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Physical activity with or without dietary intervention for the prevention of cardiovascular diseases

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journal of Sport and Health Science 2024年第6期13卷 753-755页

作者： Carl j.Lavie Salvatore Carbone Leandro Slipczuk The john Ochsner Heart and Vascular Institute Ochsner Clinical Schoolthe University of Queensland School of MedicineNew OrleansLA 70121USA Department of Kinesiology and Health Sciences College of Humanities and SciencesVirginia Commonwealth UniversityRichmondVA 23284USA Montefiore Health System/Albert einstein College of Medicine BronxNY 10461USA

We and others have published extensively on the benefits of physical activity(PA),exercise training,and cardiorespiratory fitness(CRF)to decrease the prevalence of cardiovascular diseases(CVDs)and CVD and all-cause morbidity and mortality.^(1-5)Both PA and CRF are important;however,CRF,which is mostly obtained through PA,although there is a genetic component,seems to be even more important than PA for predicting prognosis.^(1,4-6)Certainly,the wealth of data from across the world has indicated that increasing PA to enhance CRF while mitigating sedentary behavior would go a long way to lessen the world-wide obesity epidemic and reduce CVD and all-cause mortality.

关键词： mortality prevention diseases

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The initial stages of Li_(2)O_(2) formation during oxygen reduction reaction in Li-O_(2) batteries:The significance of Li_(2)O_(2) in charge-transfer reactions within devices

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journal of Energy Chemistry 2024年第1期88卷 223-231,I0006页

作者： Daniela M.josepetti Bianca P.Sousa Simone A.j.Rodrigues Renato G.Freitas Gustavo Doubek Advanced Energy Storage Division LABCenter for Innovation on New EnergiesSchool of Chemical EngineeringUniversity of CampinasAv Albert Einstein 50013083-852CampinasSPBrazil Institute of Physics&Department of Chemistry Laboratory of Computational MaterialsFederal University of Mato Grosso78060-900CuiabáMTBrazil

Lithium-oxygen batteries are a promising technology because they can greatly surpass the energy density of lithium-ion ***,this theoretical characteristic has not yet been converted into a real device with high *** with air contamination,metallic lithium reactivity,and complex discharge and charge reactions are the main issues for this technology.A fast and reversible oxygen reduction reaction(ORR)is crucial for good performance of secondary batteries',but the partial knowledge of its mechanisms,especially when devices are concerned,hinders further *** this perspective,the present work uses operando Raman experiments and electrochemical impedance spectroscopy(EIS)to assess the first stages of the discharge processes in porous carbon electrodes,following their changes cycle by cycle at initial operation.A growth kinetic formation of the discharge product signal(Li_(2)O_(2))was observed with operando Raman,indicating a first-order reaction and enabling an analysis by a microkinetic *** solution mechanism in the evaluated system was ascribed for an equivalent circuit with three time *** the time constant for the anode interface reveals to remain relatively constant after the first discharge,its surface seemed to be more *** model indicated that the reaction occurs at the Li_(2)O_(2) surface,decreasing the associated resistance during the initial discharge ***,the growth of Li_(2)O_(2) forms a hetero-phase between Li_(2)O_(2)/electrolyte,while creating a more compact and homogeneous on the Li_(2)O_(2)/cathode *** methodology here described thus offers a way of directly probing changes in surface chemistry evolution during cycling from a device through EIS analysis.

关键词： Li-O_(2)battery Operando Raman analysis Equivalent circuit modeling Time-constant distribution

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Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah E.Est-Witte Sydney R.Shannon Dennis H.Gong Kaitlyn G.Calabresi jawaun j.Harris Kaitlyn Storm Edwin j.Yoo Ariel Isser Vivek P.jani Natalie K.Livingston Mary O.Omotoso Kelly Rhodes Elana Ben-Akiva Randall A.Meyer Zoe T.Hsieh Simone Sidoli Stephany Y.Tzeng jonathan P.Schneck jordan j.Green Translational Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aAPC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

Evolution of heart transplant donor characteristics in the 21st century: A United States single center’s experience

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World journal of Transplantation 2024年第3期14卷 22-29页

作者： Alexander M Spring Christiana Gjelaj Shivank Madan Snehal R Patel Omar Saeed Sandhya Murthy Yogita Rochlani Daniel B Sims Sasha Vukelic Stephen j Forest jamil F Borgi Daniel j Goldstein Ulrich P jorde Montefiore-einstein Center for Heart and Vascular Care Montefiore Medical CenterAlbert Einstein College of MedicineBronxNY 10467United States Division of Cardiothoracic Surgery Tulane UniversityNew OrleansLA 70112United States

Despite a record setting number of heart transplants performed annually,the national donor shortage continues to plague transplant teams across the United *** we describe the barriers to adaptation of numerous“non-traditional”orthotopic heart transplant donor characteristics including donors with hepatitis C virus,those meeting criteria for donation after cardiac death,donors with coronavirus disease 19 infection,donors with the human immunodeficiency virus,and grafts with left ventricular systolic *** center’s objective was to increase our transplant volume by expanding our donor pool from“traditional”donors to these“non-traditional”*** detail how medical advances such as certain laboratory studies,pharmacologic interventions,and organ care systems have allowed our center to expand the donor pool thereby increasing transplantation volume without adverse effects on outcomes.

