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二维数字化乳腺摄影与数字乳腺断层摄影在乳腺癌筛查率和间歇乳腺癌特征中的对比研究

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国际医学放射学杂志 2018年第3期 351-351页

作者： m.Bahl S.Gaffney a.m.mc carthy K.P.Lowry P.A.Dang C.D.Lehman 魏铃 Division of Breast Imaging Department of MedicineMassachusetts General Hospital

摘要目的确定二维数字化乳腺摄影(Dm)与数字乳腺断层摄影(DBT)在筛查率和间歇癌的特征中是否存在差异。材料与方法回顾分析2009年1月—2011年2月(Dm

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Natural products:Perspectives in the pharmacological treatment of gastrointestinal anisakiasis

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Asian Pacific Journal of Tropical medicine 2015年第8期8卷 604-609页

作者： Valero A Romero mc Gómez-mateos m Hierro I Navarro mc Department of Parasitology.Faculty of Pharmacy.University of Granada Department of Pharmacology.Faculty of Pharmacy.University of Granada

Objective: To evaluate the activity of different natural products against L3 larvae of Anisakis type I. methods: Information on investigations into the activity of natural products against the L3 larvae of Anisakis simplex was collected from scientific journals, books, theses and reports via a library and electronic search(using Pubmed, Scopus, medline, Web of Science and Science Direct). The search terms included: natural products, medicinal plants, essential oils, terpenic derivatives, Anisakis, antinematodal activity. Results: In the literature reviewed numerous papers were found concerning the in vitro and in vivo activity against Anisakis type I of various natural products(plant extracts, essential oils and their major components). Analysis of the results showed that in vitro tests the melaleuca alternifolia essential oil and the ar-turmerone isolated from Curcuma longa displayed the greatest activity. In vivo, the most active compound was perillaldehyde, the main component of Perilla frutescens essential oil. Conclusions: This study shows that some natural products exhibited promising antianisakis properties.

关键词： Anisakis Anisakiasis Natural products Essential oils Terpenic derivatives

A micromechanical model for efective conductivity in granular electrode structures

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Acta mechanica Sinica 2013年第5期29卷 682-698页

作者： Julia Ott Benjamin Vlker Yixiang Gan Robert m.mc meeking marc Kamlah Institute of Applied materials Karlsruhe Institute of Technology76131 Karlsruhe Germany Department of mechanical Engineering University of CaliforniaSanta BarbaraCA 93106 USA School of Civil Engineering The University of SydneyNSW 2006 Australia materials Department University of CaliforniaSanta BarbaraCA 93106 USA School of Engineering University of AberdeenKing’s CollegeAberdeenAB24 3UE Scotland UK INm-Leibniz Institute for New materials Campus D22 66123 Saarbrücken Germany

Optimization of composition and microstructure is important to enhance performance of solid oxide fuel cells （SOFC） and lithium-ion batteries （LIB）. For this, the porous electrode structures of both SOFC and LIB are modeled as a binary mixture of electronic and ionic conducting particles to estimate effective transport properties. Particle packings of 10000 spherical, binary sized and randomly positioned particles are created numerically and densified considering the different manufacturing processes in SOFC and LIB： the sintering of SOFC electrodes is approximated geometrically, whereas the calendering process and volume change due to intercalation in LIB are modeled physically by a discrete el- ement approach. A combination of a tracking algorithm and a resistor network approach is developed to predict the con- nectivity and effective conductivity for the various densified structures. For SOFC, a systematic study of the influence of morphology on connectivity and conductivity is performed on a large number of assemblies with different compositions and particle size ratios between 1 and 10. In comparison to percolation theory, an enlarged percolation area is found, es- pecially for large size ratios. It is shown that in contrast to former studies the percolation threshold correlates to varying coordination numbers. The effective conductivity shows not only an increase with volume fraction as expected but also with size ratio. For LIB, a general increase of conductivity during the intercalation process was observed in correlation with increasing contact forces. The positive influence of cal- endering on the percolation threshold and the effective conductivity of carbon black is shown. The anisotropy caused by the calendering process does not influence the carbon black phase.

