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The role of monocytes in optic nerve injury

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Neural Regeneration Research 2023年第8期18卷 1666-1671页

作者： Xiangxiang Liu Yuan Liu Mohamed M.khodeiry Richard k.Lee Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijingChina Bascom Palmer Eye Institute Department of OphthalmologyUniversity of Miami Miller School of MedicineMiamiFLUSA

Monocytes,including monocyte-derived macrophages and resident microglia,mediate many phases of optic nerve injury *** microglia respond first,followed by infiltrating macrophages which regulate neuronal inflammation,cell proliferation and differentiation,scar formation and tissue remodeling following optic nerve ***,microglia and macrophages have distinct functions which can be either beneficial or detrimental to the optic nerve depending on the spatial context and temporal sequence of their *** divergent effects are attributed to pro-and anti-inflammatory cytokines expressed by monocytes,crosstalk between monocyte and glial cells and even microglia-macrophage *** this review,we describe the dynamics and functions of microglia and macrophages in neuronal inflammation and regeneration following optic nerve injury,and their possible role as therapeutic targets for axonal regeneration.

关键词： fibrotic scar glial scar inflammation macrophage microglia optic nerve injury regeneration

The terminology of the 2012 Atlanta consensus conference on post-inflammatory collections after acute pancreatitis:An assessment of utilization in practice

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 508-510页

作者： Santhalingam Jegatheeswaran Louise M Finch Maya C Siriwardena Ajith k Siriwardena Regional Hepato-Pancreato-Biliary Surgery Unit Manchester Royal InfirmaryOxford RoadManchester M139WLUK Warwick Medical School WarwickUK Faculty of Biology Medicine and HealthUniversity of ManchesterManchesterUK

To the Editor The report of the 1992 Atlanta consensus conference provided a framework for standardization of the terminology for description of acute pancreatitis and its complications[1].Terms such as“pancreatic phlegmon”which had historically been subjected to differential interpretation were discontinued and modern terminology was introduced[1].With subsequent clinical usage and with the accrual of new knowledge it became clear that further changes were necessary.

关键词： pancreatitis acute terminology

Conservation education and habitat restoration for the endangered Sagalla caecilian （Boulengerula niedeni） in Sagalla Hill, kenya

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Zoological Research 2016年第3期37卷 159-166页

作者： Malonza, Patrick k Herpetology Section National Museums of Kenya 40658-00100 Nairobi KENYA. kmalonza@museums.or.ke.

The Sagalla caecilian （Boulengerula niedeni） is an endangered amphibian endemic to Sagalla Hill in the Taita Hills. This burrowing worm-like species prefers soft soil with high moisture and organic matter. The major threats to the Sagalla caecilian are soil erosion caused by steep slopes, bare ground and water siphoning/soil hardening from exotic eucalyptus trees. The purpose of this study was to get a better understanding of the local people＇s attitude towards this species and how they can contribute to its continued conservation through restoration of its remaining habitat. In this study, it was found that 96% of Sagalla people are aware of the species, its habits and its association with soils high in organic matter. It was also found that 96% of Sagalla people use organic manure from cow dung in their farms. Habitat restoration through planting of indigenous plants was found to be ongoing, especially on compounds of public institutions as well as on private lands. Although drought was found to be a challenge for seedlings development especially on the low elevation sites, destruction by livestock especially during the dry season is also a major threat. In this study, it was recommended that any future habitat restoration initiative should include strong chain-link fencing to protect the seedlings from livestock activity. Recognizing that the preferred habitats for the species are in the valleys, systematic planting of keystone plant species such as fig trees （Ficus） creates the best microhabitats. These are better than general woodlots of indigenous trees.

