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Reinforced tissue matrix to strengthen the abdominal wall following reversal of temporary ostomies or to treat incisional hernias

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 823-832页

作者： Spencer P Lake Corey R Deeken Amit k agarwal Mechanical Engineering&Materials Science Washington University in St.LouisSt.LouisMO 63130United States Covalent Bio LLCSt.LouisMO 63025United States Department of Surgery McGovern Medical School at UTHealthHoustonTX 77026United States

BACkGROUND Abdominal wall deficiencies or weakness are a common complication of tem-porary ostomies,and incisional hernias frequently develop after colostomy or ileostomy *** use of synthetic meshes to reinforce the abdominal wall has reduced hernia *** meshes have also been used to enhance healing,particularly in contaminated *** tissue matrices(R-TMs),which include a biologic scaffold of native extracellular matrix and a syn-thetic component for added strength/durability,are designed to take advantage of aspects of both synthetic and biologic *** date,RTMs have not been reported to reinforce the abdominal wall following stoma *** Twenty-eight patients were selected with a parastomal and/or incisional hernia who had received a temporary ileostomy or colostomy for fecal diversion after rectal cancer treatment or *** hernia repair and proximal stoma closure,RTM(OviTex®1S permanent or OviTex®LPR)was placed to reinforce the abdominal wall using a laparoscopic,robotic,or open surgical ***-operative follow-up was performed at 1 month and 1 *** recurrence was determined by physical examination and,when necessary,via computed tomo-graphy *** endpoints included length of hospital stay,time to return to work,and hospital *** complications of the wound/repair site included presence of surgical site infection,seroma,hematoma,wound dehiscence,or fistula *** The observational study cohort included 16 male and 12 female patients with average age of 58.5 years±16.3 years and average body mass index of 26.2 kg/m^(2)±4.1 kg/m^(2).Patients presented with a parastomal hernia(75.0%),in-cisional hernia(14.3%),or combined parastomal/incisional hernia(10.7%).Using a laparoscopic(53.6%),robotic(35.7%),or open(10.7%)technique,RTMs(OviTex®LPR:82.1%,OviTex®1S:17.9%)were placed using sublay(82.1%)or intraperitoneal onlay(IPOM;17.9%)mesh *** 1-mo

关键词： Reinforced tissue matrix Reinforced forestomach matrix Ileostomy Colostomy Ostomy takedown Incisional hernia Abdominal wall

Advancements in nanotechnology for the delivery of phytochemicals

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Journal of Integrative Medicine 2024年第4期22卷 385-398页

作者： Divya Chauhan Pavan k.Yadav Nazneen Sultana Arun agarwal Saurabh Verma Manish k.Chourasia Jiaur R.Gayen Division of Pharmaceutics and Pharmacokinetics Central Drug Research InstituteCouncil of Scientific and Industrial ResearchLucknow 226031Uttar PradeshIndia Academy of Scientific and Innovative Research Ghaziabad 201002Uttar PradeshIndia

Phytosomes(phytophospholipid complex) are dosage forms that have recently been introduced to increase the stability and therapeutic effect of herbal medicine. Currently, bioactive herbs and the phytochemicals they contain are considered to be the best remedies for chronic diseases. One promising approach to increase the efficacy of plant-based therapies is to improve the stability and bioavailability of their bio-active ingredients. Phytosomes employ phospholipids as their active ingredients, and use their amphiphilic properties to solubilize and protect herbal extracts. The unique properties of phospholipids in drug delivery and their use in herbal medicines to improve bioavailability results in significantly enhanced health benefits. The introduction of phytosome nanotechnology can alter and revolutionize the current state of drug delivery. The goal of this review is to explain the application of phytosomes, their future prospects in drug delivery, and their advantages over conventional formulations.

