检索结果-南通市图书馆

Lipid-lowering effect of microencapsulated peptides from brewer’s spent grain in high-sucrose diet-fed rats

Food Bioscience 2022年第5期49卷 981-989页

作者： M.R.Ferreira a.g.garz´on M.E.Oliva R.E.Cian S.R.Drago M.E.D’Alessandro Laboratorio de Estudio de Enfermedades Metab´olicas Relacionadas con la Nutrici´on Facultad de Bioquímica y Ciencias Biol´ogicasUniversidad Nacional del LitoralCiudad UniversitariaSanta FeArgentina Instituto de Tecnología de Alimentos Facultad de Ingeniería QuímicaUniversidad Nacional del Litoral1ro de Mayo3250Santa FeArgentina Consejo Nacional de Investigaciones Científicas y T´ecnicas(CONICET) Argentina

Brewer’s spent grain(BSg)-a byproduct generated from the processing of beer-brewing industry-is currently recognized as an important source of bioactive peptides with potential health *** previous studies we demonstrated that peptides obtained from BSg(BSg-P)can exert in vitro biofunctional activities including hypolipidemic ***,there are no studies about the effects of gastrointestinal digestion on BSg lipid-lowering peptides and it is unknown whether the bioactive properties observed in vitro remain in *** aims of this work were to evaluate the microencapsulation as strategy to preserve hypolipidemic BSg-P under a simulated gastrointestinal digestion,and the bioavailability of microencapsulated BSg-P using a rodent model of hyperlipidemia and other metabolic-related disorders induced by the consumption of a high-sucrose *** vitro studies showed that microencapsulation improved the BSg-P reduced hypolipidemic activity observed under a simulated gastrointestinal digestion by increasing the inhibition of the fat digestion enzymes,pancreatic lipase and cholesterol ***,in vivo studies demonstrated that microencapsulated BSg-P were also able to reduce the increased serum lipid levels(triglycerides-Tg-cholesterol and free fatty acids),energy intake,visceral adipocytes size and Tg content observed in sucrose-rich diet-fed *** was accompanied by reduced liver lipids levels and the activities of key enzymes involved in dietary fat ***,our findings show that microencapsulation is a useful strategy to preserve the hypolipidemic activity of BSg-P and support the concept that microencapsulated BSg-P would be an interesting and cheaper natural source to prevent hyperlipidemias and its related-disorders.

关键词： Bioactive peptides Brewer’s spent grain Hyperlipidemia Sucrose-rich diet Metabolic tissue Digestive enzymes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An SPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of geotechnical Structures

引用

Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the PM4Sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level ground site,and liquefaction-induced failure of the Lower San Fernando *** agreement for liquefaction triggering and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Do Rules and Patterns Affect Design Maintainability?

引用

Journal of Computer Science & Technology 2009年第2期24卷 262-272页

作者： Javier garzás Félix garcía Mario Piattini Kybele Consulting Madrid Spain Department of Information Technologies and Systems-Escuela Superior de Informáica University of Castilla-La Mancha Alarcos Research group-Institute of Information Technologies and Systems Department of Information Technologies and Systems-Escuela Superior de Informáica University of Castilla-La Mancha

At the present time, best rules and patterns have reached a zenith in popularity and diffusion, thanks to the software community＇s efforts to discover, classify and spread knowledge concerning all types of rules and patterns. Rules and patterns are useful elements, but many features remain to be studied if we wish to apply them in a rational manner. The improvement in quality that rules and patterns can inject into design is a key issue to be analyzed, so a complete body of empirical knowledge dealing with this is therefore necessary. This paper tackles the question of whether design rules and patterns can help to improve the extent to which designs are easy to understand and modify. An empirical study, composed of one experiment and a replica, was conducted with the aim of validating our conjecture. The results suggest that the use of rules and patterns affect the understandability and modifiability of the design, as the diagrams with rules and patterns are more difficult to understand than non-rule/pattern versions and more effort is required to carry out modifications to designs with rules and patterns.

