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印度-欧亚碰撞带的动力学

世界地震译丛 2003年第2期34卷 34-56页

作者： L．M．Flesch a.j.haines W．E．Holt 王宝善李娟不详中国地震局分析预报中心

根据大地测量学、地质学、地形学和地震数据,对亚洲地区(平均深度约100 km)垂向平均偏应力场进行了简单的新的动力学计算。通过解岩石层内与重力势能差有关的偏应力平衡方程和应力边界条件产生的一阶偏应力,我们可以初步得到对垂向平均... 详细信息

根据大地测量学、地质学、地形学和地震数据,对亚洲地区(平均深度约100 km)垂向平均偏应力场进行了简单的新的动力学计算。通过解岩石层内与重力势能差有关的偏应力平衡方程和应力边界条件产生的一阶偏应力,我们可以初步得到对垂向平均偏应力的最小绝对强度和方向的估计。这种垂向平均偏应力场的初始估计与关于岩石层流变性的假设无关。其绝对值从5 MPa 变到40 MPa。假设岩石层有明显的粘滞性,与该区域其他较硬地方约1～2.5×10^(23) Pa s 的粘滞系数相比,由偏应力强度、GPS 和第四纪断层滑动速率得到的应变率,导出了西藏垂向平均粘滞系数为0.5～5×10^(22) Pa s。利用速度边界条件解力平衡方程的正向模拟,我们能改进对垂向平均有效粘滞系数分布和偏应力场的估计。总的垂向平均偏应力和有效粘滞系数场与西藏较软弱的下地壳是一致的,它们也与西藏和华南岩石层相对欧亚的东向运动一致,它们确证了重力势能差对青藏高原周围应变率的空间变化方式和强度有极深刻的影响。我们的垂向平均偏应力的结果表明,较强的岩石层部分位于孕震的上地壳内,其偏应力强度高达100～300 MPa(与实验室和理论摩擦试验一致,显示出地震的应力降是总偏应力的小部分)。

关键词：板块构造动力学垂向平均偏应力场岩石层流变性

情报界开源情报战略(2024-2026年)

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情报理论与实践 2024年第9期47卷 F0003-F0003页

作者：吴兆桐(编译) haines A D BURNS W j 中国人民大学不详

开源情报(OSINT)是专门针对特定情报优先事项、要求或差距,从公开或商业可得信息中获取的情报。人工智能和机器学习技术的发展为开源情报价值的开发及利用提供了重要机遇,也对开源情报相关风险的规避提出了更高的要求。2024年3月8日,美... 详细信息

开源情报(OSINT)是专门针对特定情报优先事项、要求或差距,从公开或商业可得信息中获取的情报。人工智能和机器学习技术的发展为开源情报价值的开发及利用提供了重要机遇,也对开源情报相关风险的规避提出了更高的要求。2024年3月8日,美国国家情报总监办公室(ODNI)和中央情报局(CIA)联合发布《情报界开源情报战略(2024—2026年)》,旨在通过利用开源情报支持国家安全决策,维护国家安全和国家利益。

关键词：人工智能机器学习技术开源情报中央情报局情报界 OSI 开发及利用优先事项

"Micro-deletions" of the human Y chromosome and their relationship with male infertility

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journal of Genetics and Genomics 2008年第4期35卷 193-199页

作者： Zheng Li Christopher j haines Yibing Han Renji Hospital School of Medicine Shanghai Jiaotong University Shanghai Institute of Andrology Shanghai 200001 China Department of Obstetrics and Gynaecology Prince of Wales Hospital The Chinese University ofHong Kong Shatin NT Hong Kong SAR China

The Y chromosome evolves from an autochromosome and accumulates male-related genes including sex-determining region of Y-chromosome （SRY） and several spermatogenesis-related genes. The human Y chromosome （60 Mb long） is largely composed of repetitive sequences that give it a heterochromatic appearance, and it consists of pseudoautosomal, euchromatic, and heterochromatic regions. Located on the two extremities of the Y chromosome, pseudoautosomal regions 1 and 2 （PAR1 and PAR2, 2.6 Mb and 320 bp long, respectively） are homologs with the termini of the X chromosome. The euchromatic region and some of the repeat-rich heterochromatic parts of the Y chromosome are called ＂male-specific Y＂（MSY）, which occupy more than 95% of the whole Y chromosome. After evolution, the Y chromosome becomes the smallest in size with the least number of genes but with the most number of copies of genes that are mostly spermatogenesis-related. The Y chromosome is characterized by highly repetitive sequences （including direct repeats, inverted repeats, and palindromes） and high polymorphism. Several gene rearrangements on the Y chromosome occur during evolution owing to its specific gene structure. The consequences of such rearrangements are not only loss but also gain of specific genes. One hundred and fifty three haplotypes have been discovered in the human Y chromosome. The structure of the Y chromosome in the GenBank belongs to haplotype R1. There are 220 genes （104 coding genes, 111 pseudogenes, and 5 other uncategorized genes） according to the most recent count. The 104 coding genes encode a total of about 48 proteins/protein families （including putative proteins/protein families）. Among them, 16 gene products have been discovered in the azoospermia factor region （AZF） and are related to spermatogenesis. It has been discovered that one subset of gene rearrangements on the Y chromosome, ＂micro-deletions＂, is a major cause of male infertility in some populations. However, controversies e

