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MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons

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Neural Regeneration Research 2024年第12期19卷 2698-2707页

作者： Bhupender sharma Melissa MTorres Sheryl Rodriguez laxman Gangwani Subodh Kumar Center of Emphasis in Neuroscience Department of Molecular and Translational MedicinePaul L.Foster School of MedicineTexas Tech University Health Sciences CenterEl PasoTXUSA Bond life Sciences Center and Department of Veterinary Pathobiology University of MissouriColumbiaMOUSA l.Frederick Francis Graduate School of Biomedical Sciences Texas Tech University Health Sciences CenterEl PasoTXUSA

Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-related *** previous study identified the upregulation of microRNA-502-3p(miR-502-3p)and downregulation of GABA type A receptor subunitα-1 in Alzheimer's disease *** study investigated a new molecular relationship between miR-502-3p and GABAergic synapse *** vitro studies were perfo rmed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and *** silico analysis identified multiple binding sites of miR-502-3p at GABA type A receptor subunitα-1 *** assay confirmed that miR-502-3p targets the GABA type A receptor subunitα-1 gene and suppresses the luciferase ***,quantitative reve rse transcription-polymerase chain reaction,miRNA in situ hybridization,immunoblotting,and immunostaining analysis confirmed that overexpression of miR-502-3p reduced the GABA type A receptor subunitα-1 level,while suppression of miR-502-3p increased the level of GABA type A receptor subunitα-1 ***,as a result of the overexpression of miR-502-3p,cell viability was found to be reduced,and the population of necrotic cells was found to be *** whole cell patch-clamp analysis of human-GABA receptor A-α1/β3/γ2l human embryonic kidney(HEK)recombinant cell line also showed that overexpression of miR-502-3p reduced the GABA current and overa.l.GABA function,suggesting a negative correlation between miR-502-3p levels and GABAergic synapse ***,the levels of proteins associated with Alzheimer s disease were high with miR-502-3p overexpression and reduced with miR-502-3p *** present study provides insight into the molecular mechanism of regulation of GABAergic synapses by *** propose that micro-RNA,in particular miR-502-3p,could be a potential the

关键词： Alzheimer's disease GABAergic synapse gamma-aminobutyric acid type A receptor subunitα-1(GABRα1) microRNA-502-3p(miR-502-3p) miRNA in situ hybridization Patch-clamp

Pharmacological potential of Manilkara zapota.l.)***(Sapodilla):a narrative review

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Journal of Traditional Chinese Medicine 2024年第2期44卷 403-407页

作者： Priyanka sharma Aakash Deep Harish Kumar Nitin Bansal Sanjiv Kumar Arun Davinder Kumar Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani 127021India Department of Pharmaceutical Sciences Maharishi Dayanand UniversityRohtak 124001India

Herbal medicine is safe and effective in treating various *** herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications,hence herbal medicine requires remarka.l. attention in further research for the development of numerous active formulations for treatment of health *** plant needs special consideration for development and research of unidentified compound and characterization of novel active molecules that overcome multiple pathological *** genus Manilkara contains 135 plants around the *** overview discusses a.l.the virtues of most important and commonly used plant Manilkara zapota.l.)***(***),also known as *** has various traditional beneficial effects in treatment of various diseases and disorders dating back to prehistoric times and used in ancient traditional system of herbal medicine.

关键词： herbal medicine Manilkara zapota phytoconstituents pharmacological activity review

Serum ferritin and the risk of ea.l.-onset colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3496-3506页

作者： Adam l Urback Kylee Martens Hannah Stowe McMurry Emerson Y Chen Caitlin Citti Anil sharma Adel Kardosh Joseph J Shatzel Division of Internal Medicine Oregon Health&Science UniversityPortlandOR 97239United States Division of Hematology and Medical Oncology Knight Cancer InstituteOregon Health&Science UniversityPortlandOR 97239United States Division of Gastroenterology&Hepatology Oregon Health&Science UniversityPortlandOR 97239United States

