检索结果-南通市图书馆

Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system

Translational Neurodegeneration 2022年第1期11卷 667-689页

作者： Douglas M.Lopes Sophie k.Llewellyn Ian F.Harrison Division of Medicine Department of ImagingCentre for Advanced Biomedical ImagingFaculty of Medical SciencesUniversity College LondonPaul O’Gorman Building72 Huntley StreetLondon WC1E 6DDUK

Many neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are characterised by the accumulation of misfolded protein deposits in the brain, leading to a progressive destabilisation of the neuronal network and neuronal death. Among the proteins that can abnormally accumulate are tau and α-synuclein, which can propagate in a prion-like manner and which upon aggregation, represent the most common intracellular proteinaceous lesions associated with neurodegeneration. For years it was thought that these intracellular proteins and their accumulation had no immediate relationship with extracellular homeostasis pathways such as the glymphatic clearance system;however, mounting evidence has now suggested that this is not the case. The involvement of the glymphatic system in neurodegenerative disease is yet to be fully defined;however, it is becoming increasingly clear that this pathway contributes to parenchymal solute clearance. Importantly, recent data show that proteins prone to intracellular accumulation are subject to glymphatic clearance, suggesting that this system plays a key role in many neurological disorders. In this review, we provide a background on the biology of tau and α-synuclein and discuss the latest findings on the cell-to-cell propagation mechanisms of these proteins. Importantly, we discuss recent data demonstrating that manipulation of the glymphatic system may have the potential to alleviate and reduce pathogenic accumulation of propagation-prone intracellular cytotoxic proteins. Furthermore, we will allude to the latest potential therapeutic opportunities targeting the glymphatic system that might have an impact as disease modifiers in neurodegenerative diseases.

关键词： Glymphatic Propagation Tauopathy Synucleinopathy Clearance Aquaporin-4

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of transmethylation reactions in alcoholic liver disease

引用

World Journal of Gastroenterology 2007年第37期13卷 4947-4954页

作者： kusum k kharbanda VA Alcohol Research Center Department of Veterans Affairs Medical Center Omaha Nebraska 68105 United States Department of Internal Medicine University of Nebraska Medical Center Omaha Nebraska 68198 United States

Alcoholic liver disease is a major health care problem worldwide. Findings from many laboratories, including ours, have demonstrated that ethanol feeding impairs several of the many steps involved in methionine metabolism. Ethanol consumption predominantly results in a decrease in the hepatocyte level of S-adenosylmethionine and the increases in two toxic metabolites, homocysteine and S-adenosylhomocysteine. These changes, in turn, result in serious functional consequences which include decreases in essential methylation reactions v/a inhibition of various methyltransferases. Of particular interest to our laboratory is the inhibition of three important enzymes, phosphatidylethanolamine methyltransferase, isoprenylcysteine carboxyl methyltransferase and protein L-isoaspartate methyltransferase. Decreased activity of these enzymes results in increased fat deposition, increased apoptosis and increased accumulation of damaged proteins- all of which are hallmark features of alcoholic liver injury. Of all the therapeutic modalities available, betaine has been shown to be the safest, least expensive and most effective in attenuating ethanol-induced liver injury. Betaine, by virtue of aiding in the remethylation of homocysteine, removes both toxic metabolites （homocysteine and S-adenosylhomocysteine）, restores S-adenosylmethionine level, and reverses steatosis, apoptosis and damaged proteins accumulation. In conclusion, betaine appears to be a promising therapeutic agent in relieving the methylation and other defects associated with alcoholic abuse.

关键词： Transmethylation S-adenosylhomocysteine Alcohol Betaine Liver Steatosis Apoptosis Methyltransferases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nonalcoholic Fatty Liver Disease(NAFLD)Name Change:Requiem or Reveille?

引用

Journal of Clinical and Translational Hepatology 2021年第6期9卷 931-938页

作者： Shivaram P.Singh Prajna Anirvan Reshu khandelwal Sanjaya k.Satapathy Department of Gastroenterology Sriram Chandra Bhanj Medical CollegeCuttackOdishaIndia Division of Hepatology Sandra Atlas Bass Center for Liver Diseases and TransplantationDonald and Barbara Zucker School of Medicine at Hofstra/Northwell HealthManhassetNYUSA

Nonalcoholic fatty liver disease(NAFLD)affects about a quarter of the world’s population and poses a major health and economic burden ***,there have been hasty attempts to rename NAFLD to metabolic-associated fatty liver disease(MAFLD)despite the fact that there is no scientific rationale for *** for a“positive criterion”to diagnose the disease and destigmatizing the disease have been the main reasons put forth for the name change.A close scrutiny of the pathogenesis of NAFLD would make it clear that NAFLD is a heterogeneous disorder,involving different pathogenic mechanisms of which metabolic dysfunction-driven hepatic steatosis is only *** NAFLD with MAFLD would neither enhance the legitimacy of clinical practice and clinical trials,nor improve clinical care or move NAFLD research *** than changing the nomenclature without a strong scientific backing to support such a change,efforts should be directed at understanding NAFLD pathogenesis across diverse populations and ethnicities which could potentially help develop newer therapeutic options.

