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Long-term changes in mandibular bone microchemical quality after radiation therapy and underlying systemic malignancy:A pilot study

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Journal of Innovative Optical Health Sciences 2021年第6期4卷 90-101页

作者： A.Palander H.Dekker M.Hyvärinen L.Rieppo I.Lyijynen E.A.J.M.Schulten C.M.Ten Bruggenkate a.koistinen A.Kullaa M.J.Turunen Institute of Dentistry University of Eastern Finland P.O.Box 162770211 KuopioFinland Department of Oral and Maxillofacial Surgery/Oral Pathology Amsterdam University Medical Centers and Academic Centre for Dentistry Amsterdam(ACTA)Vrije Universiteit Amsterdam De Boelelaan 11171081 HV AmsterdamThe Netherlands Research Unit of Medical Imaging Physics and Technology University of Oulu P.O.Box 5000 FI-90014 University of OuluFinland SIB Labs University of Eastern Finland P.O.Box 162770211 KuopioFinland Educational Dental Clinic Kuopio University Hospital P.O.Box 162770211 KuopioFinland Department of Applied Physics University of Eastern Finland P.O.Box 162770211 KuopioFinland

Radiation therapy(RT)is a treatment option for head and neck cancer(HNC),but 2%of RT patients may experience damage to the jawbone,resulting in osteoradionecrosis(ORN).The ORN can manifest years after RT exposure.Changes in the local microchemical bone quality prior to the clinical manifestation of ORN could play a key role in ORN pathogenesis.Chemical bone quality can be analyzed using Fourier transform infrared spectroscopy(FTIR),that is applied to examine the effects of cancer,chemotherapy,and RT on the quality of human man-dibular bone.Cortical mandibular bone samples were harvested from dental implant beds of 23 individuals,i.e.,patients with surgically and radiotherapeutically treated HNC(RT-HNC,n=7),surgically and radiochemotherapeutically treated HNC(CH-RT-HNC,n=3),only surgically treated HNC(SRG-HNC,n=4),and healthy controls(n=9).Infrared spectra were acquired from two representative regions of interest in cortical mandibular bone.Spectral parameters,i.e.,mineral-to-matrix ratio(MM),carbonate-to-matrix ratio(CM),carbonate-to-phosphate ratio(CP),collagen maturity(cross-linking),crystallinity,acid phosphate substitu-tion(APS),and advanced glycation end products(AGEs),were analyzed for each sample.Amide I region of the CH-RT-HNC group differed from the control group in cluster analysis(p=0.02).Apart from a minor variation trend in collagen maturity(p=0.07),there were no other signif-icant differences between the groups.Thus,the effect of radiochemotherapy on mandibular bone composition should be further investigated.In future trials,this study design is potential when the effects of the cancer burden and different HNC treatment modalities on jawbone composition are studied,in order to reveal ORN pathogenesis.

关键词： Mandibular bone radiation therapy Fourier transform infrared spectroscopy

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Cell Wall Lignin is Polymerised by Class Ⅲ Secretable Plant Peroxidases in Norway Spruce

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Journal of Integrative Plant Biology 2010年第2期52卷 186-194页

作者： Kurt V.Fagerstedt Eija M.Kukkola Ville V.T.koistinen Junko Takahashi Kaisa Marjamaa Department of Biological and Environmental Sciences Plant BiologyP.O. Box 65 FI-00014 Helsinki UniversityFinland Technical Research Center of Finland (VTT) PL 100002044 VTTFinland

Class Ⅲ secretable plant peroxidases occur as a large family of genes in plants with many functions and probable redundancy. In this review we are concentrating on the evidence we have on the catalysis of lignin polymerization by class Ⅲ plant peroxidases present in the apoplastic space in the xylem of trees. Some evidence exists on the specificity of peroxidase isozymes in lignin polymerization through substrate specificity studies, from antisense mutants in tobacco and poplar and from tissue and cell culture lines of Norway spruce （Picea abies） and Zinnia elegans. In addition, real time （RT-）PCR results have pointed out that many peroxidases have tissue specific expression patterns in Norway spruce. Through combining information on catalytic properties of the enzymes, on the expression patterns of the corresponding genes, and on the presence of monolignols and hydrogen peroxide in the apoplastic space, we can show that specific peroxidases catalyze lignin polymerization in the apoplastic space of Norway spruce xylem.