BACKGROUND The incidence of ea.l.-onset colorectal cancer(EO-CRC)is rising in the United States,and is often diagnosed at advanced *** serum ferritin is often incidenta.l. discovered in young adults,however,the indication for endoscopy in EO-CRC is *** To compare serum ferritin between patients with EO-CRC and healthy controls(HCs),and examine the association of serum ferritin in EO-CRC with patient-and disease-specific *** A retrospective study of patientsly-diagnosed EO-CRC was conducted from 1/2013-12/*** were included if serum ferritin was measured within 2 years prior to 1 year following CRC histologic *** supplement the analysis,a cohort of HCs meeting similar inclusion and exclusion criteria were identified for comparison.A sensitivity analysis including only patients with serum ferritin obtained at or before diagnosis was separately performed to minimize risk of *** Among 85 patients identified with EO-CRC(48 females),the median serum ferritin level was 26 ng/ml(rangel).Compared to HCs(n=80211),there were a higher proportion of individuals with EO-CRC with serum ferritinl(female 65%,male 40%)versus HCs(female 32.1%,male 7.2%)age 29-39 years(P=0.002 and Ply).Stage IV disease was associated with significantly higher serum ferritin compared to less advanced stages(Plower than levels obtained after *** findings were confirmed in the sensitivity *** Severe iron deficiency may indicate an increased risk of EO-CRC,particula.l. at ea.l.er *** studies defining the optimal serum ferritin threshold and routine incorporation of serum ferritin in screening algorithms is essential to develop more effective screening strategies for EO-CRC.

关键词： Ea.l.-onset Young-onset Colorectal cancer Age Ferritin Iron deficiency

An arrow in the quiver: evaluating the performance of Hyptis suaveolens(l.) Poit. in different light levels

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Ecological Processes 2024年第2期 130-147页

作者： Kanhaiya Shah Gyan Prakash sharma R.Sagar Department of Environmental Studies University of Delhi Department of Botany Banaras Hindu University

Background Hyptis suaveolens（l.） Poit.,native to the American tropics,is a pantropical annual plant and a major invasive species throughout *** was anticipated that the ava.l.bility of sunlight,coupled with its superior reproductive potential,persistent propagule bank,and dispersal ability,could lead to an increase in the growth and spread of this invader,thus potentia.l. impeding herbaceous growth and diversity in non-native *** its ecological fitness and competitive performance will be useful to manage the spread of *** in natural ecosystems that are facing a wide range of anthropogenic *** The present study is a three-tier *** the first tier,a field study was conducted to assess the patterns of *** abundance and herbaceous species diversity in response to light ava.l.bility(sun,842-1072μmol m-2s-1and shade 253-341 μmol m-2S-1) in the tropical dry deciduous ecosystems in the Vindhyan highlands,***,the impact of *** abundance on the resident native and non-native species abundance and diversity was also *** the second tier,a randomized common garden experiment was conducted to understand the trait fitness of *** in sun(940 μmol m-2s-1) and shade(300 μmol m-2s-1) *** the third tier,a plant growth chamber experiment with high-light(940 μmol m-2s-1) and low-light(300 μmol m-2s-1)treatments was done to learn how *** partitions its biomass between aboveground and belowground plant *** The field study indicated that the sunlit areas had a higher abundance of *** and a.l.wer diversity of resident herbaceous species than the shaded *** common garden experiment showed that sun-dwelling *** individuals performed better in germinative,vegetative,eco-physiological,and reproductive traits than the shade-dwelling *** growth chamber experiment exhibited that plants grown in high-light environment had greater seed germi

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Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer:Unravelling cha.l.nges and future directions

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World Journal of Gastroenterology 2024年第13期30卷 1815-1835页

作者： Samantha sharma Naresh Singh Anita Ahmed Turk Isabella Wan Akshay Guttikonda Julia.l.ly Dong Xinna Zhang Mateusz Opyrchal Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202United States Division of Hematology/Oncology Department of MedicineIndiana University School of MedicineIndianapolisIN 46202United States Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202United States

Colorectal cancer(CRC)is a complex disease with diverse etiologies and clinical *** considera.l. progress in development of CRC therapeutics,cha.l.nges remain regarding the diagnosis and management of advanced stage metastatic CRC(mCRC).In particular,the five-year survival rate is very low since mCRC is currently rarely *** the past decade,cancer treatment has significantly improved with the introduction of cancer immunotherapies,specifica.l. immune checkpoint *** aimed at blocking immune checkpoints such as PD-1,PD-l1,and CTlA-4 target inhibitory pathways of the immune system,and thereby enhance anti-tumor *** therapies thus have shown promising results in many clinical trials alone or in *** efficacy and safety of immunotherapy,either alone or in combination with CRC,have been investigated in several clinical *** trials,including KEYNOTE-164 and CheckMate 142,have led to Food and Drug Administration approval of the PD-1 inhibitors pembrolizumab and nivolumab,respectively,for the treatment of patients with unresecta.l. or metastatic microsatellite instability-high or deficient mismatch repair ***,these drugs benefit only a sma.l.percentage of patients,with the benefits of immunotherapy remaining elusive for the vast majority of CRC *** this end,primary and secondary resistance to immunotherapy remains a significant issue,and further research is necessary to optimize the use of immunotherapy in CRC and identify biomarkers to predict the *** review provides a comprehensive overview of the clinical trials involving immune checkpoint inhibitors in *** underlying rationale,cha.l.nges faced,and potential future steps to improve the prognosis and enhance the likelihood of successful trials in this field are discussed.

