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Ayurveda and in silico Approach: A Challenging Proficient Confluence for Better Development of Effective Traditional Medicine Spotlighting Network Pharmacology

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Chinese Journal of Integrative Medicine 2023年第5期29卷 470-480页

作者： Rashmi sahu Prashant kumar Gupta Amit Mishra Awanish kumar Department of Balroga Shri NPA Govt.Ayurveda CollegeRaipur(492010)ChhattisgarhIndia Ayurinformatics Lab Department of KaumarabhrityaAll India Institute of AyurvedaSarita ViharNew Delhi(110076)India Cellular and Molecular Neurobiology Unit Indian Institute of TechnologyJodhpur(342037)RajasthanIndia Department of Biotechnology National Institute of TechnologyRaipur(492010)ChhattisgarhIndia

Coalescence of traditional medicine Ayurveda and in silico technology is a rigor for supplementary development of future-ready effective traditional medicine. Ayurveda is a popular traditional medicine in South Asia, emanating worldwide for the treatment of metabolic disorders and chronic illness. Techniques of in silico biology are not much explored for the investigation of a variety of bioactive phytochemicals of Ayurvedic herbs. Drug repurposing, reverse pharmacology, and polypharmacology in Ayurveda are areas in silico explorations that are needed to understand the rich repertoire of herbs, minerals, herbo-minerals, and assorted Ayurvedic formulations. This review emphasizes exploring the concept of Ayurveda with in silico approaches and the need for Ayurinformatics studies. It also provides an overview of in silico studies done on phytoconstituents of some important Ayurvedic plants, the utility of in silico studies in Ayurvedic phytoconstituents/formulations, limitations/challenges, and prospects of in silico studies in Ayurveda. This article discusses the convergence of in silico work, especially in the least explored field of Ayurveda. The focused coalesce of these two domains could present a predictive combinatorial platform to enhance translational research magnitude. In nutshell, it could provide new insight into an Ayurvedic drug discovery involving an in silico approach that could not only alleviate the process of traditional medicine research but also enhance its effectiveness in addressing health care.

关键词： Ayurveda in silico approach conﬂuence challenge effective therapeutics

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ITERATIVE ALGORITHMS FOR SYSTEM OF VARIATIONAL INCLUSIONS IN HADAMARD MANIFOLDS

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Acta Mathematica Scientia 2022年第4期42卷 1333-1356页

作者： Qamrul Hasan ANSARI Feeroz BABU D.R.sahu Department of Mathematics Aligarh Muslim UniversityAligarh202002India Department of Applied Mathematics Aligarh Muslim UniversityAligarh202002India Department of Mathematics Banaras Hindu UniversityVaranasi 221005India

In this paper,we consider system of variational inclusions and its several spacial cases,namely,alternating point problems,system of variational inequalities,etc.,in the setting of Hadamard *** propose an iterative algorithm for solving system of variational inclusions and study its convergence *** special cases of the proposed algorithm and convergence result are also *** present application to constraints minimization problems for bifunctions in the setting of Hadamard *** the end,we illustrate proposed algorithms and convergence analysis by a numerical *** algorithms and convergence results of this paper either improve or extend known algorithms and convergence results from linear structure to Hadamard manifolds.

关键词： System of variational inclusions altering point problems monotone vector fields strictly pseudocontractive mappings Hadamard manifolds

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Investigation of the factors affecting the consistency of short-period traffic counts

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Journal of Modern Transportation 2017年第3期25卷 150-162页

作者： Solomon Yadessa kenno Prasanta.k.sahu Babak Mehran Satish Sharma Saskatchewan Ministry of Highways and Infrastructure Department of Civil Engineering Birla Institute of Technology and Science Pilani(BITS Pilani) Faculty of Engineering and Applied Science University of Regina

The main intent of this study is to investigate the accuracy of short-duration traffic counts conducted during winter months. The investigation is based on 11-year sample data collected using permanent traffic counters at various locations in Alberta, Canada. Four types of road sites： commuter, regional commuter, rural long-distance, and recreational sites are studied. The sample data consti- tute six different durations of counts （12-, 24-, 48-, 72-, 96-h, and 1 week） taken during summer and winter months. The coefficient of variation （CV） is used as the relative measure of deviation for counts of different dura- tions to measure the accuracy of short-period traffic counts. The study results indicate that 48-h count seems to be the most cost-effective counting interval during both summer and winter months. It is also found that the lowest values of CV result for counts taken at commuter sites, and the highest values are observed for recreational sites. Frequent changes in temperature and other weather events cause significant variation in traffic volume, which results in an increase in CV values for counts taken during winter months. The application of an adjustment factor to remove the effect of cold and snow from short-period counts is also included in this study. Introduced adjustment factors can reduce the values of CV for all counts taken during winter months. The findings of this study can lead highway agencies to improve the cost-effectiveness of their short- period traffic counting programs.

