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Subnanometer localization accuracy in widefield optical microscopy

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Light(Science & Applications) 2018年第1期7卷 740-754页

作者： Craig R.Copeland Jon Geist Craig D.McGray Vladimir A.Aksyuk J.Alexander liddle B.Robert Ilic Samuel M.Stavis Center for Nanoscale Science and Technology National Institute of Standards and TechnologyGaithersburgMD 20899USA Maryland NanoCenter University of MarylandCollege ParkMD 20742USA Engineering Physics Division National Institute of Standards and TechnologyGaithersburgMD 20899USA

The common assumption that precision is the limit of accuracy in localization microscopy and the typical absence of comprehensive calibration of optical microscopes lead to a widespread issue—overconfidence in measurement results with nanoscale statistical uncertainties that can be invalid due to microscale systematic errors.In this article,we report a comprehensive solution to this underappreciated problem.We develop arrays of subresolution apertures into the first reference materials that enable localization errors approaching the atomic scale across a submillimeter field.We present novel methods for calibrating our microscope system using aperture arrays and develop aberration corrections that reach the precision limit of our reference materials.We correct and register localization data from multiple colors and test different sources of light emission with equal accuracy,indicating the general applicability of our reference materials and calibration methods.In a first application of our new measurement capability,we introduce the concept of critical-dimension localization microscopy,facilitating tests of nanofabrication processes and quality control of aperture arrays.In a second application,we apply these stable reference materials to answer open questions about the apparent instability of fluorescent nanoparticles that commonly serve as fiducial markers.Our study establishes a foundation for subnanometer localization accuracy in widefield optical microscopy.

关键词： optical limit field

Twitter Sentiment in Data Streams with Perceptron

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Journal of Computer and Communications 2014年第3期2卷 11-16页

作者： Nathan Aston Jacob liddle Wei Hu Department of Computer Science Houghton College Houghton USA

With the huge increase in popularity of Twitter in recent years, the ability to draw information regarding public sentiment from Twitter data has become an area of immense interest. Numerous methods of determining the sentiment of tweets, both in general and in regard to a specific topic, have been developed, however most of these functions are in a batch learning environment where instances may be passed over multiple times. Since Twitter data in real world situations are far similar to a stream environment, we proposed several algorithms which classify the sentiment of tweets in a data stream. We were able to determine whether a tweet was subjective or objective with an error rate as low as 0.24 and an F-score as high as 0.85. For the determination of positive or negative sentiment in subjective tweets, an error rate as low as 0.23 and an F-score as high as 0.78 were achieved.

关键词： Sentiment Analysis Twitter Grams Perceptron Data Stream

青少年药物滥用的现代家庭治疗—多维度家庭治疗模式

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中国药物依赖性杂志 2002年第4期11卷 250-253页

作者：赵敏 Howard a.liddle 上海市精神卫生中心上海200030 Center for Treatment Research for Adolescent Drug Abuse

青少年药物滥用是当今社会一个重要的公共卫生问题。青少年药物滥用在欧美已发展成一门独立的学科，随着对青少年药物滥用研究的日益深入，已发展了专门的学术组织和学术刊物。家庭治疗是目前欧美青少年药物滥用最主要的一种治疗模式，... 详细信息

青少年药物滥用是当今社会一个重要的公共卫生问题。青少年药物滥用在欧美已发展成一门独立的学科，随着对青少年药物滥用研究的日益深入，已发展了专门的学术组织和学术刊物。家庭治疗是目前欧美青少年药物滥用最主要的一种治疗模式，许多研究者认为家庭治疗是青少年药物滥用及相关行为问题最有前途的一种治疗模式，因而目前在有关青少年药物滥用治疗的研究中，以对家庭治疗的研究最为广泛和深入。我国近年来青少年药物滥用问题也日益突出，但有关研究甚少。本文通过对青少年药物滥用家庭治疗的介绍，为我国青少年药物滥用的治疗和研究提供某些借鉴和启示。

关键词：青少年药物滥用现代家庭治疗多维度家庭治疗模式

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瑞典一瞥

瑞典一瞥

Sentiment Analysis on the Social Networks Using Stream Algorithms

丛书名：少年史地丛书

1926年

作者： W.liddle 汪今鸾译

共16章。简要介绍瑞士的地理、历史、城市，以及社会生活。

关键词：瑞典学科:概况

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Journal of Data Analysis and Information Processing 2014年第2期2卷 60-66页