关键词： Phytochemical Bioavailability Drug delivery system Phytosome Plant extracts

采用数值模拟方法的水斗式水轮机转轮用户定制设计

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国外大电机 2006年第4期 59-64页

作者： a.k.agarwal[印度] 程志慧（译）王正伟（校）不详清华大学

本文通过全流道的水力优化方案，对新水轮机或在原土木结构下对旧水轮机进行优化改进，使运行参数更加符合要求，获得更高的效率和出力。由于水轮机转轮对整个机组性能起着决定性的作用，所以对转轮的优化设计是得到最佳性能的关键。市... 详细信息

本文通过全流道的水力优化方案，对新水轮机或在原土木结构下对旧水轮机进行优化改进，使运行参数更加符合要求，获得更高的效率和出力。由于水轮机转轮对整个机组性能起着决定性的作用，所以对转轮的优化设计是得到最佳性能的关键。市场上可用的传统CFD软件可以解封闭及开放式管道流动的三维N-S方程，用于计算反击式水轮机的流动参数，如混流式水轮机与转桨式水轮机。但是还没有任何一种商业软件可以直接解决水斗式水轮机流体与水斗相互作用过程中出现的两相流（空气和水）问题。水斗式水轮机转轮中的水力现象非常复杂，结合了气水两相的相互作用，水分离成大小各异的液滴，液滴之间又通过混合或结合的方式形成更多的液滴及流动。这种现象的随机性，按照流动方程所建立模型的不可交换性，以及大量的几何、流动数据，让已经很难解决的问题变得更加复杂。但是，如果具备强大的计算机设备，就可以利用数学模型对这个问题精确地模拟和解决。这就是我们所说的选择性方案。BHEL研究开发了这种软件，并应用于分析和改进水斗式水轮机转轮水斗的性能。利用传统的CFD工具可以很容易实现对封闭流动区域的分析，例如导水机构和喷嘴。但是使用CFD软件估算由喷嘴流出的流体性质则要很谨慎。流体的粘性、散度、横截面上流动速度在各方向的分量都要与转轮水斗相适应，同时还需要与测量数据有附加相关性，并可以给出合理的解释。这篇论文介绍了印度NHPC有限公司的PARBATI水电项目，项目中应用内部方案，对水斗式水轮机转轮进行优化。论文中主要介绍了该方法的操作步骤、后处理结果以及模型测量结果与计算结果的比较分析。这个项目的投标引起了激烈的竞争。这个项目使用的分析方法很大程度上完善了BHEL公司在水斗式水轮机设计方面的经验，对水斗式水轮机的发展也起了极大的促进作用。利用计算机工具更方便对水斗式水轮机水斗的外形进行优化设计。同时通过分析设计方法可以正确地预测两种外形间的性能差异。经证实，我们可以在预定时间内按照用户所有的要求设计完成水轮机转轮，大大提高了整体效率。

关键词：水斗式水轮机转轮数值模拟设计

Transcranial direct current stimulation as early augmentation in adolescent obsessive compulsive disorder:A pilot proof-of-concept randomized control trial

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World Journal of Clinical Pediatrics 2024年第2期13卷 161-170页

作者： Aditya Agrawal Vivek agarwal Sujita kumar kar Amit Arya Department of Psychiatry King George Medical UniversityUttar PradeshLucknow 226003India

BACkGROUND Transcranial direct current stimulation(tDCS)is proven to be safe in treating various neurological conditions in children and *** is also an effective method in the treatment of OCD in *** To assess the safety and efficacy of tDCS as an add-on therapy in drug-naive adolescents with *** We studied drug-naïve adolescents with OCD,using a Children’s Yale-Brown obsessive-compulsive scale(CY-BOCS)scale to assess their *** active and sham groups were given fluoxetine,and we applied cathode and anode over the supplementary motor area and deltoid for 20 min in 10 *** occurred at 2,6,and 12 wk using *** Eighteen adolescents completed the study(10-active,8-sham group).CY-BOCS scores from baseline to 12 wk reduced significantly in both groups but change at baseline to 2 wk was significant in the active group *** mean change at 2 wk was more in the active group(11.8±7.77 vs 5.25±2.22,P=0.056).Adverse effects between the groups were *** tDCS is safe and well tolerated for the treatment of OCD in ***,there is a need for further studies with a larger sample population to confirm the effectiveness of tDCS as early augmentation in OCD in this population.

