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Hepatotoxic Alterations Induced by Subchronic Exposure of Rats to Formulated Fenvalerate (20% EC) by Nose Only Inhalation

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Biomedical and Environmental Sciences 2004年第3期17卷 309-314页

作者： U.MANI a.k.prasad V.SURESHkUMAR P.kUMAR kEWAL LAL B.k.MAJI k.k.DUTTA Inhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 IndiaInhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 IndiaInhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 India Inhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 IndiaInhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 India

Objective Fenvalerate (20% EC) is a synthetic pyrethroid, which is commonly used in India by farmers for the protection of many food and vegetable crops against a wide variety of insects. However, its inhalation toxicity data is very limited in the literature due to the fact that the exposure levels associated with these effects were usually not reported. Hence, inhalation exposure was carried out to investigate the hepatotoxic effects. Method Adult male rats were exposed to fen for 4 h/day, 5 days a week for 90 days by using Flow Past Nose Only Inhalation Chamber. Sham treated control rats were exposed to compressed air in the inhalation chamber for the same period. Results The results indicated hepatomegaly, increased activities of serum clinical enzymes (indicative of liver damage/dysfunction) along with pronounced histopathological damage of liver. Conclusion The hepatotoxic potential of formulated Fen (20% EC) in rats exposed by nose only inhalation is being reported for the first time and warrant adequate safety measures for human beings exposed to this insecticide, particularly by inhalation route.

关键词： Fenvalerate Rat Inhalation Hepatotoxicity

A Pair of Pseudo-differential Operators Involving Index Whittaker Transform in L_(2)^(a) (R_(+);m_(a)(x)dx)

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1420-1430页

作者： Jeetendrasingh MAAN Akhilesh prasad Department of Mathematics and Computing Indian Institute of Technology(Indian School of Mines)Dhanbad-826004India

Pseudo-differential operators(PDO)Q(x,L_(a,x))and Q(x,L_(a,x))involving the index Whittaker transform are *** for these operators in Hilbert space L_(2)^(a)(R+;m_(a)(x)dx)are obtained.A symbol classΩis *** product an... 详细信息

关键词： Pseudo-differential operator index Whittaker transform confluent hypergeometric functions Hilbert space

Design of Power System Stabilizer for DFIG-based Wind Energy Integrated Power Systems Under Combined Influence of PLL and Virtual Inertia Controller

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 524-534页

作者： Balakrushna Sahu Bibhu prasad Padhy Department of Electrical Engineering Indian Institute of Technology RoparPunjab140001India

Wind energy systems (WESs) based on doubly-fed induction generators (DFIGs) have enormous potential for meeting the future demands related to clean energy. Due to the low inertia and intermittency of power injection, a WES is equipped with a virtual inertial controller (VIC) to support the system during a frequency deviation event. The frequency deviation measured by a phase locked loop (PLL) installed on a point of common coupling (PCC) bus is the input signal to the VIC. However, a VIC with an improper inertial gain could deteriorate the damping of the power system, which may lead to instability. To address this issue, a mathematical formulation for calculating the synchronizing and damping torque coefficients of a WES-integrated single-machine infinite bus (SMIB) system while considering PLL and VIC dynamics is proposed in this paper. In addition, a power system stabilizer (PSS) is designed for wind energy integrated power systems to enhance electromechanical oscillation damping. A small-signal stability assessment is performed using the infinite bus connected to a synchronous generator of higher-order dynamics integrated with a VIC-equipped WES. Finally, the performance and robustness of the proposed PSS is demonstrated through time-domain simulation in SMIB and nine-bus test systems integrated with WES under several case studies.

关键词： Doubly-fed induction generator(DFIG) virtual inertia controller(VIC) phase locked loop(PLL) small-signal analysis synchronizing/damping torque synchronous generator power system stabilizer(PSS)

Liver transplantation as an alternative for the treatment of non-resectable liver colorectal cancer: Advancing the therapeutic algorithm

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 154-159页

作者： Badi Rawashdeh Richard Bell Abdul Hakeem Raj prasad Division of Transplant Surgery Department of General SurgeryMedical College of WisconsinMilwaukeeWI53226USA Leeds Teaching Hospital LeedsUK