关键词： Granular electrode structures Effective conductivity - Percolation

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Update on prevention and screening of cervical cancer

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World Journal of Clinical Oncology 2014年第4期5卷 744-752页

作者： Shaniqua L mc Graw Jeanne m Ferrante Rutgers-Robert Wood Johnson medical School Department of Family Medicine and Community Health Somerset New Jersey NJ 08873 United States Department of Family medicine and Community Health Cancer Institute of New Jersey New Brunswick New Jersey NJ 08903 United States

Cervical cancer is the third most common cause of cancer in women in the world. During the past few decades tremendous strides have been made toward decreasing the incidence and mortality of cervical cancer with the implementation of various prevention and screening strategies. The causative agent linked to cervical development and its precursors is the human papillomavirus(HPV). Prevention and screening measures for cervical cancer are paramount because the ability to identify and treat the illness at its premature stage often disrupts the process of neoplasia. Cervical carcinogenesis can be the result of infections from multiple high-risk HPV types that act synergistically. This imposes a level of complexity to identifying and vaccinating against the actual causative agent. Additionally, most HPV infections spontaneously clear. Therefore, screening strategies should optimally weigh the benefits and risks of screening to avoid the discovery and needless treatment of transient HPV infections. This article provides an update of the preventative and screening methodsfor cervical cancer, mainly HPV vaccination, screening with Pap smear cytology, and HPV testing. It also provides a discussion of the newest United States 2012 guidelines for cervical cancer screening, which changed the age to begin and end screening and lengthened the screening intervals.

关键词： Cervical cancer Cancer screening Pap smear Human papillomavirus Papillomavirus vaccines

Effects of live yeast on differential genetic and functional attributes of rumen microbiota in beef cattle

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Journal of Animal Science and Biotechnology 2019年第4期10卷 1101-1107页

作者： Ibukun m.Ogunade Jerusha Lay Kenneth Andries Christina J.mc manus Frederick Bebe College of Agriculture Communities and the Environment Kentucky State University

Several studies have evaluated the effects of live yeast supplementation on rumen microbial population;however,its effect on differential microbial genes and their functional potential has not been described. Thus, this study applied shotgun metagenomic sequencing to evaluate the effects of live yeast supplementation on genetic and functional potential of the rumen microbiota in beef cattle. Eight rumen-cannulated Holstein steers were randomly assigned to two treatments in a cross-over design with two 25-day experimental periods and a 10-day wash-out between the two periods. The steers were housed in individual pens and fed 50% concentrate-mix and 50% red clover/orchard hay ad libitum. Treatments were(1) control(CON;basal diet without additive) and(2) yeast(YEA;basal diet plus 15 g/d of live yeast product). Rumen fluid samples were collected at 3, 6, and 9 h after feeding on the last d of each period. Sequencing was done on an Illumina Hi Seq 2500 platform. Dietary yeast supplementation increased the relative abundance of carbohydrate-fermenting bacteria(such as Ruminococcus albus, ***, R. bromii, and R. obeum) and lactate-utilizing bacteria(such as megasphaera elsdenii, Desulfovibrio desulfuricans, and D. vulgaris). A total of 154 differentially abundant genes(DEGs) were obtained(false discovery rate mes(KEGG) annotation analysis of the DEGs revealed that 10 pathways, including amino sugar and nucleotide sugar metabolism, oxidative phosphorylation, lipopolysaccharide biosynthesis, pantothenate and coenzyme A biosynthesis, glutathione metabolism, beta-alanine metabolism,polyketide sugar unit biosynthesis, protein export, ribosome, and bacterial secretory system, were enriched in steers fed YEA. Annotation analysis of the DEGs in the carbohydrate-active enzymes(CAZy) database revealed that the abundance of genes coding for enzymes belonging to glycoside hydrolases, glycosyltransferases, and carbohydrate bindi

