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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 29-38页

作者： Emilie A.k.Warren Shishir k.Maithel Division of Surgical Oncology Winship Cancer InstituteEmory UniversityAtlantaGAUSA

Cholangiocarcinoma(CCA)represents a group of epithelial cell tumors classified based on their anatomic location along the biliary *** rare malignancy is often diagnosed at an advanced stage and deemed *** for those patients who are surgical candidates,recurrence rates are high and survival rates *** mainstay of therapy for advanced CCA remains cisplatin plus gemcitabine,with a median overall survival(mOS)under 12 months,although the TOPAZ-1 trial showed a survival benefit with the addition of programmed cell death ligand 1(PD-L1)*** recent years,molecular profiling has revealed a wealth of potentially targetable genetic alterations,including fibroblast growth factor receptor(FGFR)fusions,isocitrate dehydrogenase 1(IDH1)mutations,human epidermal growth factor receptor 2(HER2)amplification and overexpression,and microsatellite instability(MSI).These discoveries have prompted numerous clinical trials employing drugs against these specific genetic *** foundation laid by early clinical studies and the landscape of ongoing trials are both summarized *** the role of adjuvant therapy has yet to be defined in this disease,we emphasize the importance of employing targeted therapies in trials in the adjuvant and neoadjuvant spaces and discuss ways to overcome challenges due to low incidence of targetable *** medicine for this disease promises significant clinical benefit to patients,but further investigation is needed.

关键词： Cholangiocarcinoma(CCA) biliary tract cancer(BTC) targeted therapy molecular profiling

Surgical treatment of inflammatory bowel disease:From the gastroenterologist’s stand-point

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1235-1254页

作者： John k Triantafillidis Inflammatory Bowel Disease Unit “Metropolitan General”HospitalHolargos 15562AtticaGreece Hellenic Society of Gastrointestinal Oncology Haidari 12461AthensGreece

Treatment of ulcerative colitis(UC)and Crohn’s disease(CD)represents,in the majority of cases,a real challenge to the gastroenterologist’s abilities and skills as well as a clinical test concerning his/her levels of medical knowledge and *** the last two decades,our pharmaceutical arsenal was significantly strengthened,especially after the introduction of the so-called biological agents,drugs which to a large extent not only improved the results of conservative treatment but also changed the natural history of the ***,colectomy is still necessary for some patients with severe UC although smaller compared to the past,precisely because of the improvements achieved in the available conservative ***,surgeries to treat colon dysplasia and cancer are increasing to some *** the same time,satisfactory improvements in surgical techniques,the pre-and post-operative care of patients,as well as the selection of the appropriate time for performing the surgery have been *** patients with CD,the improvement of conservative treatment did not significantly change the need for surgical treatment since two-thirds of patients need to undergo surgery at some point in the course of their *** the other hand,the outcome of the operation has improved through good preoperative care as well as the wide application of more conservative surgical techniques aimed at keeping as much of the bowel in situ as *** article discusses the indications for surgical management of UC patients from the gastroenterologist’s point of view,the results of the emerging new techniques such as transanal surgery and robotics,as well as alternative operations to the classic ileo-anal-pouch *** author also discusses the basic principles of surgical management of patients with CD based on the results of the relevant *** self-evident is emphasized,that is,to achieve an excellent therapeutic result in patients with se

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease Surgery Treatment Ileo-anal-pouch anastomosis Indications Techniques

Net effect of air pollution controls on health risk in the Beijing-Tianjin-Hebei region during the 2022 winter Olympics and Paralympics

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Journal of Environmental Sciences 2024年第1期135卷 560-569页

作者： Changqing Lin Peter k.k.Louie Alexis k.H.Lau Jimmy C.H.Fung Zibing Yuan Minghui Tao Xuguo Zhang Md.Shakhaoat Hossain Chengcai Li Xiang Qian Lao Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protection Department Hong Kong Government SARHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina School of Environment and Energy South China University of TechnologyGuangzhou 510006China Hubei key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public Health and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong KongChina

Due to the non-linearity in ozone(O_(3))formation,reducing the emission of nitrogen oxides(NO_(x))may increase O_(3) *** the counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous when the assessments focus on the changes in pollutant *** this study,a risk-based method was used to gauge the net effect of air pollution controls on mortality risk in the Beijing–Tianjin–Hebei(BTH)region during the 2022 Winter Olympics and Paralympics(WOP).This mega-event presents a unique opportunity to investigate the efficacy of deep cuts in pollutant *** show that O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in the *** to the active photochemical formations,O_(3) became the dominant pollutant that affected human health during the *** the substantial O_(3) increases,the health benefits of NO_(2) reductions overwhelmed the adverse health effects of O_(3) increases in most regions of the BTH(at 81 out of 112 stations).After considering the impacts of particulate matter,the integrated health risk of air pollution mixtures declined almost everywhere in the *** results underscore the great necessity of changing the assessment paradigm of pollution control from using concentration-based methods to using risk-based *** with the carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to achieve synergistic control solutions for air pollution and climate change.

