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Propylthiouracyl-induced severe liver toxicity:An indication for alanine aminotransferase monitoring?

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World journal of Gastroenterology 2006年第38期12卷 6232-6234页

作者： M Benyounes C Sempoux C Daumerie j Rahier AP Geubel Departments of Gastroenterology Endocrinology and Pathology St Luc University Hospital Université Catholique de Louvain Brussels 1200 Belgium

Propylthiouracyl (PTU)-related liver toxicity is likely to oc- cur in about 1% of treated patients. In case of acute or subacute hepatitis, liver failure may occur in about one third. We report two further cases of PTU-induced sub- acute hepatitis, in whom the delay between occurrence of liver damage after the initiation of treatment, the un- derestimation of its severity and the delayed withdrawal of the drug were all likely responsible for liver failure. The high incidence of liver toxicity related to PTU, its potential severity and delayed occurrence after initiation of treatment are in favor of monthly alanine aminotrans- ferase monitoring, at least during the first six months of therapy.

关键词： Hepatitis Drug-induced liver toxicity Propylthiouracil Alanine aminotransferase

Mass-balance ecosystem model of the East China Sea

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Progress in Natural Science:Materials International 2009年第10期19卷 1271-1280页

作者： William W.L. Cheung Tony j. Pitcher The Fisheries Centre University of British Columbia

Using the Ecopath mass-balance trophodynamic model,this paper analyzed the trophic levels,flows,food web structure and ecosystem maturity of the East China Sea,and identified ecologically important functional groups in the *** model is based on fishery resource surveys of the East China Sea in 2000,studies on diet composition and global databases such as FishBase and the Sea Around Us Project *** results showed that trophic levels of the functional groups are between 2.86 and 4.37,with an average of ***(Engraulis japonicus),small fishes and benthic crustaceans such as shrimps and crabs are important groups in terms of the trophic structure and flow dynamics in the East China *** flows of most groups are between specific trophic levels,except file fish(Thamnaconus spp.),pomfret(Pampus spp.) and *** transfer efficiency of levels Ⅱ,Ⅲ,IV and more than V are 11.8%,21.1%,17.4% and 22.1-22.5%,*** of fishery-the largest ‘consumer’ of the ecosystemare much stronger than those exerted by biological groups in the *** model suggests that the current fishery can further reduce the complexity of the *** of the system indices suggest that maturity of the ecosystem is *** conclusion of this model indicates that it was the overfishing that caused the ecosystem of the East China Sea declined,which should be taken into account as a critical reference for fisheries management in the future.

关键词： Ecopath East China Sea Mass-balance Fishery Ecosystem

Analyses of plasma reactive sputter deposition of CN_x films by OES

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Chinese Science Bulletin 1997年第21期42卷 1792-1795页

作者： Zhao, j Kang, N Wang, jG Wang, RY Xu, jR Chinese Acad Sci Inst Phys Lab Opt Phys Beijing 100080 Peoples R China

OPTICAL emission spectroscopy (OES) is generally used in diagnosis on the various plasma filmdeposition processes to understand the mechanism of film growth. However, although the de-position precursors have been predicted such as CN radicals and nitrogen atoms, up tonow no diagnostic work on CN_x film deposition process, as we know, has been reported *** previously reported research work, the properties of CN_x film display some obvious dif-ference. For instance, some CN_x films have extreme mechanical properties with hardness

关键词： carbon nitride fiim optical emission spectras optical gap.

Synthesis of Novel Fluorine-Containing Surfactants Using Aleuritic Acid as a Starting Material

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Chinese Chemical Letters 1997年第6期8卷 497-498页

作者： Yang, j Liu, jT Wang, jQ Huang, WY Li, jY CHINESE ACAD SCI SHANGHAI INST ORGAN CHEMLAB ORGANOFLUORINE CHEMSHANGHAI 200032PEOPLES R CHINA CAF RES INST ECON ENTOMOLKUNMING 650216PEOPLES R CHINA

A novel type of fluorine-containing surfactants 5 was synthesized using aleuritic acid as a starting material in sis steps with an overall yield of 9%.

