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Hepatolithiasis:Epidemiology,presentation,classification and management of a complex disease

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World Journal of Gastroenterology 2024年第13期30卷 1836-1850页

作者： Rodrigo V.Motta Francesca Saffioti Vasileios k Mavroeidis Translational Gastroenterology and Liver Unit Nuffield Department of MedicineUniversity of OxfordOxford OX39DUUnited Kingdom Department of Gastroenterology and Hepatology Oxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxford OX39DUUnited Kingdom UCL Institute for Liver and Digestive Health and Sheila Sherlock Liver Unit Royal Free Hospital and University College LondonLondon NW32QGUnited Kingdom Department of HPB Surgery Bristol Royal InfirmaryUniversity Hospitals Bristol and Weston NHS Foundation TrustBristol BS28HWUnited Kingdom Department of Transplant Surgery North Bristol NHS TrustSouthmead HospitalBristol BS105NBUnited Kingdom Department of Gastrointestinal Surgery North Bristol NHS TrustSouthmead HospitalBristol BS105NBUnited Kingdom

The term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts,above the hilar confluence of the hepatic *** disease is more prevalent in Asia,mainly owing to socioeconomic and dietary factors,as well as the prevalence of biliary *** the last century,owing to migration,its global incidence has *** main pathophysiological mechanisms involve cholangitis,bile infection and biliary strictures,creating a self-sustaining cycle that perpetuates the disease,frequently characterised by recurrent episodes of bacterial infection referred to as syndrome of“recurrent pyogenic cholangitis”.Furthermore,long-standing hepatolithiasis is a known risk factor for development of intrahepatic *** classifications have aimed at providing useful insight of clinically relevant aspects and guidance for *** management of symptomatic patients and those with complications can be complex,and relies upon a multidisciplinary team of hepatologists,endoscopists,interventional radiologists and hepatobiliary surgeons,with the main goal being to offer relief from the clinical presentations and prevent the development of more serious *** comprehensive review provides insight on various aspects of hepatolithiasis,with a focus on epidemiology,new evidence on pathophysiology,most important clinical aspects,different classification systems and contemporary management.

关键词： Cholelithiasis Intrahepatic stones Cholangiocarcinoma Biliary parasites Recurrent pyogenic cholangitis Oriental cholangiohepatitis Hepatectomy Cholangioscopy Liver transplant Paediatric

Differential roles of seed and sprout regeneration in forest diversity and productivity after disturbance

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Forest Ecosystems 2024年第3期11卷 371-380页

作者： Marek Mejstrík Martin Svatek Martina Pollastrini Martin Sramek Radim Matula Department of Forest Ecology Faculty of Forestry and Wood SciencesCzech University of Life Sciences PragueKamýcka 12916500PragueCzech Republic Department of Forest Botany Dendrology and GeobiocoenologyFaculty of Forestry and Wood TechnologyMendel University in BrnoZemedelska 361300BrnoCzech Republic Department of Agriculture FoodEnvironment and ForestryUniversity of FirenzePiazzale Delle Cascine 2850144FirenzeItaly

Natural regeneration after disturbances is a key phase of forest development,which determines the trajectory of successional changes in tree species composition and *** trees can originate from either seeds or sprouts produced by disturbed trees with sprouting *** both regeneration strategies often develop and co-occur after a disturbance,they tend to affect forest development differently due to significant functional ***,the origin of tree regeneration is rarely distinguished in post-disturbance forest surveys and ecological studies,and the differential roles of seed and sprout regeneration in forest productivity and diversity remain poorly *** address these research gaps,we explored the role of sprout and seed regeneration in the formation of woody species diversity and above-ground biomass(AGB)productivity in early-stage forest *** were collected in two experimental forest stands in the Czech Republic,where trees were cut with varying intensities with the density of residual(uncut)trees ranging from 0 to 275 trees per *** trees were mapped and their sizes were measured before cutting and then,either as a stump with sprouts or a residual tree,remeasured 11 years *** addition,all tree saplings were mapped and measured 11 years after logging,and their origin(sprout or seed)was *** assess abundances and productivity,we estimated AGB of all2,685 sprouting stumps of 19 woody species and 504 generative(i.e.,seed origin)individuals of 16 woody species,using allometric ***-effects models were used to analyze the effects of each regeneration strategy on woody species diversity and the total AGB under varying densities of residual *** multidimensional scaling was used to evaluate the effect of regeneration strategies on species *** and diversity of sprouts were significantly higher than those of seed *** formed on average97.1%of