关键词： design patterns and rules maintainability software quality object-oriented design

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stepping up after spinal cord injury:negotiating an obstacle during walking

引用

Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Projective Hilbert modules and sequential approximations

引用

Science China Mathematics 2025年第1期 137-168页

作者： Lawrence g.Brown Huaxin Lin Department of Mathematics Purdue University Department of Mathematics East China Normal University Department of Mathematics University of Oregon Shanghai Institute for Mathematics and Interdisciplinary Sciences

We show that when A is a separable C*-algebra,every countably generated Hilbert A-module is projective（with bounded module maps as morphisms）.We also study the approximate extensions of bounded module *** the case where A is a σ-unital simple C*-algebra with strict comparison,and every strictly positive lower semicontinuous affine function on quasitraces can be realized as the rank of an element in the Cuntz semigroup,we show that the Cuntz semigroup is equivalent to unitarily equivalent classes of countably generated Hilbert A-modules if and only if A has stable rank one.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

DNA-guided hepatitis B treatment,viral load is essential,but not sufficient

引用

World Journal of gastroenterology 2009年第4期15卷 423-430页

作者： Rafael Bárcena Marugán Silvia garcía garzón Services of Liver-gastroenterology Hospital Ramón y CajalUniversity of Alcalá Department of gastroenterology Hospital Universitario de GuadalajaraUniversity of Alcalá

Hepatitis B virus （HBV） infection is a global public health problem that concerns 350 million people worldwide. Individuals with chronic hepatitis B （CriB） are at increased risk of developing liver cirrhosis, hepatic de-compensation and hepatocellular carcinoma. To maintain undetectable viral load reduces chronic infection complications. There is no treatment that eradicates HBV infection. Current drugs are expensive, are associated with adverse events, and are of limited efficacy. Current guidelines try to standardize the clinical practice. Nevertheless, controversy remains about management of asymptomatic patients with CriB who are hepatitis B e antigen （HBeAg）-positive with normal alanine aminotransferase, and what is the cut-off value of viral load to distinguish HBeAg- negative CriB patients and inactive carriers. We discuss in detail why DNA level alone is not sufficient to begin treatment of CriB.

关键词： Hepatitis B virus Viral DNA Alaninetransaminase Antiviral drug Hepatitis B e antigen Antiviral drug resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Existence of Weakly Efficient Solutions in Vector Optimization

引用

Acta Mathematica Sinica,English Series 2008年第4期24卷 599-606页

作者： Lucelina BATISTA SANTOS Marko ROJAS-MEDAR gabriel RUIZ-garzóN Departamento de Matemática Universidade Federal do Paraná.CP.019081CEP:81531990Curitiba-PRBrazil Universidad del Bío-Bío Facultad de Ciencias Departamento de Ciencias BásicasCampus Fernando MayCasilla 447ChillánChile Departamento de Estadística e I.O. Universidad de CádizE.U.E.EmpresarialesPor-vera 5411403 Jerez de la FronteraSpain

In this paper, we present an existence result for weak efficient solution for the vector optimization problem. The result is stated for invex strongly compactly Lipschitz functions.

关键词： vector optimization weak efficiency generalized convexity Clarke generalized gradient

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

引用

Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Histological assessment in peripheral nerve tissue engineering

引用

Neural Regeneration Research 2014年第18期9卷 1657-1660页

作者： Víctor Carriel Ingrid garzón Miguel Alaminos Maria Cornelissen Department of Histology (Tissue Engineering group) Faculty of MedicineUniversity of Granadaand Instituto de Investigación Biosanitariaibs Department of Basic Medical Sciences (Histology and Tissue Engineering group) Faculty of MedicineGhent University

The histological analysis of peripheral nerve regeneration is one of the most used methods to demonstrate the success of the regeneration through nerve conduits. Nowadays, it is possible to evaluate different parameters of nerve regeneration by using histological, histochemical, immunohistochemical and ultrastructural techniques. The histochemical methods are very sensible and are useful tools to evaluate the extracellular matrix remodeling and the myelin sheath, but they are poorly specific. In contrast, the immunohistochemical methods are highly specific and are frequently used for the identification of the regenerated axons, Sehwann cells and proteins associated to nerve regeneration or neural linage. The ultrastructural techniques offer the possibility to perform a high resolution morphological and quantitative analysis of the nerve regeneration. However, the use of a single histological method may not be enough to assess the degree of regeneration, and the combination of different histological techniques could be necessary.

关键词： peripheral nerve regeneration histology, histochemistry immunohistochemistry quantitative histology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of Zika virus non-structural protein mutations on hippocampal damage

引用

Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：