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Signal Transduction and Targeted Therapy 2024年第3期9卷 1174-1185页

作者： Sumit Bhattacharyya Joanne k.Tobacman Jesse Brown VA Medical Center and University of Illinois at Chicago ChicagoIL 60612USA

Immunostaining in lungs of patients who died with CovID-19 infection showed increased intensity and distribution of chondroitin sulfate and decline in N-acetylgalactostamine-4-sulfatase(Arylsulfatase B;ARSB).To explain these findings,human small airway epithelial cells were exposed to the SARS-CoV-2 spike protein receptor binding domain(SPRBD)and transcriptional mechanisms were ***-p38 MAPk and phospho-SMAD3 increased following exposure to the SPRBD,and their inhibition suppressed the promoter activation of the carbohydrate sulfotransferases CHST15 and CHST11,which contributed to chondroitin sulfate *** in ARSB was mediated by phospho-38 MAPk-induced N-terminal Rb phosphorylation and an associated increase in Rb-E2F1 binding and decline in E2F1 binding to the ARSB *** increases in chondroitin sulfotransferases were inhibited when treated with phospho-p38-MAPk inhibitors,SMAD3(SIS3)inhibitors,as well as antihistamine desloratadine and antibiotic *** the mouse model of carrageenan-induced systemic inflammation,increases in phosphop38 MAPk and expression of CHST15 and CHST11 and declines in DNA-E2F binding and ARSB expression occurred in the lung,similar to theobserved effects in this SPRBD model of COVID-19 *** accumulation of chondroitin sulfates is associated with fibrotic lung conditions and diffuse alveolar damage,increased attention to p38-MAPk inhibition may be beneficial in amelioratingCovid-19infections.

关键词： ACE2 lung inhibited

No effect of invasive tree species on aboveground biomass increments of oaks and pines in temperate forests

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Forest Ecosystems 2024年第4期11卷 401-413页

作者： Sebastian Bury Marcin k.Dyderski Institute of Dendrology Polish Academy of SciencesParkowa 562-035 KornikPoland

Prunus serotina and Robinia pseudoacacia are the most widespread invasive trees in Central *** addition,according to climate models,decreased growth of many economically and ecologically important native trees will likely be observed in the *** aimed to assess the impact of these two neophytes,which differ in the biomass range and nitrogen-fixing abilities observed in Central European conditions,on the relative aboveground biomass increments of native oaks Qucrcus robur and *** and Scots pine Pinus *** aimed to increase our understanding of the relationship between facilitation and competition between woody alien species and overstory native *** established 72 circular plots(0.05 ha)in two different forest habitat types and stands varying in age in western *** chose plots with different abundances of the studied neophytes to determine how effects scaled along the quantitative invasion ***,we collected growth cores of the studied native species,and we calculated aboveground biomass increments at the tree and stand ***,we used generalized linear mixed-effects models to assess the impact of invasive species abundances on relative aboveground biomass increments of native tree *** did not find a biologically or statistically significant impact of invasive *** or *** on the relative aboveground,biomass increments of native oaks and pines along the quantitative gradient of invader biomass or on the proportion of total stand biomass accounted for by *** neophytes did not act as native tree growth stimulators but also did not compete with them for resources,which would escalate the negative impact of climate change on pines and *** neophytes should not significantly modify the carbon sequestration capacity of the native *** work combines elements of the per capita effect of invasion with research on mixed forest management.

关键词： Invasion ecology Exotic trees Relative aboveground biomass increment Competition Facilitation Carbon sequestration

Process engineering of demineralisation of moderate to high ash Indian coals through NaOH‑HCl leaching and HF leaching

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International Journal of Coal Science & Technology 2024年第2期11卷 111-122页

作者： Heena Dhawan D.k.Sharma ANRF Ministry of ScienceNew DelhiIndia Department of Energy Science and Engineering Indian Institute of Technology DelhiNew Delhi 110016India

Chemical leaching of coals would be required to produce cleaner coals for some special applications where physical benefi-ciation may not be effective *** would also help in recovering Li and rare earth metals besides in the sequestration of CO_(2).About 20 Indian coals having complexly distributed moderate to high ash contents were sequentially treated with various alkali–acid such as NaOH-HCl,HF,HCl,HCl-HF,and NaOH-HCl-HF *** aimed to establish and design the best stepwise sequential process for the highest degree of demineralisation through a chemical leaching *** and process intensification studies were carried *** than 80%demineralisation of Madhaipur and Neemcha coals was observed using the best sequential treatment designed *** repeated stepwise treatment of the alkali and the acid was also studied,which was found to significantly enhance the degree of demineralisation of *** integrated process of alkali–acid leaching followed by solvent extraction(Organo-refining)and vice versa of the treated coal was also studied for producing cleaner coals.