关键词： ppm CD CO IR cm CF Synthesis of Novel Fluorine-Containing Surfactants Using Aleuritic Acid as a Starting Material

基于深度学习的MRI影像组学无创识别HER2低表达状态可预测乳腺癌病人的无病生存期

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国际医学放射学杂志 2024年第2期 252-253页

作者： Y.Guo X.T.Xie W.j.Tang S.Y.Chen M.Y.Wang Y.H.Fan 侯唯姝

摘要目的建立基于深度学习的MRI影像组学（DLR）特征模型，以预测人表皮生长因子受体2(HER2)低表达状态，并进一步通过DLR模型验证乳腺癌病人在预后方面的

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Epigenetics and pancreatic cancer:Pathophysiology and novel treatment aspects

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World journal of Gastroenterology 2014年第24期20卷 7830-7848页

作者： Daniel Neureiter Tarkan jger Matthias Ocker Tobias Kiesslich Institute of Pathology Paracelsus Medical University/Salzburger Landeskliniken (SALK)5020 SalzburgAustria Department of Surgery Paracelsus Medical University/Salzburger Landeskliniken (SALK)5020 SalzburgAustria Experimental Medicine Oncology Bayer Pharma AG13342 BerlinGermany Department of Internal Medicine I Paracelsus Medical University/Salzburger Landeskliniken (SALK)5020 SalzburgAustria Institute of Physiology and Pathophysiology Paracelsus Medical University5020 SalzburgAustria

An improvement in pancreatic cancer treatment represents an urgent medical goal. Late diagnosis and high intrinsic resistance to conventional chemotherapy has led to a dismal overall prognosis that has remained unchanged during the past decades. Increasing knowledge about the molecular pathogenesis of the disease has shown that genetic alterations, such as mutations of K-ras, and especially epigenetic dysregulation of tumor-associated genes, such as silencing of the tumor suppressor p16ink4a, are hallmarks of pancreatic cancer. Here, we describe genes that are commonly affected by epigenetic dysregulation in pancreatic cancer via DNA methylation, histone acetylation or miRNA (microRNA) expression, and review the implications on pancreatic cancer biology such as epithelial-mesenchymal transition, morphological pattern formation, or cancer stem cell regulation during carcinogenesis from PanIN (pancreatic intraepithelial lesions) to invasive cancer and resistance development. Epigenetic drugs, such as DNA methyltransferases or histone deactylase inhibitors, have shown promising preclinical results in pancreatic cancer and are currently in early phases of clinical development. Combinations of epigenetic drugs with established cytotoxic drugs or targeted therapies are promising approaches to improve the poor response and survival rate of pancreatic cancer patients.

关键词： Pancreatic cancer Epigenetics DNA methylation Histone modification microRNA Targeted therapy Epithelial-mesenchymal transition

Conic hyperspectral dispersion mapping applied to semiconductor plasmonics

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Light(Science & Applications) 2012年第1期1卷 48-55页

作者： Dominic Lepage Alvaro jimenez jacques Beauvais jan j Dubowski Department of Electrical and Computer Engineering Interdisciplinary Institute for Technological Innovation(3IT)Universite´de SherbrookeSherbrookeQue´.Canada

The surface plasmon resonance tracking over metal surfaces is a well-established,commercially available,biochemical quantification tool primarily applied in *** utilization of such a tool is,however,constrained to highly specialized industries,capable of justifying the human and instrumental resource investments required by the characterization *** have proposed to expand the field of application of this biosensing approach by redesigning this method through the integration and miniaturization within a semiconductor *** and broadband emission from a light-emitting semiconductor is employed to couple a continuum of surface plasmon modes over a metal–dielectric architecture interfaced with a GaAs–AlGaAs substrate.A tensor version of rigorous coupled wave theory is employed to optimize the various fabrication specifications and to predict the light scatterings over a wide range of *** then present a hyperspectral characterization microscope capable of directly mapping the dispersion relation of scattered light,including diffracted surface plasmons,as an intensity distribution versus photon energy and surface *** carried out in a buffered solution demonstrate the accurate description of the uncollimated and broadband surface plasmon ***,we introduce a simplified method of dispersion mapping,in which quasi-conic cross-sections of the light’s scattering can be acquired directly,thus monitoring surficial responses in as fast as 1.2 *** is over 300 times faster than required by implementing full dispersion *** compromising on the volume of collected information,this method,combined with the solid-state integration of the platform,shows great promise for the fast detection of biochemical agents.

