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Neural Regeneration Research 2020年第10期15卷 1867-1886页

作者： Evgeniya V.Pushchina Anatoly A.Varaksin Dmitry K.obukhov Igor M.Prudnikov A.V.Zhirmunsky National Scientific Center of Marine Biology Far Eastern BranchRussian Academy of SciencesVladivostokRussia A.A.Bogomoletz Institute of Physiology National Academy of Sciences of UkraineKievUkraine St.Petersburg State University St.PetersburgRussia

Hydrogen sulfide(H2S)is considered as a protective factor against cardiovascular ***,there are few reports on the effects of H2S in the central nervous system during stress or *** studies on goldfish have shown that astrocytic response occurs in the damaged and contralateral optic *** fibrillary acidic protein(gFAP)concentration in the optic nerves of rainbow trout has not been measured *** study further characterized the astrocytic response in the optic nerve and the brain of a rainbow trout(Oncorhynchus mykiss)after unilateral eye injury and estimated the amount of H2S-producing enzyme cystathionineβ-synthase(CBS)in the brain of the rainbow *** 1 week after unilateral eye injury,a protein band corresponding to a molecular weight of 50 kDa was identified in the ipsi-and contralateral optic nerves of the rainbow *** concentration of gFAP in the injured optic nerve increased compared to the protein concentration on the contralateral *** results of a quantitative analysis of gFAP+cell distribution in the contralateral optic nerve showed the la.g.st number of gFAP+cells and fibers in the optic nerve *** the damaged optic nerve,patterns of gFAP+cell migration and la.g. gFAP+bipolar activated astrocytes were detected at 1 week after unilateral eye *** study of H2S-producing system after unilateral eye injury in the rainbow trout was conducted using enzyme-linked immunosorbent assay,western blot analysis,and immunohistochemistry of polyclonal antibodies again st CBS in the integrative centers of the brain:telencephalon,optic tectum,and ***-linked immunosorbent assay results showed a 1.7-fold increase in CBS expression in the rainbow trout brain at 1 week after unilateral eye injury compared with that in intact *** the ventricular and subventricular regions of the rainbow trout telencephalon,CBS+radial glia and neuroepithelial cells were *** unilateral eye injury

关键词： astrocyte-like cells glial fibrillary acidic protein hydrogen sulfide neuroepithelial cells neuroprotection radial glial cells rainbow trout(Oncorhynchus mykiss) reactive oxygen species unilateral eye injury

Cosmological Constant and Energy Density of Random Electromagnetic Field

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Journal of High Energy Physics, gravitation and Cosmology 2016年第3期2卷 312-319页

作者： Ilya A. obukhov Research & Development Company “System Recourses” Moscow Russia

It is shown that the non-equilibrium electrically neutral and relativistically invariant vacuum-like state with the negative energy density and positive pressure may exist at the non-zero temperature in the system of spinor particles, antiparticles, and random electromagnetic field generated by particle-particle, particle-antiparticle, and antiparticle-antiparticle transitions. At the temperature of the order of 10 -5 K, the energy density of its state corresponds to the dark energy density in absolute magnitude. The cosmological constant for such material medium turns out to be negative.

关键词： Dark Energy Cosmological Constant Stochastic Electromagnetic Field Spinor Particles

Density of Vacuum-Like Plasma and Hubble Constant

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Journal of High Energy Physics, gravitation and Cosmology 2017年第4期3卷 572-587页

作者： Ilya A. obukhov Research & Development Company “System Resources” Moscow Russia

The model in which expansion of the Universe leads to a.g.neration of non-equilibrium vacuum-like electron-positron plasma is proposed and researched. The formulas that relate the Hubble’s constant with the concentration of plasma particles and the cosmological constant are obtained. The collective properties of vacuum-like plasma are investigated. It is shown, that the coefficient of a two-photon annihilation in such plasma is nine times less than for the free particles. A simple formula for dark energy density as a function of electron mass and cha.g. is obtained. It was demonstrated that acceleration of plasma’s chemical potential fluctuations flow proportional of dark energy density.