关键词： Heterogeneity MAFLD Metabolic NAFLD NASH Nomenclature Steatohepatitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Outcome measures following tele-rehabilitation and conventional face to face rehabilitation in paediatric cochlear implant users during COVID-19 pandemic:A pilot study in a tertiary care setup

引用

Journal of Otology 2022年第1期17卷 31-38页

作者： Himanshu Verma Banumathy N Roshani Mishra Naresh k.Panda Department of Otolaryngology and Head&Neck Surgery Post Graduate Institute of Medical Education and ResearchChandigarh160012India

Background:Following the COVID-19 pandemic,majority of paediatric cochlear implantees(CI)lost follow ups for rehabilitation and tele-therapy was *** study thus compared the outcome measures of paediatric CI users on tele-therapy versus conventional face to face therapy following COVID-19 ***:Twenty seven unilateral paediatric cochlear implantees in the age range of 2e11 years were divided into two groups based on the therapy modality,viz,tele-and face-to-face *** on the hearing age,participants were further divided into three groups,viz,0e2,2e4,and greater than four years.A complete the test battery comprising Integrated Scales of Development,Speech Intelligibility Rating scale,and Revised Categorical Auditory Perception were *** speech&language test battery was performed prior to initiating the rehabilitation and post 12 months of ***:Results of the present study revealed that conventional rehabilitation had better outcomes compared to *** rate of progress after one year of rehabilitation with respect to hearing-age showed a significant difference for the hearing-age group of 0e2 years across the domains of audition,speech and ***:The present study indicates that conventional method of the speech-language and auditory rehabilitation is far better compared to the tele rehabilitation services especially for those visiting tertiary care hospitals as most of them belong to lower and middle socioeconomic *** the results,it can be delineated that with lesser hearing experience,paediatric CI users always need to initially enroll for conventional therapy for better speech-language and auditory outcomes.

关键词： Cochlear implant Tele-therapy Conventional therapy Language outcomes Speech&language rehabilitation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pancreatic cancer: genetics, disease progression, therapeutic resistance and treatment strategies

引用

Journal of Cancer Metastasis and Treatment 2021年第1期7卷 794-808页

作者： karnika Singh Gauri Shishodia Hari k.koul Department of Radiation Oncology The Ohio State University Comprehensive Cancer CenterColumbusOH 43210USA Department of Otolaryngology/Head&Neck Cancer Surgery LSU Health Sciences CenterShreveportLA 71103USA Department of Biochemistry&Molecular Biology Urology and Stanley S Scott Cancer Center School of Medicine LSU Health Sciences CenterNew OrleansLA 70112USA.

Pancreatic cancer is a deadly disease and the third-highest cause of cancer-related deaths in the United *** has a very low five-year survival rate(<5%)in the United States as well as in the world(about 9%).The curren... 详细信息

Pancreatic cancer is a deadly disease and the third-highest cause of cancer-related deaths in the United *** has a very low five-year survival rate(ke targeted therapy and immunotherapy.

关键词： Pancreatic cancer signature mutations gemcitabine desmoplasia therapeutic resistance immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Alternating-Current Transport Properties of the Interface between Nd_(0.7)Sr_(0.3)MnO_(3) Ceramic and a Ag Electrode

引用

Chinese Physics Letters 2012年第2期29卷 186-189页

作者： CHEN Shun-Sheng YANG Chang-Ping LUO Xiao-Jing Barner k. Medvedeva I.V. Faculty of Physics and Electronic Technology Hubei UniversityWuhan 430062 Faculty of Mathematics and Physics Huangshi Institute of TechnologyHuangshi 435003 Department of Physics University of GöttingenTammanstrasse 1-37077 GöttingenGermany Institute of Metal Physics Ural Division of the Russian Academy of SciencesEkaterinburg 620219Russia State key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004

Electrical transport properties of the interface between a Nd_(0.7)Sr_(0.3)MnO_(3) ceramic and a Ag electrode are investigated using the ac impedance over a wide temperature and frequency *** ac impedance measurements give the compressed semicircle arcs at different temperatures,which are used for the analysis of different contributions to electrical transport based on an electrical equivalent circuit.A significant interface-dependent electroresistance effect of 530% is clearly developed around the metal-insulator transition temperature 130k,which is confirmed as the interface-layer dependent Curie temperature by the plot of interfacial conductance with frequency at different temperatures.