关键词： Secretable Plant Peroxidases in Norway Spruce

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Evaluating health care financing in a highly decentralized Beveridge model

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Health 2012年第11期4卷 1046-1052页

作者： Jan Klavus Ilkka Vohlonen Juha Kinnunen Veli koistinen Martti Virtanen Audiapro Ltd. Helsinki Finland Department of Health and Social Management University of Eastern Finland Kuopio Finland Department of Health and Social Management University of Eastern Finland Kuopio Finland Nordic Casemix Centre Helsinki Finland

The Finnish health care system is financed in a highly decentralized manner. In the tax-financed Beveridge model each municipality is responseble for financing and organizing health care services for its residents. This paper examined the annual incidence and treatment costs of three cost-intensive DRG-groups, and all DRG-groups together. The objective was to estimate municipal level predictions on the incidence of new illness cases and their associated costs, and to analyze whether there was greater uncertainty in anticipated specialized health care costs in municipalities with smaller populations. The dataset comprised of longitudinal hospital utilization and discharge data from Hospital Discharge Registers. The expected annual variation of illness cases and costs was assessed with respect to 95% confidence intervals estimated for each morbidity group and municipality. The results indicated that the costs of the selected morbidity groups fluctuated in a completely uncontrollable manner in municipalities with small populations. As the median size of Finnish municipalities is less than 6000, the inability to anticipate periodic health care costs constitutes an extensive financial problem and calls for the establishment of larger regional units and funding pools.

关键词： Health Care Financing Beveridge Model Predictability of Treatment Costs Risk Pooling

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International Comparison of Intercity Differences in Premature Deaths: Pyll-Rates in Canada, Finland and Russia 2010

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Health 2016年第9期8卷 818-826页

作者： Igor Krasilnikov Katerina Maximova Anna Korotkova Sylvie Stachenko Mikko Vienonen Alla Ivanova Veli koistinen Ilkka Vohlonen Epidemiology Medical Informatics and Analyses Center Saint Petersburg Russia School of Public Health University of Alberta Edmonton Alberta Canada Russian Federal Institute of Public Health Moscow Russia Health Policy Finnish Consulting Group Helsinki Finland University of Eastern Finland and Finnish Consulting Group Kuopio Finland

Background: Potential years of life lost (PYLL) rate describes the number of years lost due to pre-ventable premature death in a population. This is equal to the loss of human capital. Cause-specific PYLL-rates provide information for public health policy. Methods: PYLL-rate is calculated as an absolute difference between the age at death and the assumed length of life. Causes of preventable deaths are defined and classified according to International Classification of Diseases version 10 (ICD-10) as determined by World Health Organization. PYLL rate is age-standardized and expressed per 100,000 persons. Organization for Economic Cooperation and Development (OECD) standard of 70 years was applied as the expected length of life in Saint Petersburg (Russia), Edmonton (Canada), and Helsinki (Finland). Results: There were very big differences in PYLL rates of all causes of death between the countries compared. Total PYLL-rates were the lowest in Helsinki, slightly higher in Edmonton, and the highest in Saint Petersburg. The intercity differences in the total of PYLL-rates were considerably smaller among women than men. In each city, the three most prevalent causes of premature death were injuries, cancer and cardiovascular diseases. Magnitudes of these causes varied between the three cities. Conclusions: PYLL rate provides comparable and sensitive information about the health related well-being of a population concerning all preventable causes of death as well as cause-specific premature deaths. The study demonstrates that the reduction of cause-specific PYLL-rates is possible. It provides supplementary information for planning of health policies and evaluation of effectiveness of past interventions. Results demonstrate that these actions need to differ between countries and localities.