Colorectal cancer is a leading cause of cancerrelated mortality,with nearly half of the affected patients developing liver *** three decades,liver resection(LR)has been the primary curative strategy,yet its applicability is limited to about 20%of *** transplantation(LT)for unresectable metastases was attempted unsuccessfully in the 1990s,with high rates of perioperative death and *** is now more interest in this strategy due to improvements in systemic therapies and surgical techniques.A significant study conducted by the Oslo group showed that patients receiving liver transplants had a 60%chance of survival after five *** better results have been achieved by using advanced imaging for risk stratification and further refining selection criteria,especially in the Norvegian SECA *** review carefully charts the development and history of LT as a treatment option for colorectal cancer liver *** revolutionary path from the early days of exploratory surgery to the current situation of cautious optimism is traced,highlighting the critical clinical developments and improved patient selection standards that have made LT a potentially curative treatment for such challenging very well selected cases.

关键词： Liver transplantation Colorectal cancer liver metastases Non-resectable liver metastases

Numerical modelling of post-failure behaviors of coal specimens

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 514-531页

作者： Ajeet Yadav Bhaskara Behera Gauri Shankar prasad Singh Sanjay kumar Sharma Department of Mining Engineering Indian Institute of Technology(Banaras Hindu University)VaranasiUttar Pradesh221005India

A modelling approach consisting of best-fit relations to estimate the post-yield strength parameters is presented for simulating post-peak behavior beyond the point of residual strength of coal pillars having different w/h *** model was developed based on back-analysis of the complete stress-strain behavior of specimens belonging to six different Indian coal seams with different w/h ratios of 0.5 *** was found that the simultaneous degradation of the cohesion and friction angle of the Mohr-Coulomb rock material characterizes the post-peak strength behavior of the *** resulting expressions are simplistic as they require parameters that can be easily determined using uniaxial and triaxial compression ***,the developed model was validated by simulating the triaxial tests of coal specimens with different sizes under varying confining stresses and comparing its findings with the published test *** study showed that its implementation in the numerical model could reproduce laboratory-observed mechanical response,deformation behavior,and failure mechanism very closely.

关键词： Strain softening Dilatancy Interface Shape effect Residual strength

Exercise and exerkine upregulation:Brain-derived neurotrophic factor as a potential non-pharmacological therapeutic strategy for Parkinson’s disease

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BIOCELL 2024年第5期48卷 693-706页

作者： VIRAAJ VISHNU prasad JENNIFER SALLY SAMSON VENkATACHALAM DEEPA PARVATHI Department of Biomedical Sciences Sri Ramachandra Institute of Higher Education and ResearchChennai600116India

Physical activity and exercise have several beneficial roles in enhancing both physiological and psychological well-being of an *** addition to aiding the regulation of aerobic and anaerobic metabolism,exercise can stimulate the synthesis of exerkine hormones in the circulatory *** several exerkines that have been investigated for their therapeutic potential,Brain-derived neurotrophic factor(BDNF)is considered the most promising candidate,especially in the management of neurodegenerative *** to the ability of physical activity to enhance BDNF synthesis,several experimental studies conducted so far have validated this hypothesis and produced satisfactory results at the pre-clinical *** review highlights some of the recent animal model studies that have evaluated the efficiency of exercise in enhancing BDNF synthesis and promoting neuroprotective ***,this review focuses on understanding the therapeutic benefits of exercise-induced exerkine synthesis as a non-pharmacological strategy in Parkinson’s disease(PD).Regarding physical activity and exerkine induction,the neuromuscular electrical stimulation(NMES)strategy could be considered as an alternate treatment modality for patients affected with PD.

关键词： Exercise therapy Dopaminergic neurons Parkinson’s disease Brain-derived neurotrophic factor Electrical stimulation

Enhancing corrosion resistance of plasma electrolytic oxidation coatings on AM50 Mg alloy by inhibitor containing Ba(NO_(3))_(2) solutions

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International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 2048-2061页

作者： Jirui Ma Xiaopeng Lu Santosh prasad Sah Qianqian Chen You Zhang Fuhui Wang Corrosion and Protection Center Northeastern UniversityShenyang110819China Faculty of Engineering Hokkaido UniversityHokkaido 060-8628Japan College of New Materials and Chemical Engineering Beijing Institute of Petrochemical TechnologyBeijing 102617China