关键词： Non-Equilibrium Vacuum-Like Plasma Hubble Constant Dark Energy Electron Positron Annihilation Zero Enthalpy

Nitric oxide-factor, which regulates proliferation and apoptosis in the adult brain of amur sturgeon <i>Acipenser schrenckii</i>

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Advances in Bioscience and Biotechnology 2012年第6期3卷 788-804页

作者： Е. V. Pushchina D. К. obukhov A.V. Zhyrmunskii Institute of Marine Biology Far East Division Russian Academy of Sciences Vladivostok Russia St.Petersburg State University St. Petersburg Russia

The distribution of proliferative zones, NO-producing cells and apoptosis areas in the medulla oblongata, cerebellum, optic tectum, thalamus and hypothalamus of Amur sturgeon Acipenser schrenckii was investigated, using techniques of immunoperoxidase staining of proliferating cell nuclear antigen (PCNA), neuronal nitric oxide synthase and TU-NEL-labeling of fragmented DNA. It has been established, that in the sturgeon brain NO can act both as a cytotoxic proapoptogenic factor, and as a factor, which stimulates cell proliferation. The presence of NO-producing elements in somato- and viscerosensory areas of medulla oblongata, tectum, cerebellum and thalamus suppose, that in these brain areas NO constitutes apoptogenic factor, which induces the cells death in a territory of postmitotic neuroblasts, renders controlling effect on development and differentiating of chemosensory, visual, motor and hypophysotropic brain areas in postnatal ontogenesis. Maximal proliferating activity and high concentration of NO-ergic cells were revealed in external layers, adjoining to the medullar, cerebellar and tectum membranes, that allow to suppose NO participation in postnatal morphogenesis of these brain structures as a factor, which regulates cell proliferation. In sensory centers (tectum and nuclei of the V, VII, and X nerves), significantly varying ratios of intensities of proliferation and apoptosis were found;this is indicative of dissimilar rates of growth and differentiation in visual and chemosensory centers of the sturgeon brain. Presence of NO-producing elements in the PCNA- immuno-labeling and TUNEL-labeling brain areas allow to consider NO as a factor, which balances processes of proliferation and apoptosis in the sturgeon brain.

关键词： Adult Neurogenesis Nitric Oxide Apoptosis Sturgeon Neotenia Development of Sensory Systems

Features of adult neurogenesis and neurochemical signaling in the Cherry salmon Oncorhynchus masou brain

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Neural Regeneration Research 2013年第1期8卷 13-23页

作者： Evgeniya V. Pushchina Dmitry K. obukhov Anatoly A. Varaksin Laboratory of Cytophysiology Institute of Marine Biology Far East Branch Russian Academy of Sciences St. Petersburg State University

We investigated the distribution of gamma aminobutyric acid, tyrosine hydroxylase and nitric oxide-producing elements in a cherry salmon Oncorhynchus masou brain at various stages of postnatal ontogenesis by immunohistochemical staining and histochemical staining. The periventricular region cells exhibited the morphology of neurons and glia including radial glia-like cells and contained several neurochemical substances. Heterogeneous populations of tyrosine hydroxylase-, gamma aminobutyric acid-immunoreactive, as well as nicotinamide adenine dinucleotide phosphate diaphorase-positive cells were observed in proliferating cell nuclear antigen-immunoreactive proliferative zones in periventricular area of diencephalon, central grey layer of dorsomedial tegmentum, medulla and spinal cord. Immunolocalization of Pax6 in the cherry salmon brain revealed a neuromeric construction of the brain at various stages of postnatal ontogenesis, and this was confirmed by tyrosine hydroxylase and gamma aminobutyric acid labeling.

关键词： neural regeneration neurogenesis teleostei adult neurogenesis neurotransmitter signaling migration tyrosine hydroxylase gamma aminobutyric acid development Pax6 NADPH-diaphorase proliferation grant-supported paper neuroregeneration

Cell proliferation and apoptosis in optic nerve and brain integration centers of adult trout Oncorhynchus mykiss after optic nerve injury

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Neural Regeneration Research 2016年第4期11卷 578-590页

作者： Evgeniya V.Pushchina Sachin Shukla Anatoly A.Varaksin Dmitry K.obukhov Laboratory of Cytophysiology A.V.Zhirmunsky Institute of Marine Biology Far Eastern Branch of Russian Academy of Sciences Prof.Brien Holden Eye Research Centre L.V.Prasad Eye Institute St.Petersburg State University Universitetskaya

Fishes have remarkable ability to effectively rebuild the structure of nerve cells and nerve fibers after central nervous system ***,the underlying mechanism is poorly *** order to address this issue,we investigated the proliferation and apoptosis of cells in contralateral and ipsilateral optic nerves,after stab wound injury to the eye of an adult trout Oncorhynchus *** population of proliferating cells was investigated at 1 week after *** labeling gave a qualitative and quantitative assessment of apoptosis in the cells of optic nerve of trout 2 days after *** optic nerve injury,apoptotic response was investigated,and mass patterns of cell migration were *** maximal concentration of apoptotic bodies was detected in the areas of mass clumps of *** is probably indicative of massive cell death in the area of high phagocytic activity of macrophages/*** 1 week after optic nerve injury,we observed nerve cell proliferation in the trout brain integration centers：the cerebellum and the optic *** the optic tectum,proliferating cell nuclear antigen（PCNA）-immunopositive radial glia-like cells were *** activity of nerve cells was detected in the dorsal proliferative（matrix） area of the cerebellum and in parenchymal cells of the molecular and granular layers whereas local clusters of undifferentiated cells which formed neurogenic niches were observed in both the optic tectum and cerebellum after optic nerve *** vitro analysis of brain cells of trout showed that suspension cells compared with monolayer cells retain higher proliferative activity,as evidenced by PCNA *** contrast observation showed mitosis in individual cells and the formation of neurospheres which gradually increased during 1–4 days of *** present findings suggest that trout can be used as a novel model for studying neuronal regeneration.

