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Earth and Planetary Physics 2022年第1期6卷 42-51页

作者： Xiao-Dong Wang B.Klecker G.Nicolaou S.Barabash M.Wieser P.Wurz a.galli F.Cipriani Y.Futaana Swedish Institute of Space Physics KirunaSweden Max-Planck Institute für extraterrestrische Physik GarchingGermany Physics Institute University of BernBernSwitzerland ESA/ESTEC Research and Scientific Support DepartmentNoordwijkThe Netherlands

Energetic neutral atoms(ENAs)are produced by the neutralization of energetic ions formed by shock-accelerated gradual solar energetic particle events(SEP).These high-energy ENAs(HENAs)can reach the Earth earlier than the associated SEPs and thus can provide information about the SEPs at the lower *** HENA properties observed at Earth depend on the properties of the coronal mass ejection(CME)-driven shocks that accelerate the *** a model of HENA production in a shock-accelerated SEP event,we semi-quantitatively investigate the energy-time spectrum of HENAs depending on the width,propagation speed,and direction of the shock,as well as the density and ion abundances of the lower *** to the baseline model parameters,the cases with a wider shock width angle or a higher coronal density would increase the HENA flux observed at the Earth,while the case with an Earthpropagating shock shows a softened HENA *** comparison of expected HENA fluxes in different cases with a flight-proven ENA instrument suggests that solar HENAs can feasibly be monitored with current technologies,which could provide a lead time of 2−3 hours for SEPs at a few *** propose that monitoring of solar HENAs could provide a new method to forecast shock-driven SEP events that are capable of significant space weather impacts on the near-Earth environment.

关键词： solar energetic particles energetic neutral atoms space weather numerical simulation

Extending OpenStack Monasca for Predictive Elasticity Control

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Big Data Mining and Analytics 2024年第2期7卷 315-339页

作者： Giacomo Lanciano Filippo galli Tommaso Cucinotta Davide Bacciu Andrea Passarella Scuola Normale Superiore Pisa 56126Italy the Real-Time Systems Laboratory(RETIS) TelecommunicationsComputer Engineeringand Photonics Institute(TeCIP)Scuola Superiore Sant’AnnaPisa 56127Italy Department of Computer Science University of PisaPisa 56127Italy National Research Council Pisa56127Italy

Traditional auto-scaling approaches are conceived as reactive automations,typically triggered when predefined thresholds are breached by resource consumption *** such rules at scale is cumbersome,especially when resources require non-negligible time to be *** paper introduces an architecture for predictive cloud operations,which enables orchestrators to apply time-series forecasting techniques to estimate the evolution of relevant metrics and take decisions based on the predicted state of the *** this way,they can anticipate load peaks and trigger appropriate scaling actions in advance,such that new resources are available when *** proposed architecture is implemented in OpenStack,extending the monitoring capabilities of Monasca by injecting short-term forecasts of standard *** use our architecture to implement predictive scaling policies leveraging on linear regression,autoregressive integrated moving average,feed-forward,and recurrent neural networks(RNN).Then,we evaluate their performance on a synthetic workload,comparing them to those of a traditional *** assess the ability of the different models to generalize to unseen patterns,we also evaluate them on traces from a real content delivery network(CDN)*** particular,the RNN model exhibites the best overall performance in terms of prediction error,observed client-side response latency,and forecasting *** implementation of our architecture is open-source.

关键词： OpenStack monitoring elasticity control auto-scaling predictive operations Monasca

Type-B monoamine oxidase inhibitors in neurological diseases:clinical applications based on preclinical findings

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Neural Regeneration Research 2024年第1期19卷 16-21页

作者： Marika Alborghetti Edoardo Bianchini Lanfranco De Carolis Silvia.galli Francesco E.Pontieri Domiziana Rinaldi Neurology Unit NESMOS DepartmentFaculty of Medicine&PsychologySapienza-University of RomeSant’Andrea University HospitalRomeItaly Department of Clinical and Behavioral Neurology IRCCS-Fondazione Santa LuciaRomeItaly

