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High-intensity laser-driven secondary radiation sources using the ZEUS 45 TW laser system at the Institute of Plasma Physics and Lasers of the Hellenic Mediterranean University Research Centre

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High Power Laser Science and Engineering 2021年第4期9卷 70-85页

作者： E.L.Clark a.grigoriadis S.Petrakis I.Tazes G.Andrianaki A.Skoulakis Y.Orphanos E.Kaselouris I.Fitilis J.Chatzakis E.Bakarezos V.Dimitriou E.P.Benis N.A.Papadogiannis M.Tatarakis Institute of Plasma Physics and Lasers Hellenic Mediterranean University Research Centre74100 RethymnoGreece Department of Physics University of Ioannina45110 IoanninaGreece Department of Electronic Engineering Hellenic Mediterranean University73133 ChaniaGreece School of Production Engineering and Management Technical University of Crete73100 ChaniaGreece Department of Music Technology and Acoustics Hellenic Mediterranean University74133 RcthymnoGreece

The rapid development of high-intensity laser-generated particle and photon secondary sources has attracted widespread interest during the last 20 years not only due to fundamental science research but also because of the important applications of this developing *** instance,the generation of relativistic particle beams,betatron-type coherent X-ray radiation and high harmonic generation have attracted interest from various fields of science and technology owing to their diverse applications in biomedical,material science,energy,space,and security *** the field of biomedical applications in particular,laser-driven particle beams as well as laser-driven X-ray sources are a promising field of *** article looks at the research being performed at the Institute of Plasma Physics and Lasers(IPPL)of the Hellenic Mediterranean University Research *** recent installation of the ZEUS 45 TW laser system developed at IPPL offers unique opportunities for research in laser-driven particle and X-ray *** article provides information about the facility and describes initial experiments performed for establishing the baseline platforms for secondary plasma sources.

关键词： high power laser laser plasma secondary sources

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胰腺导管腺癌的多层CT:管电压和碘负荷对肿瘤显示和影像质量的影响

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国际医学放射学杂志 2017年第1期 104-105页

作者： L.Loizou N.Albiin B.Leidner E.Axelsson M.A.Fischer a.grigoriadis 谢双双 Division of Medical Imaging and Technology Department of Clinical Science Intervention and Technology (CLINTEC)Karolinska Institutet

摘要目的在胰腺导管腺癌(PDAC)病人中,比较伴或不伴高碘负荷的低管电压多层CT(MDCT)扫描方案与正常管电压、正常碘负荷(标准)扫描方案在肿瘤显示和影像质量

关键词：胰腺导管腺癌 CT 影像质量管电压

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CT灌注成像检测肝硬化病人肝细胞肝癌

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国际医学放射学杂志 2016年第1期 83-83页

作者： M.A.Fischer N.Kartalis a.grigoriadis L.Loizou P.Stal B.Leidner 张鑫 Department of Clinical Science Intervention and TechnologyDivision of Medical Imaging and TechnologyKarolinska Institute

摘要目的评估动态CT灌注成像(P-CT)对肝硬化病人肝细胞肝癌(HCC)检测的诊断效能。材料与方法收集怀疑HCC的肝硬化病人26例[男19例,平均年龄(69±10)岁,利用双源系统的4D螺旋模态(100/80 k V;150/175 m As/rot)行肝脏P-CT检查。2名阅片... 详细信息

摘要目的评估动态CT灌注成像(P-CT)对肝硬化病人肝细胞肝癌(HCC)检测的诊断效能。材料与方法收集怀疑HCC的肝硬化病人26例[男19例,平均年龄(69±10)岁,利用双源系统的4D螺旋模态(100/80 k V;150/175 m As/rot)行肝脏P-CT检查。2名阅片者评估:1分别独立评估动脉期肝脏灌注(ALP)、门静脉期肝脏灌注(PLP)、肝脏灌注指数