关键词： Adolescents Early augmentation Obsessive compulsive disorder Safety Transcranial direct current stimulation

Identifying the stability of housekeeping genes to be used for the quantitative real-time PCR normalization in retinal tissue of streptozotocin-induced diabetic rats

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 794-805页

作者： Muhammad Zulfiqah Sadikan Nurul Alimah Abdul Nasir Mohammad Johari Ibahim Igor Iezhitsa Renu agarwal Department of Pharmacology Faculty of MedicineManipal University College Malaysia(MUCM)Bukit BaruMelaka 75150Malaysia Centre for Neuroscience Research(NeuRon) Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia Department of Medical Education Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia Department of Biochemistry and Molecular Medicine Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia School of Medicine International Medical UniversityBukit JalilKuala Lumpur 57000Malaysia Department of Pharmacology and Bioinformatics Volgograd State Medical UniversityVolgograd 400131Russia

AIM:To investigate the stability of the seven housekeeping genes:beta-actin(ActB),glyceraldehyde-3-phosphate dehydrogenase(GAPDH),18s ribosomal unit 5(18s),cyclophilin A(CycA),hypoxanthine-guanine phosphoribosyl transferase(HPRT),ribosomal protein large P0(36B4)and terminal uridylyl transferase 1(U6)in the diabetic retinal tissue of rat ***:The expression of these seven genes in rat retinal tissues was determined using real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR)in two groups;normal control rats and streptozotocininduced diabetic *** stability analysis of gene expression was investigated using geNorm,NormFinder,Bestkeeper,and comparative delta-Ct(ΔCt)***:The 36B4 gene was stably expressed in the retinal tissues of normal control animals;however,it was less stable in diabetic *** 18s gene was expressed consistently in both normal control and diabetic rats’retinal *** this gene was the best reference for data normalisation in RT-qPCR studies that used the retinal tissue of streptozotocin-induced diabetic ***,there was no ideal gene stably expressed for use in all experimental ***:Identifying relevant genes is a need for achieving RT-qPCR validity and reliability and must be appropriately achieved based on a specific experimental setting.

关键词： housekeeping genes stability real-time reverse transcription polymerase chain reaction retinal tissue streptozotocin-induced diabetic rats

用薄板近似的二维数值模型研究印度半岛和斯里兰卡周围区域电磁感应

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地球物理学进展 1989年第3期4卷 109-109页

作者： a.k.agarwal 冰清

在最近印度南部地磁感应的数值研究的基础上,利用维多利亚大学提出的薄板算法,研究了印度半岛和斯里兰卡地区均匀源产生的三维磁感应问题、用这种算法无需假设研究区域被正常构造包围,但是区域网格的大小和给定的地壳和地幔的电导率使... 详细信息

在最近印度南部地磁感应的数值研究的基础上,利用维多利亚大学提出的薄板算法,研究了印度半岛和斯里兰卡地区均匀源产生的三维磁感应问题、用这种算法无需假设研究区域被正常构造包围,但是区域网格的大小和给定的地壳和地幔的电导率使我们只能研究周期为20分的感应场。已计算出这样的两个不同模型的解:(1)电导率差仅仅是由可变深度的海水和陆地引起的模型:(2)包括在Manowar地区的Palk海峡/海湾,Comorin洋脊下面或附近地区以及沿西岸断层具有额外的地下导体的模型。本文给出了指向北和南的用于区别均匀地磁源的不同极化效应的结果。南部台阵Parkinson矢量的观测结果和计算结果的一致性表明,该区有三个地下导体存在。

关键词：极化效应数值模型研究周期构造包维多利亚大学和南印度南部台阵

Effect of inlet elbow on rotation stall in waterjet ppropulsionpump

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Fundamental Research 2024年第4期4卷 898-906页

作者： Wei Li Shuo Li Leilei Ji Enda Li Weidong Shi Ramesh agarwal Muhammad Awais National Research Center of Pumps Jiangsu UniversityZhenjiang 212013China Institute of Fluid Engineering Equipment Technology Jiangsu UniversityZhenjiang 212009China College of Mechanical Engineering Nantong UniversityNantong 226019China departmentof Mechanical Engineering&Materials Science Washington University in StLouisSt.LouisMO6330US.

To study the influence of an elbow inlet on the rotating stall characteristics of a waterjet propulsion pump(WJPP),a three-dimensional internal flow field in a WJPP under a straight-pipe inlet and elbow inlet is numerically *** comparing the hydraulic performance of WJPP under the two inlet conditions,the internal relationship between the inlet mode and the flow pattern in the pump is *** on unsteady pressure fluctuation characteristics and wavelet analysis,the influence of the inlet mode on the rotating stall is revealed,and the stall transient propagation characteristics under critical stall conditions are *** disturbance effects of the inlet channel geometry disappear under low flow rate conditions,the main disturbance is induced by the highspeed countercurrent,and the flow pattern under the elbow inlet is better than that under the straight-pipe *** the straight-pipe inlet,the single-stall nucleus in the WJPP temporarily experiences a low-frequency and high-amplitude disturbance,which subsequently transforms into a mode of multi-stall nuclei with high-frequency circumferential *** the elbow inlet,the rotating stall always maintains a mode of high-amplitude and low-frequency disturbance,which represents the transient characteristics of a single stall core propagating in the circumferential direction inside the *** results of this study have a reference value for structural design optimization in a WJPP.

