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Genes and proteins expressed at different life cycle stages in the model protist Euplotes vannus revealed by both transcriptomic and proteomic approaches

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Science China life Sciences 2025年第1期 232-248页

作者： Yaohan Jiang Xiao Chen Chundi Wang liping lyu saleh A.Al-Farraj Naomi A.Stover Feng Gao Key laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity Ocean University of China Marine College Shandong University Zoology Department College of ScienceKing Saud University Department of Biology Bradley University laboratory for Marine Biology and Biotechnology Qingdao Marine Science and Technology Center

Sexual reproduction first appeared in unicellular protists and has continued to be an essential biological process in almost all *** protists, which contain both germline and somatic genomes within a single cell, have evolved a special form of sexual reproduction called conjugation that involves mitosis, meiosis, fertilization, nuclear differentiation, genome rearrangement, and the development of unique cellular structures. The molecular basis and mechanisms of conjugation vary dramatically among ciliates, and many details of the process and its regulation are still largely unknown. In order to better comprehend these processes and mechanisms from an evolutionary perspective, this study provides the first comprehensive overview of the transcriptome and proteome profiles during the entire life cycle of the newly-established marine model ciliate Euplotes vannus. Transcriptome analyses from 14 life cycle stages(three vegetative stages and 11 sexual stages) revealed over 26,000 genes that are specifically expressed at different stages, many of which are related to DNA replication,transcription, translation, mitosis, meiosis, nuclear differentiation, and/or genome rearrangement. Quantitative proteomic analyses identified 338 proteins with homologs associated with conjugation and/or somatic nuclear development in other ciliates, including dicer-like proteins, Hsp90 proteins, RNA polymerase Ⅱ and transcription elongation factors, ribosomal-associated proteins, and ubiquitin-related proteins. Four of these homologs belong to the PIWI family, each with different expression patterns identified and confirmed by RT-qPCR,which may function in small RNA-mediated genome rearrangement. Proteins involved in the nonhomologous end-joining pathway are induced early during meiosis and accumulate in the developing new somatic nucleus, where more than 80% of the germline sequences are eliminated from the somatic genome. A number of new candidate genes and proteins likely t

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Transfer learning on Deep Neural Networks to Detect Pornography

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Computer Systems Science & Engineering 2022年第11期43卷 701-717页

作者： saleh Albahli Department of Information Technology College of ComputerQassim UniversityBuraydahSaudi Arabia

While the internet has a lot of positive impact on society,there are negative *** to everyone through online platforms,pornography is,inducing psychological and health related issues among people of all *** a difficult task,detecting pornography can be the important step in determining the porn and adult content in a *** this paper,an architecture is proposed which yielded high scores for both training and *** dataset was produced from 190 videos,yielding more than 19 h of *** main sources for the content were from YouTube,movies,torrent,and websites that hosts both pornographic and non-pornographic *** videos were from different ethnicities and skin color which ensures the models can detect any kind of video.A VGG16,Inception V3 and Resnet 50 models were initially trained to detect these pornographic images but failed to achieve a high testing accuracy with accuracies of 0.49,0.49 and 0.78 ***,utilizing transfer learning,a convolutional neural network was designed and yielded an accuracy of 0.98.

关键词： Pornographic video detection classification convolutional neural network InceptionV3 Resnet50 VGG16

Clustered Hyperbolic Categories

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Algebra Colloquium 2018年第1期25卷 81-106页

作者： Ibrahim saleh Mathematics Department University of Wisconsin 80 Regent Street Madison Wisconsin 53715 USA

We introduce a class of categories, called clustered hyperbolic categories, which are constructed from a categorized version of preseeds called categorical preseeds using categorical mutations that are a ＂functorial＂ edition of preseed mutations. Every Weyl preseed p gives rise to a categorical preseed P which generates a clustered hyperbolic category; this is formed by copies of categories each one of which is equivalent to the category of representations of the Weyl cluster algebra H（p）. A ＂categorical realization＂ of Weyl cluster algebra is provided in the sense of defining a map Fp from any clustered hyperbolic category induced from p to the Weyl cluster algebra H（p）, where the image of Fp generates H（p）.

关键词： cluster algebras Weyl cluster algebras representations theory categorification of generalized Weyl algebras

New design simulation for a high-altitude dual-balloon system to extend lifetime and improve floating performance

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Chinese Journal of Aeronautics 2018年第5期31卷 1109-1118页

作者： Sherif saleh Weiliang HE Aviation and Aerospace Science Division Military Technical College School of Astronautics Beihang University

This paper presents a comprehensive simulation for a high-altitude dual-balloon system which consists of zero-and super-pressure balloons. Preliminary calculations were established to describe the basic concept of the new integrated system. A mathematical model was investigated to simulate the ascending and floating processes which considered the atmospheric conditions and thermodynamic variations. Based on the simulation, results showed that the floating altitude stability between daytime and nighttime was improved. This integrated system supports higher floating altitude levels than those of ordinary balloons and extends the lifetime of floating balloon systems. Moreover, results demonstrated that the integrated system was lighter than ordinary balloons, saving useful weight for effective payload. Furthermore, exploiting the advantages of both kinds of balloons while avoiding the difficulties was a significant goal in the current design to promote the floating performance of high-altitude balloons technology.

