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China CDC weekly 2022年第45期4卷 1013-1018页

作者： Binjian Yan Shuaifeng Gao Minlei Dai Thomas M.gill Xi Chen College of Economics and Management Nanjing Agricultural UniversityNanjing CityJiangsu ProvinceChina Department of Internal Medicine Yale School of MedicineNew HavenCTUS Department of Health Policy and Management Yale School of Public HealthNew HavenCTUS Department of Economics Yale UniversityNew HavenCTUS Yale Alzheimer’s Disease Research Center Yale UniversityNew HavenCTUS.

What is already known about this topic?Many health challenges have emerged due to rapid population aging,including declined cognitive ability among older *** is added by this report?Childhood circumstances have significant and lasting impacts on cognition in old *** study compared cognition data from China with both the United States(U.S.)and the European Union(EU)during 2008–2018,finding that childhood circumstances could respectively explain 65.4%[95%confidence interval(CI):59.4%,71.4%](China *** U.S.)and 38.2%(95%CI:35.1%,41.2%)(China *** EU)of the overall differences in cognition among older *** socioeconomic status explained the largest share of differences among all considered childhood *** are the implications for public health practice?Large disparities in cognition should be addressed by mitigating childhood disadvantages.

关键词： Population circumstances cognition

Beneficial Effect of Berberis amurensis Rupr. on Penile Erection

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Chinese Journal of Integrative Medicine 2018年第6期24卷 448-454页

作者： Rui Tan Yun Jung Lee Kyung Woo Cho Dae gill Kang Ho Sub Lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University Hanbang CardioRenal Syndrome Research Center Wonkwang University Brain Korea 21 Plus Team Professional Graduate School of Oriental MedicineWonkwang University

Objective： To investigate whether the methanol extract of Berberis amurensis Rupr. （BAR） augments penile erection using in vitro and in vivo experiments. Methods： The ex vivo study used corpus cavemosum strips prepared from adult male New Zealand White rabbits. In in vivo studies for intracavernous pressure （ICP）, blood pressure, mean arterial pressure （MAP）, and increase of peak ICP were continuously monitored during electrical stimulation of Sprague-Dawley rats. Results： Preconstricted with phenylephrine （PE） in isolated endothelium- intact rabbit corus cavernosum, BAR relaxed penile smooth muscle in a dose-dependent manner, which was inhibited by pretreatment with NG-nitro-L-arginine methyl ester （L-NAME）, a nitric oxide synthase inhibitor, and 1H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin-l-one, a soluble guanylyl cclase inhibitor. BAR significantly relaxed penile smooth muscles dose-dependently in ex vivo, and this was inhibited by pretreatment with L-NAME 1H-[1,2,4]- oxadiazole-[4,3-α ]-quinoxalin-l-one. BAR-induced relaxation was significantly attenuated by pretreatment with tetraethylammonium （TEA, P〈0.01）, a nonselective K＋ channel blocker, 4-aminopyridine （4-AP, P〈0.01）, a voltage-dependent K＋ channel blocker, and charybdotoxin （P〈0.01）, a large and intermediate conductance Ca2. sensitive-K＋ channel blocker, respectively. BAR induced an increase in peak ICP, ICP/MAP ratio and area under the curve dose dependently. Conclusion： BAR augments penile erection via the nitric oxide/cyclic guanosine monophosphate system and Ca2. sensitive-K＋（BK＋ and IK＋） channels in the corpus cavemosum.

关键词： penile erection Berberis amurensis Rupr. nitric oxide cyclic guanosine monophosphate K+ channel

Local excision of early rectal cancer: A multi-centre experience of transanal endoscopic microsurgery from the United Kingdom

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3114-3122页

作者： Ahmed Farid Matthew Tutton Prem Thambi TS gill Jim Khan Department of General Surgery Oncology Center Mansoura UniversityCairo 11432Egypt Department of Colorectal Surgery East Suffolk and North Essex NHS TrustColchester CO11AAEssexUnited Kingdom Department of Colorectal Surgery Portsmouth Hospitals University NHS TrustPortsmouth PO63LYHampshireUnited Kingdom Department of Surgery University Hospital of North TeesStockton on Tees TS18-TS21DarlingtonUnited Kingdom Department of General Surgery Portsmouth Hospitals NHS TrustQueen Alexandra HospitalPortsmouth PO63LYHampshireUnited Kingdom