关键词： Resprouting Seeding Residual trees Tree diversity Above-ground biomass

Tuning the optoelectronic properties for small organic compounds as organic solar cell applications

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Optoelectronics Letters 2024年第7期20卷 412-417页

作者： Hussein k.Mejbel Lafy F.Al-Badry Department of Physics College of Education for Pure ScienceUniversity of Thi-QarNassiriya 64001Iraq Department of Physics College of ScienceUniversity of Thi-QarNassiriya 64001Iraq1

Recently,organic solar cells have attracted the attention of many researchers owing to flexibility,low cost,light weight and large-area applications,and significant improvement in the power conversion efficiency(PCE).In this work,we designed chains from organic compounds as donors and replaced the core unit in each series with a variety of acceptors in order to enhance their optical and electronic characterization and performance for power conversion efficiencies in organic solar *** utilized density functional theory(DFT)and time-dependent density functional theory(TD-DFT)to investigate the geometry optimization by using the Gaussian 09 *** electronic and optical properties were determined,which involve the lowest unoccupied molecular orbital(LUMO)and the highest occupied molecular orbital(HOMO)levels,the band gap energy,maximum absorption wavelength(λ_(max)),open circuit voltage(V_(oc)),and light harvesting efficiency(LHE).Our evaluation denotes that the small compounds suggested are predicted to exhibit the best performance compared to the first series(SC1),like a lower band gap energy,a lower HOMO energy level,a greater absorption range,and a larger PCE.

关键词： orbital occupied compounds

Insm1:orchestrating cellular mimicry in the thymus medulla

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Cellular & Molecular Immunology 2024年第4期21卷 414-416页

作者： k.D.James J.E.Cowan UCL Institute of Immunity and Transplantation The Pears BuildingRowland Hill StreetLondonNW32PPUK

The thymus is the primary production site for a functional and self-tolerant T-cell *** establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TRAs)by medullary thymic epithelial cells(mTECs),which screen T-cell receptors for self-reactivity to eliminate autoreactive T *** studies have extended our understanding of mTEC heterogeneity by examining the mechanisms by which mTECs mimic the peripheral self[1].

关键词： medullary eliminate restricted

Hierarchical OptimizationMethod for Federated Learning with Feature Alignment and Decision Fusion

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Computers, Materials and Continua 2024年第1期81卷 1391-1407页

作者： Li k. Wang X. Wang H. College of Computer Science and Engineering North Minzu University Yinchuan 750021 China The key Laboratory of Images & Graphics Intelligent Processing of State Ethnic Affairs Commission North Minzu University Yinchuan 750021 China

In the realm of data privacy protection, federated learning aims to collaboratively train a global model. However, heterogeneous data between clients presents challenges, often resulting in slow convergence and inadequate accuracy of the *** shared feature representations alongside customized classifiers for individual clients emerges as a promising personalized solution. Nonetheless, previous research has frequently neglected the integration of global knowledge into local representation learning and the synergy between global and local classifiers, thereby limiting model performance. To tackle these issues, this study proposes a hierarchical optimization method for federated learning with feature alignment and the fusion of classification decisions (FedFCD). FedFCD regularizes the relationship between global and local feature representations to achieve alignment and incorporates decision information from the global classifier, facilitating the late fusion of decision outputs from both global and local classifiers. Additionally, FedFCD employs a hierarchical optimization strategy to flexibly optimizemodel parameters. Through experiments on the Fashion-MNIST, CIFAR-10 and CIFAR-100 datasets, we demonstrate the effectiveness and superiority of FedFCD. For instance, on the CIFAR-100 dataset, FedFCD exhibited a significant improvement in average test accuracy by 6.83% compared to four outstanding personalized federated learning approaches. Furthermore, extended experiments confirmthe robustness of FedFCD across various hyperparameter values. © 2024 The Authors. Published by Tech Science Press.

