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Utility of plasma D-dimer for diagnosis of venous thromboembolism after hepatectomy

World Journal of Clinical Cases 2024年第2期12卷 276-284页

作者： Taiichiro Miyake Hiroaki Yanagimoto Daisuke Tsugawa Masayuki Akita Riki Asakura Keisuke Arai Toshihiko Yoshida Shinichi So Jun Ishida Takeshi Urade Yoshihide Nanno Kenji Fukushima Hidetoshi Gon Shohei Komatsu Sadaki Asari Hirochika Toyama Masahiro kido Tetsuo Ajiki Takumi Fukumoto Division of Hepato-Biliary-Pancreatic Surgery Department of SurgeryKobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Venous thromboembolism(VTE)is a potentially fatal complication of hepatectomy.The use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the risk of postoperative bleeding.Therefore,we hypothesized that monitoring plasma D-dimer could be useful in the early diagnosis of VTE after hepatectomy.AIM To evaluate the utility of monitoring plasma D-dimer levels in the early diagnosis of VTE after hepatectomy.METHODS The medical records of patients who underwent hepatectomy at our institution between January 2017 and December 2020 were retrospectively analyzed.Patients were divided into two groups according to whether or not they developed VTE after hepatectomy,as diagnosed by contrast-enhanced computed tomography and/or ultrasonography of the lower extremities.Clinicopathological factors,including demographic data and perioperative D-dimer values,were compared between the two groups.Receiver operating characteristic curve analysis was performed to determine the D-dimer cutoff value.Univariate and multivariate analyses were performed using logistic regression analysis to identify significant predictors.RESULTS In total,234 patients who underwent hepatectomy were,of whom(5.6%)were diagnosed with VTE following hepatectomy.A comparison between the two groups showed significant differences in operative time(529 vs 403 min,P=0.0274)and blood loss(530 vs 138 mL,P=0.0067).The D-dimer levels on postoperative days(POD)1,3,5,7 were significantly higher in the VTE group than in the non-VTE group.In the multivariate analysis,intraoperative blood loss of>275 mL[odds ratio(OR)=5.32,95%confidence interval(CI):1.05-27.0,P=0.044]and plasma D-dimer levels on POD 5≥21μg/mL(OR=10.1,95%CI:2.04-50.1,P=0.0046)were independent risk factors for VTE after hepatectomy.CONCLUSION Monitoring of plasma D-dimer levels after hepatectomy is useful for early diagnosis of VTE and may avoid routine prophylactic anticoagulation in the postoperative period.

关键词： Hepatectomy Malignant tumor Postoperative complication D-dimer Early diagnosis Venous thromboembolism

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人类自然群体D20S161基因座的遗传多态性研究

人类自然群体D20S161基因座的遗传多态性研究

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第二次全国法医物证学学术交流会

作者：李英碧侯一平吴谨金泽明 H.Walter a.kido M．Prinz 华西医科大学法医学系物证教研室 Department of Human BiologyUniversity of Bremen D28332 BremenGermany Department of Legal MedicineYamanashi Medical University 409-38 Yamanashi-kenTamahoJapan Department of Forensic BiologyThe Office of the Chief Medical Examiner (OCME) 520 First AvenueNY 10016 New YorkUSA

D20S161短串联重复序列(D20S161 STR,D20S161),定位于人类第20号染色体,核心序列为(TAGA,TAGG),1995年由美国 Utah 大学遗传标记研究小组(Utah Marker Development Group)从人类基因组分离获得。至今,其在人类自然群体中的基因频率分布...

D20S161短串联重复序列(D20S161 STR,D20S161),定位于人类第20号染色体,核心序列为(TAGA,TAGG),1995年由美国 Utah 大学遗传标记研究小组(Utah Marker Development Group)从人类基因组分离获得。至今,其在人类自然群体中的基因频率分布状态尚不清楚。为了获得 D20S161 基因座在人类群体中的群体遗传学资料,本研

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Validation of the Japan Coma Scale for the prediction of mortality in children:analysis of a nationwide trauma database

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World Journal of Pediatric Surgery 2022年第2期5卷 23-28页