关键词：肝硬化 HCC 肝细胞肝癌灌注成像病人 CT

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Computational and conceptual blends: Material considerations and agency in a multi-material design workflow

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Frontiers of Architectural Research 2022年第4期11卷 618-629页

作者： Kostas grigoriadis Bartlett School of Architecture University College LondonLondon WC1H 0QBUK

The assimilation of functionally graded (or multi-) materials into architecture is deemed to enable the rethinking of current architectural design practice and bring back material considerations at the heart of the early design process. In response, the paper outlines a functionally graded material (FGM) design workflow that departs from standard early-stage CAD, which is typically performed via computer elements devoid of materiality. It then analyses this workflow from a theoretical perspective, namely through Edwin Hutchins’ materially anchored conceptual blending, Lambros Malafouris’ Material Engagement Theory (MET) and John Searle’s concepts of intentionality. The aim is to demonstrate that due to the superimposition of material considerations that precede and succeed the CAD operation, working with material-less entities during early-stage FGM design is not logically sustainable. Additionally, multi-materiality allows for the questioning of authorship in the design process and leads to a repositioning of agency from the subject to the locus of engagement with digital materials and their affordances.

关键词： Digital design Multi-materials Computer simulation Material agency Materially anchored conceptual blends

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Digital and physical materiality in contemporary architectural design: A material engagement approach

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Frontiers of Architectural Research 2022年第4期11卷 591-593页

作者： Kostas grigoriadis Kare Stokholm Poulsgaard Hao Hua Bartlett School of Architecture University College LondonLondonWC1H 0QBUK 3XN Architects and GXN Innovation Copenhagen1437Denmark School of Architecture Southeast UniversityNanjing210096China

*** research and contemporary design practice Architectural research is increasingly recognised as a field in its own right,with its particular approaches and generated knowledge(Frayling,1994;Archer,1995;Menges and Ahlquist,2011;Henschel and Nilsson,2015;Burry and the scientific and technical into its subject what sets it Burry,2016;Oxman,2017).Although often incorporating apart from science,however,is its vital link to design *** connection makes it not only intrinsically linked to its,specific site of,production,but also to constantly evolving software,fabrication tools and forms of materiality that have cometo be incorporated into thecore of the,design,process.,As a,result of this,materials research,machine learning,advanced simulation,and robotic fabrication,to name some examples,are some of the tools that inform architecture today.

关键词： architectural comet material

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Corticotropin-releasing factor receptor subtype 2 in human colonic mucosa: Down-regulation in ulcerative colitis

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World Journal of Gastroenterology 2013年第9期19卷 1416-1423页

作者： Ekaterini Chatzaki Peter A Anton Mulugeta Million Maria Lambropoulou Theodoros Constantinidis George Kolios Yvette Taché Dimitri E grigoriadis Neurocrine Biosciences Inc. San Diego CA 92121 United States Laboratory of Pharmacology Faculty of Medicine Democritus University of Thrace 68100 Alexandroupolis Greece Center for HIV Prevention Research Division of Digestive Diseases University of California at Los Angeles and VA Greater Los Angeles Healthcare System Los Angeles CA 90073 United States Digestive Diseases Research Center and Center for Neurobiology of Stress Division of Digestive Diseases University of California at Los Angeles and VA Greater Los Angeles Healthcare System Los Angeles CA 90073 United States Laboratory of Histology-Embryology Faculty of Medicine Democritus University of Thrace 68100 Alexandroupolis Greece Laboratory of Hygiene and Environmental Protection Faculty of Medicine Democritus University of Thrace 68100 Alexandroupolis Greece

