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全身动态增强MRI评估多发性骨髓瘤治疗效果的研究

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国际医学放射学杂志 2010年第2期 184-185页

作者： C.Lin a.luciani K.Belhadj J.F.Deux F.Kuhnowski M.Maatouk 谢丽璇 Department of Medical Imaging AP-HPGroupe HenriMondor Albert-Chenevier51 Avenue du Malréchal de Lattre de Tassigny94010 CréteilFrance

目的运用全身动态增强MRI比较多发性骨髓瘤(MM)病人治疗后骨髓改变的临床反应,并确定此技术是否可用于评估MM病人治疗效果。材料与方法本研究由公共审查委员会批

关键词：多发性骨髓瘤骨髓瘤浆细胞瘤动态增强 MRI 治疗效果全身

双能CT下心肌碘浓度测量对诊断心肌淀粉样变的价值:初步研究

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国际医学放射学杂志 2018年第2期 248-248页

作者： V.Chevance T.Damy V.Tacher F.Legou F.Ridouani a.luciani 李凤致 Service d’Imagerie Médicale AP-HP(Assistance Publique-H?pitaux de ParisCréteil) Groupe Hospitalier Henri Mondor-Albert Chenevier

摘要目的采用双能CT(DECT)测量心肌淀粉样变(CA)病人的心肌碘浓度(MIC)。方法 22例心肌淀粉样变病人、13例非肥厚性心肌病(CH)病人和10例对照组病人,采

关键词： EVC 碘浓度淀粉样变 CT

全身磁共振扩散成像及表观扩散系数图对弥漫性大B细胞淋巴瘤病人分期的价值

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国际医学放射学杂志 2010年第5期 509-509页

作者： a.luciani E.Itti T.EI-Gnaoui A.Vignaud A.Rahmouni 颜荣华 Imagerie Médicale AP-HPGroupe Henri-Mondor Albert-ChenevierCHU Henri Mondor51 Avenue du Malréchal de Lattre de Tassigny94010 CréteilFrance

关键词： DWI ADC图呼吸门控弥漫性大B细胞淋巴瘤分期 FDG PET/CT

病人的浆细胞疾病检查全身动态增强MRI:初步经验

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国际医学放射学杂志 2009年第3期 284-284页

作者： a.luciani K.Belhadj P.Maison A.Vignaud J.F.Deux 李华兵 Department of Medical Imaging AP-HPGroupe Henri-Mondor Albert-Chenevier51 Avenue du Malréchal de Lattre de Tassigny94010 CréteilFrance

本研究获机构审查委员会批准,并获病人知情同意。就浆细胞疾病病人所行的多站全身动态对比增强MRI进行前瞻性研究,以评估疾病的范围及弥漫性与局部性骨髓浸润的时间信号强度曲线的可行性。3名健康成年男性志愿者(年龄29～31岁)和21例病... 详细信息

本研究获机构审查委员会批准,并获病人知情同意。就浆细胞疾病病人所行的多站全身动态对比增强MRI进行前瞻性研究,以评估疾病的范围及弥漫性与局部性骨髓浸润的时间信号强度曲线的可行性。3名健康成年男性志愿者(年龄29～31岁)和21例病人(男性12例,女性9例,年龄34～79岁)进行了全身动态平扫(志愿者)和对比增强MR成像,采用18通道1.5T的MR系统。

关键词：动态增强 MRI 浆细胞效应B细胞 B-淋巴细胞全身病人

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扩散张量成像评价腓肠肌收缩运动

国际医学放射学杂志 2008年第A06期31卷 526-526页

作者： J.F.Deux P.Malzy N.Paragios G.Bassez a.luciani P.Zerbib 段小慧 Service d’Imagerie Médicale Centre Hospitalo-Universitaire H. Mondor Assistance Publique-Höpitaux de Paris INSERM UMR 705441 avMal de Lattre de Tassigny94000 Créteil France.

本研究的目的是使用扩散张量MRI评价正常志愿者腓肠肌收缩及舒张运动中的水分子扩散情况。对20名平均年龄(29±4)

关键词：扩散张量成像 MRI 骨骼肌

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The western Durkan Complex(Makran Accretionary Prism,SE Iran):A Late Cretaceous tectonically disrupted seamounts chain and its role in controlling deformation style

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Geoscience Frontiers 2021年第3期12卷 503-527页

作者： Edoardo Barbero Luca Pandolfi Morteza Delavari Asghar Dolati Emilio Saccani Rita Catanzariti Valeria.luciani Marco Chiari Michele Marroni Dipartimento di Fisica e Scienze della Terra Universitàdi FerraraVia Saragat 144123 FerraraItaly Dipartimento di Scienze della Terra Universitàdi PisaVia S.Maria 5356126 PisaItaly Istituto di Geoscienze e Georisorse CNRPisaVia G.Moruzzi 156124 PisaItaly Faculty of Earth Sciences Kharazmi UniversityShahid Mofatteh St.43TehranIran Istituto di Geoscienze e Georisorse CNRFirenzeVia La Pira 450121 FirenzeItaly