作者： Yuki Enomoto Yusuke Tsutsumi Asuka Tsuchiya Takahiro kido Koji Ishigami Masahito Togo Susumu Yasuda Yoshiaki Inoue Department of Emergency and Critical Care Medicine University of TsukubaTsukubaIbarakiJapan Department of Emergency and Critical Care Medicine Mito Medical CenterMitoIbarakiJapan Department of Emergency and Critical Care Medicine Tokai University School of Medicine Graduate School of MedicineIseharaKanagawaJapan Department of Clinical Epidemiology and Health Economics The University of TokyoBunkyo-kuTokyoJapan Department of Pediatrics University of Tsukuba HospitalTsukubaIbarakiJapan

Objective The Japan Coma Scale(JCS)is widely used in clinical practice to evaluate levels of consciousness in Japan.There have been several studies on the usefulness of JCS in adults.However,its usefulness in evaluating children has not been reported.Therefore,this study aimed to assess the usefulness of the JCS for the prediction of mortality in children.Methods This is a multicenter cohort study which used data from a national trauma registry(Japan Trauma Data Bank).This study included patients under 16 years of age who were treated between 2004 and 2015.The primary outcome measure was in-hospital mortality.Two models were used to examine each item of the Glasgow Coma Scale(GCS)and the JCS.Model A included the discrete levels of each index.In model B,data regarding age,sex,vital signs on arrival to hospital,the Injury Severity Score,and blunt trauma were added to each index.The effectivity of the JCS score was then evaluated using the area under the curve(AUC)for discrimination,a calibration plot,and the Hosmer-Lemeshow test for calibration.Results A total of 9045 patients were identified.The AUCs of the GCS and JCS were 0.929(95%confidence interval(CI)0.904 to 0.954)and 0.930(95%CI 0.906 to 0.954)in model A and 0.975(95%CI 0.963 to 0.987)and 0.974(95%CI 0.963 to 0.985)in model B,respectively.The results of the Hosmer-Lemeshow test were 0.00(p=1.00)and 0.00(p=1.00)in model A and 4.14(p=0.84)and 8.55(p=0.38)in model B for the GCS and JCS,respectively.Conclusions We demonstrated that the JCS is as valid as the GCS for predicting mortality.The findings of this study indicate that the JCS is a useful and relevant tool for pediatric trauma care and future research.

关键词： Glasgow prediction nationwide

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Identification of a TSPY co-expression network associated with DNA hypomethylation and tumor gene expression in somatic cancers

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Journal of Genetics and Genomics 2016年第10期43卷 577-585页

作者： Tatsuo kido Yun-Fai Chris Lau Division of Cell and Developmental Genetics Department of Medicine Veterans Affairs Medical Center and Institute for Human Genetics University of California

Testis specific protein Y-encoded（TSPY） is a Y-located proto-oncogene predominantly expressed in normal male germ cells and various types of germ cell tumor. Significantly, TSPY is frequently expressed in somatic cancers including liver cancer but not in adjacent normal tissues, suggesting that ectopic TSPY expression could be associated with oncogenesis in non-germ cell cancers. Various studies demonstrated that TSPY expression promotes growth and proliferation in cancer cells; however, its relationship to other oncogenic events in TSPY-positive cancers remains unknown. The present study seeks to correlate TSPY expression with other molecular features in clinical cancer samples, by analyses of RNA-seq transcriptome and DNA methylation data in the Cancer Genome Atlas（TCGA） database. A total of 53 genes,including oncogenic lineage protein 28 homolog B（LIN28B） gene and RNA-binding motif protein Y-linked（RBMY） gene, are identified to be consistently co-expressed with TSPY, and have been collectively designated as the TSPY co-expression network（TCN）. TCN genes were simultaneously activated in subsets of liver hepatocellular carcinoma（30%） and lung adenocarcinoma（10%） regardless of pathological stage, but only minimally in other cancer types. Further analysis revealed that the DNA methylation level was globally lower in the TCN-active than TCN-silent cancers. The specific expression and methylation patterns of TCN genes suggest that they could be useful as biomarkers for the diagnosis,prognosis and clinical management of cancers, especially those for liver and lung cancers, associated with TSPY co-expression network genes.

