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Recent advances and future therapy development for Alzheimer’s disease and related disorders

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Neural Regeneration Research 2024年第9期19卷 1877-1878页

作者： Megan Hong gal Bitan Department of Neurology David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCAUSA Department of Chemistry and Biochemistry University of California Los AngelesLos AngelesCAUSA Molecular Biology Institute University of California Los AngelesLos AngelesCAUSA Brain Research Institute University of CaliforniaLos AngelesCAUSA

Over 55 million people globally live with Alzheimer’s disease(AD)or related dementias(ADRD)and the number is expected to double every twenty *** i l recent l y,onl y symptomatic treatments were available to patients with AD,including acetylcholine esterase inhibitors,of which the last one,galantamine,was approved by the US Food and Drug Administration(FDA)in 2001.

关键词： Alzheimer globally patients

Intraspecific scaling and early life history determine the cost of free-flight in a large beetle(Batocera rufomaculata)

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Insect Science 2024年第2期31卷 524-532页

作者： Tomer Urcai Eran Levin Eran Gefen gal Ribak Faculty of Life Sciences School of ZoologyTel Aviv UniversityTel AvivIsrael Steinhardt Museum of Natural History Israel National Center for Biodiversity StudiesTel AvivIsrael Department of Biology University of Haifa-OranimKiryat TivonIsrael

The scaling of the energetic cost of locomotion with body mass is well documented at the interspecific ***,methodological restrictions limit our understanding of the scaling of flight metabolic rate(MR)in free-flying *** is particularly true at the intraspecific level,where variation in body mass and flight energetics may have direct consequences for the fitness of an *** applied a 13C stable isotope method to investigate the scaling of MR with body mass during free-flight in the beetle Batocera *** species exhibits large intraspecific variation in adult body mass as a consequence of the environmental conditions during larval *** show that the flight-MR scales with body mass to the power of 0.57,with smaller conspecifics possessing up to 2.3 fold higher mass-specific flight MR than larger *** the scaling exponent of free-flight MR was found to be like that determined for tethered-flight,the energy expenditure during free-flight was more than 2.7 fold higher than for *** metabolic cost of flight should therefore be studied under free-flight conditions,a requirement now enabled by the 13C technique described herein for insect flight.

关键词： allometry body mass Coleoptera free-flight insect flight stable carbon isotope tethered-flight

Influence of cerium ions on structure-dependent magnetic properties of Ba-Sr M-type hexaferrite nanocrystals

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Journal of Rare Earths 2024年第2期42卷 364-372,I0005页

作者： Ram A.Pawar Sunil M.Patange P.M.Dighe Sher Singh Meena Abdullah gal-Sehemi Mehboobali Pannipara Santosh S.Jadhav Department of Physics ArtsCommerce and Science CollegeAhmednagar413711MaharashtraIndia Department of Physics Shri Krishna MahavidyalayaGunjotiDistOsmanabad413606MaharashtraIndia Padmashri Vikhe Patil College of Arts Science and CommercePravaranagarA/P.Loni(Kd)Tal.RahataDistAhmednagar413713MaharashtraIndia Solid State Physics Division Bhabha Atomic Research CentreMumbai400085MaharashtraIndia Department of Chemistry King Khalid UniversityAbha61413Saudi Arabia Department of Physics D.S.M's ArtsCommerce and Science CollegeJintur431509MaharashtraIndia

The present study is a systematic effort to investigate the structure-sensitive magnetic parameters of Ce^(3+) substituted Ba-Sr hexaferrite nanocrystals chemically formulated as Ba_(0.5)Sr_(0.5)Ce_(x)Fe_(12-x)O_(19) where x=0.0-0.2 with Δx=*** hexaferrite powders were prepared using the sol-gel self-ignition route and structurally characterized by means of powder X-ray diffraction and Fourier transform infrared *** creation of the M-type hexaferrite phase within the synthesized samples was revealed from the Rietveld refinement of the X-ray *** occurrence of a secondary phase of CeO_(2) was revealed within the hexaferrites for the substitution,x> *** refined X-ray diffraction data were utilized to compute the lattice parameters,X-ray density,and lattice parameter *** crystal structure plotted from the refined XRD data reveals the occupancy of the ions at different lattice *** XPS data of the hexaferrite were analyzed to confirm the oxidation states of the constituent *** nanocrystalline nature of the hexaferrites was revealed from the crystallite sizes calculated using Scherer's *** analysis of FTIR spectra confirms that only a fraction of Ce^(3+)accommodated in the lattice and the remaining Ce content reside in the form of the CeO_(2) *** morphology of the hexaferrites was analyzed from the FESEM profiles of the ferrite *** magnetic behavior study was performed by analyzing the Curie temperature,hysteresis loops,and hyperfine interactions by means of susceptibility,V.S.M,and Mossbauer spectroscopy,*** hexaferrites with increasing coercivity,decreasing saturation magnetization,and decreasing Curie temperature are reported in the *** substituted Ce^(3+)ions inhibit the grain growth and create lattice imperfections giving rise to hexaferrites with tuned magnetic parameters suitable for different applications.