关键词： Orthotopic heart transplantation Hepatitis C virus COVID-19 Left ventricular systolic dysfunction Human immunodeficiency virus Donation after cardiac death

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测定岩石三轴压缩强度建议方法(修订)

岩石力学与工程学报 1985年第1期 56-63页

作者： K.Kovari A.Tisa H.H.einstein j.A.Franklin 宋琳

1.范围和序言本方法叙述三种不同类型的三轴压缩试验。这些试验都是测定圆柱形岩石试样以围压作为函数的强度。这三类试验的区别在于获得强度包络线的方式有所不同(图1a—c)。第1类试验(“单个破坏状态试验”)包络线上的每个破坏点(峰... 详细信息

1.范围和序言本方法叙述三种不同类型的三轴压缩试验。这些试验都是测定圆柱形岩石试样以围压作为函数的强度。这三类试验的区别在于获得强度包络线的方式有所不同(图1a—c)。第1类试验(“单个破坏状态试验”)包络线上的每个破坏点(峰值强度)是由若干个岩样的试验获得的(图1a);而第Ⅱ类试验(多级破坏状态试验)(图1b)和第Ⅲ类试验(连续破坏状态试验) (图1c)的包络线是用一个试验采用逐级或连续加载的方法获得的。因此从

关键词：围压轴向应力强度包络线峰值强度三轴压力室残余强度轴向荷载轴向应变

Albert einstein chief engineer of the universe = Ingenieur des Universums jürgen Renn (***.).

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丛书名： Abenteuer Wissensgeschichte =

2005年

作者： jürgen Renn (Hrsg./ed.).

来源：畅想之星图书光盘版（南... 评论

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体验宇宙爱因斯坦如是说 1版

Temperature and structure measurements of heavy-ion-heated diamond using in situ X-ray diagnostics

丛书名：巨人语丝

1994年

作者：（美）爱因斯坦（Albert einstein）龚建星刘毅强选编

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Matter and Radiation at Extremes 2024年第4期9卷 80-89页

作者： j.Lutgert P.Hesselbach M.Schorner V.Bagnoud R.Belikov P.Drechsel B.Heuser O.SHumphries P.Katrik B.Lindqvist C.Qu R.Redmer D.Riley G.Schaumann S.Schumacher A.Tauschwitz D.Varentsov K.Weyrich X.Yu B.Zielbauer Zs.Major P.Neumayer D.Kraus Institut fur Physik Universitat RostockAlbert-Einstein-Str.2318059 RostockGermany GSI Helmholtzzentrum fur Schwerionenforschung Planckstr.164291 DarmstadtGermany Institut für Angewandte Physik Goethe-Universität Frankfurt am MainMax-von-Laue-Str.160438 Frankfurt am MainGermany Institut fur Geowissenschaften Goethe-Universitat Frankfurt am MainAltenhoferallee 160438 Frankfurt am MainGermany Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstr.40001328 DresdenGermany European XFEL GmbH Holzkoppel 422869 SchenefeldGermany Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastUniversity RoadBelfast BT71NNUnited Kingdom Institut für Kernphysik Technische Universität DarmstadtSchlossgartenstr.964289 DarmstadtGermany State Key Laboratory of Nuclear Physics and Technology Institute of Heavy Ion PhysicsPeking UniversityBeijing 100871China Helmholtz Institut jena Frobelstieg 307743 JenaGermany

We present in situ measurements of spectrally resolved X-ray scattering and X-ray diffraction from monocrystalline diamond samples heatedwith an intense pulse of heavy *** this way,we determine the samples’heating dynamics and their microscopic and macroscopic structuralintegrity over a timespan of several *** the ratio of elastic to inelastic scattering with state-of-the-art density functionaltheory molecular dynamics simulations allows the inference of average temperatures around 1300 K,in agreement with predictions fromstopping power *** simultaneous diffraction measurements show no hints of any volumetric graphitization of the material,butdo indicate the onset of fracture in the diamond *** experiments pave the way for future studies at the Facility for Antiproton andIon Research,where a substantially increased intensity of the heavy ion beam will be available.

关键词： heated intense structure

Kerr-AdS黑洞的基于独立联络形式拉氏量的守恒量

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四川大学学报（自然科学版） 2024年第1期61卷 149-154页

作者：王耀郭伟杰彭俊金贵州师范大学物理与电子科学学院贵阳550001 贵州师范大学贵州省射电天文数据处理重点实验室贵阳550001

基于爱因斯坦引力理论的独立联络形式,由诺特定理可以导出一个含任意参考背景仿射联络的推广Katz-Bicak-Lynden-Bell(KBL)势,借此得到一个守恒量定义式.本文把该定义式应用于渐近anti-de Sitter(AdS)且转动的Kerr-AdS黑洞时空的质量与... 详细信息

基于爱因斯坦引力理论的独立联络形式,由诺特定理可以导出一个含任意参考背景仿射联络的推广Katz-Bicak-Lynden-Bell(KBL)势,借此得到一个守恒量定义式.本文把该定义式应用于渐近anti-de Sitter(AdS)且转动的Kerr-AdS黑洞时空的质量与角动量的定义,给出了与其他标准方法一致的结果.特别地,本文首次构造了一个比通常KBL超势中的参考背景联络更具一般性的新联络,相关结果表明KBL方法中的参考背景联络不具有唯一性,而对它的基本要求就是保持理论的协变性.

关键词： Kerr-AdS黑洞引力场的守恒荷 KBL方法 Kerr黑洞