关键词： Short-period traffic counts Average annualdaily traffic - Design hourly volume

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Influence of coke structure on coke quality using image analysis method

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International Journal of Coal Science & Technology 2018年第4期5卷 473-485页

作者： B.Ghosh B.k.Sahoo B.Chakrabortv k.k.Manjhi S.k.Das J.N.sahu Atul k.Varma Research & Development Centre for Iron and Steel Steel Authority of India Limited (SAIL)RanchiJharkhand 834002India Institute of Chenlical Technology Faculty of ChemistryUniversity of Stuttgart70550 StuttgartGermany Coal Geology and Organic Petrology Laboratory Department of Applied GeologyIITIndian School of Mines (ISM)Dhanbad 826004India South Ural State University 76Lenin Aven.ChelyabinskRussia 454080

The quality of coke affects the performance of the blast furnace, factors affecting coke quality include coal properties, coal charge granulometry and carbonization conditions. The coke properties in elude the size analysis, cold strength (Micum Indices-M4(). MI0) and hot strength (Coke Reactivity Index-CRI, Coke Strength after Reaction-CSR) properties and structural properties such as coke structure and texture. Structural properties comprise the porosity, pore-cell wall thickness and pore sizes, while textures consist of the carbon forms in the coke. In present work, advanced method such as image analysis method was used to interpret coke microstructure. Conventional methods such as determination of coke porosity by measurement of real and apparent density and mercury porosimetry have a number of limitations. Coke size, magnification, number of image frames captured, process of pellet preparations and coke properties such as M4(), M|0, CRI and CSR (low, medium and high values) were taken as variables for experimental purposes. The coke structure parameters such as porosity, length, perimeter, breadth, roundness, pore-wall thickness and pore size distribution of the pores were determined by image analysis method. This method provided average porosity in addition to pore-wall thickness and pore-size distribution. The pore wall thickness measuremenl by image analysis method provided significant correlations with M40, CRI and CSR values. This explained the usability of image analysis for coke structure measurement.

关键词： Image analysis Coke structure Porosity Micro structure Roundness Pore wall thickness

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Chlorination roasting-coupled water leaching process for potash recovery from waste mica scrap using dry marble sludge powder and sodium chloride

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International Journal of Minerals,Metallurgy and Materials 2020年第9期27卷 1203-1215页

作者： Sandeep kumar Jena Jogeshwar sahu Geetikamayee Padhy Swagatika Mohanty Ajit Dash Mineral Processing and Central Characterization Department Council of Scientific and Industrial Research(CSIR)-Institute of Minerals and Materials Technology(IMMT)BhubaneswarOdisha 751013India

The present paper reports the effective utilization of marble sludge powder(MSP)for the recovery of potash values from waste mica scrap using chlorination roasting-water leaching *** studies indicated the presence of dolomite as the major mineral phase in MSP,whereas muscovite and quartz were observed in the mica *** acid leaching studies suggest a maximum of 22%potash recovery under conditions:4 M H2SO4 acid,particle size of^100μm,stirring speed of 600 r/min,leaching temperature of 75℃,and leaching time of 90 *** chlorination roasting-water leaching process was adopted to achieve the lowest level of 80%-90%potash *** optimum conditions for the recovery of^93%potash from mica(~8.6wt%k2O)requires 900℃ roasting temperature,30 min roasting time,and 1:1:0.75 mass ratio of mica:MSP:*** roasting temperature and amount of NaCl are found to be the most important factors for the recovery *** reaction mechanism suggests the formation of different mineral phases,including sylvite(kCl),wollastonite,kyanite,and enstatite,during roasting,which were confirmed by X-ray diffraction(XRD)analyses and scanning electron microscopy(SEM)*** MSP-blended NaCl additive is more effective for potash recovery compared with the other reported commercial roasting additives.

