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国际眼科杂志 2003年第1期3卷 103-104页

作者： A.H.P.Krauss C.S.Spada D.F.Woodward a.l.nieves l.A.Wheeler D.Scott G.Sachs Allergan Inc. Irvine CAVeterans Administration Hospital CA USA

Bimatoprost (lUMIGAN) is a novel synthetic prostamide that potently lowers intraocular pressure in dogs, primates and humans. Bimatoprost is functionally and pharmacologically distinct from PGF2alpha, potently exhibits prostamide-like activities and works directly to lower IOP. In this series of studies, confocal fluorescence microscopy was employed to compare the effects

关键词： Bimatoprost PGF2α 猫瞳孔括约肌细胞药效受体

The quest for selective Cs^(+) transport in plants

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Molecular Plant 2021年第4期14卷 552-554页

作者： Manuel nieves-Cordones Francisco Rubio Departamento de Nutricion Vegetal Centro de Edafologia y Biologia Aplicada del Segura-CSICCampus de Espinardo30100 MurciaSpain

Nuclear accidents have led to the release to the environment of radioactive isotopes,mainly radioactive cesium(Cs^(+)),contaminating large areas of soil for very long periods of time(Burger and lichtscheidl,2018).These contaminated soils contain^(134)Cs^(+)and^(137)Cs^(+)radioisotopes that are readily accumulated into plants and that,through the food chain,are transferred to animals and humans,causing important health problems(Burger and lichtscheidl,2018).

关键词： readily release transport

Environmental and landscape influences on the spatial and temporal distribution of a cattle herd in a South Texas rangeland

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Ecological Processes 2020年第1期9卷 443-460页

作者： Christopher Cheleuitte-nieves Humberto l.Perotto-Baldivieso XBen Wu Susan M.Cooper Department of Ecosystem Science and Management Texas A&M University2120 TAMU320 WFES BuildingCollege StationTX 77843-2138USA Present address:Center of Comparative Medicine and Pathology Memorial Sloan Kettering Cancer CenterWeill Cornell Medicineand Hospital for Special Surgery408 East 69th StreetZ-913New YorkNY 10021USA Caesar Kleberg Wildlife Research Institute Texas A&M University-Kingsville700 University Blvd.MSC 218KingsvilleTX 78363USA Texas A&M Agrilife Research 1619 Garner Field RoadUvaldeTX 78801USA

The multiple spatial and temporal parameters affecting cattle herd distribution and activity dynamics can significantly affect resource utilization but are not fully *** aim of this study was to determine whether current animal tracking technology and spatio-temporal analysis tools can be used to integrate multi-scale information on herd distribution patterns as a function of seasonal forage production,periods of the day,animal activity,and landscape *** and activity information of 11 free-ranging cows within a 31-member herd was obtained at 5-min intervals by using GPS collars for 1 year within a 457-ha ranch in the semi-arid rangelands of South *** biomass was calculated with satellite *** analysis of cattle distribution and landscape features was conducted with *** spread was greatest during the growing *** the year,during midday,the herd showed smaller spread and greater use of shade patches than any other time of *** also aggregated under trees in winter,particularly during the *** was no statistically significant overall pattern of seasonal changes in the use of water and supplemental feeding areas,but a trend toward highest use during the ***,significantly different diurnal patterns in the use of supplemental feed and water were observed within each *** study found a strong influence of shade patches relative to the influence of water and supplemental feeding areas on the diurnal and seasonal movement patterns of cattle in shrub-dominated *** this study used only 11 tracked cows in a 31-member herd,the results indicated that techniques such as seasonal and diurnal GPS tracking,GIS,and remote sensing data enable evaluation of multiple spatial and temporal dynamics of cattle distribution and activity *** smaller spread during the dry winter season associated with the observed aggregation of individuals in water and supplemental feeding ar

关键词： Cattle behavior Cross-scale interactions GPS collars Group dispersion Normalized difference vegetation index(NDVI) Thermoregulation Ungulate grazing patterns

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Mesoscale modeling of microgel mechanics and kinetics through the swelling transition

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Applied Mathematics and Mechanics(English Edition) 2018年第1期39卷 47-62页

作者： S.NIKOlOV A.FERNANDEZ-nieves A.AlEXEEV Woodruff School of Mechanical Engineering Georgia Institute of Technology School of Physics Georgia Institute of Technology

The mechanics and swelling kinetics of polymeric microgels are simulated using a mesoscale computational model based on dissipative particle dynamics. Microgels are represented by a random elastic network submerged in an explicit viscous solvent. The model is used to probe the effect of different solvent conditions on the bulk modulus of the microgels. Comparison of the simulation results through the volume phase transition reveals favorable agreement with Flory-Rehner＇s theory for polymeric gels. The model is also used to examine the microgel swelling kinetics, and is found to be in good agreement with Tanaka＇s theory for spherical gels. The simulations show that, during the swelling process, the microgel maintains a nearly homogeneous structure, whereas deswelling is characterized by the formation of chain bundles and network coarsening.

