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World Journal of Gastroenterology 2012年第41期18卷 5986-5989页

作者： Keita Fukuyama Yasuhide Ishikawa Tetsuro Ogino Hidenobu Inoue Ryoya Yamaoka Tetsuro hirose Tomohiko Nishihira Department of Gastroenterological Surgery Takamatsu Red Cross HospitalTakamatsu 760-0017Japan Department of Pathology Takamatsu Red Cross HospitalTakamatsu 760-0017Japan

This report presents a case of massive mucosal necrosis of the small intestine in a patient with mitochondrial myopathy,encephalopathy,lactic acidosis,and stroke-like episodes(MELAS),which particularly affects the brain,nervous system and muscles.A 45-year-old Japanese female,with an established diagnosis of MELAS,presented with *** tomography showed portomesenteric venous gas and pneumatosis *** underwent a resection of the small intestine.A microscopic study showed necrosis of the mucosa and vacuolar degeneration of smooth muscle cells in the arterial *** showed anti-mitochondrial antibody to be highly expressed in the crypts adjacent the necrotic *** microscopic and immunohistochemical findings suggested the presence of a large number of abnormal mitochondria in MELAS to be closely linked to mucosal necrosis of the small intestine.

关键词： Myopathy, encephalopathy, lactic acidosis,and stroke-like episodes syndrome Acute mesentericischemia Immunohistochemistry Anti-mitochondrialantibody Pathology

碳化镍钼催化剂的制备及其甲烷干气重整活性(英文)

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催化学报 2011年第5期32卷 771-776页

作者： Taro hirose Yasushi OZAWA Masatoshi NAGAI Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and Technology Energy Engineering Research Laboratory Central Research Institute of Electric Power Industry

Nickel molybdenum carbide catalysts were prepared and their activities in the CO2 reforming of methane at a low CO2/CH4 reactant ratio were investigated using a microreactor at atmospheric pressure and at 973 *** effect of the catalyst preparation method and the Ni/Mo ratio on the increase in catalyst life and the promotion of catalytic activity were investigated using N2 adsorption,X-ray diffraction, temperature-programmed carburization,temperature-programmed reaction,and a reforming *** 25Ni75Mo catalyst that was carburized at 813 K exhibited the highest hydrogen formation ability and gave the least carbon *** incomplete carburization of the Mo oxide species in the catalyst that was carburized at a lower temperature gradually gave a more active carburized *** NiMoOxCy in the catalyst was more active in hydrogen formation during the dry reforming of methane whileβ-Mo2C andη-Mo3C2 were less active.

关键词： catalyst activation catalyst selectivity fuel dry reforming methane

Artifact suppression and analysis of brain activities with electroencephalography signals

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Neural Regeneration Research 2013年第16期8卷 1500-1513页

作者： Md. Rashed-Al-Mahfuz Md. Rabiul Islam Keikichi hirose Md. Khademul Islam Molla Department of Computer Science and Engineering Pabna University of Science and Technology Department of Information and Communication Engineering The University of Tokyo Department of Computer Science and Engineering Rajshahi University

Brain-computer interface is a communication system that connects the brain with computer （or other devices） but is not dependent on the normal output of the brain （i.e., peripheral nerve and muscle）. Electro-oculogram is a dominant artifact which has a significant negative influence on further analysis of real electroencephalography data. This paper presented a data adaptive technique for artifact suppression and brain wave extraction from electroencephalography signals to detect regional brain activities. Empirical mode decomposition based adaptive thresholding approach was employed here to suppress the electro-oculogram artifact. Fractional Gaussian noise was used to determine the threshold level derived from the analysis data without any training. The purified electroencephalography signal was composed of the brain waves also called rhythmic components which represent the brain activities. The rhythmic components were extracted from each electroencephalography channel using adaptive wiener filter with the original scale. The regional brain activities were mapped on the basis of the spatial distribution of rhythmic components, and the results showed that different regions of the brain are activated in response to different stimuli. This research analyzed the activities of a single rhythmic component, alpha with respect to different motor imaginations. The experimental results showed that the proposed method is very efficient in artifact suppression and identifying individual motor imagery based on the activities of alpha component.

关键词： neural regeneration brain activity brain waves data adaptive filtering electroencephalography electro-oculogram artifact topographic mapping Wiener filtering neuroregeneration

Rheological Behavior of Nanosilica Suspensions in Poly(Ethylene Oxide) Solutions with Sodium Chloride

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Materials Sciences and Applications 2017年第5期8卷 333-341页

作者： Yuji hirose Department of Urban Environment Systems Graduate School of Engineering Chiba University Chiba Japan

Suspensions of silica nanoparticles showed shear-thickening profiles under steady shear conditions up on addition of a small amount of poly(ethylene oxide) (PEO). The suspensions turned into gels upon shaking and their fluidity was recovered several minutes after resting. We studied the rheological properties of these shake gels with small amounts of sodium chloride (NaCl). Gelation occurred at lower shear rates upon addition of small amounts of NaCl. In addition, the time taken by the gelated samples to recover their original viscosity increased with the increasing NaCl content. The weakened repulsive interactions between the silica particles upon NaCl addition lead to particles in closer proximity, and three-dimensional networks of PEO chains are easily formed as the electric double layer of the particles becomes thinner.