关键词： Waterjet propulsion pump Inlet condition Rotation stall Flow structure Pressurefluctuation

Clinical profile and outcomes of hepatocellular carcinoma in primary Budd-Chiari syndrome

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 699-715页

作者： Ankit agarwal Sagnik Biswas Shekhar Swaroop Arnav Aggarwal Ayush agarwal Gautam Jain Anshuman Elhence Arun Vaidya Amit Gupte Ravi Mohanka Ramesh kumar Ashwani kumar Mishra Shivanand Gamanagatti Shashi Bala Paul Subrat kumar Acharya Akash Shukla Shalimar Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Gastroenterology Seth Gordhandas Sunderdas Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sir HN Reliance Foundation HospitalMumbai 400004India Department of Liver Transplant and HPB Sir HN Reliance Foundation HospitalMumbai 400004India Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Professor of Biostatistics National Drug Dependence Treatment Centre(NDDTC)All India Institute of Medical SciencesNew Delhi 110029India Department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029DelhiIndia

BACkGROUND There is scant literature on hepatocellular carcinoma(HCC)in patients with Budd-Chiari syndrome(BCS).AIM To assess the magnitude,clinical characteristics,feasibility,and outcomes of treatment in *** A total of 904 BCS patients from New Delhi,India and 1140 from Mumbai,India were *** prevalence and incidence of HCC were determined,and among patients with BCS-HCC,the viability and outcomes of interventional therapy were *** In the New Delhi cohort of 35 BCS-HCC patients,18 had HCC at index presentation(prevalence 1.99%),and 17 developed HCC over a follow-up of 4601 person-years,[incidence 0.36(0.22-0.57)per 100 person-years].BCS-HCC patients were older when compared to patients with BCS alone(P=0.001)and had a higher proportion of inferior vena cava block,cirrhosis,and long-segment vascular *** median alpha-fetoprotein level was higher in patients with BCS-HCC at first presentation than those who developed HCC at follow-up(13029 ng/mL vs 500 ng/mL,P=0.01).Of the 35 BCS-HCC,26(74.3%)underwent radiological interventions for BCS,and 22(62.8%)patients underwent treatment for HCC[transarterial chemoembolization in 18(81.8%),oral tyrosine kinase inhibitor in 3(13.6%),and transarterial radioembolization in 1(4.5%)].The median survival among patients who underwent interventions for HCC compared with those who did not was 3.5 years vs 3.1 mo(P=0.0001).In contrast to the New Delhi cohort,the Mumbai cohort of BCS-HCC patients were predominantly males,presented with a more advanced HCC[Barcelona Clinic Liver Cancer C and D],and 2 patients underwent liver *** HCC is not uncommon in patients with *** interventions and liver transplantation are feasible in select primary BCS-HCC patients and may improve outcomes.

关键词： Budd chiari syndrome Cancer Cirrhosis Thrombosis Liver Varices Transarterial chemoembolization Hepatic venous outflow tract obstruction

***: SAR Deforestation Classification of Amazon Forest for Land Use Land Cover Application

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Journal of Computer and Communications 2024年第3期12卷 68-83页

作者： Priyanka Darbari Ankush agarwal Manoj kumar Computer Engineering and Application GLA University Mathura India Department of Information Technology GGV Bilaspur India

The process of turning forest area into land is known as deforestation or forest degradation. Reforestation as a fraction of deforestation is extremely low. For improved qualitative and quantitative classification, we used Sentinel-1 dataset of State of Para, Brazil to precisely and closely monitor deforestation between June 2019 and June 2023. This research aimed to find out suitable model for classification called Satellite Imaging analysis by Transpose deep neural transformation network (SIT-net) using mathematical model based on Band math approach to classify deforestation applying transpose deep neural network. The main advantage of proposed model is easy to handle SAR images. The study concludes that SAR satellite gives high-resolution images to improve deforestation monitoring and proposed model takes less computational time compared to other techniques.

关键词： Brazilian Amazon Sentinel-1 Band Math Transpose CNN Transformation Network