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Chinese Chemical Letters 2012年第5期23卷 541-544页

作者： Chinnasamy Rajaram Prakash Sundararajan Raja.govindaraj Saravanan Department of Medicinal Chemistry DCRM Pharmacy CollegeJNTUHAndhra PradeshIndia Department of Pharmaceutical Chemistry GITAM Institute of PharmacyGITAM UniversityVizagAndhra PradeshIndia Medicinal Chemistry Research Laboratory Bapatla College of PharmacyBapatla 522 101Andhra PradeshIndia

A new series of isatin semicarbazide derivatives（7a-7j） were synthesized and characterized by spectroscopic means and elemental *** and anti-inflammatory screening was performed using tail-flick technique and the carrageenan-induced foot paw edema test *** ulcerogenicity was also determined for all the *** of the compounds showed moderate enhancement of the *** the synthesized derivatives,compound 7d showed higher analgesic, antiinflammatory and one-third of ulcer index of the reference drug.

关键词： Isatin Anti-nociceptive Schiff base Ulcerogenicity

Intra-population genetic variance for grain iron and zinc contents and agronomic traits in pearl millet

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The Crop Journal 2016年第1期4卷 48-54页

作者： Mahalingam govindaraj Kedar N.Rai Ponnusamy Shanmugasundaram International Crops Research Institute for the Semi-arid Tropics (ICRISAT) Centre for Plant Breeding and Genetics Tamil Nadu Agricultural University

Crop biofortification is a sustainable approach for fighting micronutrient malnutrition in the world. The estimation of variance components in genetically broad-based populations provides information about their genetic architecture, allowing the design of an appropriate biofortification breeding method for cross-pollinated crops such as pearl millet. The objective of this study was to estimate intra-population genetic variance using self(S1) and half-sib(HS) progenies in two populations, AIMP92901 and ICMR312. Field trials were evaluated in two contrasting seasons(2009 rainy and 2010 summer; otherwise called environments) in Alfisols at ICRISAT, Patancheru. Analyses of variance showed highly significant variation for S1 s and HS progenies, reflecting high within-population genetic variation for both micronutrients and other key traits. However, the HS showed narrow ranges and lower genetic variances than the S1 for all of the traits. The micronutrients were highly positively correlated in S1(r = 0.77 to 0.86; P < 0.01) and HS(r = 0.74 to 0.77; P < 0.01)progenies of both populations, implying concurrent genetic improvement for both micronutrients. The genetic variance component was different among populations for Fe and Zn contents across environments, with AIMP92901 showing a greater proportion of dominance and ICMR312 greater additive variance for these micronutrients. The estimates of variance(additive and dominance) were specific for each population, given their dependence on the additive and dominance effects of the segregating loci, which also differ among populations. The possible causes for such differences were discussed. The results showed that the expression of these micronutrients in pearl millet shows largely additive variance, so that breeding high-iron hybrids will require incorporation of these micronutrient traits into both parental lines.

关键词： Genetic variance Iron Micronutrient malnutrition Pearl millet Zinc

Ce-substituted Lithium Ferrite:Preparation and Electrical Relaxation Studies

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Journal of Materials Science & Technology 2014年第4期30卷 335-341页

作者： Viswarupa Mohanty Rajesh Cheruku Lakshmi Vijayan G.govindaraj Department of Physics School of PhysicalChemical and Applied SciencesPondicherry University

Ce-substituted lithium ferrite, Li0.5CexFe2.5-x04 （x = 0, 0.05 and 0.1 ） compositions were synthesized from metal nitrates and citric acid by the solution combustion process by keeping the oxidizer to fuel ratio at unity. The thermal decomposition process was investigated by thermogravimetry-differential thermal analysis, which showed a stable phase formation above 600 ℃. The phase composition and molecular bonding of Li0.5CexFe2.5_x04 were characterized by X-ray powder diffraction analysis and Fourier transform infrared spectroscopy, respectively. An extensive study of electrical relaxation process has been represented with impedance and modulus as a function of frequency at different temperatures. The activation energy obtained from both the formalisms was found to be equal within the error. The dc conductivity and hopping frequency were thermally activated and their activation energies were found to be in the range of 0.69-0.64 eV for x = 0.05. The scaling of modulus and impedance were used to understand the electrical relaxation behaviour of the compositions and they suggest the time temperature superposition principle.

