiation and survival. VEGFR-2 levels were associated with poor tumor differentiation. There was no significant prognostic value for any of the VEGF family members or their receptors except for VEGFR-1 where high levels were associated with a poor overall survival. CONCLUSION: Serum VEGF levels vary significantly in the same cohort of patients with variable clinico-pathological features and prognostic values. The simultaneous measurement of VEGF receptors levels in sera may overcome the limitations of a single biomarker assay.

关键词： Gastric cancer Serum Vascular endothelialgrowth factor Oman

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湖北均县朱家台遗址

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考古学报 1989年第1期 25-56,137-144页

作者： Changjiang Archaeological Team, ia, CASS 中国社会科学院考古所长江工作队

朱家台遗址位于鄂西北均县城南2.5公里,七里屯村东北的一块高地上,东临汉江与曾河交汇处之冲积地带,西傍均(县)草(店)公路。地貌为一长条形土丘,高出周围地面3—6米,南北长185、东西宽20—70米,面积约8000平方米,遗址保存较好(图一)。

关键词：仰韶文化口径遗址图版泥质灰陶文化遗存长方形弦纹横断面

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安阳大寒村南岗遗址

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考古学报 1990年第1期 43-68,136-141页

作者： Anyang Archaeological Team, ia, CASS 中国社会科学院考古研究所安阳队

大寒村位于河南省安阳市东南约15公里,白壁集南约2公里。遗址坐落在村南约500米的一个高7—8米的土岗上,故称南岗。岗南有一条向东流的小溪,岗的东、北、西三面有路沟环绕。遗址面积约25万平方米。1961年夏,安阳市文管会和我队在考古调... 详细信息

大寒村位于河南省安阳市东南约15公里,白壁集南约2公里。遗址坐落在村南约500米的一个高7—8米的土岗上,故称南岗。岗南有一条向东流的小溪,岗的东、北、西三面有路沟环绕。遗址面积约25万平方米。1961年夏,安阳市文管会和我队在考古调查中发现此遗址。1962年,我队曾对此遗址进行试掘。1965年,配合北京大学历史系考古专业62级同学实习,在1962年试掘地点的西南约200米处进行发掘,发掘工作自9月13日开始。

关键词：龙山文化遗址图版长方形文化遗存口径安阳市南岗大寒平底

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Structural, elastic and electronic properties for m_2 XC (m=Ti and Cr, X=Ga and Al) phases from ab initio calculations

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Acta metallurgica Sinica(English Letters) 2011年第4期24卷 255-270页

作者： B. Ghebouli m.A. Ghebouli m. Fatmi N. Bouarissa m. Benkerri I.A. Ibrahim Laboratory of Study of Surfaces and Interfaces of Solids materials Department of Physics Faculty of Science University of Setif Department of Physics University Center Research Unit on Emerging materials Ferhat Abbas University of Setif Department of Physics Faculty of Sciences King Khalid University Central metallurgical Research and Development Institute P.O. Box: 87 Helwan 11424 Cairo Egypt

The first-principles study of the structural, elastic and electronic properties of the m2XC phases depending on the type of m transition metal （m are Ti and Cr） and on X （X are Ga and A1） was reported. The calculations are performed using the pseudo-potential plane-wave approach in both the local density and generalized gradient approximations. The elastic constants are calculated using the static finite strain technique. Features such as structural and elastic parameters, Debye tem- perature, sound velocities and their pressure dependence have been investigated. In agreement with experimental and previous theoretical findings, it is found that the compressibility along a and c axis depends on the valence electron concentration （VEC）. Correlations revealing the governing role of the X and m elements on the machinability indices of the material have been examined. The electronic properties have been discussed in terms of chemical bonding showing that bonding is due to md-Cp and md-Xp hybridizations. m-C bonds are stiffer than m-X ones and A1-Ti （Cr-C） bonds are stiffer than those corresponding to Ti-C （A1-Cr）. It is shown that the stiffness of the m-X and m-C bonds increases with increasing the number of VEC.