关键词： Alkali–acid leaching Demineralisation Integrated process Rare earth elements

Commentary on“Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients”

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Asian Journal of Andrology 2024年第3期26卷 333-334页

作者： James F Jiang Narmina k Onder Akhil k Das Department of Urology University of California Irvine Orange CA 92868 USA

Laser enucleation of the prostate is a proven and effectivesize-independent method for the surgical management of symptomaticbenign prostatic hyperplasia(BPH)and is considered as the“goldstandard”by many *** major hurdles that stand in theway of this becoming a universally used procedure for BPH are thesteep learning curve associated with mastering the procedure andpossibility of perioperative transient *** advances inteaching methodologies have helped tackle the difficulty in learning itand increased the number of urologists utilizing the *** forthe second hurdle,transient incontinence rates postlaser enucleationof the prostate have improved with the advent of newer techniques *** et al.1 assesses the incidence of stress,urge,andmixed urinary incontinence following laser enucleation of the prostateby comparing en-bloc and non-en-bloc techniques in a multicenterseries of 5068 men with BPH.

关键词： urinary incontinence transient

Liquid superlubricity of lubricants containing hydroxyl groups and their aqueous solution under rolling/sliding conditions

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Friction 2024年第1期12卷 164-173页

作者： Tomáš POLÁČEk Petr ŠPERkA Ivan kŘUPkA Faculty of Mechanical Engineering Brno University of TechnologyBrno 61669Czech Republic

Macroscale rolling/sliding conditions are in the superlubricity,a little-studied topic so *** purpose of this paper is to examine the formation of elastohydrodynamic lubrication(EHL)films by water-based lubricants(glycerol and polyethylene glycol(PEG)),providing superlubricous *** were carried out on an optical ball-on-disc tribometer under rolling/sliding *** film thickness was measured by the thin film colorimetric interferometry,and the viscosity of liquids was measured by rotational and high-pressure falling body *** results show that tribochemical reactions are not the mandatory reason for friction to reach the superlubricity level when using the water-based *** studied liquids themselves are almost *** the addition of water,the signs of shear thinning behavior disappear even *** conditions for this type of lubricant can be predicted using the known Hamrock–Dowson *** anomaly in the thickness of the lubricants was observed as an abrupt change at certain *** more PEG there is in the lubricant,the higher the thickness at the beginning of the jump.

关键词： macroscale superlubricity super low traction water-based lubricants elastohydrodynamic lubrication(EHL) film thickness

Hybrid Gene Selection Methods for High-Dimensional Lung Cancer Data Using Improved Arithmetic Optimization Algorithm

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Computers, Materials & Continua 2024年第6期79卷 5175-5200页

作者： Mutasem k.Alsmadi Department of Management Information Systems College of Applied Studies and Community ServiceImam Abdulrahman Bin Faisal UniversityDammamSaudi Arabia

Lung cancer is among the most frequent cancers in the world,with over one million deaths per *** is required for lung cancer diagnosis and therapy to be effective,accurate,and *** expression microarrays have made it possible to find genetic biomarkers for cancer diagnosis and prediction in a high-throughput *** Learning(ML)has been widely used to diagnose and classify lung cancer where the performance of ML methods is evaluated to identify the appropriate *** and selecting the gene expression patterns can help in lung cancer diagnoses and ***,microarrays include several genes and may cause confusion or false ***,the Arithmetic Optimization Algorithm(AOA)is used to identify the optimal gene subset to reduce the number of selected *** can allow the classifiers to yield the best performance for lung cancer *** addition,we proposed a modified version of AOA which can work effectively on the high dimensional *** the modified AOA,the features are ranked by their weights and are used to initialize the AOA *** exploitation process of AOA is then enhanced by developing a local search algorithm based on two neighborhood ***,the efficiency of the proposed methods was evaluated on gene expression datasets related to Lung cancer using stratified 4-fold *** method’s efficacy in selecting the optimal gene subset is underscored by its ability to maintain feature proportions between 10%to 25%.Moreover,the approach significantly enhances lung cancer prediction *** instance,Lung_Harvard1 achieved an accuracy of 97.5%,Lung_Harvard2 and Lung_Michigan datasets both achieved 100%,Lung_Adenocarcinoma obtained an accuracy of 88.2%,and Lung_Ontario achieved an accuracy of 87.5%.In conclusion,the results indicate the potential promise of the proposed modified AOA approach in classifying microarray cancer data.

