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High Power Laser Science and Engineering 2019年第2期7卷 34-39页

作者： L.Volpe R.Fedosejevs G.Gatti J.A.Pérez-Hernández C.Méndez J.Apinaniz X.Vaisseau C.Salgado M.Huault S.Malko G.Zeraouli V.Ospina a.longman D.De Luis K.Li O.Varela E.García I.Hernandez J.D.Pisonero J.Garcia Ajates J.M.Alvarez C.García M.Rico D.Arana J.Hernandez-Toro L.Roso Centro de Laseres Pulsados(CLPU) Edicio M5.Parque Cientco.C/Adaja&37185VillamayorSalamancaSpain Laser-Plasma Chair at the University of Salamanca SalamancaSpain Department of Electrical and Computer Engineering University of AlbertaEdmontonAlberta T6G2V4Canada University of Salamanca SalamancaSpain

The Centro de Laseres Pulsados in Salamanca,Spain has recently started operation phase and the first user access period on the 6 J 30 fs 200 TW system(VEGA 2)already started at the beginning of *** this paper we report on two commissioning experiments recently performed on the VEGA 2 system in preparation for the user *** 2 system has been tested in different configurations depending on the focusing optics and targets *** configuration(long focal length F=130 cm)is for underdense laser-matter interaction where VEGA 2 is focused onto a low density gas-jet generating electron beams(via laser wake field acceleration mechanism)with maximum energy up to 500 MeV and an X-ray betatron source with a 10 keV critical energy.A second configuration(short focal length F= 40 cm)is for overdense laser-matter interaction where VEGA 2 is focused onto a 5 μm thick Al target generating a proton beam with a maximum energy of 10 MeV and temperature of 2.5 *** this paper we present preliminary experimental results.

关键词： high power laser laser-plasma particle acceleration

Microbial manipulation as primary therapy for Crohn's disease

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World Journal of Gastroenterology 2013年第10期19卷 1513-1516页

作者： Randy S longman Arun Swaminath Division of Digestive and Liver Disease Department of MedicineColumbia University Medical CenterNew YorkNY 10032United States

While antimicrobials are clinically effective in preventing post-operative recurrence,the role for antibiotics in primary therapy for Crohn's disease(CD) remains *** recent multicenter phase 2 trial by Prantera et al received wide attention because it demonstrated an increase in the week 12 remission rate in patients with moderately active CD treated with rifaximin and renewed interest in microbial manipulation as primary therapy for *** this commentary,we discuss aspects of durability,immune cell polarization,and safety of microbial manipulation as primary therapy for CD.

关键词： Inflammatory bowel disease Rifaximin Microbiome

Takayasu's arteritis following Crohn's disease in a young woman:Any evidence for a common pathogenesis?

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World Journal of Gastroenterology 2008年第25期14卷 4087-4090页

作者： Melissa AL Farrant Justin C Mason Newton ACS Wong Robert J longman Department of Surgery Bristol Royal Infirmary Marlborough Street Rheumatology Unit Imperial College London Hammersmith Hospital Department of Histopathology Bristol Royal Infirmary Marlborough Street Colorectal Unit Bristol Royal Infi rmary Marlborough Street

Takayasu's arteritis and Crohn's disease are chronic in-flammatory diseases of uncertain aetiology. They rarely occur together, with only twenty nine cases of co-ex-istent Takayasu's arteritis and Crohn's disease reported in the literature. In 88% of these cases, Takayasu's arteritis was diagnosed simultaneously or following a diagnosis of Crohn's disease. We present a case of a young Caucasian medical student, incidentally found to have bilateral carotid bruits on auscultation by a colleague. Magnetic resonance angiography revealed stenoses of the common carotid arteries with estab-lished collaterals, and a diagnosis of Type 1 Takayasu's arteritis was made. An 18F-fluorodeoxyglucose positron emission tomography scan revealed no active disease. Nine months later, she presented with a short history of abdominal pain, vomiting and abdominal disten-sion. Barium follow-through and computer tomography revealed a terminal ileal stricture and proximal small bowel dilation. An extended right hemicoloectomy was performed and histopathology supported a diagnosis of Crohn's disease. This case report is presented with a particular focus on the temporal relationship between these two disease processes and explores whether their concurrence is more than just co-incidence.