作者： Nathan Aston Timothy Munson Jacob liddle Garrett Hartshaw Dane Livingston Wei Hu Department of Computer Science Houghton College Houghton USA

The rising popularity of online social networks (OSNs), such as Twitter, Facebook, MySpace, and LinkedIn, in recent years has sparked great interest in sentiment analysis on their data. While many methods exist for identifying sentiment in OSNs such as communication pattern mining and classification based on emoticon and parts of speech, the majority of them utilize a suboptimal batch mode learning approach when analyzing a large amount of real time data. As an alternative we present a stream algorithm using Modified Balanced Winnow for sentiment analysis on OSNs. Tested on three real-world network datasets, the performance of our sentiment predictions is close to that of batch learning with the ability to detect important features dynamically for sentiment analysis in data streams. These top features reveal key words important to the analysis of sentiment.

关键词： Modified Balanced Winnow Sentiment Analysis Twitter Online Social Networks Feature Selection Data Streams

父母物质滥用和精神疾病对青少年精神疾病的影响

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中国药物依赖性杂志 2004年第2期13卷 146-149页

作者：赵敏 Arlene Frank Gayle Dakof Howard liddle 上海市精神卫生中心上海200030 美国迈阿密青少年药物滥用治疗研究中心迈阿密大学33160

目的:了解父母物质滥用和精神疾病对青少年精神疾病的影响.方法:研究对象为181名物质滥用青少年及其父母,调查了青少年精神疾病诊断情况并分析了父母物质滥用合并精神疾病对青少年精神疾病的影响.结果:父母对照组青少年和父母共患组青... 详细信息

目的:了解父母物质滥用和精神疾病对青少年精神疾病的影响.方法:研究对象为181名物质滥用青少年及其父母,调查了青少年精神疾病诊断情况并分析了父母物质滥用合并精神疾病对青少年精神疾病的影响.结果:父母对照组青少年和父母共患组青少年合并精神疾病诊断数分别为2.2±s 1.7和3.7±s 2.1(P＜0.01),父母物质依赖合并精神疾病的青少年患广场恐怖伴惊恐发作、注意缺陷多动障碍(ADHD)、逆反性障碍的危险性分别是父母无物质依赖和精神疾病的青少年的5.0、2.4和4.1倍(P＜0.05).结论:父母物质滥用合并精神疾病与青少年发生较多精神疾病有关,父母物质滥用合并精神疾病是青少年发生广场恐怖伴惊恐发作、ADHD和逆反性障碍的危险因素,需要加强相应评估和干预措施.

关键词：父母物质滥用精神疾病青少年精神障碍药物滥用

Spontaneous and Bleomycin-Induced <i>γ</i>H2AX Signals in CHO9 Metaphase Chromosomes

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Advances in Bioscience and Biotechnology 2014年第7期5卷 603-616页

作者： María Vittoria Di Tomaso Silvia Basso Laura Lafon-Hughes Gustavo Saona Beatriz López-Carro Ana Laura Reyes-ábalos Pablo liddle Environmental Quality Evaluation and Control Service Municipality of Montevideo Montevideo Uruguay Genetics Department Instituto de Investigaciones Biológicas Clemente Estable Montevideo Uruguay

