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利用旋转磁场驱动电流技术产生和维持FRC的实验

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物理学报 1988年第3期 452-459页

作者：吴成 a.knight I.R.JONES 中国科学院物理研究所 School of Physical Science Flinders University of South Australia Bedford Park S.A.5042

利用旋转磁场驱动电流技术产生场反向磁场位形(FRC)。实验中未观察到任何等离子体不稳定性。FRC的寿命由所加旋转磁场的时间(40 ms)决定。

关键词：旋转磁场电子轻子 FRC 驱动电流

Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders

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Neural Regeneration Research 2024年第6期19卷 1256-1261页

作者： Helen M.knight Merve DemirbugenÖz Adriana PerezGrovas-Saltijeral Division of Cells Organisms and Molecular GeneticsSchool of Life SciencesUniversity of NottinghamNottinghamUK Department of Pharmaceutical Toxicology Faculty of PharmacyAnkara UniversityAnkaraTurkey

The study of modified RNA known as epitranscriptomics has become increasingly relevant in our understanding of disease-modifying *** of N6 adenosine(m^(6)A)and C5 cytosine(m^(5)C)bases occur on mRNAs,tRNA,mt-tRNA,and rRNA species as well as non-coding *** emerging knowledge of RNA binding proteins that act as writer,reader,and eraser effector proteins,comes a new understanding of physiological processes controlled by these *** processes when spatiotemporally disrupted within cellular nanodomains in highly specialized tissues such as the brain,give rise to different forms of *** this review,we discuss accumulating evidence that changes in the m^(6)A and m^(5)C methylation systems contribute to neurocognitive *** studies first identified mutations within FMR1 to cause intellectual disability Fragile X syndromes several years before FMR1 was identified as an m^(6)A RNA reader ***,familial mutations within the m^(6)A writer gene METTL5,m^(5)C writer genes NSUN2,NSUN3,NSUN5,and NSUN6,as well as THOC2 and THOC6 that form a protein complex with the m^(5)C reader protein ALYREF,were recognized to cause intellectual development ***,differences in expression of the m^(5)C writer and reader effector proteins,NSUN6,NSUN7,and ALYREF in brain tissue are indicated in individuals with Alzheimer's disease,individuals with a high neuropathological load or have suffered traumatic brain ***,an abundance of m^(6)A reader and anti-reader proteins are reported to change across brain regions in Lewy bodies diseases,Alzheimer's disease,and individuals with high cognitive reserve.m^(6)A-modified RNAs are also reported significantly more abundant in dementia with Lewy bodies brain tissue but significantly reduced in Parkinson's disease tissue,whilst modified RNAs are misplaced within diseased cells,particularly where synapses are *** parahippocampal brain tissue,m^(6)A modification is enri

关键词： 5-methylcytosine methylation Alzheimer's disease cognitive diseases epitranscriptomics intellectual disability Lewy body diseases N6 adenosine RNA modification

Pelvic fractures in blunt trauma patients:A comparative study

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World Journal of Orthopedics 2024年第5期15卷 418-434页

作者： Alexander A Fokin Joanna Wycech knight Madison E Tharp Kyler C Brinton Phoebe K Gallagher Justin Fengyuan Xie Russell D Weisz Ivan Puente Trauma and Critical Care Services Delray Medical CenterDelray BeachFL 33484United States Charles E Schmidt College of Medicine Department of SurgeryFlorida Atlantic UniversityBoca RatonFL 33431United States Trauma and Critical Care Services Broward Health Medical CenterFort LauderdaleFL 33316United States Charles E Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFL 33431United States Herbert Wertheim College of Medicine Department of SurgeryFlorida International UniversityMiamiFL 33199United States

