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Modulation of valosin-containing protein by Kyoto University Substances(KUS) as a novel therapeutic strategy for ischemic neuronal diseases

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Neural Regeneration Research 2017年第8期12卷 1252-1255页

作者： Masayuki hata Hanako Ohashi Ikeda Department of Ophthalmology and Visual Sciences Kyoto University Graduate School of Medicine Neuroprotective Treatment Project for Ocular Diseases Institute for Advancement of Clinical and Translational Science Kyoto University Hospital

Retinal ischemia causes several vision-threatening diseases, including diabetic retinopathy, retinal artery occlusion, and retinal vein occlusion. Intracellular adenosine triphosphate（ATP） depletion and subsequent induced endoplasmic reticulum（ER） stress are proposed to be the underlying mechanisms of ischemic retinal cell death. Recently, we found that a naphthalene derivative can inhibit ATPase activity of valosin-containing protein, universally expressed within various types of cells, including retinal neural cells, with strong cytoprotective activity. Based on the chemical structure, we developed novel valosin-containing protein modulators, Kyoto University Substances（KUSs）, that not only inhibit intracellular ATP depletion, but also ameliorate ER stress. Suppressing ER stress by KUSs is associated with neural cell survival in animal models of several neurodegenerative diseases, such as glaucoma and retinal degeneration. Given that a major pathology of ischemic retinal diseases, other than intracellular ATP depletion, is ER stress-induced cell death, KUSs may provide a novel strategy for cell protection in ischemic conditions. Hence, we investigated the efficacy of KUS121 in a rat model of retinal ischemic injury. Intravitreal injections of KUS121, which is clinically preferable route of drug administration in retinal diseases, significantly suppressed inner retinal thinning and retinal cell death, and maintained visual functions. Valosin-containing protein modulation by KUS is a promising novel therapeutic strategy for ischemic retinal diseases.

关键词： adenosine triphosphatase C/EBP homologous protein central retinal artery occlusion endoplasmicreticulum stress neuroprotective therapy retinal ganglion cell

Evaluation of excavation damaged zones(EDZs)in Horonobe Underground Research Laboratory(URL)

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 365-378页

作者： Koji hata Sumio Niunoya Kazuhei Aoyagi Nobukatsu Miyara Obayashi Corporation Technology Research InstituteTechnology DivisionKiyoseTokyo204-8558Japan Obayashi Corporation Nuclear Facilities DivisionSinagawaTokyo108-8502Japan Japan Atomic Energy Agency Horonobe Underground Research CenterHoronobeHokkaido098-3224Japan

Excavation of underground caverns,such as mountain tunnels and energy-storage caverns,may cause the damages to the surrounding rock as a result of the stress *** this influenced zone,new cracks and discontinuities are created or propagate in the rock ***,it is effective to measure and evaluate the acoustic emission(AE)events generated by the rocks,which is a small elastic vibration,and permeability *** authors have developed a long-term measurement device that incorporates an optical AE(O-AE)sensor,an optical pore pressure sensor,and an optical temperature sensor in a single multi-optical measurement probe(MOP).Japan Atomic Energy Agency has been conducting R&D activities to enhance the reliability of high-level radioactive waste(HLW)deep geological disposal *** a high-level radioactive disposal project,one of the challenges is the development of methods for long-term monitoring of rock mass ***,in January 2014,the long-term measurements of the hydro-mechanical behavior of the rock mass were launched using the developed MOP in the vicinity of 350 m below the surface at the Horonobe Underground Research *** measurement results show that AEs occur frequently up to 1.5 m from the wall during *** addition,hydraulic conductivity increased by 2e4 orders of *** analysis revealed that the hydraulic behavior of the rock mass affected the pore pressure fluctuations and caused *** on this,a conceptual model is developed to represent the excavation damaged zone(EDZ),which contributes to the safe geological disposal of radioactive waste.

关键词： Excavation damaged zone(EDZ) Optical sensor Long-term monitoring Acoustic emission(AE) Shaft sinking

Simulation of 3D Needle-Tissue Interaction with Application to Image Guided Prostate Brachytherapy

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Transactions of Tianjin University 2010年第1期16卷 28-32页

作者：姜杉 hata Nobuhiko 肖渤瀚安蔚瑾 School of Mechanical Engineering Tianjin University Tianjin Key Laboratory of Advanced Manufacturing Technologies and Equipments Department of Radiology Brigham and Women's Hospital and Harvard Medical School Department of Radiology Tianjin Medical University Cancer Institute and Hospital

To improve global control of disease and reduce global toxicity, a complex seed distribution pattern should be achieved with great accuracy during ***, the interaction between the needle and prostate will cause large deformation of soft *** a result, seeds will be misplaced, sharp demarcation between irradiated volume and healthy structures is unavailable and this will cause side effects such as impotence and urinary *** this paper, a 3D nonlinear dynamic finite element s...