Type-B monoamine oxidase inhibitors,encompassing selegiline,rasagiline,and safinamide,are available to treat Parkinson's *** drugs ameliorate motor symptoms and improve motor fluctuation in the advanced stages of the *** is also evidence suppo rting the benefit of type-B monoamine oxidase inhibitors on non-motor symptoms of Parkinson's disease,such as mood deflection,cognitive impairment,sleep disturbances,and *** studies indicate that type-B monoamine oxidase inhibitors hold a strong neuroprotective potential in Parkinson's disease and other neurodegenerative diseases for reducing oxidative stress and stimulating the production and release of neurotrophic factors,particularly glial cell line-derived neurotrophic factor,which suppo rt dopaminergic ***,safinamide may interfere with neurodegenerative mechanisms,countera cting excessive glutamate overdrive in basal ganglia motor circuit and reducing death from *** to the dual mechanism of action,the new generation of type-B monoamine oxidase inhibitors,including safinamide,is gaining interest in other neurological pathologies,and many supporting preclinical studies are now *** potential fields of application concern epilepsy,Duchenne muscular dystrophy,multiple scle rosis,and above all,ischemic brain *** purpose of this review is to investigate the preclinical and clinical pharmacology of selegiline,rasagiline,and safinamide in Parkinson's disease and beyond,focusing on possible future therapeutic applications.

关键词： glial cell line-derived neurotrophic factor(GDNF) glutamate neurological disorders neuroprotection Parkinson's disease preclinical studies rasagiline safinamide selegiline type-B monoamine oxidase(MAO_(B))inhibitors

Cold ischemia time in liver transplantation:An overview

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World Journal of Hepatology 2024年第6期16卷 883-890页

作者： Manuela Cesaretti Alessandro Izzo Roberta Anna Pellegrino Alessandro galli Orestes Mavrothalassitis Department of HPB and Liver Transplantation Brotzu HospitalCagliari 09122Italy Department of Nanophysic Istituto Italiano di TecnologiaGenova 16163Italy Department of Critical Care Medicine and Anesthesia ASST Papa Giovanni XXIIIBergamo 24100Italy Department of Anesthesia and Perioperative Care University of California San FranciscoSan FranciscoCA 94143United States

The standard approach to organ preservation in liver transplantation is by static cold storage and the time between the cross-clamping of a graft in a donor and its reperfusion in the recipient is defined as cold ischemia time(CIT).This simple definition reveals a multifactorial time frame that depends on donor hepatectomy time,transit time,and recipient surgery time,and is one of the most important donor-related risk factors which may influence the graft and recipient’s ***,the growing demand for the use of marginal liver grafts has prompted scientific exploration to analyze ischemia time factors and develop different organ preservation *** review details the CIT definition and analyzes its different *** also explores the most recent strategies developed to implement each timestamp of CIT and to protect the graft from ischemic injury.

关键词： Cold ischemia time Liver transplantation Organ donation Donation after cardiac death Warm ischemia time Machine perfusion

Correlation between Intestinal Health and Coccidiosis Prevalence in Broilers during Different Seasons of the Year in Brazil from 2012 to 2018

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Food and Nutrition Sciences 2024年第3期15卷 179-198页

作者： Fabio Luis Gazoni Gabriela Miotto galli Marcel Manente Boiago Lenita Moura Stefani Aline Zampar Marco A. Juárez-Estrada Guillermo Tellez-Isaias Aleksandro S. da Silva Animal Health and Reproduction Veterinary Medicine Graduate Program Federal University of Santa Maria (UFSM) Santa Maria Brazil Animal Science Graduate Program Federal University of Rio Grande do Sul (UFRGS) Porto Alegre Brazil Animal Science Graduate Program Santa Catarina State University (UDESC) Chapecó Brazil Departamento de Medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autonoma de Mexico Ciudad Universitaria Ciudad de Mexico Mexico Department of Poultry Science Division of Agriculture University of Arkansas Fayetteville AR USA

Coccidiosis is a disease caused by intracellular protozoan parasites, specifically belonging to the genus Eimeria. These parasites target the gastrointestinal tract in different types of hosts, causing sores in the intestinal lining. The presence of these lesions reduces the animal’s ability to digest and absorb nutrients, significantly impacting their overall performance. The current study aimed to explore the potential correlation between seasonal variations and the incidence of Eimeria spp-induced lesions in broiler chickens’ gastrointestinal tracts in Brazil from 2012 to 2018. A total of 8,607 broiler chickens, aged 14 to 42 days, were sampled from 103 poultry integrated companies in Brazil to conduct intestinal health examinations. The sampling process involved selecting 3 to 6 chickens from each poultry house for examination. The assessment included various abnormalities such as shedding of intestinal cells and excessive fluid and mucus presence, thickening and tension of the intestines, food movement, roughened mucosal surface resembling a Turkish towel in the small intestine, tissue death, duodenal inflammation, intestinal inflammation, gizzard erosion, presence of worms and bedding material, and ingestion of mealworms. During the seasons, winter exhibited the highest average occurrence of Eimeria maxima microorganisms at 52.83%, with E. acervulina following closely at 26.42% in second place. In spring, E. maxima had an occurrence of 11.31%, while in fall, E. tenella had the lowest occurrence at 6.74%. When analyzing the seasonal occurrence of Eimeria, it was observed that E. maxima micro was more common during winter compared to summer (P = 0.0491). However, no discernible variation was observed in the occurrence of the remaining species across different seasons. Research findings suggest that subclinical coccidiosis is most prevalent during the winter season in Brazil. Likewise, clinical disease caused by E. acervulina is also prevalent during this time. I