关键词： Local people Caecilian Awareness,Protection, Habitat rehabilitation

Numerical Validation of Asphaltene Precipitation and Deposition during CO2 miscible flooding

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Petroleum Research 2020年第3期5卷 235-243页

作者： Fahad I.Syed Shahin Neghabhan Arsalan Zolfaghari Amirmasoud k.Dahaghi University of kansas USA ADNOC Offshore UAE

Asphaltene precipitation,flocculation,and deposition can significantly reduce oil production by impacting wellbores,flowlines,and more importantly,formations’pore space around the *** alteration in the temperature,pressure and fluid composition can trigger asphaltene *** ability to predict the occurrence and magnitude of the asphaltene deposition is a major step for flow *** accurate prediction of the deposition envelope enables the operator to systematically categorize different cases based on their impact on the *** critical knowledge can be used to predict the occurrence and magnitude of asphaltene deposition,which could potentially save the expense of installing unnecessary equipment and injecting chemical inhibitors when they are not *** asphaltene-related flow assurance issues requires robust physically-based modeling capabilities for capturing the asphaltene’s deposition tendencies as a function of the prevailing field’s operating *** available simulators are found to be useful for predicting asphaltene’s phase behavior,precipitation tendency,and instability curves,they often overlook important physical characteristics of the *** properties may have a detrimental role in obtaining a realistic representation of the asphaltene deposition *** this paper,the experimental and the numerical investigations are combined to present a comprehensive methodology for studying the thermodynamics of asphaltene precipitation and deposition.A wide range of pressures and CO2 concentrations are covered that are relevant to actual CO2 flooding in a Middle East oil *** do so,a series of lab experiments including routine and special PVT analyses where the Asphaltene Onset Pressure(AOP)and Saturation Pressures(Psat)were measured for different mixtures of CO2 and the reservoir *** of 50 mol%CO2 concentration mixture was tested to measure the AOP and *** amount of asphaltene

关键词： Asphaltene AOP AOC EOS Tuning Asphaltic fluid&CO2 field problems

对激光等离子体中X射线的产生与辐射加热研究

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物理学报 2002年第3期51卷 590-595页

作者：王薇张杰 V.k.Senecha 中国科学院物理研究所光物理开放实验室首都师范大学物理系北京100037 Laser Plasma Division Centre for Advanced TechnologyIndore-452013India

利用一维辐射流体力学程序MULTI数值模拟研究了功率为 10 1 4 W cm2 、脉冲宽度为 30 0ps、波长为 0 .44 μm的强激光辐照平面Au靶时产生X射线的过程 ,给出了X射线转换效率和能谱分布 .通过将靶物质划分为对所产生的X射线光学薄的转化... 详细信息

利用一维辐射流体力学程序MULTI数值模拟研究了功率为 10 1 4 W cm2 、脉冲宽度为 30 0ps、波长为 0 .44 μm的强激光辐照平面Au靶时产生X射线的过程 ,给出了X射线转换效率和能谱分布 .通过将靶物质划分为对所产生的X射线光学薄的转化区和光学厚的再发射区 ,得到了作为黑体辐射热源的最佳靶厚度 ,并给出了辐射加热靶所产生的等离子体的密度和温度的空间分布 .

关键词：辐射流体力学激光等离子体 X射线转换辐射热波辐射加热数值模拟靶天体物理

Characteristics of Liver Abscess in Department of Infectious Diseases at Fann Teaching University Hospital in Dakar, Senegal

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Advances in Infectious Diseases 2018年第1期8卷 23-31页

作者： Viviane Marie Pierre Cisse Diallo Louise Fortes Deguenonvo Noel Magloire Manga Daye ka Sylvie Audrey Diop Abdoulaye Seck Ndeye Aissatou Lakhe khardiata Diallo Mbaye Assane Diouf Ndeye Mery Dia Badiane Ndeye Fatou ngom Gueye Cheikh Tacko Diop Masserigne Soumare Cheikh Tidiane Ndour Moussa Seydi Infectious and Tropical Diseases Department Fann Teaching University HospitalDakarSenegal Department of Health Ziguinchor UniversityZiguinchorSenegal Department of Health Thies UniversityThiesSenegal Pasteur Institute Dakar DakarSenegal Department of Health Gaston Berger UniversitySaint LouisSenegal Fann Teaching University Hospital in Dakar DakarSenegal

