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Intra-and interobserver reliability of ocular surface analyzer LacryDiag

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1418-1422页

作者： Eva.kos Valentina Cigić Mladen Bušić Mirjana Bjeloš Daliborka Miletić Biljana KuzmanovićElabjer University Eye Clinic University Hospital“Sveti Duh”Sveti Duh 64Zagreb 10000Croatia Faculty of Dental Medicine and Health Care Osijek Faculty of Medicine OsijekUniversity Josip Juraj Strossmayer in OsijekOsijek 31000Croatia

AIM:To invastigate intra-and interobserver reliability of interferometry,tear meniscus height(TMH)measurement and meibography(MBG)of an ocular surface analyzer,LacryDiag(Quantel Medical,France).METHODS:Five consecutive measurements and subsequent analysis of interferometry,TMH,and MBG were recorded by two examiners using the *** assess intra-and interobserver reliability,we used Cohen’s kappa for categorical variables(interferometry),or intraclass correlation coefficient for continuous variables(TMH,MBG).RESULTS:Thirty eyes of 30 examinees were *** both observers,there was excellent intraobserver reliability for MBG(0.955 and 0.970 for observer 1 and 2,respectively).Intraobserver reliability for observer 1 was substantial for interferometry(0.799),and excellent for TMH(0.863).Reliability for observer 2 was moderate for interferometry(0.535)and fair to good for TMH(0.431).Interobserver reliability was poor for interferometry(0.074)and fair to good for TMH(0.680)and MBG(0.414).CONCLUSION:LacryDiag ocular surface analyzer in our study proves to be a reliable noninvasive tool for the evaluation of TMH and *** for interferometry,poor interobserver reliability,fair to good intraobserver reliability for observer 1,and moderate for observer 2,leave room for improvement.

关键词： dry eye ocular surface analyzer interferometry tear meniscus height meibography

Incorporating physiological knowledge into correlative species distribution models minimizes bias introduced by the choice of calibration area

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Marine Life Science & Technology 2024年第2期6卷 349-362页

作者： Zhixin Zhang Jinxin Zhou Jorge García Molinos Stefano Mammola Ákos Bede‑Fazekas Xiao Feng Daisuke Kitazawa Jorge Assis Tianlong Qiu Qiang Lin CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Guangdong Provincial Key Laboratory of Applied Marine Biology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Marine Biodiversity and Ecological Evolution Research Center South China Sea Institute of OceanologyGuangzhou 510301China Global Ocean and Climate Research Center South China Sea Institute of OceanologyGuangzhou 510301China Institute of Industrial Science The University of Tokyo5-1-5 KashiwanohaKashiwaChiba 277-8574Japan Arctic Research Center Hokkaido UniversitySapporoHokkaido 001-0021Japan Finnish Museum of Natural History University of HelsinkiHelsinkiFinland Molecular Ecology Group(MEG) Water Research Institute(IRSA)National Research Council of Italy(CNR)28922 Verbania PallanzaItaly National Biodiversity Future Center(NBFC) PalermoItaly Institute of Ecology and Botany HUN-REN Centre for Ecological ResearchVácrátótHungary Department of Environmental and Landscape Geography ELTE Eötvös Loránd UniversityBudapestHungary Department of Biology University of North CarolinaChapel HillNC 27599USA Centre of Marine Sciences University of AlgarveCampus de GambelasFaroPortugal CAS Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

Correlative species distribution models(SDMs)are important tools to estimate species’geographic distribution across space and time,but their reliability heavily relies on the availability and quality of occurrence *** can be biased when occurrences do not fully represent the environmental requirement of a *** tested to what extent species’physiological knowledge might influence SDM *** on the Japanese sea cucumber Apostichopus japonicus within the coastal ocean of East Asia,we compiled a comprehensive dataset of occurrence *** then explored the importance of incorporating physiological knowledge into SDMs by calibrating two types of correlative SDMs:a naïve model that solely depends on environmental correlates,and a physiologically informed model that further incorporates physiological information as *** further tested the models’sensitivity to calibration area choices by fitting them with different buffered areas around known *** with naïve models,the physiologically informed models successfully captured the negative influence of high temperature on *** and were less sensitive to the choice of calibration *** naïve models resulted in more optimistic prediction of the changes of potential distributions under climate change(i.e.,larger range expansion and less contraction)than the physiologically informed *** findings highlight benefits from incorporating physiological information into correlative SDMs,namely mitigating the uncertainties associated with the choice of calibration *** these promising features,we encourage future SDM studies to consider species physi-ological information where available.