关键词： Altitude stability Ascending trajectory Compressor performance High altitude balloons long endurance

Joint slip investigation based on finite element modelling verified by experimental results on wind turbine lattice towers

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Frontiers of Structural and Civil Engineering 2018年第3期12卷 341-351页

作者： saleh YAGHOOBI Ahmad SHOOSHTARI Civil Engineering Department Ferdowsi University of Mashhad Mashhad Iran

Slippage corresponds to the relative displacement of a bolted joint subjected to shear loads since the construction clearance between the bolt shank and the bolthole at assembly can cause joint slip. Deflections of towers with joint slippage effects is up to 1.9 times greater than the displacements obtained by linear analytical methods. In this study, 8 different types of joints are modelled and studied in the finite element program, and the results are verified by the experimental results which have been done in the laboratory. Moreover, several types of joints have been modelled and studied and load-deformation curves have also been presented. Finally, joint slip data for different types of angles, bolt diameter and bolt arrangements are generated. Thereupon, damping ratios （ζ） for different types of connections are reported. The study can be useful to help in designing of wind turbine towers with a higher level of accuracy and safety.

关键词： Joint slip cyclic loading Finite element modelling Experimental joint behavior damping ratios (ζ)

Investigation of sensitivity and threshold voltage shift of commercial MOSFETs in gamma irradiation

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Nuclear Science and Techniques 2016年第6期27卷 166-171页

作者： saleh Ashrafi Baharak Eslami Faculty of Physics University of Tabriz Department of Physics Payame Noor University

This article is about the absorbed-dose-dependent threshold voltage shift of the MOSFET *** of the MOSFETs has been tested in different gate *** of the transistors for 662 ke V gamma ray is studied in 1–5 Gy dose *** was found that for transistors irradiated in biased mode,significant changes in the threshold voltage occurred,and the sensitivity to gamma rays increased with the bias voltage.

关键词：阈值电压漂移 MOSFET γ射线照射敏感性商业吸收剂量偏置电压晶体管

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

DNA Sequence Analysis for Brain Disorder Using Deep learning and Secure Storage

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Computers, Materials & Continua 2022年第6期71卷 5949-5962页

作者： Ala saleh Alluhaidan Departmemt of Information Systems College of Computer and Information SciencePrincess Nourah Bint Abdulrahman UniversityRiyadh 11671Saudi Arabia

Analysis of brain disorder in the neuroimaging of Magnetic Resonance Imaging(MRI),Positron Emission Tomography(PET),and Computed Tomography(CT)needs to understand the functionalities of the brain and it has been performed using *** learning algorithms have also been applied in genomics data *** brain disorder diseases of Alzheimer,Schizophrenia,and Parkinson are analyzed in this *** main issue in the traditional algorithm is the improper detection of disorders in the neuroimaging *** paper presents a deep learning algorithm for the classification of brain disorder using Deep Belief Network(DBN)and securely storing the image using a Deoxyribonucleic Acid(DNA)Sequence-based Joint Photographic Experts Group(JPEG)Zig Zag Encryption Algorithm(DBNJZZ).In this work,DBNJZZ implements an efficient and effective prediction model for disorders using the open-access datasets of Alzheimer’s Disease Neuroimaging Initiative(Adni),the Center for Biomedical Research Excellence(Cobre),the Open Access Series of Imaging Studies(Oasis),the Function Biomedical Informatics Research Network(Fbirn),a Parkinson’s dataset of 55 patients and 23 subjects with Parkinson’s syndromes(Ntua),and the Parkinson’s Progression Markers Initiative(Ppmi).This algorithm is implemented and tested using performance metric measures of accuracy,Root Mean Square Error(RMSE),Mean Absolute Error(MAE),and Mean Absolute Percentage Error(MAPE).DBNJZZ gives better performance with an accuracy of 99.21%and also surpasses previous methods on other measures.

关键词： DBN Zig zag deep learning MAPE RMSE DNA genomics

Synthesis and Formation Mechanisms of Calcium Ferrite Compounds

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Journal of Materials Science & Technology 2004年第5期20卷 530-534页

作者： Hesham I.saleh Inorganic Chemistry Department National Research CenterDokkiCairoEgypt

Calcium ferrite compounds were prepared using calcium nitrate and iron nitrate with different molar ratios, 1:1, 0.5:1, and 1:0.5, respectively. The reactions of formation were investigated at different temperatures following the differential thermal analysis (DTA) results. Calcium ferrite compounds are CaFeO3, Ca2FeO3.5, Ca2Fe2O5, CaFe2O4, CaFe4O7, Ca7.2Fe0.8Fe30O53, Ca3Fe15O25, Ca4Fe14O25, and Ca4Fe9O17. Other reactive species of calcium nitrate are still present after firing at 450℃. Compounds were characterized using X-ray diffraction (XRD), DTA, TG, magnetic susceptibility, infrared spectra and scanning electron microscope (SEM). It is concluded that the formation mechanism of Ca-ferrite compounds depends mainly on the valency of iron cations which in role depends on its molar ratio and the existing atmosphere.

关键词： Ca-ferrite Formation mechanism Magnetic susceptibility