关键词： Co-expression network DNA methylation Gene expression signature Cancer subclassification Y chromosome genes TSPY Cancer/testis antigens

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Roles of the Y chromosome genes in human cancers

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Asian Journal of Andrology 2015年第3期17卷 373-380页

作者： Tatsuo kido Yun-Fai Chris Lau Division of Cell and Developmental Genetics Department of Medicine Veterans Affairs Medical Center Institute for Human Genetics University of California San Francisco California 94121 USA

Male and female differ genetically by their respective sex chromosome composition, that is, XY as male and XX as female. Although both X and Y chromosomes evolved from the same ancestor pair of autosomes, the Y chromosome harbors male-specific genes, which play pivotal roles in male sex determination, germ cell differentiation, and masculinization of various tissues. Deletions or translocation of the sex-determining gene, SRY, from the Y chromosome causes disorders of sex development （previously termed as an intersex condition） with dysgenic gonads. Failure of gonadal development results not only in infertility, but also in increased risks of germ cell tumor （GCT）, such as gonadoblastoma and various types of testicular GCT. Recent studies demonstrate that either loss of Y chromosome or ectopic expression of Y chromosome genes is closely associated with various male-biased diseases, including selected somatic cancers. These observations suggest that the Y-linked genes are involved in male health and diseases in more frequently than expected. Although only a small number of protein-coding genes are present in the male-specific region of Y chromosome, the impacts of Y chromosome genes on human diseases are still largely unknown, due to lack of in vivo models and differences between the Y chromosomes of human and rodents. In this review, we highlight the involvement of selected Y chromosome genes in cancer development in men.

关键词： germ cell tumors RBMY, Y-linked somatic cancers TSPY Y chromosome

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Producing micro-droplet of dilute sulphuric acid on pure iron surface and observing its corrosion behaviour by atomic force microscopy

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中国有色金属学会会刊：英文版 2006年第B2期16卷 749-752页

作者： Mitsuo kido Koji MUKAI Faculty of EngineeringHiroshima Institute of Technology 1-2-1 MiyakeSaeki-KuHiroshima 731-5193Japan

A simple method was presented to produce a micro-droplet of sulphuric acid on a pre-selected micro-zone on a pure iron surface with the tip of an AFM cantilever. The three-dimensional shape of the droplet was imaged with the AC non-contact mode of the AFM, and the liquid/solid interface was observed in situ during corrosion using the contact mode. The substrate surface beneath the droplet was lowered by approximately 19 nm after 3.6 ks of adhesion. This method has important implications for experimental studies of micro-zone corrosion or lubrication.

关键词：纯铁表面腐蚀稀释硫酸微滴原子力显微镜钢

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子宫内膜癌MRI分期:欧洲泌尿生殖放射学会最新指南

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国际医学放射学杂志 2019年第2期42卷 253-253页

作者： S.Nougaret M.Horta E.Sala Y.Lakhman I.Thomassin-Naggara a.kido 杨凯(译) 赵世华(校) IRCM Montpellier Cancer Research institute208 Ave des Apothicaires34295 MontpellierFrance 不详

目的对2009欧洲泌尿生殖放射学会(ESUR)子宫内膜癌指南进行更新,并提出子宫内膜癌MRI分期规范化影像采集、解读及报告的策略。方法采用RAND-UCLA合理性方法(RAM)对已发表的基于证据的数据和专家意见进行结合,作为这些共识指南的基础。

关键词：子宫内膜癌放射学会泌尿生殖 MRI

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Analysis of air adsorptive on solid surfaces by AFM and XPS

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中国有色金属学会会刊：英文版 2006年第B2期16卷 753-758页

作者： Mitsuo kido Faculty of EngineeringHiroshima Institute of Technology 1-2-1 MiyakeSaeki-KuHiroshima 731-5193Japan

Solid surfaces of HOPG, pure copper, chromium, zinc, copper and SUS304 steel were observed in ambient air with an a.c. non-contact mode of atomic force microscope(AFM). A type of film-like-domains (adsorptive) was detected on the above surfaces. The thickness of the adsorptive was about 1.2-2.4 nm in this case. The film-like-adsorptive was confirmed to be a liquid layer by the static contact-mode scanning, the measurement of the elasticity and viscosity images, and the detection of the condensation/ evaporation phenomena when the relative humidity changed. The liquid layer is considered to be condensed water covered with organic contaminant.