BACKGROUND Total mesorectal excision remains the gold standard for the management of rectal cancer however local excision of early rectal cancer is gaining popularity due to lower morbidity and higher acceptance by the elderly and frail *** To investigate the results of local excision of rectal cancer by transanal endoscopic microsurgery(TEMS)approach carried out at three large cancer centers in the United *** TEMS database was retrospectively reviewed to assess demographics,operative findings and post operative clinical and oncological *** is a retro-spective review of the prospective databases,which included all patients operated with TEMS approach,for early rectal cancer(Node-negative T1-T2),selected T3 in unfit/frail *** Two hundred and twenty-two patients underwent TEMS *** included 144 males(64.9%)and 78 females(35.1%),Median age was 71 *** median distance of the tumours from the anal verge 4.5 *** tumour size was 2.6 *** most frequent operative position of the patient was lithotomy(32.3%),Full-thickness rectal wall excision was done in 204 *** operating time was 90 *** blood loss was *** were two 90-day *** excision of the tumour with free microscopic margins by>1mm were accomplished in 171 patients(76.7%).Salvage total mesorectal excision was performed in 42 patients(19.8%).Median disease-free survival was 65 months(range:3-146 months)(82.8%),and median overall survival was 59 months(0-146 months).CONCLUSION TEMS provides a promising option for early rectal cancers(Large adenomas-cT1/cT2N0),and selected therapy-responding ***-thickness complete excision of the tumour is mandatory to avoid jeopardising the oncological outcomes.

关键词： Local excision Transanal endoscopic microsurgery Early rectal cancer Rectum preservation Rectum saving

Genomic prediction of Fusarium head blight resistance in early stages using advanced breeding lines in hard winter wheat

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The Crop Journal 2022年第6期10卷 1695-1704页

作者： Jinfeng Zhang Harsimardeep S.gill Navreet K.Brar Jyotirmoy Halder Shaukat Ali Xiaotian Liu Amy Bernardo Paul St.Amand Guihua Bai Upinder S.gill Brent Turnipseed Sunish K.Sehgal Department of Agronomy Horticulture&Plant ScienceSouth Dakota State UniversityBrookingsSD 57007USA School of Computing Queen’s UniversityKingstonON K7L 3N6Canada USDA-ARS Hard Winter Wheat Genetics Research UnitManhattanKS 66506USA Department of Plant Pathology North Dakota State UniversityFargoND 58108USA

Fusarium head blight(FHB),also known as scab,is a devastating fungal disease of wheat that causes significant losses in grain yield and *** inheritance and cumbersome phenotyping make FHB resistance a challenging trait for direct selection in wheat *** selection to predict FHB resistance traits has shown promise in several ***,we used univariate and multivariate genomic prediction models to evaluate the prediction accuracy(PA)for different FHB traits using 476elite and advanced breeding lines developed by South Dakota State University hard winter wheat breeding *** breeding lines were assessed for FHB disease index(DIS),and percentage of Fusarium damaged kernels(FDK)in three FHB nurseries in 2018,2019,and 2020(TP18,TP19,and TP20)and were evaluated as training populations(TP)for genomic prediction(GP)of FHB *** observed a moderate PA using univariate models for DIS(0.39 and 0.35)and FDK(0.35 and 0.37)using TP19 and TP20,respectively,while slightly higher PA was observed(0.41 for DIS and 0.38 for FDK)when TP19 and TP20(TP19+20)were combined to leverage the advantage of a large training *** GP with multivariate approach including plant height and days to heading as covariates did not significantly improve PA for DIS and FDK over univariate models,PA for DON increased by 20%using DIS,FDK,DTH as covariates using multi-trait model in ***,we used TP19,TP20,and TP19+20 in forward prediction to calculate genomic-estimated breeding values(GEBVs)for DIS and FDK in preliminary breeding lines at an early stage of the breeding *** observed moderate PA of up to 0.59 for DIS and 0.54for FDK,demonstrating the promise in genomic prediction for FHB resistance in earlier stages using advanced *** results suggest GP for expensive FHB traits like DON and FDK can facilitate the rejection of highly susceptible materials at an early stage in a breeding program.

关键词： FHB GBS Genomic selection Multi-trait models Winter wheat Wheat scab

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T. S. Eliot＇s Spiritual Journey in Designing The Cocktail Party as a Drama of Conversion

丛书名：外研社丽声拼读故事会

2011年

作者： (英) Clare Kirtley gill Howell

本书是故事: 奇怪的宠物、老师! 老师! 、这和那、鱼和薯条、爱唱歌的爸爸、鸭子医生的学习大纲, 包括介绍拼读规则、拼读指导和拓展训练。

ISBN: (纸本)9787513509268;7513509263;9787894788085

本书是故事: 奇怪的宠物、老师! 老师! 、这和那、鱼和薯条、爱唱歌的爸爸、鸭子医生的学习大纲, 包括介绍拼读规则、拼读指导和拓展训练。

关键词：英语

来源：畅想之星图书光盘版（南... 评论

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Journal of Philosophy Study 2016年第6期6卷 367-376页

