检索结果-南通市图书馆

Nano–Bio Interactions of Extracellular Vesicles with Gold Nanoislands for Early Cancer Diagnosis

Research 2018年第1期2018卷 105-114页

作者： S.Bathini D.Raju S.Badilescu A.Kumar R.J.Ouellette a.ghosh M.Packirisamy Optical Bio-Microsystems Laboratory Department of Mechanical Industrial and Aerospace EngineeringConcordia UniversityMontrealCanada Atlantic Cancer Research Institute MonctonNew BrunswickCanada

Extracellular vesicles or exosomes are membrane encapsulated biological nanometric particles secreted virtually by all types of cells throughout the animal *** carry a cargo of active molecules to proximal and distal cells of the body as mechanism of physiological communication,to maintain natural homeostasis as well as pathological *** carry a tremendous potential for liquid biopsy and therapeutic ***,there is a global demand for simple and robust exosome isolation methods amenable to point-of-care diagnosis and quality control of therapeutic exosome *** can be achieved by molecular profling of the exosomes for use with specifc sets of molecular-markers for diagnosis and quality *** biopsy is undoubtedly the most promising diagnosis process to advance“personalized medicine.”Currently,liquid biopsy is based on circulating cancer cells,cell free-DNA,or *** potentially provide promise for early-stage diagnostic possibility;in order to facilitate superior diagnosis and isolation of exosomes,a novel platform is developed to detect and capture them,based on localized surface plasmon resonance(LSPR)of gold nanoislands,through strong afnity between exosomes and peptide called Venceremin or *** modeling,based on the characteristics of the gold nanoislands and the bioentities involved in the sensing,is also developed to determine the detection capability of the platform,which is optimized experimentally at each *** results and modeling present a relationship between the plasmonic shif and the concentration of exosomes and,essentially,indicate possibilities for label-free early diagnosis.

关键词： diagnosis carry doubt

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thermo-mechanical properties of mullite–zirconia composites derived from reaction sintering of zircon and sillimanite beach sand: Effect of CaO

引用

Transactions of Nonferrous Metals Society of China 2016年第9期26卷 2397-2403页

作者： P.KUMAR M.NATH a.ghosh H.S.TRIPATHI Refractories Division CSIR–Central Glass and Ceramic Research Institute Academy of Scientific and Innovative Research (AcS IR) CSIR–Central Glass & Ceramic Research Institute

Mullite–zirconia composites containing 20% zirconia（mass fraction） were prepared by reaction sintering route utilizing Indian coastal zircon flour and sillimanite beach sand. 4%-12% of CaO（mole fraction） with respect to zirconia was used as additive. The effect of additive on densification, microstructure as well as various mechanical and thermo-mechanical properties was studied. Incorporation of CaO reduced the densification temperature of the composites to 1550 ℃ compared to 1600 ℃（for CaO free samples）. CaO formed small amount of liquid phase（calcium aluminosilicate）, which facilitated sintering. Average grain size of the composites decreased up to 4% CaO addition, afterwards grain size increased with further addition of CaO. Samples with 4% CaO exhibited ～225 MPa of flexural strength, ～6 MPa·m^1/2 of fracture toughness and significant improvement in thermal shock resistance. CaO stabilized the tetragonal zirconia phase and thus improved the mechanical properties.

关键词： reaction sintering mullite-zirconia composites flexural strength refractory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Epstein-Barr病毒特异性T细胞对重组痘苗病毒表达LMP和EBNA2的靶细胞的识别

引用

病毒学报 1991年第2期7卷 125-131页

作者：陈小毅 a.ghosh M.Moore John Arrand 广东湛江医学院病理教研室英国曼彻斯特柏特森癌症研究院免疫学实验室英国曼彻斯特柏特森癌症研究院分子生物学实验室

本文用EB病毒转化自体淋巴细胞所建立的类淋巴母细胞系(LCL),以及用EB病毒潜伏感染膜蛋白(LMP)基因和核蛋白-2(EBNA2)基因与痘苗病毒重组的重组病毒(Vac-LMP和Vac-EBNA2)感染的自身纤维母细胞,同时作为刺激细胞和靶细胞,以^(51)Cr释放... 详细信息