关键词： nerve regeneration proliferation apoptosis optic nerve brain radial glia cells neurogenic niches neurospheres neural regeneration

Effectiveness of Radiofrequency Inductively Coupled Plasma Sources for Space Propulsion

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高电压技术 2013年第9期39卷 2077-2088页

作者： V. A. Riaby P E. Masherov V. A. obukhov V. P. Savinov Research Institute of Applied Mechanics and Electrodynamics of the Moscow Aviation Institute National Research University 5 Leningrad Rd. Moscow 125080 Russia Physical Department Moscow State University named alter M. V. Lomonosov Lenin Hills Moscow 119991 Russia

Evolution of geometric forms of antenna coils for radiofrequency(RF)inductively coupled plasma(ICP)sources is *** effectiveness of flat ICPSs generating plasma"tablet"is *** effective are ICPSs using antenna coils enhanced with ferromagnetic cores(FMICPS).It is found that the design of flat ICPSs is simpler and more convenient for the arra.g.ment of plasma diagnostics in comparison with ICPSs of other *** flat FMICPS models of different diameters ra.g.ng from 10 cm to 100cm are *** are given for development engineers dealing with ICPS devices in general and with radio frequency ion thrusters(RITs)in particular.

关键词：电感耦合等离子体等离子体源空间推进射频等离子体诊断几何形式 ICPS 离子推进器

The Content of Some Types of Cytokines in Women of Reproductive Age with Exacerbation and Remission of Chronic Herpes Infection

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Advances in Bioscience and Biotechnology 2014年第4期5卷 316-321页

作者： Olga obukhovа Aleksandr Trunov Olga.g.rbenko Alya Shvayk Liliya Trunovа Research Center of Clinical and Experimental Medical Siberian Branch of Russian Academy of Medical Sciences Novosibirsk Russia

There were investigated levels of pro-inflammatory and regulatory cytokines (IL-1b, IL-6 and IFN-g) in women of reproductive age in periods of exacerbation and remission of chronic infection caused by the herpes simplex virus in purpose to study the pathogenetic features of the course of HSV infection. It is shown that both the period of exacerbation, and the period of clinical remission of chronic herpes infection are characterized by increased production of IFN-g, IL-1b and IL-6. However, only the mean values of IL-1b were significantly different in periods of exacerbation and remission. Moreover, patients with chronic herpes infection revealed significant heterogeneity of individual values of measured cytokines (IL-1b, IL-6 and IFN-g), which does not depend on the period of clinical disease.

关键词： Cytokines Herpes Infection Chronic Inflammation Immune Response

Interaction of Atoms with grain Surfaces in Steel: Periodic Dependence of Binding Energy on Atomic Number and Influence on Wear Resistance

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Engineering（科研） 2012年第10期4卷 76-79页

作者： E. V. Pushchina D. K. obukhov A. V. Zhirmunski Institute of Marine Biology Far East Division Russian Academy of Sciences ul. Pal'chevskii 17 Vladivostok 690059 Russia ru St. Petersburg State University Universitetskaya Naberezhnaya 7/9 St. Petersburg 199034 Russia

The data of our investigations contribute to understanding of cellular mechanisms of the teleost fishes CNS forming in postembryonic development. The revealed peculiarities of structural and neurochemical organization and description of basic histogenetic processes (proliferation, migration and neuronal cell differentiation) during the brain forming in fish, which have signs of fetal organization, widen the existing knowledge about histogenesis of these structures in postembryonic development. It seems conceivable, that during postembrional development in teleost fishes some neurotransmitters and gaseous mediators (NO and H2S) act as factors, which initiate and regulate the cellular and the tissues processes of genetic program during the brain development. Materials of this investigation define a new experimental model for studying of postembrional neurogenesis processes.

关键词： Teleostei Postnatal Neurogenesis Proliferative Cell Nuclear Antigen (PCNA) Neurotransmitter Signaling Migration Tyrosine Hydroxylase gABA Development Pax6 NADPH-diaphorase Nitric Oxide Hydrogen Sulfide Proliferation.