关键词： Eimeria Epidemiology Intestinal Pathology Broiler Chickens Brazil

Tunable ferroelectricity in oxygen-deficient perovskites with Grenier structure

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npj Computational Materials 2023年第1期9卷 118-125页

作者： Yongjin Shin Giulia.galli Pritzker School of Molecular Engineering University of ChicagoChicagoIL 60637USA Department of Chemistry University of ChicagoChicagoIL 60637USA Center for Molecular Engineering and Materials Science Division Argonne National LaboratoryLemontIL 60439USA

Using first-principles calculations,we predict that tunable ferroelectricity can be realized in oxide perovskites with the Grenier structure and ordered oxygen ***,we show that R_(1/3)A_(2/3)FeO_(2.67) solids(where R is a rare-earth ion and A an alkaline-earth cation)exhibit polar phases,with a spontaneous polarization tunable by an appropriate choice of R and *** find that larger cations combined with small R elements lead to a maximum in the polarization and to a minimum in the energy barriers required to switch the sign of the *** arises from cooperative distortions of octahedral and tetrahedral units,where a combination of rotational and sliding modes controls the emergence of polarization within three-dimensional connected *** results indicate that polar Grenier phases of oxide perovskites are promising materials for microelectronic applications and,in general,for the study of phenomena emerging from breaking inversion symmetry in solids.

关键词： polarization ferroelectric structure

Vibrationally resolved optical excitations of the nitrogen-vacancy center in diamond

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npj Computational Materials 2022年第1期8卷 2258-2266页

作者： Yu Jin Marco Govoni Giulia.galli Department of Chemistry University of ChicagoChicagoIL60637USA Pritzker School of Molecular Engineering University of ChicagoChicagoIL60637USA Materials Science Division and Center for Molecular Engineering Argonne National LaboratoryLemontIL60439USA

A comprehensive description of the optical cycle of spin defects in solids requires the understanding of the electronic and atomistic structure of states with different spin multiplicity,including singlet states which are particularly challenging from a theoretical *** present a general framework,based on spin-flip time-dependent density function theory,to determine the excited state potential energy surfaces of the many-body singlet states of spin defects;we then predict the vibrationally resolved absorption spectrum between singlet shelving states of a prototypical defect,the nitrogen-vacancy center in *** results,which are in very good agreement with experiments,provide an interpretation of the measured spectra and reveal the key role of specific phonons in determining absorption processes,and the notable influence of non-adiabatic *** insights gained from our calculations may be useful in defining strategies to improve infrared-absorption-based magnetometry and optical pumping *** theoretical framework developed here is general and applicable to a variety of other spin defects and materials.

关键词： vacancy resolved singlet

Cat scratch disease in childhood: a 10-year experience of an Italian tertiary care children’s hospital

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World Journal of Pediatrics 2023年第2期19卷 189-193页

作者： Lara Fusani Elisabetta Venturini Elena Chiappini Luisa.galli Postgraduate School of Pediatrics University of FlorenceMeyer Children’s HospitalFlorenceItaly Infectious Diseases Unit Meyer Children’s HospitalViale Pieraccini 24FlorenceItaly Department of Health Sciences University of FlorenceFlorenceItaly

Cat scratch disease(CSD),an infection caused by Bartonella henselae,is uncommon in Europe,whereas 24,000 cases per year have been reported in the United States[1,2].The typical manifestation of CSD consists of fever and subacute,solitary or regional,painful and self-limited lymphadenopathy in a patient with a history of previous scratching,biting,or contact with a kitten or cat[3].In 85%of patients,only one regional lymph node is involved,which is located in the axillary and epitrochlear regions in approximately half of the cases[4,5].One or more round,red-brown nontender papules can develop at the inoculation site or near the scratch after a few days and may persist until two to three weeks[6].