关键词： Functional potential Live yeast Rumen

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When worlds collide: Th17 and Treg cells in cancer and autoimmunity

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Cellular & molecular Immunology 2018年第5期15卷 458-469页

作者： Hannah m.Knochelmann Connor J.Dwyer Stefanie R.Bailey Sierra m.Amaya Dirk m.Elston Joni m.mazza-mc.Crann Chrystal m.Paulos Department of microbiology and Immunology Medical University of South CarolinaCharlestonSCUSA Department of Dermatology and Dermatologic Surgery Medical University of South CarolinaCharlestonSCUSA

The balance between Th17 cells and regulatory T cells(Tregs)has emerged as a prominent factor in regulating autoimmunity and ***17 cells are vital for host defense against pathogens but have also been implicated in causing autoimmune disorders and cancer,though their role in carcinogenesis is less well *** are required for self-tolerance and defense against autoimmunity and often correlate with cancer *** review addresses the importance of a functional homeostasis between these two subsets in health and the consequences of its disruption when these forces collide in ***,we discuss the ability of Th17 cells to mediate cancer regression in immunotherapy,including adoptive transfer and checkpoint blockade therapy,and the therapeutic possibilities of purposefully offsetting the Th17/Treg balance to treat patients with cancer as well as those with autoimmune diseases.

关键词： autoimmunity cancer immunotherapy Th17 Treg

Impact of all oral anti-hepatitis C virus therapy:A metaanalysis

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World Journal of Hepatology 2015年第5期7卷 806-813页

作者： Siddharth Bansal Ashwani K Singal Brendan m mc Guire Bhupinder S Anand Department of Internal medicine University of Alabama Birmingham Department of Gastroenterology and Hepatology University of Alabama Birmingham Department of Gastroenterology and Hepatology Michael E.DeB akey VA Medical Center and Baylor College of Medicine

AIm:To investigate the efficacy,safety,and cost of treatment of direct acting antivirals(DAAs) with and without peg interferon alfa2a(P),and/or ribavirin(R) in treating hepatitis C virus(HCV) genotype 1 ***:mEDLINE was searched for randomized controlled trials(RCT) using DAAs for HCV *** 1 trials and studies with investigational drugs on genotype 2 or 3,and on human immunodeficiency virus patients were *** were pooled for sustained virologic response(SVR),serious adverse effects,and drug discontinuation rate on various treatment arms in trials:P + R;1st generation DAA(telaprevir or boceprevir) + P + R;2nd generation DAA(sofosbuvir or simeprevir) + P + R;2nd generation DAA + R;two 2nd generation DAA + R;and two 2nd gen *** were analyzed separately for each arm for treatment naive and non-responders(NR) to previous *** cost of treatment with each regimen for achieving one SVR was also ***:Twenty three RCTs(n = 9354,62% male,11% cirrhosis) were *** oral(P free) regimens with combination of 2 DAA achieved SVR above 95%.The cost of treatment to achieve an SVR with DAA based regimens was lower for NR compared to P+R ***,the cost per SVR remained higher for treatment naive ***:Second generation and emerging DAAs are promising agents in HCV treatment,with a very high level of safety and *** important drawback is their high ***,the present meta-analysis shows that the cost per SVR for non responders(but not for naive patients) was lower compared to P + *** finding together with the superior safety profile and better compliance makes these drugs highly *** is possible that further reduction in treatment duration may make them even more cost effective.