关键词： Suspension Nanoparticles Shake Gel Sol-Gel Transition Electric Double Layer

The Need for Standard Policies on State Recognition： The Case of the Russia-Georgia War, Georgia, and Azerbaijan From 2008 to Early 2012

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International Relations and Diplomacy 2014年第1期2卷 1-15页

作者： Yoko hirose Keio University Kanagawa Japan

A major problem today is the existence of territories, usually breakaway regions that have been part of a larger union under dissatisfactory conditions, which have set themselves up as states but does not recognized by much of the world. Such regions present both regional and global problems. In this study, the Russia-Georgia War and its accompanying domestic politics are examined, including the policies of unrecognized states, using Georgia and Azerbaijan as examples. The Russian factor caused difficulties for Azerbaijan and Georgia in terms of recovering their land; however, the lack of a common standard for state recognition in the international community is also to blame for their difficulties. This study aims to demonstrate the need for a new common standard that considers historical backgrounds and legal aspects in helping such troubled territories return to normal.

关键词： Russia-Georgia War unrecognized states Azerbaijan Georgia

Resolution of hemolysis from pump thrombus during left ventricular assist device exchange

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World Journal of Clinical Cases 2014年第8期2卷 373-376页

作者： Shinya Unai Hitoshi hirose John WC Entwistle III Louis E Samuels Division of Cardiothoracic Surgery Department of SurgeryThomas Jefferson UniversityPhiladelphiaPA 19107United States

A 50-year-old male who underwent a Heart Mate Ⅱ left ventricular assist device placement for ischemic cardiomyopathy presented with discolored urine and hemolysis 3 mo after the operation. His hemolysis was thought to be due to thrombosis within the pump. Imaging studies were not able to visualize a left ventricular thrombus. Medical management with anticoagulation failed and he underwent surgery for a pump exchange. Intraoperatively, a firm thrombus was found within the pump of the Heart Mate Ⅱ, and the color of the urine changed dramatically from cola-colored to yellow which enabled us to confirm the diagnosis.

关键词： Cardiac surgery Hemolysis Left ventricular assist device Thrombosis

A method for predicting critical load evaluating adhesion of coatings in scratch testing

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2003年第6期4卷 88-92页

作者：陈溪芳,严密,杨德人,hirose Yukio Dept.of Material Science and Engineering Dept.of Material Science and Engineering Dept.of Material Science and Engineering Dept.of Material Science and Engineering Zhejiang University Hangzhou 310027 China Zhejiang University Hangzhou 310027 China Zhejiang University Hangzhou 310027 China Kanazawa University Kanazawa Japan

In this paper based on the experiment principle of evaluating adhesion property by scratch testing, the peeling mechanism of thin films is discussed by applying contact theory and surface physics theory. A mathematical model predicting the critical load is proposed for calculating critical load as determined by scratch testing. The factors for correctly evaluating adhesion of coatings according to the experimental data are discussed.

关键词： Coating Adhesion Scratch testing Critical load prediction

Environmental Conditions Determining the Timing of the Lifetime Maximum Intensity of Tropical Cyclones over the Western North Pacific and Their Frequency of Occurrence

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Journal of Tropical Meteorology 2022年第1期28卷 1-11页

作者： QIN Xiao-hao YAMAGUCHI Munehiko USUI Norihisa.hirose Nariaki State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029 China Department of Applied Meteorology Meteorological Research InstituteJapan Meteorological AgencyTsukubaIbaraki 305-0052 Japan Department of Atmosphere Oceanand Earth System Modeling ResearchMeteorological Research InstituteJapan Meteorological AgencyTsukubaIbaraki 305-0052 Japan

Environmental conditions determining the timing of the lifetime maximum intensities of tropical cyclones(TCs)are investigated for the TCs over the western North Pacific during the period *** results show that the land controls the timings of the lifetime maximum intensities in 42% of the TCs over this basin,indicating that accurate track forecasts are beneficial for TC intensity *** respect to other TCs that are not affected by the land(i.e.,Ocean-TCs),the timings of their lifetime maximum intensities are determined by multiple oceanic *** particular,interactions between TCs and cold-core eddies occur in a large proportion(nearly 60%)of Ocean-TCs at or shortly after the times of their lifetime maximum intensities,especially in strong TCs(categories 4 and 5),suggesting that a consideration of the above interactions is necessary for improving TC intensity forecasting *** addition,unfavorable oceanic heat content conditions become common as the latitude increases over 25°N,influencing half of the *** vertical wind shear contributes detrimentally to the atmospheric environment in 17% of the TCs over this basin,especially in moderate and weak *** contrast,neither the maximum potential intensity nor the humidity in the middle level of the atmosphere plays dominant roles when TCs turn from their peak intensities to weakening.