AIM: To assess corticotropin-releasing factor receptor 2 (CRF 2 ) expression in the colon of healthy subjects and patients with ulcerative colitis (UC). METHODS: We examined CRF2 gene and protein expression in the distal/sigmoid colonic mucosal biopsies from healthy subjects and patients with UC (active or disease in remission), human immunodeficiency virus (HIV) and functional bowel disease (FBD) by reverse transcriptionpolymerase chain reaction and immunofluorescence. RESULTS: Gene expression of CRF2 was demonstrated in the normal human colonic biopsies, but not in the human colorectal adenocarcinoma cell line Caco2. Receptor protein localization showed immunoreactive CRF 2 receptors in the lamina propria and in the epithelial cells of the distal/sigmoid biopsy samples. Interestingly, CRF 2 immunoreactivity was no longer observed in epithelial cells of patients with mild-moderately active UC and disease in remission, while receptor protein expression did not change in the lamina propria. No differences in CRF 2 expression profile were observed in distal/sigmoid intestinal biopsies from HIV infection and FBD patients, showing no signs of inflammation. CONCLUSION: The down-regulation of the CRF2 receptor in the distal/sigmoid biopsies of UC patients is indicative of change in CRF 2 signalling associated with the process of inflammation.

关键词： Colonic mucosa Corticotropin-releasing factor Corticotropin-releasing factor receptor Human immunodeficiency virus Ulcerative colitis Urocortin

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Hematopoietic stem cells from peripheral blood the perspective of non-mobilized peripheral blood

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Health 2010年第6期2卷 519-527页

作者： Vassilios Katsares Zissis Paparidis Eleni Nikolaidou Anastasia Petsa Iliana Karvounidou Karina-Alina Ardelean Nikolaos Peroulis Nikolaos grigoriadis John grigoriadis 不详

The peripheral blood is a major source of hematopoietic stem cells. Almost for two decades the peripheral blood has been mobilized, in order to enhance the CD34+ concentration. The isolated stem cells from the mobilized peripheral blood are used as an alternative, or in addition to bone marrow derived stem cells. In this paper, a new perspective is being discussed;the use of non-mobilized peripheral blood as an alternative source for hematopoietic progenitor cells. The number of isolated hematopoietic stem cells is evaluated using flow cytometry. The viability can be evaluated using the trypan blue exclusion test, the flow cytometry or automated assays. The isolated hematopoietic stem cells could be used for ex vivo expansion either in static systems or in proper bioreactor systems, prior to cryopreservation and/or transplantation.

关键词： Non-Mobilized Peripheral Blood Hematopoietic Stem Cells Ex Vivo Expansion

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肿瘤坏死因子α对小鼠破骨细胞分化的影响

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北京大学学报（医学版） 2005年第4期37卷 433-435页

作者：赵玉鸣葛立宏 Agi E.grigoriadis 北京大学口腔医学院儿童口腔科北京100081 英国伦敦国王学院盖氏医院颅面发育系

目的:在诱导破骨细胞分化的体外骨髓细胞培养系统中,研究破骨细胞分化因子(RANKL)存在和不存在的情况下,肿瘤坏死因子α(TNF-α)对破骨细胞分化的影响。方法:选用小鼠巨噬细胞集落刺激因子(M-CSF)依赖性非附着性骨髓细胞,在含有25μg/LM... 详细信息

目的:在诱导破骨细胞分化的体外骨髓细胞培养系统中,研究破骨细胞分化因子(RANKL)存在和不存在的情况下,肿瘤坏死因子α(TNF-α)对破骨细胞分化的影响。方法:选用小鼠巨噬细胞集落刺激因子(M-CSF)依赖性非附着性骨髓细胞,在含有25μg/LM-CSF和0,1,10,100μg/LTNF-α的α-MEM培养液中培养5d后,观察抗酒石酸酸性磷酸酶染色(TRAP)阳性多核细胞的形成;细胞在含有25μg/LM-CSF和30μg/LsRANKL的α-MEM培养液中进行培养,比较加入和不加入10μg/LTNF-α培养4、5、6和9d后,所形成的TRAP(+)多核细胞的数目和骨吸收面积。结果:TNF-α在没有RANKL的情况下,不能诱导小鼠骨髓细胞形成破骨细胞。在RANKL存在的情况下,TNF-α可促进破骨样细胞的形成和骨吸收,但对破骨细胞分化的促进作用仅表现在培养的早期。结论:在RANKL存在的情况下TNF-α可促进破骨细胞的分化,但不能取代RANKL。TNF-α加速破骨细胞的形成,却并不延长其生存时间。