BACKGROUND Pelvic fractures(PF)with concomitant injuries are on the rise due to an increase of high-energy *** of the elderly population with age related comorbidities further complicates the *** organ injuries are kindred with PF due to the proximity to pelvic *** of contrast blush(CB)on computed tomography in patients with PF is considered a sign of active bleeding,however,its clinical significance and association with outcomes is *** To analyze polytrauma patients with PF with a focus on the geriatric population,co-injuries and the value of contrast *** This retrospective cohort study included 558 patients with PF admitted to level 1 trauma center(01/2017-01/2023).Analyzed variables included:Age,sex,mechanism of injury(MOI),injury severity score(ISS),Glasgow coma scale(GCS),abbreviated injury scale(AIS),co-injuries,transfusion requirements,pelvic angiography,embolization,laparotomy,orthopedic pelvic surgery,intensive care unit and hospital lengths of stay,discharge disposition and *** study compared geriatric and non-geriatric patients,patients with and without CB and abdominal *** score matching was implemented in comparison *** PF comprised 4%of all trauma admissions.89 patients had CB.286(52%)patients had concomitant injuries including 93(17%)patients with abdominal *** patients compared to non-geriatric had more falls as MOI,lower ISS and AIS pelvis,higher GCS,less abdominal co-injuries,similar CB and angio-embolization rates,less orthopedic pelvic surgeries,shorter lengths of stay and higher *** propensity matching,orthopedic pelvic surgery rates remained lower(8%vs 19%,P<0.001),hospital length of stay shorter,and mortality higher(13%vs 4%,P<0.001)in geriatric *** of 89 patients with CB,45(51%)were *** propensity matching,patients with CB compared to without CB had more pelvic angiography(71%vs 12%,P<0.001),hi

关键词： Pelvic fractures Geriatric trauma patients Abdominal co-injuries Contrast blush Contrast extravasation Angioembolization Polytrauma patients Surgical interventions Blunt trauma External and internal fixation for pelvic stabilization

螺旋采样联合动态压缩传感高速信号采集技术在单次屏气腹部4D血流MR成像中的应用

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国际医学放射学杂志 2015年第3期 283-283页

作者： H.Dyvorne a.knight-Greenfield G.Jajamovich C.Besa Y.Cui A.Stalder 李心海 Department of Radiology/Translational and Molecular Imaging Institute Icahn School of Medicine at Mount Sinai1470 Madison Ave New York NY 10029

目的研究一种基于螺旋采样及动态压缩传感信号采集技术的高速相位对比心脏门控容积流量测量(4D流量)MR成像技术,并与已有的相位对比成像技术进行比较,

关键词：相位对比动态压缩采集技术 MR 血流单次螺旋腹部躯干

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加拿大央行打响了背离美联储的第一枪

商业周刊（中文版） 2024年第9期 20-22页

作者： Erik Hertzberg Randy Thanthong-knight Jay Zhao-Murray 杨(译) 不详

加拿大央行行长蒂夫·麦克勒姆明确表示,尽管加元可能面临下行压力,但加拿大的利率政策不需要与美国亦步亦趋。加拿大央行行长蒂夫·麦克勒姆(Tiff Macklem)率先在七国集团(G-7)中降息,他对这一举措的信心,或有助于让其他央行放下心来,... 详细信息

加拿大央行行长蒂夫·麦克勒姆明确表示,尽管加元可能面临下行压力,但加拿大的利率政策不需要与美国亦步亦趋。加拿大央行行长蒂夫·麦克勒姆(Tiff Macklem)率先在七国集团(G-7)中降息,他对这一举措的信心,或有助于让其他央行放下心来,他们也可以在美联储之前降息。

关键词：七国集团克勒姆降息利率政策央行第一枪美联储加拿大

Genomic Mutations Within the Host Microbiome: Adaptive Evolution or Purifying Selection

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Engineering 2023年第1期20卷 96-102页

作者： Jiachao Zhang Rob knight School of Food Science and Engineering Hainan UniversityHaikou 570228China Department of Pediatrics University of California San DiegoLa JollaCA 92093USA Center for Microbiome Innovation Jacobs School of EngineeringUniversity of California San DiegoLa JollaCA 92093USA Department of Bioengineering University of California San DiegoLa JollaCA 92093USA Department of Computer Science and Engineering University of California San DiegoLa JollaCA 92093USA

Next-generation sequencing technology has transformed our ability to assess the taxonomic composition functions of host-associated microbiota and microbiomes. More human microbiome research projects—particularly those that explore genomic mutations within the microbiome—will be launched in the next decade. This review focuses on the coevolution of microbes within a microbiome, which shapes strain-level diversity both within and between host species. We also explore the correlation between microbial genomic mutations and common metabolic diseases, and the adaptive evolution of pathogens and probiotics during invasion and colonization. Finally, we discuss advances in methods and algorithms for annotating and analyzing microbial genomic mutations.