The Durkan Complex is a key tectonic element of the Makran accretionary prism(SE Iran)and it has been interpreted as representing a continental margin *** present here a multidisciplinary study of the western Durkan Complex,which is based on new geological,stratigraphic,biostratigraphic data,as well as geochemical data of the volcanic and meta-volcanic rocks forming this *** data show that this complex consists of distinct tectonic slices showing both non-metamorphic and very low-grade metamorphic deformed *** and biostratigraphic data allow us to recognize three types of ***-Ⅰis composed by a Coniacian-early Campanian pelagic succession with intercalation of pillow lavas and minor volcaniclastic ***-Ⅱsuccession includes a volcanic sequence passing to a volcano-sedimentary sequence with Cenomanian pelagic limestones,followed by a hemipelagic *** succession is characterized by abundant mass-transport ***-Ⅲsuccession includes volcanic and volcano-sedimentary sequences,which are stratigraphically covered by a Cenomanian platform *** latter is locally followed by a hemipelagic *** volcanic rocks in the different successions show alkaline geochemical affinity,suggesting an origin from an oceanic within-plate *** new results indicate that the western Durkan Complex represents fragments of seamounts tectonically incorporated in the Makran accretionary wedge during the latest Late *** propose that incorporation of seamounts in the frontal prism caused a shortening of the whole convergent margin and possibly contributed to controlling the deformation style in the Makran Accretionary Wedge during Late Cretaceous-Paleocene times.

关键词： Tectonically disrupted seamounts Makran Late Cretaceous Iran Neo-Tethys

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In-depth profiling of tumor tissue derived from malignant pleural mesothelioma patients identifies potential biomarkers predicting response to immune-checkpoint inhibitor therapy

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Genes & Diseases 2024年第6期11卷 28-31页

作者： Dmitri Shek Bo Gao Hema Mahajan Adnan Nagrial Matteo S.Carlino Fabio luciani Scott A.Read Golo Ahlenstiel Blacktown Clinical School Western Sydney UniversitySydneyNSW 2148Australia Westmead Institute for Medical Research SydneyNsw 2145Australia Blacktown Mt Druitt Hospital SydneyNSW 2148Australia Westmead Hospital SydneyNsw 2145Australia Westmead Clinical School University of SydneySydneyNSW 2145Australia Institute of Clinical Pathology and Medical Research SydneyNSW 2145Australia Melanoma Institute Australia SydneyNSW 2065Australia School of Medical Sciences University of New South WalesSydneyNSW 2052Australia Garvan Institute for Medical Research SydneyNSW 2010Australia

Malignant pleural mesothelioma(MPM)is a rare and aggressive cancer with low survival probability as it is generally diagnosed at later stages.'Using a combination of immune-checkpoint inhibitors(ICls)ipilimumab(IPl)and nivolumab(NivO)as a first-line treatment for unresectable MPM,the CheckMate 743 trial reported higher overall survival and prolonged duration of response compared with traditional chemotherapy.

关键词： pleural chemotherapy immune

Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring

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Asian Journal of Andrology 2016年第6期18卷 930-936页

作者： Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio luciani Lutz Krause Margaret J Morris Department of Pharmacology School of Medical Sciences UNSW Australia Sydney NSW 2052 Australia Inflammation and Infection Research School of Medical Sciences UNSW Australia Sydney NSW 2052 Australia Adult Cancer Program Lowy Cancer Research Centre and Prince of Wales Clinical School UNSW Australia Sydney NSW 2052 Australia QIMR Berghofer Medical Research Institute Herston Brisbane Queensland 4006 Australia University of Queensland Diamantina Institute Translational Research Institute University of Queensland 37 Kent Street Woolleongabba Queensland 4102 Australia

There is now strong evidence that the paternal contribution to offspring phenotype at fertilisation is more than just DNA. However, the identity and mechanisms of this nongenetic inheritance are poorly understood. One of the more important questions in this research area is： do changes in sperm DNA methylation have phenotypic consequences for offspring？ We have previously reported that offspring of obese male rats have altered glucose metabolism compared with controls and that this effect was inherited through nongenetic means. Here, we describe investigations into sperm DNA methylation in a new cohort using the same protocol. Male rats on a high-fat diet were 30% heavier than control-fed males at the time of mating （16-19 weeks old, n = 14/14）. A small （0.25%） increase in total 5-methyl-2＇-deoxycytidine was detected in obese rat spermatozoa by liquid chromatography tandem mass spectrometry. Examination of the repetitive fraction of the genome with methyI-CpG binding domain protein-enriched genome sequencing （MBD-Seq） and pyrosequencing revealed that retrotransposon DNA methylation states in spermatozoa were not affected by obesity, but methylation at satellite repeats throughout the genome was increased. However, examination of muscle, liver, and spermatozoa from male 27-week-old offspring from obese and control fathers （both groups from n = 8 fathers） revealed that normal DNA methylation levels were restored during offspring development. Furthermore, no changes were found in three genomic imprints in obese rat spermatozoa. Our findings have implications for transgenerational epigenetic reprogramming. They suggest that postfertilization mechanisms exist for normalising some environmentally-induced DNA methylation changes in sperm cells.

关键词： methylation obesity spermatozoa