关键词： Italian scratch Barton

Practical insights into chronic management of hepatic Wilson’s disease

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World Journal of Clinical Cases 2022年第14期10卷 4334-4347页

作者： Erica Nicola Lynch Claudia Campani Tommaso Innocenti Gabriele Dragoni Paolo Forte Andrea.galli Gastroenterology Research Unit Department of Experimental and Clinical Biomedical Sciences“Mario Serio”University of FlorenceFlorence 50134Italy Department of Experimental and Clinical Medicine University of FlorenceFlorence 50134Italy Department of Medical Biotechnologies University of SienaSiena 53100Italy Division of Gastroenterology University Hospital“Careggi”Florence 50134Italy

Wilson’s disease(WD)is a rare inherited disorder of human copper metabolism,with an estimated prevalence of 1:30000-1:50000 and a broad spectrum of hepatic and neuropsychiatric *** healthy individuals,the bile is the main route of elimination of *** WD patients,copper accumulates in the liver,it is released into the bloodstream,and is excreted in *** can also be accumulated in the brain,kidneys,heart,and osseous matter and causes damage due to direct toxicity or oxidative *** WD is commonly but not exclusively diagnosed in childhood or young ***,non-cirrhotic WD patients seem to have a normal life ***,chronic management of patients with Wilson’s disease is challenging,as available biochemical tests have many limitations and do not allow a clear identification of non-compliance,overtreatment,or treatment *** provide optimal care,clinicians should have a complete understanding of these limitations and counterbalance them with a thorough clinical *** aim of this review is to provide clinicians with practical tools and suggestions which may answer doubts that can arise during chronic management of patients with hepatic *** particular,it summarises current knowledge on Wilson’s disease clinical and biochemical monitoring and *** also analyses available evidence on pregnancy and the role of low-copper diet in *** research should focus on trying to provide new copper metabolism tests which could help to guide treatment adjustments.

关键词： Wilson’s disease Urinary copper excretion Non-ceruloplasmin-bound copper D-penicillamine Trientine Zinc salts

Specific alterations of regional myocardial work in strength-trained athletes using anabolic androgenic steroids compared to athletes with genetic hypertrophic cardiomyopathy

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Journal of Sport and Health Science 2023年第4期12卷 477-485页

作者： Antoine Grandperrin Frédéric Schnell Erwan Donal Elena.galli Christophe Hedon Olivier Cazorla Stéphane Nottin Avignon University LaPEC UPR 4278Avignon F-84000France Rennes University CHU RennesInsermLTSI-UMR 1099Rennes F-35000France Montpellier University PhyMedExpINSERMCNRSPhysiology and Experimental Heart and Muscle MedicineMontpellier 34295France

Background:Strength-trained athletes using anabolic androgenic steroids(AAS)have left ventricular(LV)hypertrophy and myocardial fibrosis that can lead to sudden cardiac death.A similar feature was described in athletes with hypertrophic cardiomyopathy(HCM),which complicates the diagnosis for *** this context,we aimed to compare the LV function of the 2 populations by measuring global and regional strain and myocardial work using speckle-tracking ***:Twenty-four strength-trained asymptomatic athletes using AAS(AAS-Athletes),22 athletes diagnosed with HCM(HCM-Athletes),and 20 healthy control athletes(Ctrl-Athletes)underwent a resting echocardiography to assess LV *** evaluated LV global and regional strains and myocardial work,with an evaluation of the constructive work(CW),wasted work,and work efficiency(WE).Results:Compared to Ctrl-Athletes,both AAS-Athletes and HCM-Athletes had a thicker interventricular septum,with maj ored values in *** strain was reduced in AAS-Athletes and even more in ***,global WE was significantly diminished in both AAS and HCM-Athletes(93%±2%in Ctrl-Athletes,90%±4%in AAS-Athletes,and 90%±5%in HCM-Athletes(mean±SD);p<0.05).Constructive work and WE regional analysis showed specific alterations,with the basal septal segments preferentially affected in AAS-Athletes,and both septal and apical segments affected in ***:The regional evaluation of myocardial work reported specific alterations of the major LV hypertrophy induced by the regular use of AAS compared to the LV hypertrophy due to *** finding could help clinicians to differentiate between these 2 forms of pathological hypertrophy.

关键词： Anabolic androgenic steroids Hypertrophic cardiomyopathy Left ventricular function Myocardial work Speckle-tracking echocardiography