关键词： human Y-chromosome micro-deletion male infertility

Involvement of Lipid Rafts and Cellular Actin in AcMNPV GP64 Distribution and Virus Budding

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Virologica Sinica 2009年第4期24卷 333-349页

作者： F. j. haines C. M. Griffiths R. D. Possee C. R. Hawes L. A. King School of Life Science Oxford Brookes University Veterinary Laboratories Agency-Wey-bridge New Haw Addlestone Surrey KT15 3NB UK. NERC Centre for Ecology & Hydrology (Oxford)

GP64 is the major envelope glycoprotein associated with the budded virus (BV) of Autographa californica nucleopolyhedrovirus (AcMNPV) and is essential for attachment and budding of BV particles. Confocal microscopy and flotation assays established the presence of lipid raft domains within the plasma membranes of AcMNPV-infected Sf9 cells and suggested the association of GP64 with lipid rafts during infection. GP64 and filamentous actin (F-actin) were found to co-localise at the cell cortex at 24 and 48 hpi and an additional restructuring of F-actin during infection was visualised, resulting in a strongly polarised distribution of both F-actin and GP64 at the cell cortex. Depletion of F-actin, achieved by treatment of Sf9 cells with latrunculin B (LB), resulted in the redistribution of GP64 with significant cytoplasmic aggregation and reduced presence at the plasma membrane. Treatment with LB also resulted in reduced production of BV in Sf9 cells. Analysis of virus gene transcription confirmed this reduction was not due to decreased trafficking of nucleocapsids to the nucleus or to decreased production of infectious progeny nucleocapsids. Reduced BV production due to a lack of GP64 at the plasma membrane of AcMNPV-infected Sf9 cells treated with LB, suggests a key role for F-actin in the egress of BV.

关键词： Autographa californica nucleopolyhedrovirus (AcMNPV) Actin Lipid rafts Egress

Mutations of t-complex testis expressed gene 5 transcripts in the testis of sterile t-haplotype mutant mouse

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Asian journal of Andrology 2008年第2期10卷 219-226页

作者： Yibing Han Xue-Xiong Song Huai-Liang Feng Che-Kwok Cheung Po-Mui Lam Chi-Chiu Wang Christophe john haines Department of Obstetrics and Gynaecology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong China Department of Animal Sciences Laiyang Agricultural College Qingdao Shandong 266109 China Center for Human Reproduction North Shore University Hospital NYU School of Medicine Manhasset NY 11030 USA Li Ka Shing Institute of Health Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong China

Aim： To determine the possible roles of the t-complex testis expressed gene 5 （Tctex5） on sperm functions, the fulllength sequence of mRNA was studied and compared in the testis between the normal wild-type and the sterile t-haplotype mutant mice. Methods： We applied rapid amplification of cDNA ends, Northern blot and reverse transcription polymerase chain reaction to analyze the full length of Tctex5 mRNAs isolated from testes of the wild-type and the t-haplotype mice. Reverse transcription polymerase chain reaction was used to semi-quantitatively compare expression of Tctex5 transcripts in the 16 tissues and 9.5 day stage embryos in the wild-type mice. E-translation was applied to estimate the amino acid sequences. Results： One long and one short transcript of Tctex5 mRNA were discovered in mouse testis of wild-type （Tctex5^long-＋ and Tctex5^short-＋） and t-haplotype （Tctex5^long-＋ and Tctex5^short-＋） mice, respectively. Being enhanced only in the testis, Tctex5^long-＋ had 17 point mutations and one 15-bp-deletion in the exon 1 region, comparing with the Tctex5^long-＋, whereas the Tctex5^short-＋ was similar to the Tctex5^short-＋. The short isoforms of Tctex5 mRNAs in the two models encoded exactly the same peptides, but the long isoforms did not. The estimated peptide encoded by Tctex5^long-＋ had significant mutations on putative sites of phosphorylation and PP1 binding. Conclusion： We established that mutations that occur in the Tctex5 long transcript of the t-haplotype mice are important for normal sperm function, whereas the short transcript of Tctex5 might have a conserved function among different tissues. （Asian j Androl 2008 Mar; 10： 219-226）

关键词： t-complex testis expressed gene 5 transcripts testis mice

Pregnancies from subzonal insemination of unfertilized oocytes after conventional IVF

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Chinese Medical journal 1997年第6期110卷 81-83页

作者： E.P.L.Loong T.T.Y.Chiu C.j.haines Department of Obstetrics and Gynaecology The Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong

ＰｒｅｇｎａｎｃｉｅｓｆｒｏｍｓｕｂｚｏｎａｌｉｎｓｅｍｉｎａｔｉｏｎｏｆｕｎｆｅｒｔｉｌｉｚｅｄｏｏｃｙｔｅｓａｆｔｅｒｃｏｎｖｅｎｔｉｏｎａｌＩＶＦＥ．Ｐ．Ｌ．Ｌｏｏｎｇ，Ｔ．Ｔ．Ｙ．ＣｈｉｕａｎｄＣ．Ｊ．Ｈａｉ... 详细信息

ＰｒｅｇｎａｎｃｉｅｓｆｒｏｍｓｕｂｚｏｎａｌｉｎｓｅｍｉｎａｔｉｏｎｏｆｕｎｆｅｒｔｉｌｉｚｅｄｏｏｃｙｔｅｓａｆｔｅｒｃｏｎｖｅｎｔｉｏｎａｌＩＶＦＥ．Ｐ．Ｌ．Ｌｏｏｎｇ，Ｔ．Ｔ．Ｙ．ＣｈｉｕａｎｄＣ．Ｊ．ＨａｉｎｅｓｂｊｅｃｔｉｖｅＴｏｅｖａｌ...

关键词： INTRACYTOPLASMIC SPERM INjECTION IN-VITRO FERTILIZATION INVITRO REINSEMINATION PENETRATION CLEAVAGE SUZI ICSI

STRUCTURAL AND MAGNETIC CHARACTERISATION OF ORGANOMETALLIC SALTS OF TCNQ AND DCNQI

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STRUCTURAL AND MAGNETIC CHARACTERISATION OF ORGANOMETALLIC S...

Destructive and Nondestructive Determination of <sup>226</sup>Ra and <sup>228</sup>Ra in Drinking Water by Gamma Spectrometry

Sixteenth Congress of the International Union of Crystallography

作者： R.Büchner j.S.Field R.j.haines Department of Chemistry University of NatalP.O.Box 375Pieter-maritzburg 3200South Africa

The dinuclear electron-rich thiolato-bridged donor [FeCp*(CO)(μ-SEt)](Cp =pentamethylcyclopentadienide) reacts with TCNQ(7,7,8,8-tetracyanoquinodimethane) to afford the 1:1 charge-transfer salt [FeCp*(CO)(y-SEt)](TCNQ).X-ray diffraction studies reveal that the donor cations(D·+) and acceptor anions(A.-) stack in the crystal in the sequence ???D’A?~?D?-???with the anions present as diamagnetic pairs(TCNQ).the room temperature magnetic susceptibility confirms a S=1/2 ***

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journal of Environmental Protection 2020年第4期11卷 257-268页

作者： A. j. Khan A. Bari M. A. Torres D. K. haines T. j. Hoffman T. M. Semkow Wadsworth Center New York State Department of Health Albany NY USA Department of Environmental Health Sciences School of Public Health University at Albany State University of New York Rensselaer NY USA

The Safe Drinking Water Act (SDWA) mandates that the drinking water should be monitored for 226Ra and 228Ra isotopes and establishes the Maximum Contaminant Level of 185 mBq/L (5 pCi·L-1) for the sum. In addition, SDWA regulates the Detection Limit (DL) of 37.0 mBq/L (1 pCi/L) for each isotope. The purpose of this work is to develop a working method for the determination of radium isotopes in drinking water satisfying the regulatory requirements of U.S. Environmental Protection Agency by utilizing our extensive experience in low-background gamma spectrometry at this laboratory. Two versions of the method were studied: destructive and non-destructive. Destructive method used the BaSO4 coprecipitation as well as 133Ba tracer for chemical recovery. We have used three gamma spectrometers: low-background 102% and 134% efficient with top muon guards, as well as an ultralow-background 140% efficient with full muon guard. We obtained a range of DLs from 5.3 to 22.6 mBq/L for 226Ra and from 7.4 to 30.4 mBq/L for 228Ra using the destructive method. For non-destructive method, the DL range was 26.0 to 26.9 mBq/L for 226Ra and 27.6 to 28.6 mBq/L for 228Ra using the 140% detector. To verify the methods, 7 to 10 laboratory control samples were spiked with both 226Ra and 228Ra at two different activities of 37.0 and 185 mBq/L. The results were evaluated by performing a combined location/variance chi-square test at a right-tail significance of 0.01 (99% Confidence Level), as stipulated by EPA. The verification results passed the chi-square tests at both activity levels. The destructive method can be accomplished using low-background gamma spectrometry, whereas non-destructive method requires ultralow-background gamma spectrometry.

关键词： Radioactive Pollution Germanium Detector Detection Limit Chi-Square Test

Nitric Oxide Inhibits Apoptosis-Related Gene Expression Vias-Nitrosyiation in a Caspase-9 Dependent Fashion

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Nitric Oxide Inhibits Apoptosis-Related Gene Expression Vias...