关键词： Ba-Sr hexaferrite Ce^(3+)substitution XPS Saturation magnetization Coercivity M?ssbauer spectroscopy

Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-galán Cristina Jiménez-Luna Isabel Rodriguez Elisabeth Maza Carlos García-Collado Antonio Rodríguez-Fernández Javier Luis López-Hidalgo Octavio Caba Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of Medicina Nuclear Virgen de las Nieves University HospitalGranada 18014Spain Department of Anatomía Patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUND Metastatic pancreatic ductal adenocarcinoma(PDAC)is a lethal malignancy with dispiriting survival *** is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor *** describe a case of metastatic PDAC effectively treated with *** SUMMARY We report the case of a 67-year-old woman with unresectable locally advanced PDAC,treated with gemcitabine plus nab-paclitaxel followed by radiotherapy plus *** nine months,pancreatic tumor progression was observed at the level of the hepatic hilum with the appearance of a new pulmonary nodule suggestive of a second primary,confirmed by left lung *** immunotherapy was then initiated with pembrolizumab,an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor *** patient showed a complete metabolic response that was maintained throughout the *** patient continues to be disease-free at 5.6 years since the start of *** These results suggest that the administration of pembrolizumab after chemoradiotherapy has a beneficial effect in patients with metastatic *** our knowledge,this is the first reported case of a patient with metastatic PDAC and metastatic lung cancer showing such a long-lasting complete response after pembrolizumab treatment without curative *** studies are required to determine biomarkers that identify PDAC patients most likely to benefit from this immunotherapy.

关键词： Pancreatic ductal adenocarcinoma Lung cancer Immunotherapy Pembrolizumab Programmed cell death protein-1 Case report

Lab results of COVID-19 patients:Omicron vs delta variants

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World Journal of Virology 2024年第2期13卷 71-77页

作者： Dana Avraham Amir Herman gal Shaham Arkady Shklyar Elina Sulim Maria Oulianski Orthopedic Department Kaplan Medical CenterRehovot 7661041Israel Department of Medicine Lithuanian University of Health SciencesKaunas 44307Lithuania Emergency Department Kaplan Medical CenterRehovot 7661041Israel

BACKGROUND The coronavirus disease 2019(COVID-19)virus has been a world-known pan-demic since February *** variances had been established;the most common variants in Israel were omicron and *** To analyze and compare laboratory values in the"omicron"and"delta"variants of the coronavirus by conducting follow-up examinations and laboratory audits on COVID-19 patients admitted to our *** A retrospective study,two groups,50 patients in each *** examined positive for COVID-19 were divided into groups according to the common variant at the given *** reviewed demographic data and laboratory results such as complete blood count and full chemistry,including electrolytes and coagulation *** The mean age was 52%,66.53±21.7 were *** significance was found comparing laboratory results in the following disciplines:Blood count,hemo-globin,and lymphocytes(P=0.41,P=0.87,P=0.97).Omicron and delta variants have higher neutrophil counts,though they are not significantly different(P=0.38).Coagulation tests:Activated paritial thromoplastin test and international normalized ratio(P=0.72,P=0.68).We found no significance of abnormality for all *** The study compares laboratory results of blood tests between two variants of the COVID-19 virus–omicron and *** found no significance between the *** results show the need for further research with larger data as well as the need to compare all COVID-19 variants.

关键词： COVID-19 Coronavirus Omicron variant Delta variant

Metabolic cost of flight and aerobic efficiency in the rose chafer,Protaetia cuprea(Cetoniinae)

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Insect Science 2022年第5期29卷 1361-1372页

作者： Tomer Urca Eran Levin gal Ribak School of Zoology Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Steinhardt Museum of Natural History Israel National Center for Biodiversity StudiesTel AvivIsrael

Rose chafer beetles(Protetia cuprea)are pollinators as well as agricultural pests,flying between flowers and trees while foraging for pollen and *** the energy they expend on flying during foraging activity faces the challenge of measuring the metabolic rate(MR)of free-flying insects in an open *** overcame this challenge by using the bolus injection of ^(13)C Na-bicarbonate technique to measure their metabolic energy expenditure while flying in a large flight ***,we tracked the insects with high-speed cameras to extract their flight trajectory,from which we calculated the mechanical power invested in flying for each flight *** found that the chemical(metabolic)energy input converted to mechanical flight energy output at a mean efficiency of 10.4%±5.2%,with a trend of increased efficiency in larger conspecifics(efficiency scaled with body mass to the power of 1.4).The transition in the summer from a diet of pollen to that of fruits may affect the energy budget available for *** ***,feeding on apples ad libitum,increased their body mass by an average of 6%in 2 *** to our calculations,such a meal can power a 630-m flight(assuming a carbohydrate assimilation efficiency of 90%).Pollen,with a low water and carbohydrate content but rich in proteins and lipids,has a higher caloric content and should assimilate differently when converting food to flight *** high cost of aerial locomotion is inherent to the foraging behavior of rose chafers,explaining their short flight bouts followed by prolonged feeding activity.