关键词： Lithium ferrite Solution combustion synthesis Inverse spinel Electrical relaxation process and scaling

A Novel Framework for DDoS Attacks Detection Using Hybrid LSTM Techniques

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Computer Systems Science & Engineering 2023年第6期45卷 2553-2567页

作者： Anitha Thangasamy Bose Sundan Logeswari govindaraj Department of Computer Science and Engineering College of Engineering GuindyAnna UniversityChennai-600025TamilndauIndia

The recent development of cloud computing offers various services on demand for organization and individual users,such as storage,shared computing space,networking,*** Cloud Computing provides various advantages for users,it remains vulnerable to many types of attacks that attract cyber *** Denial of Service(DDoS)is the most common type of attack on cloud ***,Cloud computing professionals and security experts have focused on the growth of preventive processes towards DDoS *** DDoS attacks have become increasingly widespread,it becomes difficult for some DDoS attack methods based on individual network flow features to distinguish various types of DDoS ***,the monitoring pattern of traffic changes and accurate detection of DDoS attacks are most important and *** this research work,DDoS attack detection methods based on deep belief network feature extraction and Hybrid Long Short-Term Memory(LSTM)model have been proposed with NSL-KDD *** Hybrid LSTM method,the Particle Swarm Optimization(PSO)technique,which is combined to optimize the weights of the LSTM neural network,reduces the prediction *** deep belief network method is used to extract the features of IP packets,and it identifies DDoS attacks based on PSO-LSTM ***,it accurately predicts normal network traffic and detects anomalies resulting from DDoS *** proposed PSO-LSTM architecture outperforms the classification techniques including standard Support Vector Machine(SVM)and LSTM in terms of attack detection performance along with the results of the measurement of accuracy,recall,f-measure,precision.

关键词： Cloud computing distributed denial of service particle swarm optimization long short-term memory attack detection

A Study on the Nonlinear Caputo-Type Snakebite Envenoming Model with Memory

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Computer Modeling in Engineering & Sciences 2023年第9期136卷 2487-2506页

作者： Pushpendra Kumar Vedat Suat Erturk V.govindaraj Dumitru Baleanu Department of Mathematics National Institute of Technology PuducherryKaraikal609609India Department of Mathematics Faculty of Arts and SciencesOndokuz Mayis UniversityAtakumSamsun55200Turkey Department of Mathematics Cankaya UniversityAnkara06530Turkey Institute of Space Sciences MagureleBucharestR76900Romania Department of Computer Science and Mathematics Lebanese American UniversityBeirut11022801Lebanon

In this article,we introduce a nonlinear Caputo-type snakebite envenoming model with *** well-known Caputo fractional derivative is used to generalize the previously presented integer-order model into a fractionalorder *** numerical solution of the model is derived from a novel implementation of a finite-difference predictor-corrector(L1-PC)scheme with error estimation and stability *** proof of the existence and positivity of the solution is given by using the fixed point *** the necessary simulations,we justify that the first-time implementation of the proposedmethod on an epidemicmodel shows that the scheme is fully suitable and time-efficient for solving epidemic *** work aims to show the novel application of the given scheme as well as to check how the proposed snakebite envenoming model behaves in the presence of the Caputo fractional derivative,including memory effects.

关键词： Mathematical model Caputo fractional derivative L1-predictor-corrector method error estimation stability graphical simulations

Variations in texture of beach sediments in the vicinity of the Tirumalairajanar river mouth of India

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International Journal of Sediment Research 2011年第4期26卷 460-470页

作者： Senapathi VENKATRAMANAN Thirunavukkarasu RAMKUMAR Irudhayanathan ANITHAMARY govindaraj RAMESH Research scholar Department of Earth SciencesAnnamalai UniversityAnnamalainagar608002.TamilnaduIndia Department of Earth Sciences Annamalai University

The distribution of grain size parameters along 11 km stretch of the beach sediments between Karikal and Nagore,reveals that the mean grain size exhibits a marked decreasing trend on either side of the mouth of the Tirumalairajanar River which flow from west to *** sediments are mainly of medium to coarse grained,moderately sorted,near-symmetrical skewed to fine skewed and leptokurtic to mesokurtic in *** of various parameters shows bimodal nature of sediments having dominance of medium to coarse *** major part of the sediment fall in a coarse to fine grained category(sand and silt).Based on the CM(Coarser one percentile value in micron) pattern,the sediment fall in rolling and suspension *** factors includes the sediments discharged from the river mixes with offshore sediments and with the sediments eroded from a source *** effect of wave sorting, and the northward drifting of sediments by littoral current are *** indicate that the Tirumalairajanar River is the most important source for modern sediments in the study *** agitation by waves is an important sorting mechanism in the study area,and the net sediment transport in the study area is *** findings are based on the grain sizes and also corroborated by shortterm observations of the beach sediment dynamics and transport during the monsoon and summer seasons between Karaikal and Nagore region.

关键词： Grain size analysis Beach sediments Tirumalairajanr East coast

Trajectory controllability of fractional dynamical systems

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Journal of Control and Decision 2017年第2期4卷 114-130页

作者： Venkatesan govindaraj Muslim Malik Raju K.George Department of Mathematics Indian Institute of Space Science and TechnologyTrivandrumIndia School of Basic Sciences Indian Institute of Technology MandiMandiIndia

In this paper,we discuss the trajectory controllability of linear and nonlinear fractional dynamical systems represented by the fractional differential equations in the sense of Caputo fractional derivative by using the Mittag-Leffler function and Gronwall-Bellman *** the nonlinear system,we assume Lipschitz-type conditions on the *** are given to illustrate the theoretical results.