关键词： Bayesian approach Climate change Habitat suitability Physiological knowledge Species distribution model

A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis

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International Journal of Oral Science 2024年第2期16卷 265-279页

作者： Alfredo Torres M.Angélica Michea Ákos Végvári Marion Arce Valentina Pérez Marcela Alcota Alicia Morales Rolando Vernal Mauricio Budini Roman A.Zubarev Fermín E.González Laboratory of Experimental Immunology&Cancer Faculty of DentistryUniversity of ChileSantiagoChile Department of Conservative Dentistry Faculty of DentistryUniversity of ChileSantiagoChile Division of Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden Periodontal Biology Laboratory Faculty of DentistryUniversidad de ChileSantiagoChile Laboratory of Cellular and Molecular Pathology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases,yet its association with progressive periodontitis remains *** investigate the involvement and significance of ferroptosis in periodontitis progression,we assessed sixteen periodontitis-diagnosed *** progression was clinically monitored over twelve weeks via weekly clinical evaluations and gingival crevicular fluid(GCF)collection was performed for further *** metrics,proteomic data,in silico methods,and bioinformatics tools were combined to identify protein profiles linked to periodontitis progression and to explore their potential connection with *** western blot analyses validated key ***,a single-cell RNA sequencing(scRNA-seq)dataset(GSE164241)for gingival tissues was analyzed to elucidate cellular dynamics during periodontitis *** progression was identified as occurring at a faster rate than traditionally *** samples from progressing and non-progressing periodontal sites showed quantitative and qualitatively distinct proteomic *** addition,specific biological processes and molecular functions during progressive periodontitis were revealed and a set of hub proteins,including SNCA,CA1,HBB,SLC4A1,and ANK1 was strongly associated with the clinical progression status of ***,we found specific proteins-drivers or suppressors-associated with ferroptosis(SNCA,FTH1,HSPB1,CD44,and GCLC),revealing the co-occurrence of this specific type of regulated cell death during the clinical progression of ***,the integration of quantitative proteomic data with scRNA-seq analysis suggested the susceptibility of fibroblasts to *** analyses reveal proteins and processes linked to ferroptosis for the first time in periodontal patients,which offer new insights into the molecular mechanisms of progressive periodontal *** findings may le

关键词： finding progression faster

Diversity and surge in abundance of native parasitoid communities prior to the onset of Torymus sinensis on the Asian chestnut gall wasp(Dryocosmus kuriphilus) in Slovenia,Croatia and Hungary

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Journal of Forestry Research 2021年第4期32卷 1327-1336页

作者： Katarina.kos Nikola Lacković George Melika Dinka Matošević Department of Agronomy Biotechnical FacultyUniversity of LjubljanaJamnikarjeva 1011000 LjubljanaSlovenia Department for Forest Protection and Game Management Croatian Forest Research InstituteCvjetno naselje 4110450 JastrebarskoCroatia Plant Health and Molecular Biology Laboratory Directorate of Plant ProtectionSoil Conservation and Agri-environmentNational Food Chain Safety Offi ceBudaörsi u.141-145Budapest 1118Hungary Antuna Mihanovića 4 10450 JastrebarskoCroatia

Since the rapid spread of the Asian chestnut gall wasp(ACGW) throughout south-east Europe in the last few years,the possibilities of its control have been increasingly *** to constraints in available suppression measures in forest stands,biological control is recognized as the most suitable action to lower the abundance of the new invasive *** sinensis,as a specialized parasitoid chalcid wasp of ACGW,was introduced to suppress the pest in Italy in 2005,and later in Croatia,Hungary(2014) and Slovenia(2015).We investigated the native parasitoid complex associated with ACGW in Slovenia,Croatia and Hungary over 8 years of *** found 41 species of native parasitoids,eight of which are the first records on ACGW in Europe,adding up to a total of 51 species known to parasitize *** findings represent a large complex of cynipid-parasitoid ***,the abundance of native parasitoid populations on ACGW have demonstrated a temporal surge between the invasion of a new alien host(ACGW) and the onset of its specialized parasitoid,*** results indicate that the introduced parasitoid acts as a very successful biocontrol of ACGW,outcompeting native *** outcome should be considered as beneficial through the maintenance of ecological balance in affected forest ecosystems.

关键词： Invasive pest ACGW Biological control Native parasitoids Torymus sinensis

Centrifugal model test on a riverine landslide in the Three Gorges Reservoir induced by rainfall and water level fluctuation

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Geoscience Frontiers 2022年第3期13卷 196-209页

作者： Fasheng Miao Yiping Wu Ákos Török Linwei Li Yang Xue Faculty of Engineering China University of GeosciencesWuhan 430074China Engineering Research Center of Rock-Soil Drilling&Excavation and Protection Ministry of EducationWuhan 430074China Department of Construction Materials and Engineering Geology Budapest University of Technology and EconomicsBudapestHungary College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China