关键词： aerobic eficieney bolus injection of^(13)C-Na-bicarbonate feeding capacity flight metabolic rate flower chafer bele free flight mechanical power

Feature engineering methodology for congestion forecasting

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第6期9卷 1055-1068页

作者： Ayelet gal-Tzur Shlomo Bekhor Yana Barsky Department of Industrial Engineering and Management Ruppin Academic CenterEmek Hefer 40250Israel Faculty of Civil and Environmental Engineering Israel Institute of TechnologyHaifa 32000Israel Transportation Research Institute Israel Institute of TechnologyHaifa 32000Israel

Short-term traffic forecasting is a key element in proactive traffic management,e.g.,mitigating the negative effect of impending congestion through appropriate capacity allocation at signalized *** this study,we develop a data-driven methodology for reliably and robustly predicting impending stable *** incorporating feature engineering techniques into an iterative machine learning process,we develop a prediction model that can be intuitively understood by traffic experts and is amenable to diagnostics during *** iterative machine learning process combines the embedded and filter approaches for feature selection with the use of expert knowledge to create aggregative input *** embedded approach is represented by application of a decision tree algorithm,while the filter approach is reflected in use of the mean decrease in accuracy output of a random forest algorithm for identifying expressive *** tested the methodology by applying it to field data from a sub-network in Tel *** demonstrated a reduction in the number of decision tree input variables from 66 raw variables to the five most effective aggregative ones,while achieving statistically significant improvement in all performance *** identification rate of stable congestion increased from 65%to 74%while the robustness of the results was enhanced:the standard deviations of the identification and false alarm rates fell from 8%to 3%,respectively,to 5%and 2%.

关键词： Intelligent transportation systems Advanced traffic management systems Congestion forecasting Data mining Feature engineering

An optimized approach for estimating benzene in ambient air within an air quality monitoring network

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Journal of Environmental Sciences 2022年第1期34卷 164-174页

作者： David galán-Madruga Jesús P.García-Cambero Atmospheric Pollution Area National Center for Environment HealthCarlosⅢHealth Institute28220 MadridSpain Toxicology Area National Center for Environment HealthCarlosⅢHealth Institute28220 MadridSpain

Benzene is a carcinogenic air pollutant for which European legislation has set an annual limit and criteria for the number of fixed monitoring sites within air quality networks(AQMN).However,due to the limited number of fixed sites for benzene measurement,exposure data are *** the relationship between benzene levels and other variables monitored within an AQMN,such as NO_(2),O_(3),temperature,solar radiation,and accumulated precipitation,this study proposes an approach for estimating benzene air concentrations from the related *** the data of the aforementioned variables from23 fixed stations during 2016-2017,the proposed approach was able to forecast benzene concentration for 2018 with high confidence,providing enriched data on benzene exposure and its ***,the spatial distribution of the estimated versus the most representative benzene levels was quite ***,an artificial neural network identified the most representative fixed benzene monitoring sites within the AQMN.

关键词： Ambient air Air quality network Benzene NO_(2)/O_(3)ratio Meteorological variables Prediction model

Flexible active antenna arrays

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npj Flexible Electronics 2022年第1期6卷 829-839页

作者： Matan gal-Katziri Austin Fikes Ali Hajimiri Department of Electrical Engineering California Institute of TechnologyPasadenaCA 91125USA School of Electrical Engineering Ben-Gurion UniversityBe’er-Sheva 8443944Israel

Complex and dynamic control of radiated fields are advantageous for flexible radio systems,which naturally move,roll,bend,twist,deform,and *** challenges hinder the proliferation of these antenna *** work shows how using radiofrequency microchips reduces system component count,decreases mass to~0.1 g cm−2,and increases functionality and mechanical *** develop a general platform for large scale flexible arrays and demonstrate two different 256-elements,30×30 cm2 flexible *** varying supply distribution methods and radiators we show how performance can be optimized for maximum power delivery or physical *** demonstrated systems conform to curved surfaces with radii of curvatures as low as 23 cm and wirelessly deliver~80 mW of DC power to a 6.7 cm×11 cm-receiver over one meter *** paves the way towards the integration of smart arrays in flexible wearables and deployable lightweight airborne systems.

关键词： antenna arrays hinder