关键词： brachytherapy soft tissue finite element method dynamic simulation

Topic highlight on texture and color enhancement imaging in gastrointestinal diseases

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World Journal of Gastroenterology 2024年第14期30卷 1934-1940页

作者： Osamu Toyoshima Toshihiro Nishizawa Keisuke hata Department of Gastroenterology Toyoshima Endoscopy ClinicTokyo 157-0066Japan Department of Gastroenterology and Hepatology International University of Health and WelfareNarita HospitalNarita 286-8520Japan Department of Gastroenterology Nihonbashi Muromachi Mitsui Tower Midtown ClinicTokyo 103-0022Japan

Olympus Corporation developed texture and color enhancement imaging(TXI)as a novel image-enhancing endoscopic *** topic highlights a series of hot-topic articles that investigated the efficacy of TXI for gastrointestinal disease identification in the clinical setting.A randomized controlled trial demonstrated improvements in the colorectal adenoma detection rate(ADR)and the mean number of adenomas per procedure(MAP)of TXI compared with those of white-light imaging(WLI)observation(58.7%vs 42.7%,adjusted relative risk 1.35,95%CI:1.17-1.56;1.36 vs 0.89,adjusted incident risk ratio 1.48,95%CI:1.22-1.80,respectively).A cross-over study also showed that the colorectal MAP and ADR in TXI were higher than those in WLI(1.5 vs 1.0,adjusted odds ratio 1.4,95%CI:1.2-1.6;58.2%vs 46.8%,1.5,1.0-2.3,respectively).A randomized controlled trial demonstrated non-inferiority of TXI to narrow-band imaging in the colorectal mean number of adenomas and sessile serrated lesions per procedure(0.29 vs 0.30,difference for non-inferiority-0.01,95%CI:-0.10 to 0.08).A cohort study found that scoring for ulcerative colitis severity using TXI could predict relapse of ulcerative colitis.A cross-sectional study found that TXI improved the gastric cancer detection rate compared to WLI(0.71%vs 0.29%).A cross-sectional study revealed that the sensitivity and accuracy for active Helicobacter pylori gastritis in TXI were higher than those of WLI(69.2%vs 52.5%and 85.3%vs 78.7%,res-pectively).In conclusion,TXI can improve gastrointestinal lesion detection and qualitative ***,further studies on the efficacy of TXI in clinical practice are required.

关键词： Endoscopy Texture and color enhancement imaging White-light imaging Narrow-band imaging Colorectal neoplasm Gastric cancer Adenoma Ulcerative colitis Helicobacter infections Colonoscopy

Instantaneous Creep in Face-centered Cubic Metals at Ultra- low Strain Rates by a High-resolution Strain Measurement

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Journal of Wuhan University of Technology(Materials Science) 2013年第6期28卷 1096-1100页

作者： SHEN Junjie Ikeda Kenichi hata Satoshi Nakashima Hideharu School of Mechanical Engineering Tianjin University of Technology Department of Electrical and Materials Science Faculty of Engineering SciencesKyushu University

Instantaneous creep in face-centered cubic metals, 5N Al（99.999%）, 2N Al （99%） and 4N Cu （99.99%） with different grain sizes, was firstly investigated by sudden stress-change experiments at ultra- low strain rates ε ≤10-10 s-1 and temperature T 〈 0.32 Tn. The experimental results indicate that the observed instantaneous creep is strongly dependent on grain size, the concentration of impurity, and stacking fault energy. Creep in high-purity aluminum, 5N Al, with a very large grain size, d 〉 1600μm, shows non-viscous behavior, and is controlled by the recovery of dislocations in the boundary of dislocation cells. On the other hand, for 5N A1 with a small grain size, d=30μm, and low-purity aluminum, 2N A1, with d8= 25μm, creep shows viscous behavior and may be related to ＇low temperature grain boundary sliding＇. For high-purity copper, 4N Cu, with d= 40 grn and lower stacking fault energy, creep shows a non-viscous behavior, and is controlled by the recovery process of dislocations. For all of the samples, creep shows anelastic behavior.