Introduction: Abscesses of the liver are due to an infection of bacterial, parasitic or fungal origin. Through amoebiological imaging and serology, their diagnosis was facilitated. The aim of this study was to determine the epidemiological, clinical, diagnostic and evolutionary aspects of these liver abscesses at the Department of Infectious and Tropical Diseases in Fann Teaching University Hospital. Patients and Methods: This was a retrospective and descriptive study, based on records of patients hospitalized for abscess of the liver over a period of 8 years, from January 1, 2008 to December 31, 2015. Results: We collected 20 cases of abscesses including 12 cases of confirmed amoebic abscesses and 5 cases of pyogenic abscesses. The mean age of the patients was 43.15 ± 15.12 years. There were 18 men and 2 women. The average hospital stay was 32 days. The most common clinical signs were abdominal pain (100%), fever (75%), hepatomegaly (80%). A leukocytosis greater than 12,000 Gb/mm3 was found in 13 patients. The amoebic serology was positive in 71% of cases and negative in 29% of cases. No germ was isolated from the blood culture. On hepatic ultrasound the abscess was unique in 90%. Treatment was exclusively medical in 11 patients (55%). The trend was favorable in 85% of cases. Conclusion: The incidence of liver abscesses has significantly decreased. It is important to develop diagnostic tools better in the case of pyogenic abscesses.

关键词： Amoebic Liver Abscess Pyogenic Abscess Dakar Senegal

Quanta-A platform for rapid control and monitoring of heterogeneous rbots

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Digital Communications and Networks 2020年第4期6卷 452-462页

作者： S.Sankhar Reddy CH. Anita Agrawal Anupama k.R. E.E.E Department BITS PilaniK K Birla Goa CampusGoa403726India

Rapid prototyping,real-time control and monitoring of various events in robots are crucial requirements for research in the fields of modular and swarm robotics.A large quantities of resources(time,man power,infrastructure,etc.)are often invested in programming,interfacing the sensors,debugging the response to algorithms during prototyping and operational phases of a robot development *** cost of developing an optimal infrastructure to efficiently address such control and monitoring requirements increases significantly in the presence of mobile *** numerous solutions have been developed for minimizing the resources spent on hardware prototyping and algorithm validation in both static and mobile scenarios,it can be observed that researchers have either chosen methodologies that conflict with the power and infrastructure constraints of the research field or generated constrained solutions whose applications are restricted to the field *** paper develops a solution for addressing the challenges in controlling heterogeneous mobile robots.A platform named Quanta-a cost effective,energy efficient and high-speed wireless infrastructure is prototyped as a part of the research in the field of modular *** is capable of controlling and monitoring various events in/using a robot with the help of a light-weight communication protocol independent of the robot hardware architecture(s).

关键词： modular robotics Swarm robotics Concurrent control and monitoring Event scheduling Centralized/decentralized communication

IGF1-PI3k-induced physiological cardiac hypertrophy:Implications for new heart failure therapies,biomarkers,and predicting cardiotoxicity

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Journal of Sport and Health Science 2021年第6期10卷 637-647,I0001页

作者： Sebastian Bass-Stringer Celeste M.k.Tai Julie R.McMullen Baker Heart and Diabetes Institute MelbourneVIC 3004Australia Department of Physiology Anatomy and MicrobiologyLa Trobe UniversityBundooraVIC 3086Australia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourneVIC 3004Australia Department of Physiology and Department of Medicine Alfred Hospital Monash UniversityMelbourneVIC 3004Australia

Heart failure represents the end point of a variety of cardiovascular *** is a growing health burden and a leading cause of death *** date,limited treatment options exist for the treatment of heart failure,but exercise has been well-established as one of the few safe and effective interventions,leading to improved outcomes in ***,a lack of patient adherence remains a significant barrier in the implementation of exercise-based therapy for the treatment of heart *** insulin-like growth factor 1(IGF1)phosphoinositide 3-kinase(PI3k)pathway has been recognized as perhaps the most critical pathway for mediating exercisedinduced heart growth and ***,we discuss how modulating activity of the IGF1PI3k pathway may be a valuable approach for the development of therapies that mimic the protective effects of exercise on the *** outline some of the promising approaches being investigated that utilize PI3k-based therapy for the treatment of heart *** discuss the implications for cardiac pathology and cardiotoxicity that arise in a setting of reduced PI3k ***,we discuss the use of animal models of cardiac health and disease,and genetic mice with increased or decreased cardiac PI3k activity for the discovery of novel drug targets and biomarkers of cardiovascular disease.

关键词： Cardiac protection Cardiotoxicity Exercise Heart failure IGF1 PI3k Therapies