关键词： Lung cancer gene selection improved arithmetic optimization algorithm and machine learning

Exploration of chromene-based BioAIEgens

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National Science Review 2024年第3期11卷 47-48页

作者： Fritz E.kühn Department of Chemistry&Catalysis Research Center School of Natural Sciences Technical University of Munich

Photoemission efficiency is usually higher in solution than in solid *** compounds however, display a reverse behavior. Such a behavior is called aggregation-induced emission(AIE).

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EVOLUTION AND INTERACTION OFδ-WAVES IN THE ZERO-PRESSURE GAS DYNAMICS SYSTEM

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Acta Mathematica Scientia 2024年第5期44卷 1801-1836页

作者： Abhishek DAS k.T.JOSEPH Centre for Data Science Institute of Technical Education and Research(ITER)Siksha‘O’Anusandhan(Deemed to be University)BhubaneswarOdisha751030India Centre for Applicable Mathematics Tata Institute of Fundamental ResearchSharada NagarBangalore560065KarnatakaIndia

Evolution and interaction of plane waves of the multidimensional zero-pressure gas dynamics system leads to the study of the corresponding one dimensional *** this paper,we study the initial value problem for one dimensional zero-pressure gas dynamics *** the first equation is the Burgers equation and the second one is the continuity *** consider the solution with initial data in the space of bounded Borel *** we prove a general existence result in the algebra of generalized functions of *** we study in detail special solutions withδ-measures as initial *** study interaction of waves originating from initial data concentrated on two point sources and interaction with classical shock/rarefaction *** gives an understanding of plane-wave interactions in the multidimensional *** use the vanishing viscosity method in our analysis as this gives the physical solution.

关键词： zero-pressure gas dynamics delta-waves interaction of waves

Controlled deployment of a long tether to operate as a partial space elevator

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Astrodynamics 2024年第2期8卷 311-321页

作者： Jinbang Huang Arun k.Misra Department of Mechanical Engineering McGill UniversityMontrealQCH3A 0C3Canada

The deployment of a long tether to operate as a partial space elevator,starting from a nucleus in geostationary orbit,is *** deployment is an inherently unstable process because the center of orbit gradually decreases from the geostationary altitude when deployment *** is also observed that the elasticity of the tether has an important effect on deployment *** is shown that the application of a transverse force on the main spacecraft,determined by using linear state feedback and appropriate gains,can stabilize the *** LQR controller is *** of the dynamics of the system are carried out using this controller for various parametric values of tether elasticity,deployment rates,etc.,to evaluate the efficacy of the controller.

关键词： tether space elevator deployment stability control

Classification of Conversational Sentences Using an Ensemble Pre-Trained Language Model with the Fine-Tuned Parameter

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Computers, Materials & Continua 2024年第2期78卷 1669-1686页

作者： R.Sujatha k.Nimala Department of Networking and Communications SRM Institute of Science and TechnologyKattankulathurChengalpattuTamilnadu603203India

Sentence classification is the process of categorizing a sentence based on the context of the *** categorization requires more semantic highlights than other tasks,such as dependence parsing,which requires more syntactic *** existing strategies focus on the general semantics of a conversation without involving the context of the sentence,recognizing the progress and comparing *** ensemble pre-trained language model was taken up here to classify the conversation sentences from the conversation *** conversational sentences are classified into four categories:information,question,directive,and *** classification label sequences are for analyzing the conversation progress and predicting the pecking order of the *** of Bidirectional Encoder for Representation of Transformer(BERT),Robustly Optimized BERT pretraining Approach(RoBERTa),Generative Pre-Trained Transformer(GPT),DistilBERT and Generalized Autoregressive Pretraining for Language Understanding(XLNet)models are trained on conversation corpus with *** tuning approach is carried out for better performance on sentence *** Ensemble of Pre-trained Language Models with a Hyperparameter Tuning(EPLM-HT)system is trained on an annotated conversation *** proposed approach outperformed compared to the base BERT,GPT,DistilBERT and XLNet transformer *** proposed ensemble model with the fine-tuned parameters achieved an F1_score of 0.88.

关键词： Bidirectional encoder for representation of transformer conversation ensemble model fine-tuning generalized autoregressive pretraining for language understanding generative pre-trained transformer hyperparameter tuning natural language processing robustly optimized BERT pretraining approach sentence classification transformer models