To enhance the long-term corrosion resistance of the plasma electrolytic oxidation(PEO)coating on the magnesium(Mg)alloy,an inorganic salt combined with corrosion inhibitors was used for posttreatment of the *** this study,the corrosion performance of PEO-coated AM50 Mg was significantly improved by loading sodium lauryl sulfonate(SDS)and sodium dodecyl benzene sulf-onate into Ba(NO_(3))_(2) post-sealing *** electron microscopy,X-ray photoelectron spectroscopy,X-ray diffraction,Fourier transform infrared spectrometer,and ultraviolet-visible analyses showed that the inhibitors enhanced the incorporation of BaO_(2) into PEO *** impedance showed that post-sealing in Ba(NO_(3))_(2)/SDS treatment enhanced corrosion resistance by three orders of *** total impedance value remained at 926Ω·cm^(2)after immersing in a 0.5wt%NaCl solution for 768 h.A salt spray test for 40 days did not show any obvious region of corrosion,proving excellent post-sealing by Ba(NO_(3))_(2)/SDS *** corrosion resistance of the coating was enhanced through the synergistic effect of BaO2 pore sealing and SDS adsorption.

关键词： Mg plasma electrolytic oxidation posttreatment corrosion resistance

Impact factors and pathways of halonitromethanes formation from aspartic acid during LED-UV_(265)/chlorine disinfection

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 129-144页

作者： Liangwen Zhu Tao Wang Qian Tang Qing Wang Lin Deng Jun Hu Chaoqun Tan Rajendra prasad Singh key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education School of Civil EngineeringSoutheast UniversityNanjing 211189China College of Environment Zhejiang University of TechnologyHangzhou 310014China

Light emitting diode (LED-UV)/chlorine disinfection can replace UV/chlorine disinfection in wastewater treatment plants and water supply plants. Halonitromethanes (HNMs) are a class of novel nitrogenous disinfection by-products, which are characterized by higher cytotoxicity and genotoxicity than regulated disinfection by-products. Herein, the impact factors and pathways of HNMs formation from aspartic acid (ASP) were investigated during LED-UV_(265)/chlorine disinfection. The results showed that three types of chlorinated-HNMs (Cl-HNMs) were found during LED-UV265/chlorine disinfection, and their concentrations increased first and then declined as the reaction progressed. Cl-HNMs yields increased with increasing LED-UV_(265) intensity, free chlorine dosage, and ASP concentration, which declined with increasing pH (6.0–8.0). Meantime, the important impact of the coexisting ions contained in water matrices on HNMs formation from ASP was observed during LED-UV_(265)/chlorine disinfection. It was found that copper ions (Cu^(2+)) promoted Cl-HNMs formation. Furthermore, when bromide (Br–) appeared during LED-UV265/chlorine disinfection, nine types of HNMs were detected simultaneously. Moreover, Br– not only converted Cl-HNMs toward brominated (chlorinated)-HNMs and brominated-HNMs but also showed a marked effect on HNMs concentrations and species. Subsequently, the possible pathways of HNMs formation from ASP were proposed during LED-UV_(265)/chlorine disinfection. At last, it was proved that the formation trends of HNMs obtained in the real waters were similar to those in simulated waters. This work elaborated on the influence factors and pathways of HNMs formation, which is conducive to controlling the HNMs produced during LED-UV_(265)/chlorine disinfection.

关键词： LED-UV265 chlorine HNMs Aspartic acid Bromide Copper ions

Design of a Multi-Stage Ensemble Model for Thyroid Prediction Using Learning Approaches

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Intelligent Automation & Soft Computing 2024年第1期39卷 1-13页

作者： M.L.Maruthi prasad R.Santhosh Department of Computer Science and Engineering Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatoreTamil NaduIndia

This research concentrates to model an efficient thyroid prediction approach,which is considered a baseline for significant problems faced by the women *** major research problem is the lack of automated model to attain earlier *** existing model fails to give better prediction ***,a novel clinical decision support system is framed to make the proper decision during a time of *** stages are followed in the proposed framework,which plays a substantial role in thyroid *** steps include i)data acquisition,ii)outlier prediction,and iii)multi-stage weight-based ensemble learning process(MS-WEL).The weighted analysis of the base classifier and other classifier models helps bridge the gap encountered in one single classifier *** classifiers aremerged to handle the issues identified in others and intend to enhance the prediction *** proposed model provides superior outcomes and gives good quality prediction *** simulation is done in the MATLAB 2020a environment and establishes a better trade-off than various existing *** model gives a prediction accuracy of 97.28%accuracy compared to other models and shows a better trade than others.

关键词： Thyroid machine learning pre-processing classification prediction rate