关键词：肿瘤坏死因子α 破骨细胞骨髓细胞幸存

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小鼠骨髓细胞和脾细胞诱导形成破骨细胞潜能的比较

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现代口腔医学杂志 2006年第1期20卷 49-51页

作者：赵玉鸣葛立宏 A E grigoriadis 北京大学口腔医学院口腔医院儿童口腔科 100081 英国Guy’s Hospital King’s College London SE19RT

目的在体外破骨细胞分化因子（RANKL）和巨噬细胞集落刺激因子（M-CSF）联合应用的情况下，比较小鼠骨髓细胞和脾细胞形成破骨细胞的能力。方法选用小鼠M-CSF依赖性非附着性骨髓细胞和脾细胞，以不同的细胞密度在舍有25ng／ml sM-CSF和... 详细信息

目的在体外破骨细胞分化因子（RANKL）和巨噬细胞集落刺激因子（M-CSF）联合应用的情况下，比较小鼠骨髓细胞和脾细胞形成破骨细胞的能力。方法选用小鼠M-CSF依赖性非附着性骨髓细胞和脾细胞，以不同的细胞密度在舍有25ng／ml sM-CSF和30ng／ml sRANKL的（-MEM培养液中培养5、9天后，计数形成的抗酒石酸酸性磷酸酶染色（TRAP）阳性多核细胞的数目和骨吸收面积。结果脾细胞形成的破骨样细胞与骨髓形成的细胞形态与功能均无明显差异，但所需的细胞密度为骨髓细胞的10～20倍。结论在特殊情况下，脾细胞可替代骨髓细胞进行体外破骨细胞实验．但培养条件应适当调整。

关键词：破骨细胞分化生长因子巨噬细胞集落刺激因子脾细胞骨髓细胞破骨细胞

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转化生长因子β对体外破骨细胞分化的影响

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实用口腔医学杂志 2006年第1期22卷 38-40页

作者：赵玉明葛立宏 A E grigoriadis 北京大学口腔医学院儿童口腔科 100081 Guy's Hospital King's College London

目的:研究在核因子κB受体活化因子配基(RANKL)和巨噬细胞集落刺激因子(M-CSF)联合应用诱导体外骨髓细胞培养系统中,转化生长因子(TGF-β)对破骨细胞分化的影响。方法:选用小鼠M-CSF依赖性非附着性骨髓细胞,在含有25 ng/m l sM-CSF和30 ... 详细信息

目的:研究在核因子κB受体活化因子配基(RANKL)和巨噬细胞集落刺激因子(M-CSF)联合应用诱导体外骨髓细胞培养系统中,转化生长因子(TGF-β)对破骨细胞分化的影响。方法:选用小鼠M-CSF依赖性非附着性骨髓细胞,在含有25 ng/m l sM-CSF和30 ng/m l sRANKL的α-MEM培养液中进行培养,比较加入和不加入1 ng/m lTGF-β1培养4、9 d后,所形成的抗酒石酸酸性磷酸酶染色(TRAP)阳性多核细胞的数目和骨吸收面积。结果:小鼠骨髓细胞在RANKL和M-CSF共同作用下可形成TRAP阳性多核巨细胞,并具有骨吸收功能。加入TGF-β后,破骨样细胞的数目及骨吸收面积显著增加。结论:TGF-β对RANKL和M-CSF诱导的破骨细胞的分化及其功能的促进作用,可能为炎症状态下发生过度骨吸收的机制之一。

关键词：巨噬细胞集落刺激因子破骨细胞骨髓细胞转化生长因子β 细胞分化

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