关键词： Colorectal cancer Immune checkpoint inhibitors Clinical trials Immunotherapy Microsatellite instability Microsatellite stability DNA mismatch repair

Effect of Nano-Filler on the Properties of Polymer Nanocomposite Films of PEO/PAN Complexed with NaPF6

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材料科学与工程（中英文B版） 2015年第11期5卷 418-434页

作者： Chandni Bhatt Ram Swaroop Anil Arya a.l. sharma Centre for Physical Sciences Central University of Punjab Mansa Road Bathinda-151001 Punjab India

Free standing transparent PNC (Polymer nanocomposite) films based on PEO/PAN + NaPF6 with different concentration (wt./wt.) filler of nano sized (TiO2) is synthesized by using standard solution cast technique. HRXRD (High resolution X-ray diffraction) and FESEM (Field emission scanning electron microscopy) have been performed to see the structural and microstructural behavior of the PNC films. The microscopic interaction among polymer, salt and nano-ceramic filler has been analyzed by FTIR (Fourier transformed infra-red) spectroscopy. The reduction of ion pair formation in polymeric separator is clea.l. observed on addition of nano-filler in the polymer salt complex film. Electrical (ionic/electronic) conductivity has been estimated (~ 10-4 S/cm) optimized PNC films concentration of nanofiller (15 Wt.%). The estimated value of electrical conductivity is well corroborated by FTIR study. Thermal analysis has been done with thermo gravimetry analysis to find out thermal stability of PNC films. Transport properties associated due to majority mobile carriers ions and only negligible participation from electrons was observed through transport number analysis. The band gap (i. e. direct as well as indirect) decreases on the addition of nano-filler observed from the optical analysis. The estimated result of the prepared PNC films are at par with desired value for the device application.

关键词：薄膜性能纳米复合纳米填料聚合物聚丙烯腈环氧乙烷傅立叶变换红外光谱扫描电子显微镜

Manifestation of earthquake preparation zone in the ionosphere before 2021 Sonitpur,Assam earthquake revealed by GPS-TEC data

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Geodesy and Geodynamics 2022年第3期13卷 230-237页

作者： Gopal sharma North Eastern Space Applications Centre Umiam793103MeghalayaIndia

Global Positioning System(GPS)Continuously Operating Reference Station(CORS)data analysis shows that the ionosphere’s electron density variability is linked to the deformation and stress accumulation in the Earth’s *** in ionosphere total electron content(TEC)variability before 2021 M6.4 Sonitpur,Assam earthquake were detected using l1 and l2 GPS frequencies that showed three distinct abnormalities on April 3,9,10,***’s correlation coefficient(r)of TEC decreases in the CORS that lies away from the earthquake epicenter,indicating the possibilities of a positive relationship between TEC variability and earthquake *** concentration also decreases towards the epicenter within the earthquake preparation zone(EPZ).It is also observed that the Pearson’s correlation coefficient(r)of TEC decreases linea.l. near the *** study demonstrates the possibilities of determining the TEC anomalous zone in the ionosphere that coincides with the EPZ in the crustal *** research indicated the possibilities of magnitude estimation of an impending earthquake based on the TEC anomalous zone in the ionosphere using closely spaced dense CORS network data.

关键词： GPS TEC Sonitpur earthquake Ionosphere perturbation TEC anomaly Magnitude estimation

Influence of pyrolysis temperature on rice straw biochar properties and corresponding effects on dynamic changes in bispyribac-sodium adsorption and leaching behavior in soil

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Pedosphere 2023年第3期33卷 463-478页

作者： Pervinder KAUR Neha sharma Khushwinder KAUR Department of Agronomy Punjab Agricultural UniversityLudhianaPunjab 141004(India) Department of Chemistry Punjab Agricultural UniversityLudhianaPunjab 141004(India) Department of Chemistry Panjab UniversityChandigarh 160014(India)