关键词： Fractional derivative trajectory controllability Mittag-Leffler function Gronwall-Bellman inequality Lipschitz continuity

PsRNA:A Computing Engine for the Comparative Identification of Putative Small RNA Locations within Intergenic Regions

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Genomics, Proteomics & Bioinformatics 2010年第2期8卷 127-134页

作者： Jayavel Sridhar govindaraj Sowmiya Kanagaraj Sekar Ziauddin Ahamed Rafi Centre of Excellence in Bioinformatics School of BiotechnologyMadurai Kamaraj University Bioinformatics Centre Indian Institute of Science Supercomputer Education and Research Centre Indian Institute of Science

Small RNAs （sRNAs） are non-coding transcripts exerting their functions in the cells directly. Identification of sRNAs is a difficult task due to the lack of clear sequence and structural biases. Most sRNAs are identified within genus specific intergenic regions in related genomes. However, several of these regions remain un-annotated due to lack of sequence homology and/or potent statistical identification tools. A computational engine has been built to search within the intergenic regions to identify and roughly annotate new putative sRNA regions in Enterobacteriaceae genomes. It utilizes experimentally known sRNA data and their flanking genes/KEGG Orthology （KO） numbers as templates to identify similar sRNA regions in related query genomes. The search engine not only has the capability to locate putative intergenic regions for specific sRNAs, but also has the potency to locate conserved, shuffled or deleted gene clusters in query genomes. Because it uses the KO terms for locating functionally important regions such as sRNAs, any further KO number assignment to additional genes will increase the sensitivity. The PsRNA server is used for the identification of putative sRNA regions through the information retrieved from the sRNA of interest. The computing engine is available online at http：//bioserver 1 .***/psrna/and http：//***： 8081/psrna/.

关键词： small RNA KEGG Orthology flanking genes intergenic regions

A stochastic SIR model for analysis of testosterone suppression of CRH-stimulated cortisol in men

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International Journal of Modeling, Simulation, and Scientific Computing 2022年第3期13卷 223-229页

作者： A.Manickam Pushpendra Kumar K.Dasunaidu V.govindaraj Dheeraj Kumar Joshi School of Advanced Sciences 8 Languages Department of Mathematics VIT Bhopal University Kottri Kalan(Village)466114 Sehore(District) Madhya PradeshIndia Department of Mathematics National Institute of Technology Puducherry Karaikal 609609 India Department of Basic Sciences 8 Humanities GMR Institute of Technology Rajam 532127 Srikakulam(Dt)Andhra PradeshIndia DIT University Dehradun 248009 UttarakhandIndiamanickammaths2011@***.kxumarsaraswatpk@*****dasunaidu.k@gmrit.edu.in ttgovindaraj.maths@*** t+maths.dj44010@***

A stochastic SIR influenza vertical transmission model is examined in this paper where vaccination and an incidence rate that is not linear are *** determine whether testosterone regulates lower sintering HPA axis function in males,we used a stochastic SIR epidemic procedure with divergent influences on ACTH and *** suppressive effects on cortisol can be attributed to a peripheral(adrenal)*** that,we came to the conclusion that experimental solutions have been discovered and the requisite statistical findings have been ***,we deduce that the given mathematical model and the results are relevant to medical *** the future,this research can be further extended to simulate more results in the medical field.

关键词： ACTH cortisol CRH estradiol HPA SIR model testosterone

Sex differences in SARS-CoV-2 infections,anti-viral immunity and vaccine responses

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Asian Pacific Journal of Tropical Medicine 2022年第3期15卷 97-105页

作者： Abhishek Mohanty Aanchal Sawhney Shefali Gupta Vishal Rao Periyasamy govindaraj Sambit Mohanty Vandana Jain Rajiv Gandhi Cancer Institute and Research Centre New DelhiIndia HCG Cancer Hospitals BangaloreIndia All India Institute of Medical Sciences Rae BareliIndia Centre for DNA Finger Printing and Diagnostics HyderabadIndia CORE Diagnostics GurgaonHaryanaIndia

The COVID-19 pandemic has revealed sex-based differences in anti-viral responses,with a higher rate of SARS-CoV-2 infections as well as a higher rate of morbidity and mortality in men than in *** and females also show disparate immune responses to COVID-19 infection,which may be important contributors to lower rates of infection,disease severity and deaths in women than in ***,the authors review sex differences in SARS-CoV-2 infections,anti-viral immunity and vaccine responses,putting forth the importance of sex,the underappreciated variables in vaccine response and disease infectivity.

关键词： SARS-CoV-2 Antiviral immunity Sex based mitochondrial differences Vaccine responses Innate immunity Sex differences COVID-19 pandemic