关键词： Premature Death Canada Finland Russia PYLL

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1050℃的离子碳——氮共渗

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热处理技术与装备 1986年第1期24卷 12-16页

作者： W.L.GRUBE D.P.koistinen 谭家骏北京工业大学

人们往往喜欢用碳——氮共渗代替渗碳,因为含氮的渗层显示出更好的淬透性,从而,可使低碳钢制造的小型零件采用油淬。本文报导的结果证明:如果对高速、高温离子渗碳技术加以改进,就可以成功地用于碳—氮共渗。但是,工艺条件必须调整到保... 详细信息

人们往往喜欢用碳——氮共渗代替渗碳,因为含氮的渗层显示出更好的淬透性,从而,可使低碳钢制造的小型零件采用油淬。本文报导的结果证明:如果对高速、高温离子渗碳技术加以改进,就可以成功地用于碳—氮共渗。但是,工艺条件必须调整到保证在碳—氮共渗周期的最后阶段既无碳也无氮的损失。这就需要在碳—氮共渗和扩散阶段维持C/N离子的比率。

关键词：共渗层钢试样离子氮化渗氮离子渗碳

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东芬兰豪基韦西湖缝合线和Ni、Cu的远景储量

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世界地质 1988年第2期 96-96页

作者： Tapio koistinen 青晓

豪基韦西湖缝合线是瑞卡造山运动(1.8～1.9Ma)期间发育的主要变形构造的一部分,接近前大陆边缘。它已被作为叠瓦带,或者更确切地说作为真的与俯冲带有关构造的引证。强应变不完整的混合岩与明显变质分带使得该区域具有深程度的侵蚀特征... 详细信息

豪基韦西湖缝合线是瑞卡造山运动(1.8～1.9Ma)期间发育的主要变形构造的一部分,接近前大陆边缘。它已被作为叠瓦带,或者更确切地说作为真的与俯冲带有关构造的引证。强应变不完整的混合岩与明显变质分带使得该区域具有深程度的侵蚀特征。众多构造片体的一个或两个其特征似乎是含Ni、Cu的基性到超基性侵入体的主要

关键词：缝合线沉积构造西湖侵入体 Cu Ni

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跨境合作的“游戏规则”:芬兰—俄罗斯犯罪预防中的立法和行政差异

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国际行政科学评论（中文版） 2018年第4期84卷 157-174页

作者：安娜-丽莎·休萨拉亚尔莫·科伊斯蒂宁杨阳(译) 杨柳(审校) 芬兰赫尔辛基大学亚历山德里研究所芬兰俄罗斯研究卓越中心芬兰国家调查局不详

本文阐释了在立法和行政方面差异悬殊的两个国家,在双边跨境合作中的动态变化,所用的分析材料是芬兰一俄罗斯犯罪预防双边合作案例研究的经验结果。当前,无论是国家层面的立法差异,还是快速变化的行政环境,都使这一合作面临挑战。该案... 详细信息

本文阐释了在立法和行政方面差异悬殊的两个国家,在双边跨境合作中的动态变化,所用的分析材料是芬兰一俄罗斯犯罪预防双边合作案例研究的经验结果。当前,无论是国家层面的立法差异,还是快速变化的行政环境,都使这一合作面临挑战。该案例研究显示,作为欧盟成员国与俄罗斯之间主要合作形式的双边合作,目前受到多种因素的影响:不连贯的甚至相互竞争的多边和双边结构、犯罪法律和程序的差异、国际条约和国内立法的差距、地域和地方实践的不一致、体制信任的脆弱和政策变化的无常。研究结果表明,跨境合作网络的有效性不能严格根据量化结果进行评估。更深入的长期合作不仅需要了解立法和行政的现实制约之处,而且需要国家层面和超国家层面的高度政治认同。

关键词：转型中的行政行政文化立法文化安全比较法

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