关键词： environmental conditions lifetime maximum intensity tropical cyclones frequency of occurrence

Trophic factors are essential for the survival of grafted oligodendrocyte progenitors and for neuroprotection after perinatal excitotoxicity

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Neural Regeneration Research 2020年第3期15卷 557-568页

作者： Megumi hirose-Ikeda Brian Chu Paul Zhao Omar Akil Elida Escalante Laurent Vergnes Carlos Cepeda Araceli Espinosa-Jeffrey Intellectual and Developmental Disabilities Research Center Jane and Terry Semel Institute for Neuroscience and Human BehaviorDepartments of NeurobiologyPsychiatry&Biobehavioral SciencesUniversity of CaliforniaLos AngelesCAUSA Department of Human Genetics David Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA

The consequences of neonatal white matter injury are devastating and represent a major societal problem as currently there is no ***,low weight birth and maternal pre-natal infection are the most frequent causes of acquired myelin deficiency in the human neonate leading to cerebral palsy and cognitive *** the developing brain,oligodendrocyte(OL)maturation occurs perinatally,and immature OLs are particularly *** replacement therapy is often considered a viable option to replace progenitors that die due to glutamate *** previously reported directed specification and mobilization of endogenous committed and uncommitted neural progenitors by the combination of transferrin and insulin growth factor 1(TSC1).Here,considering cell replacement and integration as therapeutic goals,we examined if OL progenitors(OLPs)grafted into the brain parenchyma of mice that were subjected to an excitotoxic insult could rescue white matter *** that purpose,we used a well-established model of glutamate excitotoxic ***-day-old mice received a single intraparenchymal injection of the glutamate receptor agonist N-methyl-D-aspartate alone or in conjunction with TSC1 in the presence or absence of OLPs grafted into the brain *** and expression of stress proteins and OL developmental specific markers were examined.A comparison of the proteomic profile per treatment was also *** found that OLPs did not survive in the excitotoxic environment when grafted *** contrast,when combined with TSC1,survival and integration of grafted OLPs was ***,energy metabolism in OLPs was significantly increased by N-methyl-D-aspartate and modulated by *** proteomic profile after the various treatments showed elevated ubiquitination and stress/heat shock protein 90 in response to *** changes were reversed in the presence of TSC1 and ubiquitination was *** results obtained i

关键词： myelin regeneration myelination oligodendrocytes periventricular leukomalacia premature birth proteomics trophic factors white matter injury

The naked planet Earth:Most essential pre-requisite for the origin and evolution of life

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Geoscience Frontiers 2013年第2期4卷 141-165页

作者： S.Maruyama M.Ikoma H.Genda K.hirose T.Yokoyama M.Santosh Department of Earth and Planetary Sciences Tokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo 152-8551Japan Department of Earth and Planetary Science.The University of Tokyo 7-3-1 HongoBunkyo-kuTokyo 113-0033.Japan Department of Earth and Planetary Sciences.Tokyo Institute of Technology 2-12-1 OokayamaMeguro-ku.Tokyo 152-8551Japan School of Earth Sciences and Resources China University of Geosciences(Beijing) Faculty of Science Kochi UniversityKochi 780-8520Japan

Our blue planet Earth has long been regarded to carry full of nutrients for hosting life since the birth of the *** we speculate the processes that led to the birth of early life on Earth and its aftermath, finally leading to the evolution of *** evaluate：（1） the source of nutrients,（2） the chemistry of primordial ocean,（3） the initial mass of ocean,and（4） the size of *** the life-building nutrients,phosphorus and potassium play a key *** three types of rocks can serve as an adequate source of nutrients：（a） continent-forming TTG（granite）,enabling the evolution of primitive life to metazoans;（b） primordial continents carrying anorthosite with KREEP（Potassium,Rare Earth Elements, and Phosphorus） basalts,which is a key to bear life;（c） carbonatite magma,enriched in radiogenic elements such as U and Th,which can cause mutation to speed up evolution and promote the birth of new species in continental rift *** second important factor is ocean *** primordial ocean was extremely acidic（pH = 1-2） and enriched in halogens（CI,F and others）,S,N and metallic elements（Cd,Cu,Zn,and others）,inhibiting the birth of *** tectonics cleaned up these elements which interfered with *** ocean finally appeared in the Phanerozoic with pH = 7 through extensive interaction with surface continental crust by weathering,erosion and transportation into *** initial ocean mass was also *** birth of life and aftermath of evolution was possible in the habitable zone with 3-5 km deep ocean which was able to supply sufficient nutrients. Without a huge landmass,nutrients cannot be supplied into the ocean only by ridge-hydrothermal circulation in the ***,the size of the planet plays a crucial *** of massive planets is less efficient than smaller ones,so that return-flow of seawater into mantle does not occur until central stars finish their main *** to the suitable size of Earth,the dawn of Phaneroz

关键词： Earth Life Habitable planet Initial ocean mass Metazoan Nutrients