关键词： data heterogeneity decision fusion feature alignment Federated learning hierarchical optimization

Effect of Moringa oleifera on semen quality profiles in endangered Teressa goat under tropical humid island ecosystem

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Asian pacific Journal of Reproduction 2024年第2期13卷 89-96页

作者： P.Perumal Jai Sunder A.k.De A.k.Nahak D.k.Chaurasia T.C.Balamurugan D.Bhattacharya ICAR-Central Island Agricultural Research Institute Port Blair-744105Andaman and Nicobar IslandsIndia OUAT-College of Veterinary Science and Animal Husbandry Bhubaneswar-751003OdishaIndia TANUVAS-Veterinary College and Research Institute Salem-636112Tamil NaduIndia

Objective:To investigate the effect of Moringa oleifera leaf extract on semen quality parameters in Teressa goat ***:A total of 25 semen samples from six bucks were selected for the *** of 150×10^(6) were incubated in 0,300,500 and 700μg of leaf extract as groupⅠ,Ⅱ,Ⅲ and Ⅳ,*** stored semen samples were analysed for motility,viability,total sperm abnormalities,plasma membrane,acrosomal and nuclear integrities,seminal plasma intracellular enzymes[aspartate aminotransferase(AST),alanine aminotransferase(ALT)and lactate dehydrogenase(LDH)]and total antioxidant capacity(TAC)and spermatozoa malondialdehyde(MDA)and cholesterol efflux in comparison with the control group(groupⅠ)for up to 72 ***:Moringa oleifera leaf extract(500μg/150×10^(6) spermatozoa)-treated semen had significantly higher motility,viability,plasma membrane,acrosomal and nuclear integrities,and TAC(Pkage of intra-cellular enzymes and cholesterol efflux showed a decreasing trend from group Ⅰto group Ⅲand then an opposite trend from group Ⅲ to group Ⅳ at different hours of liquid ***:Moringa oleifera leaf extract 500μg/150×10^(6) spermatozoa can be used for liquid semen preservation in Teressa goat at Andaman and Nicobar Islands.

关键词： Moringa oleifera Semen Teressa goat Andaman and Nicobar Islands

LiDAR-based estimation of bounding box coordinates using Gaussian process regression and particle swarm optimization

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Biomimetic Intelligence & Robotics 2024年第1期4卷 24-35页

作者： Vinodha k. E.S.Gopi Tushar Agnibhoj Department of Electronics and Communication Engineering National Institute of Technology TiruchirappalliTamil Nadu620015India

Camera-based object tracking systems in a given closed environment lack privacy and *** this study,light detection and ranging(LiDAR)was applied to track objects similar to the camera tracking in a closed environment,guaranteeing privacy and *** primary objective was to demonstrate the efficacy of the proposed technique through carefully designed experiments conducted using two *** Scenario I,the study illustrates the capability of the proposed technique to detect the locations of multiple objects positioned on a flat surface,achieved by analyzing LiDAR data collected from several locations within the closed *** II demonstrates the effectiveness of the proposed technique in detecting multiple objects using LiDAR data obtained from a single,fixed ***-time experiments are conducted with human subjects navigating predefined *** individuals move within an environment,while LiDAR,fixed at the center,dynamically tracks and identifies their locations at multiple *** demonstrate that a single,strategically positioned LiDAR can adeptly detect objects in motion around ***,this study provides a comparison of various regression techniques for predicting bounding box *** process regression(GPR),combined with particle swarm optimization(PSO)for prediction,achieves the lowest prediction mean square error of all the regression techniques examined at *** tuning of GPR using PSO significantly minimizes the regression *** of the experiment pave the way for its extension to various real-time applications such as crowd management in malls,surveillance systems,and various Internet of Things scenarios.