关键词： potash recovery mica scrap marble sludge powder chlorination roasting water leaching

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Analysis and modeling of highway truck traffic volume variations during severe winter weather conditions in Canada

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Journal of Modern Transportation 2015年第3期23卷 228-239页

作者： Hyuk-Jae Roh Satish Sharma Prasanta.k.sahu Sandeep Datia City of Regina Faculty of Engineering and Applied Science University of Regina Department of Civil Engineering Birla Institute of Technology Pilani City of Edmonton

This paper investigates the impact of cold and snow on daily and hourly truck traffic volume on a primary highway in Alberta, Canada. This research is based on a detailed case study of 5 years of weigh-in-motion data recorded continuously at Leduc site on Highway 2A. Influence of the winter conditions on truck type distribution is examined by classifying trucks into single-unit trucks, single-trailer, and multi-trailer units. It is evident from the study that proportion of the three truck classes in the total truck traffic remained essentially stable over the study period （2005-2009）. Dummy-variable regression models are used to relate daily and hourly truck traffic volume with snowfall and categorized cold as independent variables. The statistical significance of all the independent variables used in the model is established by conducting tests such as R2, F test, incremental F test, and t test. The study results suggested that the truck volume is not significantly affected by the normal snowfall or the typical cold temperatures, i.e., average daily snowfall about less than 15 cm or temperatures higher than -25 ℃ are not likely to affect the truck traffic patterns. It is believed that the findings of this study can benefit highway agencies in developing programs and policies for efficient monitoring of truck traffic throughout the year and snow removal during the winter season in Canada.

关键词： Truck traffic ·Snowfall · Cold temperature ·Weather·Alberta· Canada

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Assessment of self-reacting bobbin tool friction stir welding for joining AZ31 magnesium alloy at inert gas environment

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Journal of Magnesium and Alloys 2019年第4期7卷 661-671页

作者： Prakash kumar sahu Nikhil P Vasudevan Bipul Das Sukhomay Pal Department of Mechanical Engineering and IDM Joint Lab Tsinghua UniversityBeijing 100084China Larsen and Toubro Limited HaziraSuratGujarat 394510India Department of Mechanical Engineering National Institute of Technology Silchar788010 AssamIndia Department of Mechanical Engineering Indian Institute of Technology Guwahati781039 AssamIndia

Research work presented in this study has the primary target of exploring joint attributes of AZ31 magnesium alloys using friction stir welding process with a modified tool referred as bobbin *** of inert and open atmosphere on mechanical properties are evaluated over a wide range of welding speed and tool rotation *** of the research findings from the inert atmosphere bobbin tool were made with the traditional process of friction stir *** results depicted improved joint properties for inert atmosphere *** and intermediate range of tool rotational speed is found to be favorable for bobbin tool friction stir welding without and with an inert medium,*** atmosphere due to inert medium leads to less oxidation of the AZ31 Mg alloy leading to superior joint *** investigations are also made with the aim of evaluating the impact of bobbin tool and inert medium on joint *** each aspect for joining of AZ31 Mg alloy,bobbin tool with inert medium is found to be an effective solution for joining with improved mechanical properties compared to without inert bobbin tool as well as conventional tool friction stir welding.

关键词： Mg FSW Bobbin tool Process parameters Mechanical properties Fractography Microstructural characterization

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Vision-based tip position tracking control of two-link flexible manipulator

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IET Cyber-Systems and Robotics 2020年第2期2卷 53-66页

作者： Umesh kumar sahu Dipti Patra Bidyadhar Subudhi Department of Electrical Engineering National Institute of TechnologyRourkela 769008India Department of Electronics and Telecommunication G H Raisoni College of EngineeringNagpurMaharashtra-440016India School of Electrical Sciences Indian Institute of Technology GoaPondaGoa-401403India

Owing to the non-collocation of actuators and sensors in a flexible-link manipulator(FLM)it becomes difficult to achieve accurate tip position *** resolve this issue,a vision sensor is used for direct measurement of the tip position instead of employing the traditional mechanical *** the different visual servoing(VS)control schemes,image-based VS(IBVS)is more ***,there are many challenges in the IBVS scheme such as singularities in the interaction matrix and local minima in trajectories that affect the system performance in real-time *** this study,the moment-based new visual feature is selected to address the aforesaid issues that arise in the IBVS ***,a new two-time scale IBVS controller is developed for addressing the tip-tracking control problem of the two-link flexible manipulator(TLFM).In the proposed control scheme,the dynamics of the FLM is decomposed into two-time scale models,namely a slow subsystem and a fast *** performance and robustness of the proposed new two-time scale IBVS controller for TLFM are verified by pursuing simulation *** is observed from the obtained results that the proposed controller effectively stabilises the oscillatory dynamics and tracks the reference trajectory accurately.