本文用EB病毒转化自体淋巴细胞所建立的类淋巴母细胞系(LCL),以及用EB病毒潜伏感染膜蛋白(LMP)基因和核蛋白-2(EBNA2)基因与痘苗病毒重组的重组病毒(Vac-LMP和Vac-EBNA2)感染的自身纤维母细胞,同时作为刺激细胞和靶细胞,以^(51)Cr释放法检测5例血清中EB病毒VCA—IgA抗体阳性者及1例阴性健康者外周血单个核细胞(PBMC)的特异性T细胞杀伤效应。结果表明,用自身LCL激活的EB病毒特异性T细胞杀伤效应高峰出现在第14～28天;参与杀伤性细胞免疫反应的T细胞亚群主要是T3、T8阳性的细胞毒性T细胞,其对靶细胞的识别及杀伤受HLA-I的限制。用重组牛痘病毒感染的纤维母细胞作靶细胞或刺激细胞,有1例供者可接受LMP,另1例可接受EBNA2的刺激,并对相应的靶细胞产生特异性T细胞杀伤反应,表明EB病毒-LMP和EBNA2可能既是EB病毒特异性T细胞的刺激抗原,又是其识别的靶抗原。

关键词： EB病毒重组痘苗病毒特异T细胞

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

全域表观扩散系数(ADC)直方图预测神经母细胞瘤MYCN扩增:初步结果

引用

国际医学放射学杂志 2023年第1期46卷 122-123页

作者： a.ghosh E.Yekeler D.Dalal A.Holroyd L.States 张慧慧

摘要目的探讨全域表观扩散系数(ADC)直方图预测神经母细胞瘤MYCN扩增的价值。方法回顾性分析62例神经母细胞瘤病人的影像资料[中位年龄15(7,24)个月,女38

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

MRI影像组学在预测神经母细胞瘤MYCN扩增中的作用

引用

国际医学放射学杂志 2023年第6期 751页

作者： a.ghosh E.Yekeler S.R.Teixeira D.Dalal L.States 周新哲

摘要目的评估MR影像组学并开发基于机器学习的分类器算法来预测神经母细胞瘤中的MYCN扩增情况。方法纳入120例具有基线MR影像的神经母细胞瘤病人，其中

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

FLOSSWorld全球调查结果显示服务器更多使用开源软件

引用

中国教育网络 2007年第1期 39-39页

作者： Rishab a.ghosh 刘佐达（整理）荷兰马斯特里希特大学教授清华大学网络中心

FLOSSWorld调查的主体由5部分构成,包括:个人(Private sector)、政府(Government sector)、开源社区参与者(Open Source participants community)、高校管理者(Heigher Education Institutes--Administrators)、高校信息部门主管(Heigher Education Institute--IT Managers).每部分的问题都是针对调查问卷的受众量身定做的,有一定的共同点,也有很大的区别.各成员国根据自己的职责开展相应的调查,以下是FLOSSWorld中一些具有代表性的问卷题目的调查结果,较好地反映了项目的成果.

关键词： World 开源软件调查结果服务器显示参与者

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Epstein—Barr病毒特异性T细胞对重组痘苗病毒表达LMP和EBNA2的靶细胞的识别

引用

广东医科大学学报 1993年第Z1期 211-211页

作者：陈小毅,a.ghosh,M.Moore,John Arrand 湛江医学院湛江医学院湛江医学院湛江医学院

本文用EB病毒转化自体淋巴细胞所建立的类淋巴母细胞系（LCL）,以及用EB病毒潜伏感染膜蛋白（LMP）基因和核蛋白—2（EBNA2）基因与痘苗病毒重组的重组病毒（Vac—LMP和Vac—EBNA2）感染的自身纤维母细胞,同时作为刺激细胞和靶细胞,以5... 详细信息

本文用EB病毒转化自体淋巴细胞所建立的类淋巴母细胞系（LCL）,以及用EB病毒潜伏感染膜蛋白（LMP）基因和核蛋白—2（EBNA2）基因与痘苗病毒重组的重组病毒（Vac—LMP和Vac—EBNA2）感染的自身纤维母细胞,同时作为刺激细胞和靶细胞,以51Cr释放法检测5例血清中EB病毒VCA—IgA抗体阳性者

关键词：靶细胞刺激细胞 EBNA2 Barr Epstein LMP 特异性

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Diabetic foot attack:Managing severe sepsis in the diabetic patient

引用

World Journal of Critical Care Medicine 2025年第1期14卷 1-13页

作者： Kisshan Raj Balakrishnan Dharshanan Raj Selva Raj Sabyasachi ghosh Gregory AJ Robertson Department of Trauma and Orthopaedics Wrexham Maelor HospitalWrexham LL137TDUnited Kingdom Department of Trauma and Orthopaedics The Robert Jones and Agnes Hunt Orthopaedic HospitalOswestry SY107AGUnited Kingdom