In eukaryotes, a cascade of events named DNA damage response (DDR) has evolved to handle DNA lesions. DDR engages the recruitment of signaling, checkpoint control, repair and chromatin remodeling protein complexes, allowing cell cycle delay, DNA repair or induction of apoptosis. An early DDR event involves the phosphorylation of the histone variant γH2AX on serine 139 (H2AX139 phosphorylation) originating the so-called γH2AX. DDR-related H2AX139 phosphorylation have been extensively studied in interphase nuclei. More recently, γH2AX signals on mitotic chromosomes of asynchronously growing cell cultures were observed. We performed a quantitative analysis of γH2AX signals on γH2AX immunolabeled cytocentrifuged metaphase spreads, analyzing the γH2AX signal distributions of CHO9 chromosomes harboring homologous regions both in control and bleomycin (BLM)-treated cultures. We detected γH2AX signals in CHO9 chromosomes of controls which significantly increase after BLM-exposure. γH2AX signals were uniformly distributed in chromosomes of controls. However, the γH2AX signal distribution in BLM exposed cells was significantly different between chromosomes and among chromosome regions, with few signals near the centromeres and a tendency to increase towards the telomeres. Interestingly, both basal and BLM-induced γH2AX signal distribution were statistically equal between CHO9 homologous chromosome regions. Our results suggest that BLM exerts an effect on H2AX139 phosphorylation, prevailing towards acetylated and gene-rich distal chromosome segments. The comparable H2AX139 phosphorylation of homologous regions puts forward its dependence on chromatin structure or function and its independence of the position in the karyotype.

关键词： H2AX Phosphorylation on Serine 139 γH2AX Signals Metaphase Chromosomes Homologous Chromosome Regions CHO9 Chinese Hamster Cell Line

青少年药物滥用和父母药物滥用及共患精神疾病的关系

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青少年药物滥用和父母药物滥用及共患精神疾病的关系

青少年物质滥用与父母物质滥用及精神疾病的关系

第七届全国药物依赖性学术会议

作者：赵敏 CINDY ROWE CRAIG HENDERSON ARLENE FRANK HUA Li GAYLE DAKOF HOWARD liddle 上海市自愿戒毒中心上海市精神卫生中心青少年药物滥用治疗研究中心迈阿密大学

＜正＞目的:了解青少年药物滥用和其它行为问题与父母药物滥用及共患精神疾病的关系。方法:研究对象来自美国迈阿密大学青少年药物滥用治疗研究中心进行的一项对多维度家庭治疗疗效的随机对照研究,参与该研究的是药物滥用青少年和他们... 详细信息

＜正＞目的:了解青少年药物滥用和其它行为问题与父母药物滥用及共患精神疾病的关系。方法:研究对象来自美国迈阿密大学青少年药物滥用治疗研究中心进行的一项对多维度家庭治疗疗效的随机对照研究,参与该研究的是药物滥用青少年和他们的父母,根据青少年父母药物滥用和精神疾病患病情况将研究对象分为三组:父母既没有药物滥用也没有精神疾病（对照组）;父母仅有药物滥用而没有精神疾病（药物滥用组）;父母药物滥用也有精神疾病（共患组）。比较了三组青少年的开始使用酒精或大麻的年龄、过去一个月中使用酒精或大麻的频度、药物滥用的程度、行为问题和精神疾病。

关键词：父母物质滥用共患精神疾病青少年药物滥用

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神经疾病与精神卫生 2004年第1期4卷 5-7页

作者：赵敏 Howard liddle Gayle Dakof Cindy Rowe Cralg Henderson Arlene Frank 张明园上海市精神卫生中心 200030 美国迈阿密大学青少年药物滥用治疗研究中心

目的　分析青少年药物滥用及其他精神行为问题与父母药物滥用及共患精神疾病的关系。方法　研究对象为 181名药物滥用青少年和及其父母 ,根据父母的药物滥用和精神疾病史将青少年分成父母对照组、父母药物滥用组和父母共患组 ,比较了青... 详细信息

目的　分析青少年药物滥用及其他精神行为问题与父母药物滥用及共患精神疾病的关系。方法　研究对象为 181名药物滥用青少年和及其父母 ,根据父母的药物滥用和精神疾病史将青少年分成父母对照组、父母药物滥用组和父母共患组 ,比较了青少年物质滥用及其他精神行为问题和家庭环境在三组间的差异。结果　与父母对照组和父母药物滥用组青少年相比 ,父母共患组青少年行为问题问卷各量表分均大于其他两组 (P <0 .0 1) ,父母共患组家庭矛盾较多、家庭组织性较差 (P <0 .0 1)。结论　父母共患药物滥用和精神疾病的青少年药物滥用者可能属于不同亚群 ,其家庭矛盾较多、家庭组织性较差 ,青少年具有更多的精神行为问题 ,应加强相应的治疗和干预措施。

关键词：青少年父母精神疾病药物滥用家庭环境