关键词： m2XC phases ab initio Pressure effect Band structures

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Oxygen Permeability of Polypropylene Containing Polyisobutene with magnesium Acetate

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International Journal of minerals,metallurgy and materials 2000年第2期14卷 118-121页

作者： Wei Tian Raymond T. Woodhams(material Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China)(Dept. of Chemical Engineering and Applied Chemistry, University of Toronto, Torono m5S ia4, Canada) Univ Sci & Technol Beijing Sch Mat Sci & Engn Beijing 100083 Peoples R China Univ Toronto Dept Chem Engn & Appl Chem Toronto ON M5S 1A4 Canada

The oxygen permeabilities of polypropylene films are reduced by adding a minor percentage of a polyisobutene ionomer. The polyisobutene ionomers were prepared by in situ salt exchange of magnesium acetate with maleated polyisobutenes of commercially available low relative molecular mass. The more polar magnesiurn salts aided phase separaion during crystallization from the molten polypropylene mixtusre. Scanning electron microscope photographs revealed that the polyisobotene ionomer is largely concentratd in the amorphous regions between the polypropylene spherulites, where the ionomer tends to concentrate during crystallization. The influence of the polyisobutene ionomer on the oxygen permeability of polypropylene was found to be slightly dependent upon the relative molecular mass of the polyisobutene precursor. Under optimum conditions, the oxygen permeability of polypropylene is reduced by 20%with only 1% additive.

关键词： oxygen permeability polypropylene polyisobutene

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Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation

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Journal of molecular Cell Biology 2015年第4期7卷 351-365页

作者： Fahima madouri Noelline Guillou Louis Fauconnier Tiffany marchiol Nathalie Rouxel Pauline Chenuet Aurelie Ledru Lionel Apetoh franc¸ois Ghiringhelli mathias Chamaillard Song Guo Zheng Fabrice Trovero Valerie F.J.Quesniaux Bernhard Ryffel Dieudonnee Togbe Laboratory of Experimental and molecular Immunology and Neurogenetics(INEm) UMR 7355 CNRS-University of OrleansF-45071 Orleans-Cedex2France Artimmune SAS 45100 Orle´ansFrance Faculte´de me´decine University of BourgogneDijonFrance INSERm U866DijonFrance Centre Georges franc¸ois Leclerc DijonFrance CIIL–Center for Infection and Immunity of Lille INSERM U1019Institut PasteurLilleFrance Division of Rheumatology Penn State Milton S.Hershey Medical CenterHersheyPA 17033USA Clinical Immunology Section Third Affiliated Hospital at Sun Yat-Sen UniversityGuangzhou 510630China

The cysteine protease caspase-1(Casp-1)contributes to innate immunity through the assembly of NLRP3,NLRC4,AIm2,and NLRP6 *** we ask whether caspase-1 activation plays a regulatory role in house dust mite(HDm)-induced experimental allergic airway *** report enhanced airway inflammation in caspase-1-deficient mice exposed toHDmwith a marked eosinophil recruitment,increased expression of IL-4,IL-5,IL-13,aswell as full-length and bioactive ***,mice deficient for NLRP3 failed to control eosinophil influx in the airways and displayed augmented Th2 cytokine and chemokine levels,suggesting that the NLPR3 inflammasome complex controls HDm-induced ***-33 neutralization by administration of soluble ST2 receptor inhibited the enhanced allergic inflammation,while administration of recombinant IL-33 during challenge phase enhanced allergic inflammation in caspase-1-deficient ***,we show that caspase-1,NLRP3,and ASC,but not NLRC4,contribute to the upregulation of allergic lung ***,we cannot exclude an effect of caspase-11,because caspase-1-deficient mice are deficient for both ***,absence of caspase-1 is associated with increased expression of IL-33,uric acid,and spleen tyrosine kinase(Syk)*** study highlights acritical role of caspase-1 activation andNLPR3/ASCinflammasomecomplex in the down-modulation of IL-33 in vivo and in vitro,thereby regulating Th2 response in HDm-induced allergic lung inflammation.

关键词： house dust mite allergic asthma caspase-1 inﬂammasomes IL-33 spleen tyrosine kinase(Syk) uric acid

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Influence of FCA Welding Process Parameters on Distortion of 409m Stainless Steel for Rail Coach Building

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Journal of Iron and Steel Research International 2013年第1期20卷 71-78页

作者： m V Venkatesan N murugan B m Prasad A manickavasagam Department of mechanical Engineering Coimbatore Institute of TechnologyCoimbatore 641014TNIndia Integral Coach Factory Indian RailwaysChennai 600038TNIndia

The influence of flux cored arc welding （FCAW） process parameters such as welding current, travel speed, voltage and CO2 shielding gas flow rate on bowing distortion of 409m ferritic stainless steel sheets of 2 mm in thickness was discussed. The bowing distortions of the welded plates were measured using a simple device called profile tracer. An experimental regression equation was developed to predict the bowing distortion and with this equation, it is easy to select optimized process parameters to achieve minimum bowing distortion. It is revealed that the FCAW process parameters have significant influence on bead profile and the bowing distortion.