关键词： face-centered cubic metals instantaneous creep ultra-low strain rate high strain resolution measurement

Argyrophilic grain disease is common in older adults and may be a risk factor for suicide:a study of Japanese forensic autopsy cases

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Translational Neurodegeneration 2023年第1期12卷 654-665页

作者： Koji Yoshida Yukiko hata Shojiro Ichimata Keitaro Okada Naoki Nishida Department of Legal Medicine Faculty of MedicineUniversity of Toyama2630 SugitaniToyama-shiToyama 930-0194Japan Tanz Centre for Research in Neurodegenerative Disease Krembil Discovery TowerUniversity of Toronto60 Leonard Ave Toronto OnTorontoON M5T 0S8Canada Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada.

Background Neuropathological diagnosis of argyrophilic grain disease(AGD)is currently based primarily on the combination of argyrophilic grain(AG)visualized using Gallyas-Braak silver staining,phosphorylated tau-positive pretangles,coiled bodies,and ballooned neuron *** AGD is common in patients with dementia and/or prominent psychiatric symptoms,whether it is a distinct neurological disease entity or a by-product of the aging process remains *** In 1449 serial forensic autopsy cases>40 years old(823 males and 525 females,aged 40-101 years,mean age 70.0±14.1 years),we examined the frequency and comorbid pathology of AGD cases and investigated the clini-cal appearance by comparing those with non-AGD cases using the propensity *** Of the 1449 cases,we detected 342 AGD cases(23.6%;mean age 79.7 years;177 males and 165 females).The AGD frequency and stage increased with age(P<0.001).Among AGD cases,80(23.4%)patients had dementia,and 51(15.2%)had a history of psychiatric hospital *** frequency of suicide and history of psychiatric disorders were significantly higher in AGD cases than in AGD-negative cases,matched for age,sex,and comorbidity pathol-ogy,with a relative risk of suicide of 1.72(1.30-2.26).The frequency of suicide was significantly higher in AGD cases than in non-AGD cases in female but not male *** relative risk of suicide increased to 2.27(1.20-4.30)and 6.50(1.58-26.76)in AGD patients with Lewy and progressive supranuclear palsy pathology,respectively,and decreased to 0.88(0.38-2.10)in those with advanced AD *** AGD cases,23.4%had dementia;however,the difference was not significant after controlling for age,sex,and comorbid *** Our study demonstrated that AGD is a significant and isolated risk factor for psychiatric hospital visits and suicide *** older adults,AGs may contribute to the progression of functional impairment of the limbic system,which leads to psychiatric dis

关键词： Amygdala Argyrophilic grains Dementia Forensic autopsy Psychiatric disorder Suicide

Fast-moving bimorph actuator based on electrochemically treated millimeter-long carbon nanotube electrodes and ionic liquid gel

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International Journal of Smart and Nano Materials 2012年第4期3卷 263-274页

作者： Kentaro Yamato Ken Mukai Kenji hata Kinji Asaka Health Research Institute National Institute of Advanced Industrial Science and Technology(AIST)1-8-31 MidorigaokaIkedaOsaka 563-8577Japan Nanotube Research Center National Institute of Advanced Industrial Science and Technology(AIST)Central 51-1-1 HigashiTsukubaIbaraki 305-8565Japan

The development is described of an electromechanical bimorph actuator composed of ionic liquid gel sandwiched by electrochemically treated millimeter-long single-walled carbon nanotubes(SG-SWNT).Electrochemical doping of the SG-SWNT and electrochemical polymerization of polypyrrole on the surface of the SG-SWNT improved the performance of a previously reported actuator using non-treated *** conductivity of the SG-SWNT sheets treated at the anodic potential(doped)was found to be three times larger than that of the original *** generated strain of the actuator prepared from the doped SG-SWNT sheets was increased compared to that prepared from non-doped ***,the generated strain of the actuator from the doped SG-SWNT sheets swelled with ionic liquid(IL)was increased to twice that without *** electropolymerization of pyrrole on the surface of the SG-SWNT sheet was carried *** conductivity of the SG-SWNT was seven times larger after the *** generated strain of the SG-SWNT actuator prepared from the SG-SWNT sheets with electropolymerization was twice as large as that without the electropolymerization at low *** higher frequency,both actuators provide almost the same *** actuators exhibit mechanical resonance at about 100 Hz.

关键词： carbon nanotube polypyrrole electrochemical doping ionic liquid bimorph actuator