关键词： soft matter dissipative particle dynamics micromechanics hydrogels

Association patterns reveal dispersalaggregation dynamics among cattle in a South Texas Rangeland,USA

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Ecological Processes 2018年第1期7卷 323-332页

作者： Christopher Cheleuitte-nieves Humberto l.Perotto-Baldivieso X.Ben Wu Susan M.Cooper Department of Ecosystem Science and Management Texas A&M University2120 TAMU320 WFES BuildingCollege StationTX 77843-2138USA Present Address:Center of Comparative Medicine and Pathology Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center1300 York Ave.E-703ENew YorkNY 10065USA Caesar Kleberg Wildlife Research Institute Texas A&M University-Kingsville700 University Blvd.MSC 218KingsvilleTX 78363USA Texas A&M Agrilife Research 1619 Garner Field RoadUvaldeTX 78801USA

Introduction:The spatial association dynamics of free-ranging cattle herds are not fully understood;however,they can have a direct influence on the spatial patterns of resource *** aim of our study was to examine new analytical methods of identifying the spatio-temporal patterns of behavioral dynamics that determine cattle herd dispersal in the semi-arid rangelands of South *** fitted 10 free-ranging cows with global positioning system collars and obtained positions every 5 min for each animal for 21-day trials,twice during the summer and winter *** used an association pattern recognition software(ASSOC1)and the herd center of gravity to identify the spatial and temporal thresholds that defined dispersion-aggregation patterns and individual position to determine their relation to social ***:The association pattern defining herd membership was that animals spent 70%of their time within 200 m of each *** ranking did not appear to influence association membership or position within the *** cattle showed a more dispersed distribution during summer,but in winter,herd members behaved in a more aggregated *** distribution is contrary to patterns described in more northerly and mountainous ***:The spatial thresholds of the cattle herd and the overall distance of all members to the center of the herd were smaller during winter and larger during summer,indicating that this study herd congregated during the winter and dispersed during the *** this study uses a herd of 10 individuals in a 100 ha pasture to evaluate spatio-temporal dynamics,our results provide evidence of the ability of current tracking and spatial association tools to detect and quantify seasonal changes in cattle herd dispersion-aggregation *** use of these data collection and analysis methods could prove useful in larger cattle herds,increase our understanding of herd spatiotemporal behavior,and subsequently he

关键词： Bos taurus Global positioning system(GPS) GPS collar Herd dispersal Social dominance Sub-herd Spatiotemporal pattern of resource use

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

PtRu nanoparticles supported on noble carbons for ethanol electrooxidation

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Journal of Energy Chemistry 2022年第3期31卷 168-180,I0006页

作者： Alberto Rodríguez-Gómez Enrico lepre luz Sánchez-Silva nieves lópez-Salas Ana Raquel de la Osa Faculty of Chemical Sciences and Technologies University of Castilla-La ManchaEnrique Costa Novella Building.Avda.Camilo Jose Cela1213071 Ciudad RealSpain Colloid Chemistry Department Max Planck Institute of Colloids and InterfacesAm Mühlenberg 114476 PotsdamGermany

In this work,three cytosine derived nitrogen doped carbonaceous materials(noble carbons,NCs)with different atomic C/N ratios and porous networks have been synthesized and used as supports for Pt Ru electrocatalysts in the ethanol oxidation reaction(EOR)for clean hydrogen ***,the metal phase and the carbon support play critical roles in the electrocatalysts final *** NPs size distribution was obtained over supports with low atomic C/N ratios(i.e.,4 and 6)and defined porosity(i.e.,1701 m^(2)g^(-1)for Pt Ru/CNZ and 1834 m^(2)g^(-1)for Pt Ru/ClZ,respectively).In contrast,a lower C/N ratio and poor porous network(i.e.,65 m^(2)g^(-1),Pt Ru/ClK)led to the largest particle size and fostered an increase of the alloying degree between Pt and Ru NPs(i.e.,3%for C/N~6 and 28%for C/N~3).Electrochemical active surface area was found to increase with decreasing NPs size and the alloy extent,due to a higher availability of Pt active *** degradation tests showed that Pt Ru/NCs outperform similar to Pt Ru NPs on commercial carbon pointing at the stabilizing effect of *** Ru/CNZ exhibited the best electrochemical performance(i.e.,69.1 m A mgPt-1),outperforming Pt Ru/ClZ and Pt Ru/ClK by3-and 9-fold,respectively,due to a suitable compromise between particle sizes,degree of alloy,textural properties and elemental *** anodes were scaled-up to a proton exchange membrane cell and Pt Ru/CNZ was proved to provide the best electrocatalytic activity(262 m A cm^(-2)and low energy requirements),matching the values obtained by the state of the art of EOR electrocatalysts.

关键词： Noble carbon Cytosine H2 production Ethanol electrooxidation PtRu anode PEM cell

Template-Induced Graphitic Nanodomains in Nitrogen-Doped Carbons Enable High-Performance Sodium-Ion Capacitors

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Energy & Environmental Materials 2024年第4期7卷 295-303页

作者： Chun li Zihan Song Minliang liu Enrico lepre Markus Antonietti Junwu Zhu Jian liu Yongsheng Fu nieves lópez-Salas Key laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and TechnologyNanjing 210094China Colloid Chemistry Department Max Planck Institute of Colloids and InterfacesAm M»uhlenberg 114476PotsdamGermany School of Engineering Faculty of Applied ScienceUniversity of British ColumbiaKelownaBritish Columbia V1V1V7Canada

Sodium-ion capacitors(SICs)have great potential in energy storage due to their low cost,the abundance of Na,and the potential to deliver high energy and power *** article demonstrates a template-assisted method to induce graphitic nanodomains and micro-mesopores into nitrogen-doped *** study elucidates that these graphitic nanodomains are beneficial for Na+*** obtained N-doped carbon(As8Mg)electrode achieved a reversible capacity of 254 mA h g^(-1)at 0.1 A g^(-1).Moreover,the As8Mg-based SIC device achieves high combinations of power/energy densities(53 W kg^(-1)at 224 Wh kg^(-1)and 10410 W kg^(-1)at 51 Wh kg^(-1))with outstanding cycle stability(99.7%retention over 600 cycles at 0.2 A g^(-1)).Our findings provide insights into optimizing carbon’s microstructure to boost sodium storage in the pseudocapacitive mode.

关键词： anode graphitic nanodomains N-doped carbons sodium-ion capacitor template