关键词： bowing distortion ferritic stainless steel flux cored arc welding statistical model rail coach distortion measurement

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Holmium Oxide Film as a Saturable Absorber for 2μm Q-Switched Fiber Laser

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Chinese Physics Letters 2017年第5期34卷 48-51页

作者： m.F.A.Rahman m.F.m.Rusdi m.Q.Lokman m.B.H.mahyuddin A.A.Latiff A.H.A.Rosol K.Dimyati S.W.Harun Department of Electrical Engineering University of Malaya Kuala Lumpur 50603 Malaysia Photonics Research Centre University of Malaya Kuala Lumpur 50603 Malaysia Faculty of Electrical Engineering University Teknologi Mara Shah Alam 40450 Malaysia

This work reports on the use of the holmium oxide （Ho2O3） polymer film as a saturable absorber （SA） for generating stable Q-switching pulses operating in a 2μm region in a thulium-doped fiber laser cavity. The SA is prepared by diluting a commercial Ho3O2 powder and then mixing it with polyvinyI alcohol （PVA） solution to form a Ho2O3-PVA film. A tiny part of the film about 1mm×1 mm in size is sandwiched between two fiber ferrules with the help of index matching gel. When incorporated in a laser cavity driven by a 1552-nm pump, stable Q-switching pulses are observed at 1955nm within the pump power range of 363 491 roW. As the pmnp power increases within this range, the repetition rate rises from 26 kHz to 39 kHz, as the pulse width drops from 4.22μs to 2.57μs. The laser operates with a signal-to-noise ratio of 47dB, and the maximum output power and the pulse energy obtained are 2.67mW and 69ng, respectively. Our results successfully demonstrate that the Ho2O3 film can be used as a passive SA to generate a 2μm pulse laser.

关键词： m Q-Switched Fiber Laser SA FESEm

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陕西彬县断泾遗址发掘报告

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考古学报 1999年第1期 73-96,123-126页

作者： Jing-Wei Archaeological Team, ia, CASS 中国社会科学院考古研究所泾渭工作队

The Duanjing-cun site is on the right bank of the Jinghe River,under the juristiction of Xinbaozi township,Binxian county, Shaanxi province, and in the territory of Binyi recorded in ancient texts. In order to explore the predynastic Zhou culture of the time when the Zhou people lived in the Bin area,the Jing-Wei Archaeological Team,ia,CASS,excavated the site in 1995. Six squares were excavated, and one ash-trench, 22 ash-pits and four graves of the Shang period were revealed. The ash-pits are generally oval in plan. The graves are all rectangular earth shafts and measure 4. 92m in length and 3.8m in width for the largest. Among the artifacts, including excavated and collected, there are bronze axes, knives and arrowheads, gold ornaments, pottery li tripods, yan steamers, gui basins, dou stemmed vessels and jars, stone axes and knives, and bone spades and oracle bones. The Shang period remains at the site can be divided into two stages. The first stage, characterized by the li with a decorative border appliqued along the rim, a high collar, a split crotch and pointed hollow legs, is estimated to be of roughly the same date as the first phase of the Yin Ruins at Anyang. This must be the predynastic Zhou culture of the Bin-occupied period. In the second stage, the li was slightly changed, with cord design appliqued on the neck and the crotch becoming arched. Its date roughly corresponds to that of the predynastic Zhou culture remains of the Qi-occupied period. meanwhile, the foot-pit in the tombs and the shapes of gold ornaments and bronze axes all show distinct stylistic features of the Rong, Di and Gulf aug cultures. The whole batch of material may verify the historical records on the Zhou people once living in the Bin area and provides important clues for further identifying the location of Binyi.

关键词：陕西彬县绳纹陶器残片二层台遗存先周文化遗址口部附加图版

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