关键词： LiDAR Data acquisition Bounding box Gaussian process regression Particle swarm optimization(PSO)

Immunotherapy of gastric cancer:Present status and future perspectives

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World Journal of Gastroenterology 2024年第8期30卷 779-793页

作者： John k Triantafillidis Manousos M konstadoulakis Apostolos E Papalois Inflammatory Bowel Disease Unit “Metropolitan General”HospitalHolargos 15562AtticaGreece.Hellenic Society for Gastrointestinal Oncology354 Iera OdosChaidari 12461AtticaGreece Second Department of Surgery University of Athens School of MedicineAretaieion HospitalAthens 11528AtticaGreece Unit of Surgical Research and Training Second Department of SurgeryUniversity of AthensSchool of MedicineAretaieion HospitalAthens 11528AtticaGreece

In this editorial,we comment on the article entitled“Advances and key focus areas in gastric cancer immunotherapy:A comprehensive scientometric and clinical trial review(1999-2023),”which was published in the recent issue of the World Journal of *** focused on the results of the authors’bibliometric analysis concerning gastric cancer immunotherapy,which they analyzed in depth by compiling the relevant publications of the last 20 *** that,we briefly describe the most recent data concerning the epidemiological parameters of gastric cancer(GC)in different countries,attempting to give an interpretation based on the etiological factors involved in the etiopathogenesis of the *** then briefly discuss the conservative treatment(chemotherapy)of the various forms of this malignant *** describe the treatment of resectable tumors,locally advanced neoplasms,and unresectable(advanced)*** attention is given to modern therapeutic approaches with emphasis on immunotherapy,which seems to be the future of GC treatment,especially in combination with *** is also a thorough analysis of the results of the study under review in terms of the number of scientific publications,the countries in which the studies were conducted,the authors,and the scientific centers of origin,as well as the clinical studies in ***,an attempt is made to draw some conclusions and to point out possible future directions.

关键词： Gastric cancer Chemotherapy Immunotherapy Immune checkpoint inhibitors Bibliometrics Scientometrics

Experimental and numerical study of effecting core configurations on the static and dynamic behavior of honeycomb plate with aluminum material

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Defence Technology（防务技术） 2024年第9期39卷 177-192页

作者： Nehad Abid Allah Hamza Fatima Mohammed k.AL-Fatlwe Muna Ali Talib Engineering College Al-Qasim Green University51013BabylonIraq Engineering Technical College of Al-Najaf Al-Furat Al-Awsat Technical University(ATU)Najaf54003Iraq

The sandwich panel incorporated a honeycomb core,a widely utilized composite structure recognized as a fundamental classification of composite *** a core resembling a honeycomb,possessing thickness and softness,and is flank by rigid face sheets that sandwich various shapes and *** paper presents an examination of the static and dynamic analysis of lightweight plates made of aluminum honeycomb sandwich *** sandwich plate samples are 300 mm long,and 300 mm wide,the heights of the core have been varied at four values ranging from 10 to 25 *** honeycomb core is manufactured from Aluminum material by using a novel technique namely resistance spot welding(RSW)instead of using adhesive material,which is often used when an industrial flaw is *** optimization based on response surface methodology(RSM)and design of experiment software(DOE)was used to verify the current work.A theoretical examination of the crashworthiness behavior(maximum bending load,maximum deflection)and vibration attributes(natural frequency,damping ratio,transient temporal response)of honeycomb sandwich panels with different design parameters was also carried *** addition,the finite element method-based ANSYS software was used to confirm the theoretical *** findings of the present work showed that the relationship between the natural frequency,core height,and cell size is *** contrast,the relationship between the natural frequency and the thickness of the cell wall is ***,the damping ratio is inversely proportional to the core height and cell size but directly proportional to the thickness of the cell *** study indicates that altering the core height within 10-25 mm leads to a significant increase of 82%in the natural frequency and a notable decrease of 49%in the damping *** findings are based on a specific cell size value of 0.01 m and a cell wall thickness of 0.001 ***,the results indicate

关键词： Honeycomb Load Transient response Free vibration Natural frequency