关键词： biosensors light scattering optical devices semiconductors surface plasmon resonance

Avalanche boron fusion by laser picosecond block ignition with magnetic trapping for clean and economic reactor

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High Power Laser Science and Engineering 2016年第4期4卷 1-9页

作者： H.Hora G.Korn S.Eliezer N.Nissim P.Lalousis L.Giuffrida D.Margarone A.Picciotto G.H.Miley S.Moustaizis j.-M.Martinez-Val C.P.j.Barty G.j.Kirchhoff Department of Theoretical Physics University of New South Wales ELI-Beamline Project Inst. PhysicsASCRPALS Center Institute of Nuclear Fusion Polytechnic University of Madrid Soreq Research Center Institute of Electronic Structure and Lasers FORTH Micro-Nano Facility Fondazione Bruno Kessler Department of Nuclear Plasma & Radiological Engineering University of Illinois Technical University Crete Laboratory of Matter Structure and Laser Physics Lawrence Livermore National Laboratory UjK Management GmbH

Measured highly elevated gains of proton–boron(HB11) fusion(Picciotto et al., Phys. Rev. X 4, 031030(2014))confirmed the exceptional avalanche reaction process(Lalousis et al., Laser Part. Beams 32, 409(2014); Hora et al.,Laser Part. Beams 33, 607(2015)) for the combination of the non-thermal block ignition using ultrahigh intensity laser pulses of picoseconds duration. The ultrahigh acceleration above 10^(20) cm s^(-2)for plasma blocks was theoretically and numerically predicted since 1978(Hora, Physics of Laser Driven Plasmas(Wiley, 1981), pp. 178 and 179) and measured(Sauerbrey, Phys. Plasmas 3, 4712(1996)) in exact agreement(Hora et al., Phys. Plasmas 14, 072701(2007)) when the dominating force was overcoming thermal processes. This is based on Maxwell's stress tensor by the dielectric properties of plasma leading to the nonlinear(ponderomotive) force f_(NL)resulting in ultra-fast expanding plasma blocks by a dielectric explosion. Combining this with measured ultrahigh magnetic fields and the avalanche process opens an option for an environmentally absolute clean and economic boron fusion power reactor. This is supported also by other experiments with very high HB11 reactions under different conditions(Labaune et al., Nature Commun.4, 2506(2013)).

关键词： boron fusion energy dielectric nonlinear force explosion economic reactor environmentally clean energy picosecond-non-thermal plasma block ignition

Softening of phonon spectra in metallic glasses

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npj Computational Materials 2016年第1期2卷 31-35页

作者： Reza Mahjoub Nicholas E Hamilton Kevin j Laws Michael Ferry School of Materials Science and Engineering The University of New South WalesSydneyNSWAustralia

The vibrational spectra of a series of MgZnCa amorphous alloys were computed using density functional theory and implementing the small displacement *** atomic structures of the alloys were obtained by ab initio molecular dynamics *** vibrational thermodynamic properties were calculated as a function of temperature and,in particular,the specific heat at low temperature was approximated by temperature cubed based on the Debye *** computed the contribution of Mg vibrations to the specific heat and investigated the softening of Mg phonon spectra,where the maximum allowed vibrational frequency is lowered and highly collective diffusion processes are *** statistical correlation between the reported critical casting thickness of the alloys and softening of Mg phonons was *** calculations were performed for two distinctively different amorphous ZrTiCuAl alloys with large and small reported critical casting thickness,*** findings were consistent with those of the MgZnCa alloys.

关键词： alloys softening casting