作者： gill Kurtulus Bilkem University

In his quest for spiritual fulfillment, Thomas Stearns Eliot conducts a meticulous religious study which teaches him distinctive interpretations of human existence and their various functions that they are supposed to assume in the world. Eliot＇s personal attachment to religious knowledge and his reflections of religious studies inevitably manifest themselves in his literary works; be it his dramas or poems, mostly in the forms of philosophical and psychoanalytical analysis of his characters and the detected problems observed in their relationships. The Cocktail Party, a play starting off as a drawing-room comedy soon converts to a serious analysis of human psychology and the nature of human interactions. While engaging with these particular points, the play offers possibilities to discuss several religious allusions, though dealt with subtly. Integrated with religion, characters＇ attitudes towards a given situation and their final decision position them in their quest either in ＂hypothetical＂ enlightenment or in a ＂supposed＂ repetition of a vicious circle. The enforcing power behind the play is interestingly a psychiatrist, who adds dynamism and mystery to the plot and has a special task in making the play a drama of conversion. The inner conflicts of the characters which ultimately lead to a series of problems in their relationships are the main concern which causes the characters search for different solutions. Accordingly, they make their own choices to cease their inner struggles. This paper aims to explore the concept of conversion in Eliot＇s The Cocktail Party with references to the playwright＇s religious journey in his literary career.

关键词： T. S. Eliot drama of conversion verse drama modem poetic drama Buddhism

Targeting inflammation in pancreatic cancer: Clinical translation

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World Journal of Gastrointestinal Oncology 2016年第4期8卷 380-388页

作者： Colin William Steele Nina Angharad Kaur gill Nigel Balfour Jamieson Christopher Ross Carter Department of Pancreaticobiliary Surgery Glasgow Royal Infirmary Department of General Surgery South Glasgow University Hospital

Preclinical modelling studies are beginning to aid development of therapies targeted against key regulators of pancreatic cancer progression. Pancreatic cancer is an aggressive, stromally-rich tumor, from which few people survive. Within the tumor microenvironment cellular and extracellular components exist, shielding tumor cells from immune cell clearance, and chemotherapy, enhancing progression of the disease. The cellular component of this microenvironment consists mainly of stellate cells and inflammatory cells. New findings suggest that manipulation of the cellular component of the tumor microenvironment is possible to promote immune cell killing of tumor cells. Here we explore possible immunogenic therapeutic strategies. Additionally extracellular stromal elements play a key role in protecting tumor cells from chemotherapies targeted at the pancreas. We describe the experimental findings and the pitfalls associated with translation of stromally targeted therapies to clinical trial. Finally, we discuss the key inflammatory signal transducers activated subsequent to driver mutations in oncogenic Kras in pancreatic cancer. We present the preclinical findings that have led to successful early trials of STAT3 inhibitors in pancreatic adenocarcinoma.

关键词： Pancreatic cancer Inflammation Stroma Microenvironment

Virtual reality for immersive multi-user firefighter-training scenarios

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Virtual Reality & Intelligent Hardware 2022年第5期4卷 406-417页

作者： Philipp BRAUN Michaela GRAFELMANN Felix gill Hauke STOLZ Johannes HINCKELDEYN Ann-Kathrin LANGE Hamburg University of Technology Hamburg 21073Germany

Background Virtual reality(VR)applications can be used to provide comprehensive training scenarios that are difficult or impossible to represent in physical *** includes team training for emergency services such as *** a high level of immersion is essential for achieving effective virtual *** this respect,motion-capture systems offer the possibility of creating highly immersive multi-user training experiences,including full-body *** This study presents a preliminary prototype that helps extin-guish a virtual fire on a container ship as a VR training *** prototype provides a full-body and multi-user VR experience based on the synthesis of position data provided by the motion-capture system and orientation data from the VR ***,the prototype facilitates an initial evaluation of the *** The results confirm the value of using VR for training procedures that are difficult to implement in the real ***,the results show that motion-capture-based VR technologies are particularly useful for firefighting training,in which participants can collaborate in difficult-to-access ***,this study also indicates that increasing the immersion in such training remains a *** This study presents a prototypical VR application that enables the multi-user training of maritime *** research should evaluate the initial results,provide more extensive training scenarios,and measure the training progress.

关键词： Virtual reality Multi-user Motion capture Training Firefighting

DMP(1,1,1-Triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one):A novel catalyst for synthesis of 2-substituted benzimidazoles derivatives

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Chinese Chemical Letters 2009年第8期20卷 893-897页

作者： Sanjay K.Dabhade Rajesh O.Bora Mazahar Farooqui Charansingh H.gill Department of Chemistry Dr.Babasaheb Ambedkar Marathwada UniversityAurangabadMaharashtra 431 004 India Maulana Azad Post Graduate Research Centre AurangabadMaharashtra 431 001 India

Various 2-arylbenzimidazoles were synthesized from o-phenylenediamine and aldehydes via one-step process using DMP （Dess-Martin-periodinane） reagent as an oxidant. The method was proved to be simple, convenient and the products were isolated with good yields （80-90%）. ？2009 Charansingh H. gill. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Dess-Martin-periodinane Benzimidazole Aryl aldehydes Benzimidazole Oxidation

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