关键词： Crohn's disease Granuloma Takayasu'sarteritis

Prevalence and factors associated with vitamin C deficiency in inflammatory bowel disease

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World Journal of Gastroenterology 2022年第33期28卷 4834-4845页

作者： Benjamin Langan Gordon Jonathan S Galati Stevie Yang Randy S longman Dana Lukin Ellen J Scherl Robert Battat Department of Medicine New York Presbyterian/Weill Cornell Medical CenterNew YorkNY 10065United States Department of Gastroenterology and Hepatology New York Presbyterian/Weill Cornell Medical CenterNew YorkNY 10021United States

BACKGROUND Patients with inflammatory bowel disease(IBD) are prone to several nutritional deficiencies. However, data are lacking on vitamin C deficiency in Crohn’s disease(CD) and ulcerative colitis(UC) patients, as well as the impact of clinical, biomarker and endoscopic disease severity on the development of vitamin C *** To determine proportions and factors associated with vitamin C deficiency in CD and UC *** In this retrospective study, we obtained clinical, laboratory and endoscopic data from CD and UC patients presenting to the IBD clinic at a single tertiary care center from 2014 to 2019. All patients had an available plasma vitamin C level. Of 353 subjects who met initial search criteria using a cohort discovery tool, 301ultimately met criteria for inclusion in the study. The primary aim described vitamin C deficiency(≤ 11.4 μmol/L) rates in IBD. Secondary analyses compared proportions with deficiency between active and inactive IBD. Multivariate logistic regression analysis evaluated factors associated with *** Of 301 IBD patients, 21.6% had deficiency, including 24.4% of CD patients and 16.0% of UC patients. Patients with elevated C-reactive protein(CRP)(39.1% vs 16.9%, P < 0.001) and fecal calprotectin(50.0% vs 20.0%, P = 0.009) had significantly higher proportions of deficiency compared to those without. Penetrating disease(P = 0.03),obesity(P = 0.02) and current biologic use(P = 0.006) were also associated with deficiency on univariate analysis. On multivariate analysis, the objective inflammatory marker utilized for analysis(elevated CRP) was the only factor associated with deficiency(odds ratio = 3.1, 95%confidence interval: 1.5-6.6, P = 0.003). There was no difference in the presence of clinical symptoms of scurvy in those with vitamin C deficiency and those *** Vitamin C deficiency was common in IBD. Patients with elevated inflammatory markers and penetrating disease had higher rates of vitamin

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Vitamin C deficiency Scurvy Malnutrition

Causal Relationship Between Complement C3,C4,and Nonalcoholic Fatty Liver Disease:Bidirectional Mendelian Randomization Analysis

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Phenomics 2021年第5期1卷 211-221页

作者： longman Li Lulu Huang Aimin Yang Xiuming Feng Zengnan Mo Haiying Zhang Xiaobo Yang Center for Genomic and Personalized Medicine Guangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Medical UniversityNanning 530021GuangxiChina Nanhu Zhuxi Community Healthcare Center Qingxiu DistrictNanning 530021GuangxiChina School of Public Health The University of Hong KongHong Kong SAR 999077China Department of Occupational Health and Environmental Health School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Department of Urology Institute of Urology and NephrologyThe First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Department of Public Health School of MedicineGuangxi University of Science and TechnologyLiuzhou 545006GuangxiChina

The complement system is activated during the development of nonalcoholic fatty liver disease(NAFLD).We aimed to evaluate the causal relationship between serum C3 and C4 levels and *** exclusion criteria,a total of 1600 Chinese Han men from the Fangchenggang Area Male Health and Examination Survey cohort were enrolled in cross-sectional analysis,while 572 participants were included in the longitudinal analysis(average follow-up of 4 years).We performed a bidirectional Mendelian randomization(MR)analysis using two C3-related,eight C4-related and three NAFLD-related gene loci as instrumental variables to evaluate the causal associations between C3,C4,and NAFLD risk in cross-sectional *** SD increase in C3 levels was significantly associated with higher risk of NAFLD(OR=1.65,95%CI 1.40,1.94)in cross-sectional analysis while C4 was not(OR=1.04,95%CI 0.89,1.21).Longitudinal analysis produced similar results(HR_(C3)=1.20,95%CI 1.02,1.42;HR_(C4)=1.10,95%CI 0.94,1.28).In MR analysis,there were no causal relation-ships for genetically determined C3 levels and NAFLD risk using unweighted or weighted GRS_C3(β_(E_unweighted)=−0.019,95%CI−0.019,−0.019,p=0.202;β_(E_weighted)=−0.019,95%CI−0.019,−0.019,p=0.322).Conversely,serum C3 lev-els were significantly effected by the genetically determined NAFLD(β_(E_unweighted)=0.020,95%CI 0.020,0.020,p=0.004;β_(E_weighted)=0.021,95%CI 0.020,0.021,p=0.004).Neither the direction from C4 to NAFLD nor the one from NAFLD to C4 showed significant *** results support that the change in serum C3 levels but not C4 levels might be caused by NAFLD in Chinese Han men.