Frequent soil landslide events are recorded in the Three Gorges Reservoir area,China,making it necessary to investigate the failure mode of such riverside *** centrifugal test is considered to be the most realistic laboratory model,which can reconstruct the required *** this study,the Liangshuijing landslide in the Three Gorgers Reservoir area is selected for a scaled centrifugal model experiment,and a water pump system is employed to retain the rainfall *** the techniques of digital photography and pore water pressure transducers,water level fluctuation is controlled,and multi-physical data are thus obtained,including the pore water pressure,earth pressure,surface displacement and deep *** analysis results indicate that:Three stages were set in the test(waterflooding stage,rainfall stage and drainage stage).Seven transverse cracks with wide of 1–5 mm appeared during the model test,of which 3 cracks at the toe landslide were caused by reservoir water fluctuation,and the cracks at the middle and rear part were caused by *** rainfall process,the maximum displacement of landslide model reaches 3 *** the maximum deformation of the model exceeds 12 cm at the drainage *** failure process of the slope model can be divided into four stages:microcracks appearance and propagation stage,thrust-type failure stage,retrogressive failure stage,and holistic failure *** the thrust-type zone caused by rainfall was connected or even overlapped with the retrogressive failure zone caused by the drainage,the landslide would start,which displayed a typical composite failure *** failure mode and deformation mechanism under the coupling actions of water level fluctuation and rainfall are revealed in the model test,which could appropriately guide for the analysis and evaluation of riverside landslides.

关键词： Riverine landslide The Three Gorges Reservoir Centrifugal model test Rainfall Fluctuation of water level

Selective dorsal rhizotomy in cerebral palsy spasticity-a newly established operative technique in Slovenia: A case report and review of literature

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World Journal of Clinical Cases 2019年第10期7卷 1133-1141页

作者： Tomaz Velnar Peter Spazzapan Zoran Rodi Natasa.kos Roman Bosnjak Department of Neurosurgery University Medical Centre LjubljanaLjubljana 1000Slovenia AMEU-ECM Maribor Ljubljana 1000Slovenia Department of Neurophysiology University Medical Centre LjubljanaLjubljana 1000Slovenia Medical Rehabilitation Unit University Medical Centre LjubljanaLjubljana 1000Slovenia

BACKGROUND Spasticity affects a large number of children,mainly in the setting of cerebral palsy,however,only a few paediatric neurosurgeons deal with this *** is mainly due to the fact that until 1979,when Fasano has published the first series of selective dorsal rhizotomy(SDR),neurosurgeons were able to provide such children only a modest *** therapy of spasticity has made a great progress since ***,peroral drugs,intramuscular and intrathecal medicines are available,that may limit the effects of the *** addition,surgical treatment is gaining importance,appearing in the form of deep brain stimulation,peripheral nerve procedures and *** these options offer the affected children good opportunities of improving the quality of *** SUMMARY A 15-year old boy is presented that was surgically treated for spasticity as a result of cerebral *** at L1 level was performed and L1 to S1 nerve roots were isolated and divided in smaller ***,the SDR was *** We describe a patient report and surgical technique of SDR that was performed in Slovenia for the first time.

关键词： Cerebral palsy Spasticity Selective dorsal rhizotomy Operation Case report

Possibilities of Using Dam Reservoir Sediments in Earthworks

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Journal of Environmental Science and Engineering(B) 2015年第7期4卷 380-387页

作者： Karolina.kos Department of Hydraulic Engineering and Geotechnics Faculty of Environmental Engineering and Land Surveying University ofAgriculture Cracow 30-059 Poland

A possibility of using bottom sediments from dam reservoir as a material for earthen embankments was considered in the paper. It was stated that sediments cannot be used for road or hydrotechnical embankments without improving their geotechnical parameters. Thanks to low values of the permeability coefficient, they can be used for sealing elements in embankments or for low levees. In order to verify usability of this material for mentioned levees, stability and filtration calculations were carried out using Finite Element Method （FEM） analysis. It was stated the levee built from bottom sediments is stable even at the height of 8.0 m, despite the boundary conditions on the upstream side.

关键词： Dam reservoirs dredging stability.

Severe dystrophy in DiGeorge syndrome

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World Journal of Gastroenterology 2009年第11期15卷 1391-1393页

作者： Barnabás Rózsai kos Kiss Gyrgyi Csábi Márta Czakó Tamás Decsi Department of Pediatrics University of PécsPécs H-7623 Hungary Department of Medical Genetics and Child Development University of PécsPécs H-7623Hungary

We present the case history of a 3-year-old girl who was examined because of severe *** the background,cow’s milk allergy was found,but her body weight was unchanged after eliminating milk from her *** types of malabsorption were *** on nasal regurgitation and facial dysmorphisms,the possibility of DiGeorge syndrome was suspected and was confirmed by fluorescence in situ *** authors suggest a new feature associated with DiGeorge syndrome.

关键词： DiGeorge syndrome Dystrophy Cow's milkallergy Nasal regurgitation Hypoparathyroidism

Towards Integrated Heterogeneous Nanosystems

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Towards Integrated Heterogeneous Nanosystems