关键词： Ozone Nitrogen dioxide Health risk Carbon neutrality Mega-events

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Heating of nanoparticles and their environment by laser radiation and applications

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Nanotechnology and Precision Engineering 2024年第1期7卷 78-115页

作者： Victor k.Pustovalov Belarusian National Technical University Pr.Independency65Minsk 220013Belarus

This review considers the fundamental dynamic processes involved in the laser heating of metal nanoparticles and their subsequent *** particular interest are the absorption of laser energy by nanoparticles,the heating of a single nanoparticle or an ensemble thereof,and the dissipation of the energy of nanoparticles due to heat exchange with the *** goal is to consider the dependences and values of the temperatures of the nanoparticles and the environment,their time scales,and other parameters that describe these *** results and analytical studies on the heating of single metal nanoparticles by laser pulses are discussed,including the laser thresholds for initiating subsequent photothermal processes,how temperature inﬂuences the optical properties,and the heating of gold nanoparticles by laser *** studies of the heating of an ensemble of nanoparticles and the results of an analytical study of the heating of an ensemble of nanoparticles and the environment by laser radiation are *** methods for nanoparticles under laser heating are considered,including changes in the refractive indices of metals and spectral thermometry of optical scattering of nanoparticles,Raman spectroscopy,the thermal distortion of the refractive index of an environment heated by a nanoparticle,and thermochemical phase transitions in lipid bilayers surrounding a heated *** the sequence of events after radiation absorption and their time scales underlies many applications of *** applicationﬁelds for the laser heating of nanoparticles are reviewed,including thermochemical reactions and selective nanophotothermolysis initiated in the environment by laser-heated nanoparticles,thermal radiation emission by nanoparticles and laser-induced incandescence,electron and ion emission of heated nanoparticles,and optothermal chemical *** of the laser heating of nanoparticles in la

关键词： Nanoparticles Laser Heating Modeling Nanothermometry Applications

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Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal Anand Abhijit Dey Arvind k.Singh Chandel Rupa Sanyal Amarnath mishra Devendra kumar Pandey Valentina De Falco Arun Upadhyay Ramesh kandimalla Anupama Chaudhary Jaspreet kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu Jose M.Perez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal Anand[a].Instead of"Department of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&Development LLP,k-51,UPSIDA Industrial Area,kursi Road(Lucknow),***,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

Marine yeast Rhodotorula paludigena VA 242 a pigment enhancing feed additive for the Ornamental Fish koi Carp

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Aquaculture and Fisheries 2024年第1期9卷 66-70页

作者： R.Rekha k.A.Nimsi k.Manjusha T.k.Sirajudheen Faculty of Ocean Science&Technology Kerala University of Fisheries and Ocean Studies(KUFOS)CochinKerala682506India

Skin colour is an important criterion in determining the aesthetic appeal of ornamental fishes,and thus their market *** the pigment enhancement in ornamental fishes has been the subject of extensive research by using various synthetic as well as natural pigment *** composition is one of the most important elements that influence the development of pigmentation in *** study is an attempt to assess the possibility of using carotenogenic marine yeast as pigment enhancer in fish diet for koi carp,Cyprinus *** 60 days feeding experiment was done by using feed incorporated with mangrove associated marine yeast Rhodotorula paludigena *** pigmentation in the scales of fishes fed with experimental feed was observed than that fed with the control diet(normal pellet feed).Furthermore the improved growth rate and general wellbeing in fishes fed with experimental feed provides scope for further studies in this field with respect to the growth and survival of fishes.

关键词： Marine yeasts Carotenoids Ornamental fishes Pigment enhancer Feed additive Rhodotorula sp

REMnO3（RE=Pr,Nd,Sm,Eu,Gd） perovskite as efficient catalysts for oxygen reduction reaction

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Journal of Rare Earths 2024年第11期42卷 2078-2087页

作者： Rakesh Ranjan Mahalik Siba Soren Ipsha Hota A.k.Debnath k.P.Muthe Purnendu Parhi Department of Chemistry Ravenshaw University Technical Physics Division Bhabha Atomic Research Centre

Rare earth metal based perovskite emerges as important catalytic material for energy production and *** ABO3type materials are now the focus of research in the field of oxygen reduction and evolution ***,in this work we evaluated the oxygen reduction properties of the synthesized one-dimensional REMnO3（RE=Pr,Nd,Sm,Eu and Gd）.The one-dimensional REMnO3prepared by the hydrothermal synthesis route results in pure phase perovskite on *** perovskite was characte rized with X-ray diffraction,Fourier transform-infrared（FT-IR）,field emission-scanning electron microscopy（FE-SEM）,transmission electron microscopy（TEM） and X-ray photoelectron spectroscopy（XPS）.The oxygen reduction reaction activities were investigated with the help of electrochemical workstation that consists of three-electrode system immersed in 0.1 mol/L kOH electrolyte solution saturated with *** koutechy-Levich plot obtained from rotating ring disk electrode shows all the prepared catalysts follow 4e-processes during oxygen *** effect of "A" site cation variation in REMnO3 on oxygen reduction reaction is ***3showed better onset potential for oxygen reduction reaction among the prepared rare earth ***3having high RE:Mn ratio（A-site rich co mpositions） promotes oxygen reduction reaction（ORR） *** the perovs kites showed good oxygen reduction property with high stability and methanol tolerance.

