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国际医学放射学杂志 2014年第2期 186-187页

作者： J,Hodel P.Besson A.Rahmouni E.Petit a.lebret B.Grandjacques 张倩 Service de Neuroradiologie Hpital Roger Salengro59037 LilleFrance

目的建立自动化变形模型以评估手术治疗前后脑积水病人脑脊液(CSF)容积的变化。方法采用Jacobian行列式对变形场术前、术后的图像进行非线性配准后,计算脑

关键词：脑脊液脑积水 MRI 变形模型 SPACE MR序列

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Relationship of preoperative androgen levels and metabolic syndrome with quality of life and erectile function in patients who are to undergo radical prostatectomy

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Asian Journal of Andrology 2021年第5期23卷 520-526页

作者： Yann Neuzillet Jean-Francois Dreyfus Jean-Pierre Raynaud Mathieu Rouanne Marc Schneider Morgan Roupret Sarah Drouin Marc Galiano Xavier Cathelineau Thierry lebret Henry Botto Department of Urology Hopital FochUVSQ-Paris-Saclay UniversitySuresnes 92150France Department of Clinical Research and Innovation Hopital FochUVSQ-Paris-Saclay UniversitySuresnes 92150France Sorbonne University Paris 75013France Department of Urology Hfipital Louis PasteurColmar 68000France Department of Urology Hopital Pitie-SalpetriereAssistance Publique-Hopitaux de ParisSorbonne UniversityParis 75013France Department of Urology Institut Mutualiste MontsourisParis-Descartes UniversityParis 75014France

This study aims to investigate whether clinical and biological preoperative characteristics of patients who were to undergo radical prostatectomy were associated with impairment in patient-reported quality of life(QoL)and erectile dysfunction immediately before *** evaluated patient-reported outcomes among 1019 patients(out of 1343)of the AndroCan study,willing to score the Aging Male Symptom(AMS)and the International Index of Erectile Function 5-item(IIEF-5)*** linear regression and robust multiple regression were used to ascertain the relationship between demographic,clinical,and hormonal parameters and global AMS or IIEF-5 *** a result,most patients(85.1%)of the Androcan cohort agreed to complete *** higher IIEF-5 global scores were found in non-Caucasian and obese patients,with larger waist circumference,metabolic syndrome,diabetes mellitus,cardiovascular disease,hypertension,high blood sugar,concomitant medications,and hypogonadism,while the AMS global score was significantly higher in patients with larger waist circumference,metabolic syndrome,high blood pressure,raised glycemia,and concomitant *** IIEF-5 global score was correlated to age,dehydroepiandrosterone(DHEA),fat mass percentage,and androstenediol(D5).The AMS global score was significantly correlated to DHEA,D5,and DHEA ***,the multivariate models showed that QoL and erectile function were significantly affected,before surgery,by symptoms and signs that are usually considered as pertaining to the metabolic syndrome,while sexual hormones are essentially correlated to erectile dysfunction.

关键词： erectile function metabolic syndrome quality of life radical prostatectomy testosterone

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Metabolic syndrome,levels of androgens,and changes of erectile dysfunction and quality of life impairment 1 year after radical prostatectomy

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Asian Journal of Andrology 2021年第4期23卷 370-375页

作者： Yann Neuzillet Mathieu Rouanne Jean-François Dreyfus Jean-Pierre Raynaud Marc Schneider Morgan Roupret Sarah Drouin Marc Galiano Xavier Cathelinau Thierry lebret Henry Botto Department of Urology Hospital FochUVSQ-Paris-Saclay UniversitySuresnes 92150France Department of Clinical Research and Innovation Hospital FochUVSQ-Paris-Saclay UniversitySuresnes 92150France Sorbonne University Paris 75013France Department of Urology Hospital Louis PasteurColmar 68000France Department of Urology Hôpital Pitié-SalpêtrièreAssistance Publique-Hôpitaux de ParisSorbonne UniversityParis 75013France Department of Urology Montsouris InstituteParis-Descartes UniversityParis 75014France

Robust data evaluating the association of preoperative parameters of the patients with quality of life after radical prostatectomy are *** investigated whether clinical and biological preoperative characteristics of the patients were associated with impaired patient-reported quality of life(QoL)and sexual outcomes 1 year after radical *** evaluated patient-reported outcomes among the 1343 men participating in the AndroCan trial(NCT02235142).QoL and erectile dysfunction(ED)were assessed before and 1 year after radical prostatectomy using validated self-assessment questionnaires(Aging Male's Symptoms[AMS]and the 5-item abridged version of the International Index of Erectile Function[IIEF5]).At baseline,1194 patients(88.9%)accepted to participate.A total of 750(55.8%)patients answered the 1-year postoperative *** of them,only 378(50.4%of responders)provided answers that could be used for *** year after prostatectomy,ED had worsened by 8.0(95%confidence interval[CI]:7.3–8.7;P<0.0001)out of a maximum of *** global AMS score has worsened by 2.8(95%CI:1.7–3.8;P<0.0001).ED scores 1 year postsurgery were positively correlated with preoperative age and percentage of fat mass,and negatively correlated with total cholesterol,dehydroepiandrosterone(DHEA),and androstenediol(D5);AMS were poorly correlated with preoperative *** and sexual symptoms significantly worsened after radical *** bioavailable testosterone levels were significantly correlated with smaller changes on AMS somatic subscores *** findings may be used to inform patients with newly diagnosed prostate cancer.

关键词： metabolic syndrome quality of life radical prostatectomy sexual outcomes testosterone deficiency

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低剂量BCG膀胱灌注治疗TaG3膀胱肿瘤:复发、进展及成功率

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中华泌尿外科杂志 2000年第5期21卷 64-64页

作者： lebret T 李金华章咏裳

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多节段3DSPACEMR序列的全脑脊液体积成像:在脑积水病人中的可行性

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国际医学放射学杂志 2013年第4期 398-398页

作者： J. Hodel A. lebret E. Petit X. Leclerc M. Zins A. Vignaud 毛子婧 Department of Radiology H?pital Saint Joseph185 Rue Raymond LosserandParis France

目的评价应用SPACE(sampling perfection with application optimized contrast using different flip-angle evolution)MR序列行全脑脊液(CSF)体积成像的可行性。方法对12例健康志愿者和26例连续的脑积水病人的脑和脊髓行1.5T SPACE序列检查。根据CSF与背景信号强度的比值差异评估影像的对比度。依据CSF形状的几何学特征和局部解剖学假设对CSF节段进行分割。对志愿者和病人的蛛网膜下腔和脑室的CSF空间体积进行评估,并对其进行线性识别分析。结果 CSF和脑的影像对比度为0.94,CSF和脊髓的影像对比度为0.90。以体模研究为对照,CSF体积测量的准确度为98.5%。应用线性识别分析能够清楚识别病人和健康志愿者。健康志愿者脑室(Vv)和全部蛛网膜下腔的CSF体积(Vs)呈显著的线性回归,Vv=0.083Vs。结论对健康志愿者和脑积水病人行全部CSF体积成像是可行的。可获得CSF体积的整体测量。该方法可用于脑积水病人的诊断与随访。要点①MRI评估CSF体积在健康志愿者/脑积水病人均是可行的。②CSF体积可以整体测量。③健康志愿者蛛网膜下腔与脑室的CSF比值是恒定的。④CSF线性识别分析能够区分病人和健康志愿者。⑤全部CSF体积成像对脑积水的诊断和随访有用。

关键词：脑脊液脑积水 MRI 全身成像 SPACE MR序列

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