Bispyribac-sodium is a wea.l. acidic herbicide with high water solubility and is thus a potential source of groundwater *** the risk inherent to the use of this herbicide,this study assessed the impacts of rice straw(RS)and biochar amendments on the adsorption and leaching behavior of bispyribac-sodium in *** were produced from RS at different pyrolysis temperatures and characterized using various spectral *** straw had a surface area of 3.996×10^(4)m^(2)kg^(-1),which increased under pyrolysis;biochars prepared at 350 and 550℃(RS350 and RS550)in a closed furnace with limited oxygen supply had a surface area of 5.763×10^(4)and 6.890×10^(4)m^(2)kg^(-1),respectively,and biochar prepared by purging the pyroformer with N2(RSC)had the highest surface area of 12.173×10^(4)m^(2)kg^(-1).After amendment with RS and biochar,soil Freundlich adsorption capacity(KF ads)increased to varying extents in the order RSC>RS350>RS550,from 2.89×10^(3)to 29.57×10^(3)mg^(1-1)/nkg^(-1)l1/n,compared to1.55×10^(3)mg^(1-1)/nkg^(-1)l1/nin unamended *** variability in KF ads of bispyribac-sodium amongst the RS-and biochar-amended soils was dependent on the surface area of the *** desorption of bispyribac-sodium decreased in the RS-and biochar-amended soils and varied from90.45%to 95.20%in unamended soils and from 60.95%to 89.50%in amended *** adsorption and desorption of bispyribac-sodium varied significantly depending on its concentration and the type and application rate of soil *** leaching risk evaluation indices,viz.,modified leach index(***),leach index(lEACH),groundwater ubiquity score(GUS),Hornsby index(HI),leaching index(lIN),and pesticide leaching potential(PlP)index,were used to assess the susceptibility of groundwater to herbicide *** reduce the repetitive effects of common parameters in each index,a new index was developed by employing principal component analysis(PCA)to condense their infor

关键词： desorption Freundlich model groundwater contamination leaching potential leaching risk evaluation index pesticide soil amendment Temkin isotherm

A review on co-pyrolysis of agriculture biomass and disposa.l. medical face mask waste for green fuel production:recent advances and thermo-kinetic models

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化学科学与工程前沿:英文版 2023年第9期17卷 1141-1161页

作者： Melvin X.J.Wee Bridgid l.F.Chin Agus Saptoro Chung l.Yiin Jiuan J.Chew Jaka Sunarso Suzana Yusup Abhishek sharma Department of Chemical and Energy Engineering Faculty of Engineering and ScienceCurtin University MalaysiaCDT 250Miri 98009Malaysia Energy and Environment Research Cluster Faculty of Engineering and ScienceCurtin University MalaysiaCDT 250Miri 98009Malaysia Department of Chemical Engineering and Energy Sustainability Faculty of EngineeringUniversiti Malaysia Sarawak(UNIMAS)Kota Samarahan 94300Malaysia Institute of Sustaina.l. and Renewa.l. Energy(ISuRE) Universiti Malaysia Sarawak(UNIMAS)Kota Samarahan 94300Malaysia Research Centre for Sustaina.l. Technologies Faculty of EngineeringComputing and ScienceSwinburne University of TechnologyKuching 93350Malaysia Generation Unit(Fuel Technology&Combustion) Tenaga Nasional Berhad(TNB)Research Sdn BhdKajang 43000Malaysia Department of Chemical Engineering Manipal University JaipurJaipur 303007India Chemical&Environmental Engineering School of EngineeringRMIT UniversityMelbourneVictoria 3000Australia

The Association of Southeast Asian Nations is blessed with agricultural resources,and with the growing population,it will continue to prosper,which follows the abundance of agricultural *** biomass attracted researchers’interest in extracting bio-oil from these ***,the resulting bio-oil has low heating values and undesira.l. physical ***,co-pyrolysis with plastic or polymer wastes is adopted to improve the yield and quality of the ***,with the spread of the novel coronavirus,the surge of single-use plastic waste such as disposa.l. medical face mask,can potentia.l. set back the previous plastic waste reduction ***,studies of existing technologies and techniques are referred in exploring the potential of disposa.l. medical face mask waste as a candidate for co-pyrolysis with *** parameters,utilisation of catalysts and technologies are key factors in improving and optimising the process to achieve commercial standard of liquid *** copyrolysis involves a series of complex mechanisms,which cannot be explained using simple iso-conversional ***,advanced conversional models are introduced,followed by the evolutionary models and predictive models,which can solve the non-linear catalytic copyrolysis reaction *** outlook and cha.l.nges for the topic are discussed in deta.l.

关键词： biomass COVID-19 wast catalyst pyrolysis kinetics