关键词： ceramic interface impedance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The impact of ipsilateral testicular atrophy on semen quality and sperm DNA fragmentation response to varicocele repair

引用

Asian Journal of Andrology 2021年第2期23卷 146-149页

作者： Parviz k kavoussi Natasha Abdullah Melissa S Gilkey Caitlin Hunn G Luke Machen Shu-Hung Chen keikhosrow M kavoussi Amy Esqueda J David Wininger Shahryar k kavoussi Austin Fertility and Reproductive Medicine/Westlake IVF 300 Beardsley LaneBuilding BSuite 200AustinTX 78746USA

Varicoceles adversely impact semen quality and sperm DNA fragmentation,which typically improve with surgical *** men with varicoceles have ipsilateral testicular atrophy due to damage from the *** study assessed semen quality and the sperm DNA fragmentation index(DFI)response to varicocele repair in men with ipsilateral testicular atrophy(TA)versus men with no testicular atrophy(NTA).Semen parameter values and DFI in both groups were compared preoperatively and *** Mann-Whitney U test and the Wilcoxon signed-rank test were used where *** were 20 men in the TA group and 121 men in the NTA group with no difference in age,varicocele grade,or preoperative semen parameter values between the two *** NTA group had a higher preoperative DFI than the TA *** groups showed improvement in semen quality postoperatively,only the TA group showed a significant improvement in DFI,whereas the NTA group showed significant improvements in several parameter values and *** change from preoperative to postoperative parameter values when comparing the two groups revealed a difference in total sperm motile count and DFI,with a larger mean improvement in the NTA group than in the TA *** TA and NTA groups showed improved semen quality and DFI after varicocele repair,but the NTA group had more improvement than the TA ***,only total motile count(TMC)and DFI had a significantly greater mean change in preoperative to postoperative response in the NTA group than in the TA group.

关键词： spermatozoa testicular atrophy varicocele

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Innate immunity in inflammatory bowel disease

引用

World Journal of Gastroenterology 2007年第42期13卷 5577-5580页

作者： Jesus k Yamamoto-Furusho Daniel k Podolsky Gastrointestinal Unit and Center for the Study of Inflammatory BowelDisease Massachusetts General Hospital and Harvard MedicalSchool Boston MA 02114 United States

The human intestinal tract is home to an enormous bacterial flora. The host defense against microorganisms can be divided into innate and adaptive immunity. The former is the most immediate line of response to immunologic challenges presented by bacteria, viruses, and fungi. The mucosal immune system has evolved to balance the need to respond to pathogens while co-existing with commensal bacteria and food antigens. In inflammatory bowel disease （IBD）, this hyporesponsiveness or tolerance breaks down and inflammation supervenes driven by the intestinal microbial flora. Bacteria contain compounds and are recognized by a variety of receptors, including Toll-like receptors （TLRs） and NODs （a family of intracellular bacterial sensors） and are potent stimuli of innate immune responses. Several mutations in these receptors have been associated with development of IBD.

关键词： Innate Immunity Toll-like receptors Inflammatory bowel disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diffuse large B-Cell lymphoma:from novel molecular classifications to tailored targeted therapies

引用

Journal of Cancer Metastasis and Treatment 2022年第1期8卷 501-525页

作者： Jennifer k.Lue Grzegorz S.Nowakowski Department of Medicine Lymphoma ServiceMemorial Sloan Kettering Cancer CenterNew YorkNY 10021United States Department of Medicine Mayo ClinicRochesterMinnesotaMN 55902United States

Diffuse large B-cell lymphoma(DLBCL)is a heterogeneous disease comprising multiple genetic subtypes that translates and impacts clinical outcomes after standard *** initial understanding of the complex biological subtypes of DLBCL began with the identification of cell of origin(COO),and now has evolved to include even more specific subtypes defined by genetic signatures and *** newer classifications lend themselves to the application of precision-based medicine,allowing us to tailor new treatment platforms that target specific oncogenic drivers in order to improve DLBCL *** to this is the development of genetic assays and tools that are reliable and readily available to assist in the application of these molecular classifications to real-world *** this review,we discuss the history of DLBCL classification systems and their implication on clinical investigation as well as novel therapeutic options in DLBCL.

关键词： DLBCL tumor heterogeneity activated-B-cell germinal center molecular targets

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The role of dietary nitrate supplementation in neurovascular function

引用

Neural Regeneration Research 2021年第7期16卷 1419-1420页

作者： Masahiro Horiuchi Gabriella M.k.Rossetti Samuel J.Oliver Division of Human Environmental Science Mount Fuji Research InstituteYamanashiJapan School of Sport Health and Exercise SciencesCollege of Human SciencesBangor UniversityBangorUK

A healthy diet combined with increased physical activity levels may protect against cerebrovascular dysfunction and cognitive impairments(Gorelick et al., 2011).Compared with the number of studies on the effects of physical activity, studies on how diet affects cerebral blood flow(CBF) regulation and cognitive function are relatively ***, we focus on the potential role of dietary nitrate supplementation in CBF regulation and cognitive function under normoxic and hypoxic conditions.

关键词： al. nitrate conditions.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：