关键词： Gut microbiota Genomic mutations Adaptive evolution Purifying selection Single-nucleoti de variants

Sediment Transport in Rivers with Overbank Flow

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四川大学学报（工程科学版） 2005年第S1期37卷 16-29页

作者： Donald W knight Water Eng. The Univ.of BirminghamUK

Some concepts related to sediment transport in rivers with overbank flow are *** a description of the physical processes that are involved when a river inundates its floodplains,some simple com- putational methods are presented which permit the depth-averaged velocity and boundary shear stress to be pre- dicted within a cross section of variable,but prismatic *** methoda account for the strong transverse shear in velocity that occurs when the stage is just above bankfull,as well as ...

关键词： sediment transport overbank flow

Detailed characterization of kHz-rate laser-driven fusion at a thin liquid sheet with a neutron detection suite

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High Power Laser Science and Engineering 2024年第1期12卷 13-23页

作者： Benjamin M.knight Connor M.Gautam Colton R.Stoner Bryan V.Egner Joseph R.Smith Chris M.Orban Juan J.Manfredi Kyle D.Frische Michael L.Dexter Enam A.Chowdhury Anil K.Patnaik Department of Engineering Physics Air Force Institute of TechnologyWPAFBOHUSA Physics Department Marietta CollegeMariettaOHUSA Department of Physics The Ohio State UniversityColumbusOHUSA Department of Materials Science and Engineering and Department of Electrical and Computer ScienceThe Ohio State UniversityColumbusOHUSA Intense Energy Solutions LLCPlain CityOHUSA

We present detailed characterization of laser-driven fusion and neutron production(-10^(5)/second) using 8 mJ, 40 fs laser pulses on a thin(<1 μm) D_2O liquid sheet employing a measurement suite. At relativistic intensity(~ 5 × 10^(18)W/cm^(2))and high repetition rate(1 kHz), the system produces deuterium±deuterium(D-D) fusion, allowing for consistent neutron generation. Evidence of D-D fusion neutron production is verified by a measurement suite with three independent detection systems: an EJ-309 organic scintillator with pulse-shape discrimination, a ~3He proportional counter and a set of 36 bubble detectors. Time-of-flight analysis of the scintillator data shows the energy of the produced neutrons to be consistent with 2.45 MeV. Particle-in-cell simulations using the WarpX code support significant neutron production from D-D fusion events in the laser±target interaction region. This high-repetition-rate laser-driven neutron source could provide a low-cost, on-demand test bed for radiation hardening and imaging applications.

关键词： high-repetition-rate laser-driven fusion laser-plasma interaction liquid target neutron detectors

Lateral distributions of streamwise velocity in compound channels with partially vegetated floodplains

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Science China(Technological Sciences) 2009年第11期52卷 3357-3362页

作者： knight Donald W School of Civil Engineering The University of Birmingham Birmingham B15 2TT UK

Natural rivers are commonly characterized by a main channel for primary flow conveyance and a floodplain, often partially covered with vegetation such as shrubs or trees, to carry extra flow during floods. The hydraulic resistance due to vegetation on the floodplain typically causes a further reduction of flow velocity and increases the velocity difference between the main channel and the floodplain. As a consequence a strong lateral shear layer leads to the exchange of mass and momentum between the main channel and floodplain, which in turn affects the overall channel conveyance and certain fluvial processes. The prediction of the lateral velocity distribution is important for many flood alleviation schemes, as well as for studies on sediment transport and dispersion in such channels. The present paper proposes a method for predicting the depth-averaged velocity in compound channels with partially vegetated floodplains, based on an analytical solution to the depth-integrated Reynolds-Averaged Navier-Stokes equation with a term included to account for the effects of vegetation. The vegetation is modelled via an additional term in the momentum equation to account for the additional drag force. The method includes the effects of bed friction, drag force, lateral turbulence and secondary flows, via four coefficients f, CD, λ & Γ respectively. The predicted lateral distributions of depth-averaged velocity agree well with the experimental data. The analytical solutions can also be used to predict the distribution of boundary shear stresses, which adds additional weight to the method proposed.

关键词： vegetation compound channel floodplain velocity