关键词：固体表面空气吸附成分分析原子力显微镜 XPS 水有机污染物

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全膝关节置换术中根据胫骨近端前后轴线调整髓外定位远端截骨导向器的效果

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临床骨科杂志 2024年第1期27卷 116-116页

作者： MIZU-UCHI H kido H CHIKAMA T 胡孔足(摘译) 不详

全膝关节置换术中使用髓外定位进行胫骨截骨只有60%~80%患者获得理想的3°以内冠状位力线。这可能是因为髓外定位远端参考点为踝关节,不能很好地反映胫骨扭转状况,髓外定位远端参考点的旋转必须与胫骨近端前后轴线一致。使用传统髓外定... 详细信息

全膝关节置换术中使用髓外定位进行胫骨截骨只有60%~80%患者获得理想的3°以内冠状位力线。这可能是因为髓外定位远端参考点为踝关节,不能很好地反映胫骨扭转状况,髓外定位远端参考点的旋转必须与胫骨近端前后轴线一致。使用传统髓外定位装置可能导致远端参考点与理想位点显著分离。

关键词：胫骨近端髓外定位全膝关节置换术参考点导向器踝关节胫骨截骨冠状位

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Long-Term Outcomes of Systemic-to-Pulmonary Artery Shunt in Patients with Functional Single Ventricle and Heterotaxy Syndrome

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Congenital Heart Disease 2023年第4期18卷 399-411页

作者： Shota Kawai Takashi kido Yuta Teguri Koji Miwa Tomomitsu Kanaya Yoichiro Ishii Hisaaki Aoki Futoshi Kayatani Sanae Tsumura Department of Cardiovascular Surgery Osaka Women’s and Children’s HospitalIzumiOsakaJapan Department of Pediatric Cardiology Osaka Women’s and Children’s HospitalIzumiOsakaJapan

Objectives: We sought to determine the long-term outcomes and mortality-associated factors after systemic-topulmonaryartery shunt (SPS) in patients with heterotaxy syndrome. Methods: We retrospectively analyzed allpatients with a functional single ventricle and heterotaxy syndrome who underwent SPS at our center from January2001 to April 2022. Results: This study involved 84 patients. Restrictive pulmonary blood flow requiringearly modulation was presented in 34 (40%) patients. Compared with patients without restrictive pulmonaryblood flow (N = 50 [60%]), the postnatal survival of these 34 patients was significantly lower at 10 years (log rank:p = 0.04), but the statistical significance disappeared at 20 years (log rank: p = 0.18). Among 31 patients whounderwent SPS, 11 (35%) had extracardiac total anomalous pulmonary venous connection (TAPVC). The survivalrate after SPS was 80% at 10 years. Cox regression analysis showed that extracardiac TAPVC (hazard ratio6.44, 95% confidence interval 1.23–33.7, p = 0.03) and pulmonary venous obstruction (PVO) at TAPVC repair(hazard ratio 11.2, 95% confidence interval 2.13–58.5, p = 0.004) were significantly associated with death. In25 patients who underwent bidirectional cavopulmonary shunt (BCPS), surgical interventions on the pulmonaryartery (PA) were performed after SPS in 7 of 9 patients with PA coarctation, 3 of 4 with non-confluent PAs, and4 of 12 with normal PAs. At SPS, primary central PA plasty was performed in three patients with PA coarctationand 2 with non-confluent PAs. There was no significant difference in the PA index before BCPS between patientswith and without primary central PA plasty (p = 0.49). Among 20 patients who underwent total cavopulmonaryconnection (TCPC), adverse events occurred in 7 (35%) patients, including death in 1 (5%), intervention for pulmonaryarteriovenous malformation (PAVM) in 3 (15%), and surgical intervention for PVO in 3 (15%). TheB-type natriuretic peptide concentration was significantly higher in patients with than without adverse

关键词： Heterotaxy syndrome single ventricle total anomalous of pulmonary venous connection pulmonary artery coarctation

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