关键词： Nonalcoholic fatty liver disease C3 C4 Mendelian randomization

Body Language,Use It Everyday to Communicate

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语言教育 1996年第8期 37-39页

作者： ElizabethLaird longman 林纪平

If you can speak English,you know a lot of English *** can read,speak and *** there is another kind oflanguage you need to know-the language of the body,a part ofwhat is called nonverbal *** over the world,people“talk”with their hands,with theirheads and with their *** Japanese people meet,they *** Indians meet,they put their hands ***

关键词： speak hands Japanese polite sometimes everyone 交际语言 themselves Britain someone

longman advanced American dictionary. 2nd ed.

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1000年

作者： longman

来源：畅想之星图书光盘版（南... 评论

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Wolf Ho

语言教育 1992年第11期 42-43页

作者： Harold longman 罗明辉

In America, in states such as Iowa and Kansas, it iscommon enough to see vast stretches of farmland withonly a lonely farmhouse breaking the horizon. Thefarm family often has no neighbors within miles. In manyparts of Europe, things are quite different. Thereit is the custom for farmers to live together in littlevillages, with close-set houses. Each day they go out totead their fields, which may be miles away.

关键词： farmland breaking custom things horizon Kansas enough houses 现在分词 village

东南亚地区第三纪碳酸盐岩储层光明的油气远景

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国外油气勘探 1995年第2期7卷 168-172页

作者： Mark W.longman 吴传芝地矿部石油海洋地质局培训化探中心

全世界各种时代的碳酸盐岩建隆型油气藏的储量近400亿桶。其中的40%,即相当于160亿桶储存在东南亚地区第三纪时代的碳酸盐岩建隆之中。这样大量的储量使得这些建隆,尤其是中新世的,成为世界上碳酸盐岩建隆储集层中唯一最重要的一套储集... 详细信息

全世界各种时代的碳酸盐岩建隆型油气藏的储量近400亿桶。其中的40%,即相当于160亿桶储存在东南亚地区第三纪时代的碳酸盐岩建隆之中。这样大量的储量使得这些建隆,尤其是中新世的,成为世界上碳酸盐岩建隆储集层中唯一最重要的一套储集层,而且,中新世建隆中的估计储量仍在不断增加。 Occidental石油公司及Vaalco和Shell公司近期分别在马来西亚东部的沙捞越(Sarawak)盆地和菲律宾巴拉望盆地中所获得的大量油气发现尚不包括在上述估计数中。

关键词：第三纪碳酸盐岩储集层储量东南亚地区

多变量最小拍控制及其用于抑制机械手振动的研究

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上海交通大学学报 1992年第5期26卷 24-30页

作者：张列平 R.W.longman 上海交通大学系统工程研究所美国哥伦比亚大学机械系

本文研究了多变量最小拍控制原理,给出了多变量开环系统最小拍控制值的计算公式,对多变量闭环系统最小拍控制的物理意义作了进一步的论证.着重研究将最小拍控制用于抑制机械手振动的思想和控制方法的建立,并给出了在计算机上伤真及在装... 详细信息

本文研究了多变量最小拍控制原理,给出了多变量开环系统最小拍控制值的计算公式,对多变量闭环系统最小拍控制的物理意义作了进一步的论证.着重研究将最小拍控制用于抑制机械手振动的思想和控制方法的建立,并给出了在计算机上伤真及在装置上的试验结果.

关键词：多变量最小拍控制振动机械手