关键词： Electrocatalytic activity Oxygen reduction reaction (ORR) Perovskite Rare earths REMnO3 SmMnO3

Failure pattern in ceramic metallic target under ballistic impact

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Defence Technology（防务技术） 2024年第10期40卷 173-190页

作者： M.A.Iqbal M.k.khan Department of Civil Engineering Indian Institute of Technology RoorkeeRoorkee 247667India Department of Civil Engineering Aligarh Muslim UniversityAligarh202002India

The ballistic resistance and failure pattern of a bi-layer alumina 99.5%-aluminium alloy 1100-H12 target against steel 4340 ogival nosed projectile has been explored in the present experimental cum numerical *** the experimental investigation,damage induced in the ceramic layer has been quantified in terms of number of cracks developed and failure zone *** resultant damage in the backing layer has been studied with variation in the bulge and perforation hole in the backing layer with the varying incidence *** discussion of the experimental results has been further followed by three dimensional finite element computations using ABAQUS/Explicit finite code to investigate the behaviour of different types of bi-layer targets under multi-hit projectile *** JH-2 constitutive model has been used to reproduce the behaviour of alumina 99.5%and JC constitutive model has been used for steel 4340 and aluminium alloy *** total energy dissipation has been noted to be of lesser magnitude in case of sub-sequential impact in comparison to simultaneous impact of two *** distance between the impact points of two projectiles also effected the ballistic resistance of bi-layer *** ballistic resistance of single tile ceramic front layer and four tile ceramic of equivalent area found to be dependent upon the boundary conditions provided to the target.

关键词： Ballistic resistance Bi-layer target Ceramic metal armour Multi-hit impact Finite element modelling

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A Hybrid Machine Learning Approach for Improvised QoE in Video Services over 5G Wireless Networks

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Computers, Materials & Continua 2024年第3期78卷 3195-3213页

作者： k.B.Ajeyprasaath P.Vetrivelan School of Electronics Engineering Vellore Institute of TechnologyChennaiTamil Nadu600127India

Video streaming applications have grown considerably in recent *** a result,this becomes one of the most significant contributors to global internet *** to recent studies,the telecommunications industry loses millions of dollars due to poor video Quality of Experience(QoE)for *** the standard proposals for standardizing the quality of video streaming over internet service providers(ISPs)is the Mean Opinion Score(MOS).However,the accurate finding of QoE by MOS is subjective and laborious,and it varies depending on the user.A fully automated data analytics framework is required to reduce the inter-operator variability characteristic in QoE *** work addresses this concern by suggesting a novel hybrid XGBStackQoE analytical model using a two-level layering *** one combines multiple Machine Learning(ML)models via a layer one Hybrid *** ML models at level one are trained using the entire training data *** level two Hybrid XGBStackQoE-Model is fitted using the outputs(meta-features)of the layer one ML *** proposed model outperformed the conventional models,with an accuracy improvement of 4 to 5 percent,which is still higher than the current traditional *** proposed framework could significantly improve video QoE accuracy.

关键词： Hybrid XGBStackQoE-model machine learning MOS performance metrics QoE 5G video services

Enhancing Multicriteria-Based Recommendations by Alleviating Scalability and Sparsity Issues Using Collaborative Denoising Autoencoder

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Computers, Materials & Continua 2024年第2期78卷 2269-2286页

作者： S.Abinaya k.Uttej kumar School of Computer Science&Engineering Vellore Institute of TechnologyChennaiTamilnadu600127India

A Recommender System(RS)is a crucial part of several firms,particularly those involved in *** conventional RS,a user may only offer a single rating for an item-that is insufficient to perceive consumer ***,businesses in industries like e-learning and tourism enable customers to rate a product using a variety of factors to comprehend customers’*** the other hand,the collaborative filtering(CF)algorithm utilizing AutoEncoder(AE)is seen to be effective in identifying user-interested ***,the cost of these computations increases nonlinearly as the number of items and users *** triumph over the issues,a novel expanded stacked autoencoder(ESAE)with kernel Fuzzy C-Means Clustering(kFCM)technique is proposed with two *** the first phase of offline,the sparse multicriteria rating matrix is smoothened to a complete matrix by predicting the users’intact rating by the ESAE approach and users are clustered using the kFCM *** the next phase of online,the top-N recommendation prediction is made by the ESAE approach involving only the most similar user from multiple *** the ESAE_kFCM model upgrades the prediction accuracy of 98.2%in Top-N recommendation with a minimized recommendation generation *** experimental check on the Yahoo!Movies(YM)movie dataset and TripAdvisor(TA)travel dataset confirmed that the ESAE_kFCM model constantly outperforms conventional RS algorithms on a variety of assessment measures.

关键词： Recommender systems multicriteria rating collaborative filtering sparsity issue scalability issue stacked-autoencoder kernel Fuzzy C-Means Clustering