关键词： Hepatitis C meta-analysis Direct actingantivirals Oral agents Newer agents Hepatitis C virus

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人体-座椅接触面测量参数的研究初探

仪表技术与传感器 2011年第1期 92-94页

作者：刘卓夫罗中明 Vincenzo Cascioli Louise mazzeo Andrewl Heusch Peter W m^c carthy 哈尔滨理工大学测控技术与通信工程学院测控技术及仪器黑龙江省高校重点实验室黑龙江哈尔滨150080 murdoch University Chiropractic Clinic MurdochWestern Australia6150 WIOC University of GlamorganPontypriddUnited KingdomCF37 1DL

文中介绍了一种集力、温度和湿度传感器信息的座椅舒适度检测系统。传感器的布放采用已发表文章中所介绍的布放方式:温度和湿度传感器分别放置在左、右腿和尾臀骨下方;4个力传感器分别放在左、右腿和左、右坐骨结节的下方。在进行人体... 详细信息

文中介绍了一种集力、温度和湿度传感器信息的座椅舒适度检测系统。传感器的布放采用已发表文章中所介绍的布放方式:温度和湿度传感器分别放置在左、右腿和尾臀骨下方;4个力传感器分别放在左、右腿和左、右坐骨结节的下方。在进行人体实验前,对力、温度和湿度传感器的输出一致性进行了测试。测量数据显示:温度传感器标准方差为±0.2℃;湿度传感器标准方差为±0.3%,压力传感器标准方差为±0.09 V(其中加载负荷5 kg～15 kg,力传感器输出电压的变化为3.67～4.31 V),这表明所有的传感器具有一致的输出特性。在三天内,共有10人/次利用该检测系统对3种坐垫(泡沫、木质和压模坐垫)的舒适度进行了评估。为了避免次序效应对测量结果的影响,整个实验采用了拉丁方设计方法。通过将坐姿调整时间、最大温度和平均相对湿度与舒适度主观评测问卷进行对比分析,结果表明传感器的原始数据和相关参数的变化与人对座椅舒适度的主观评价之间存在一定的联系。

关键词：座椅舒适度力温度相对湿度

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Up-regulation of micro RNA-210 inhibits proliferation of hepatocellular carcinoma cells by targeting YES1

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World Journal of Gastroenterology 2015年第46期21卷 13030-13041页

作者： Weiqi Tan Seng-Gee Lim Theresa mc Tan Department of Biochemistry Yong Loo Lin School of MedicineNational University of Singapore Department of medicine Yong Loo Lin School of MedicineNational University of Singapore

AIm: To determine the expression of micro RNA-210(mi R-210) in hepatocellular carcinoma(HCC) and to examine its role using HCC ***: The expression of mi R-210 was determined in 21 pairs of HCC samples and the corresponding surrounding non-tumor tissues. The effects of mi R-210 on proliferation and cell cycle progression were examined using Hep G2 and Hu H7 cells. Overexpression and inhibition of mi R-210 was achieved by transfection of the cells with mi R-210 mimic or inhibitor. Luciferase reporter constructs were used to identify the mi R-210 interacting site on Yes1. Yes1 expression was examined after mi R-210 transfection,as well as in the HCC ***: mi R-210 was significantly up-regulated by 3.4 fold(P mor samples. The over-expression of mi R-210 significantly reduced cell proliferation compared to the mock-treated cells(68.9% ± 7.4% and 53.6% ± 5.0%,P mi R-210 mimic by flow cytometry showed that the cells took a longer time to reach the G2/m phase. The interaction between mi R-210 and the 3'UTR of the Yes1 transcript was confirmed using a luciferase reporter assay. Over-expression of mi R-210 reduced the expression of Yes1 protein in both Hu H7 and Hep G2 cells. Tumors with a greater than fourfold increase in the expression of mi R-210 showed consistently lower expressions of Yes1 in the *** nocodazole-treated cells with a significant G2/m cell population,Yes1 protein was significantly reduced and pre-inhibition of mi R-210 in Hu H7 cells was able to prevent the reduction of Yes1 protein expression. Knock-down of Yes1 by si RNA also led to reduced cell proliferation(70.8% ± 7.5%,P mi R-210 inhibits cell proliferation. Yes1 is a target of mi R-210 and affects cell proliferation in HCC.

关键词： micro RNA-210 Hepatocellular carcinoma Proliferati