关键词： subsystem scheme manipulator

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Tracing overlapping biological signals in mid-infrared using colonic tissues as a model system

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World Journal of Gastroenterology 2017年第2期23卷 286-296页

作者： Ranjit kumar sahu Ahmad Salman Shaul Mordechai Department of Physics Ben Gurion University Department of Medicine University of Virginia Department of Physics SCE-Shamoon College of Engineering

AIMTo understand the interference of carbohydrates absorbance in nucleic acids signals during diagnosis of malignancy using Fourier transform infrared (FTIR) *** used formalin fixed paraffin embedded colonic tissues to obtain infrared (IR) spectra in the mid IR region using a bruker II IR microscope with a facility for varying the measurement area by varying the aperture available. Following this procedure we could measure different regions of the crypt circles containing different biochemicals. Crypts from 18 patients were measured. Circular crypts with a maximum diameter of 120 μm and a lumen of about 30 μm were selected for uniformity. The spectral data was analyzed using conventional and advanced computational *** the various components that are observed to contribute to the diagnostic capabilities of FTIR, the carbohydrates and nucleic acids are prominent. However there are intrinsic difficulties in the diagnostic capabilities due to the overlap of major absorbance bands of nucleic acids, carbohydrates and phospholipids in the mid-IR region. The result demonstrates colonic tissues as a biological system suitable for studying interference of carbohydrates and nucleic acids under ex vivo conditions. Among the diagnostic parameters that are affected by the absorbance from nucleic acids is the RNA/DNA ratio, dependent on absorbance at 1121 cm-1 and 1020 cm-1 that is used to classify the normal and cancerous tissues especially during FTIR based diagnosis of colonic malignancies. The signals of the nucleic acids and the ratio (RNA/DNA) are likely increased due to disappearance of interfering components like carbohydrates and phosphates along with an increase in amount of *** present work, proposes one mechanism for the observed changes in the nucleic acid absorbance in mid-IR during disease progression (carcinogenesis).

关键词： Spectral interference Fourier transform infrared diagnosis Nucleic acids Malignancy Colonic tissue

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Depth profiles of lithogenic and anthropogenic mercury in the sediments from Thane Creek,Mumbai,India

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International Journal of Sediment Research 2014年第3期29卷 431-439页

作者： S.k.sahu R.C.BHANGARE M.TIWARI P.Y.AJMAL G.G.PANDIT Environmental Monitoring and Assessment Section Bhabha Atomic Research Centre Environmental.Monitoring and Assessment Section Bhabha Atomic Research Centre

Mercury(Hg) is well known as one of the most toxic elements to *** coastal environments adjacent to industrial areas are reported to often be contaminated with *** becomes more toxic in the form of methylmercury(Me-Hg) which is converted from inorganic mercury in aqueous systems by microbial activity and can bio-magnify through the food chain.A simple method for the determination of total mercury and methylmercury in sediments was optimized by slightly modifying an old method using the direct mercury analyzer *** sediment samples from Thane Creek,Mumbai,India were collected and analysed for total mercury and *** Hg concentration in the creek varied between 0.54 to 16.03 μg gwhile Me-Hg concentrations ranged between0.04 to 1.07 μg *** surface sediment,mercury concentrations ranged from 4.33 μg gto 12.16μg *** organic carbon content was found to be around 2 percent in different layers of the *** enrichment factors,which indicate the extent of pollution in sediments,were estimated to range from 26 to 50 at different locations in the *** and anthropogenic concentrations of mercury in the creek were also determined to compare the impact of anthropogenic and natural *** inventories were about 5-70 times more in concentration than the lithogenic in the different core sediments.

关键词： Total mercury Methylmercury Enrichment factor Anthropogenic concentration TOC

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