Diabetic foot attack(DFA)is the most severe presentation of diabetic foot disease,with the patient commonly displaying severe sepsis,which can be limb or life *** can be classified into two main categories:Typical and atypical.A typical DFA is secondary to a severe infection in the foot,often initiated by minor breaches in skin integrity that allow pathogens to enter and *** form often progresses rapidly due to the underlying diabetic pathophysiology of neuropathy,microvascular disease,and hyperglycemia,which facilitate infection spread and tissue *** form of DFA can present as one of a number of severe infective pathologies including pyomyositis,necrotizing fasciitis,and myonecrosis,all of which can lead to systemic sepsis and multiorgan *** atypical DFA,however,is not primarily *** can occur secondary to either ischemia or Charcot *** of the typical DFA involves prompt diagnosis,aggressive infection control,and a multidisciplinary *** can be guided by the current International Working Group on the Diabetic Foot/Infectious Diseases Society of America guidelines on diabetic foot infections,and the combined British Orthopaedic Foot and Ankle Society-Vascular Society *** article highlights the importance of early recognition,comprehensive management strategies,and the need for further research to establish standardized protocols and improve clinical outcomes for patients with DFA.

关键词： Diabetic foot attack Diabetic foot infection Diabetes mellitus Sepsis Systemic sepsis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of dietary fibre on the gastrointestinal microbiota during critical illness:A scoping review

引用

World Journal of Critical Care Medicine 2025年第1期14卷 49-59页

作者： Angajendra N ghosh Calum J Walsh Matthew J Maiden Tim P Stinear Adam M Deane Department of Intensive Care The Northern HospitalEpping 3076VictoriaAustralia Department of Microbiology and Immunology The Peter Doherty Institute for Infection and ImmunityMelbourne 3052VictoriaAustralia Department of Intensive Care The Royal Melbourne HospitalThe University of MelbourneParkville 3050VictoriaAustralia Department of Intensive Care Medicine The Royal Melbourne HospitalParkville 3050VictoriaAustralia

The systemic effects of gastrointestinal(GI)microbiota in health and during chronic diseases is increasingly *** strategies to modulate the GI microbiota during chronic diseases have demonstrated *** changes in dietary intake can rapidly change the GI microbiota,the impact of dietary changes during acute critical illness on the microbiota remain *** fibre is metabolised by carbohydrate-active enzymes and,in health,can alter GI *** aim of this scoping review was to describe the effects of dietary fibre supplementation in health and disease states,specifically during critical *** controlled trials and prospective cohort studies that include adults(>18 years age)and reported changes to GI microbiota as one of the study outcomes using non-culture methods,were *** show dietary fibres have an impact on faecal microbiota in health and *** fibre,inulin,has a marked and specific effect on increasing the abundance of faecal *** chain fatty acids produced by Bifidobacteria have been shown to be beneficial in other patient *** few trials have evaluated the effect of dietary fibre on the GI microbiota during critical *** research is necessary to establish optimal fibre type,doses,duration of intervention in critical illness.

关键词： Gastrointestinal microbiota Dietary fibre Health Critical illness Short chain fatty acids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Long-term follow-up result of short metaphyseal femoral stem in primary total hip arthroplasty:A retrospective study

引用

World Journal of Orthopedics 2025年第1期16卷 40-45页

作者： Manoj Kumar Ayush Sharma Vivek P Ksheerasagar Akash K ghosh Mukund Lal Department of Orthopaedics Indira Gandhi Medical College and HospitalShimla 171001Himāchal PradeshIndia Department of Orthopaedics Post Graduate Institute of Medical Education and ResearchChandigarh 160012ChandīgarhIndia

BACKGROUND Total hip arthroplasty(THA)has increased along with an increasing demand for improved quality of *** with prolonged life expectancy,the number of revision surgeries is expected to *** shielding is a significant issue with traditional femoral stems used in THA,making revision surgeries particularly challenging in younger *** has sparked renewed interest in studying safety and functional outcomes of short metaphyseal femoral stems,which have the potential to alleviate these challenges and simplify revision *** To evaluate the long-term outcomes of short-stem *** A total of 124 hips that underwent THA using the short femoral stem(TRILOCK®Depuy)between May 2006 and November 2008 were included in this *** were followed for a period of 15 *** were assessed in terms of pain relief,hip joint range of motion,improvement in mobility,and functional outcomes using the modified Harris Hip Score,Oxford hip score,and Western Ontario and McMaster Universities Osteoarthritis index *** A total of 124 hips in 98 patients were *** improvements in functional outcomes were observed over the 15-year follow-up period,with no cases of subsidence,implant loosening,or complications necessitating revision *** only complication reported was heterotopic ossification in 1 *** Short metaphyseal stems provide better functional outcomes with early mobilization,and its long-term follow-up without subsidence,implant loosening,or proximal femoral bone loss simplifies revision surgery in younger patients.

关键词： Short stem total hip replacement Short metaphyseal stem Uncemented hip replacement Proximal femur osteolysis Proximal femur bone loss

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：