检索结果-南通市图书馆

An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-Ha jeong jarno Hiemstra Patrick V.Blokzijl Rebeca Damian-Ferrara Danilo Martins dos Santos jéssica H.L.da Fonseca Min-Ho Kang jihyun Kim Dilara Yilmaz-Aykut Mei L.L.cham-Pérez jeroen Leijten Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

运用LV-METRIC软件自动分析左室壁的节段性运动

引用

国际医学放射学杂志 2008年第A6期31卷 492-493页

作者： N.C.Codella j.W.Weinsaft M.D.cham M.janik M.R Prince 李翠玲 Department of Physiology Biophysics and Systems Bi-ologyWeill Medical College of Cornell University575 Lexington Ave3rd FloorNewYorkNYUSA.

本研究对现有资料进行了回顾性分析,并得到学术审查委员会批准,属于HIPPA依从研究,免除了病人的知情同意。

关键词： LV-METRIC 学术审查左室心肌左室壁知情同意肌小梁左室容积体素射血分数相关系数

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

半夏泻心汤人含药血清对HP感染GES-1细胞TGF-β/Smad信号通路的影响

引用

中国实验方剂学杂志 2018年第14期24卷 91-96页

作者：黄彦平詹达法黄海陈少芳福建中医药大学中医学院福州350122 福建中医药大学药学院福州350122

目的：探讨半夏泻心汤人含药血清对幽门螺杆菌（Helicobacter pylori,HP）感染人胃黏膜上皮GES-1细胞转化生长因子-β（TGF-β）/信号转导蛋白（Smad）信号通路的影响,以揭示该方治疗消化性溃疡可能的作用机制。方法：GES-1细胞分为空白... 详细信息

目的：探讨半夏泻心汤人含药血清对幽门螺杆菌（Helicobacter pylori,HP）感染人胃黏膜上皮GES-1细胞转化生长因子-β（TGF-β）/信号转导蛋白（Smad）信号通路的影响,以揭示该方治疗消化性溃疡可能的作用机制。方法：GES-1细胞分为空白组,HP感染模型组,健康人血清组,雷贝拉唑血清组,用药前血清组,10%半夏泻心汤血清组,20%半夏泻心汤血清组。除空白组外,其余各组均接种HP造成幽门螺杆菌感染模型,采用雷贝拉唑、半夏泻心汤含药血清及用药前、健康人血清进行干预,24 h后收集细胞及其上清液,噻唑蓝（MTT）比色法检测细胞增殖情况;蛋白质免疫印迹法（Western blot）检测Smad2/3,Smad7,TGF-β1及磷酸化Smad2/3（p-Smad2/3）,磷酸化Smad7（p-Smad7）蛋白的表达。结果：与空白组比较,HP可明显抑制GES-1细胞的增殖,降低GES-1细胞内Smad2/3,TGF-β1及p-Smad2/3蛋白表达,增加Smad7及p-Smad7蛋白表达（P〈0.05,P〈0.01）;与HP感染模型组比较,雷贝拉唑血清组及10%,20%半夏泻心汤血清组可明显降低HP对GES-1细胞增殖的抑制,增加GES-1细胞内Smad2/3,TGF-β1,p-Smad2/3蛋白表达,并明显降低Smad7,p-Smad7蛋白表达（P〈0.05,P〈0.01）;与用药前血清组比较,加入雷贝拉唑、半夏泻心汤含药血清后均可降低HP对GES-1细胞增殖的抑制,其中雷贝拉唑血清组及20%半夏泻心汤血清组可增加GES-1细胞内Smad2/3,TGF-β1,p-Smad2/3蛋白表达,降低Smad7,p-Smad7蛋白表达（P〈0.05,P〈0.01）。结论：半夏泻心汤能够减轻HP诱导GES-1细胞的损伤,促进GES-1细胞增殖,治疗HP相关性消化性溃疡,提高溃疡愈合质量,其机制可能与其调控TGF-β/Smad信号通路有关。

关键词：半夏泻心汤幽门螺杆菌人胃黏膜上皮GES-1细胞转化生长因子-β(TGF-β)/信号转导蛋白(Smad)信号通路

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

应用低剂量胸部CT扫描的冠状动脉钙化评分预测心血管疾病死亡

引用

国际医学放射学杂志 2011年第1期34卷 78-页

作者： j.Shemesh C.I.Henschke D.Shaham R.Yip A.O.Farooqi M.cham 于静 Department of Cardiology Grace Ballas Cardiac Research UnitSheba Medical Center

目的对低剂量胸部CT扫描显示的冠状动脉钙化(CAC)进行视觉评分,评估其预测心血管疾病死亡的价值。材料与方法根据机构审查委员会批准的方案。

关键词：低剂量胸部躯干心血管疾病冠状动脉 CT

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Magma chamber growth models in the upper crust: A review of the hydraulic and inertial constraints

引用

Geoscience Frontiers 2019年第3期10卷 1211-1218页

作者： Eugenio Aragón Fernando j.D'Eramo Lucio P.Pinotti Manuel Demartis josé María Tubía Roberto F.Weinberg jorge E.Coniglio Centro de Investigaciones Geologicas (CONICET-Universidad Nacional de La Plata).Diagonal 113 N° 275 Universidad Nacional de Río Cuarto CONICET Departamento de Geología (Ruta Nac.N° 36 Km 601) Departamento de Geodinámica Universidad del País Vasco (UPV/EHU) School of Earth Atmosphere and Environment Monash University

Finite volumes of magma moving in confinement, store hydraulic potential energy for the generation,control and transmission of power. The Pascal's principle in a hydraulic jack arrangement is used to model the vertical and lateral growth of sills. The small input piston of the hydraulic jack is equivalent to the feeder dike, the upper large expansible piston equivalent to the magmatic chamber and the inertial force of the magma in the dike is the input force. This arrangement is particularly relevant to the case of sills expanding with blunt tips, for which rapid fracture propagation is inhibited. Hydraulic models concur with experimental data that show that lateral expansion of magma into a sill is promoted when the vertical ascent of magma through a feeder dike reaches the bottom contact with an overlying, flat rigid-layer. At this point, the magma is forced to decelerate, triggering a pressure wave through the conduit caused by the continued ascent of magma further down(fluid-hammer effect). This pressure wave can provide overpressure enough to trigger the initial hydraulic lateral expansion of magma into an incipient sill, and still have enough input inertial force left to continue feeding the hydraulic system. The lateral expansion underneath the strong impeding layer, causes an area increase and thus, further hydraulic amplification of the input inertial force on the sides and roof of the incipient sill, triggering further expansion in a self-reinforcing process. Initially, the lateral pressure increase is larger than that in the roof allowing the sill to expand. However, expansion eventually increases the total integrated force on the roof allowing its uplift into either a laccolith, if the roof preserves continuity, or into a piston bounded by a circular set of fractures. Hydraulic models for shallow magmatic chambers, also suggest that laccolith-like intrusions require the existence of a self-supported chamber roof. In contrast, if the roof of magmatic cham

关键词： Pascal’s principle Geologic hydraulic jack Emplacement Sills growth Fluid hammer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of the thin cell layer technique in the induction of somatic embryos in Pinus patula Schl. et cham

引用

journal of Forestry Research 2019年第4期30卷 1535-1539页

作者： Marco A.Ramirez-Mosqueda Lourdes G.Iglesias-Andreu Arturo A.Armas-Silva Esmeralda j.Cruz-Gutierrez jose F.de la Torre-Sanchez Otto R.Leyva-Ovalle Carlos M.Galan-Paez Instituto de Biotecnologfa y Ecologfa Aplicada(INBIOTECA) Universidad Veracruzana.Av.de las Culturas Veracruzanas No.101Campus para la Culturalas Artes y el DeporteCol.Emiliano ZapataC.P.91090 XalapaVeracruzMexico Centro Nacional de Recursos Geneticos-INIFAP Boulevard de la Biodiversidad No.400 Rancho las CrucesC.P.47600 Tepatitlan de MorelosJaliscoMexico Facultad de Ciencias Bioldgicas y Agropecuarias Region Cordoba-Orizaba Universidad VeracruzanaC.P.94945 Amatlan de los ReyesVeracruzMexico

Pinus patula is a species commonly used for reforestation in ***,efficient methods for the mass production seedlings are *** particularly by somatic embryogenesis provides an option for the rapid multiplication of high-quality,genetically improved *** study induces somatic embryogenesis in this species using the thin cell layer(TCL)*** sources of explants(complete immature embryos;lTCL segments from immature embryos)were *** efficiency of TCL from longitudinal sections[lTCL]and transverse[tTCL]was *** results show using thin cell layers from immature embryos cultivated in 16 light/8 dark hours achieves induction of somatic embryos.A higher percentage of embryogenic callus was obtained when tTCL segments were used as an explant *** results produced somatic embryos from tTCL segments of an immature embryo without germinating the seed,making the process more time *** addition,this technique can be used to generate somatic embryogenesis in forest species that have low germination rates.

关键词： Pinus patula Somatic embryos Micropropagation Thin cell layer Maturation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

血小板源生长因子诱导血管平滑肌细胞迁移及机构

引用

中国动脉硬化杂志 1998年第1期6卷 10-14页

作者：谢良地吴可贵陈达光 A.D.Hughes Z.Clunn j.Lymn 福建医科大学附属第一医院心内科福建省高血压研究所福建省教委英国文化委员会英国帝国理工医学院临床药理系

为探讨血小板源生长因子诱导血管平滑肌细胞迁移和细胞内信号传递机制。以体外培养的平滑肌细胞为对象，用血小板源生长因子ＢＢ二聚体作诱导刺激物，采用改良的Ｂｏｙｄｅｎ微孔膜双槽法进行细胞迁移实验，荧光染料Ｆｕｒａ－２法测定... 详细信息

为探讨血小板源生长因子诱导血管平滑肌细胞迁移和细胞内信号传递机制。以体外培养的平滑肌细胞为对象，用血小板源生长因子ＢＢ二聚体作诱导刺激物，采用改良的Ｂｏｙｄｅｎ微孔膜双槽法进行细胞迁移实验，荧光染料Ｆｕｒａ－２法测定细胞内游离钙离子浓度。结果发现，血小板源生长因子ＢＢ二聚体能明显诱导体外培养的平滑肌细胞迁移，使细胞内游离钙离子浓度（［Ｃａ２＋］ｉ）明显升高（Ｐ＜０．０１），峰值浓度位于５ｇ／Ｌ。１００ｍｏｌ／Ｌ钙离子螯合剂ＢＡＰＴＡ和酪氨酸激酶抑制剂５０ｍｏｌ／Ｌ　Ｇｅｎｉｓｔｅｉｎ既能抑制血小板源生长因子－ＢＢ诱发的升高，也能抑制血小板源生长因子对平滑肌细胞的诱导趋化迁移作用。实验结果提示，血小板源生长因子是诱导平滑肌细胞迁移的趋化物；升高是平滑肌细胞对血小板源生长因子反应的早期细胞内信号传递通路之一；血小板源生长因子诱发的平滑肌细胞迁移既依赖于升高，又依赖于酪氨酸蛋白激酶活性。

关键词： PDGF 平滑肌细胞迁移动脉粥样硬化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：