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Evolution of costs of cancer drugs in a Portuguese hospital

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World Journal of Clinical Oncology 2014年第2期5卷 164-169页

作者： Vania Peixoto Ana Luísa.faria Márcia Gon?alves Joana Macedo Sónia Rego Emilio Macías Aldiro Magano Márcia Loureiro António Araújo Department of Medical Oncology Centro Hospitalar de Entre Douro e Vouga Pharmacy Department Centro Hospitalar de Entre Douro e Vouga

AIM:To analyze the costs of cancer drugs administered in a Portuguese Hospital compared with the Karolinska Institute ***:To evaluate spending on cancer drugs, we retrospectively analyzed data on the overall costs of cancer drugs, obtained at the Department of Medical Oncology of the Centro Hospitalar de Entre Douro e Vouga, between 2004 and 2010. In this comparative study we selected only drugs belonging to the following groups:chemotherapy, targeted therapy, immunotherapy and endocrine therapy. The selected drugs were further grouped according to their market placement year:≤ 1998, 1999 to 2002, 2003 to 2005, and 2006 to 2010. Drugs used as supportive therapy and bisphosphonates were ***:The overall costs of cancer drugs increased gradually between 2004 and 2008(from €1911947 to €3666284), with an increase in the number of patients treated during this period. The expenditure decreased in 2009(€3438155) and increased again in 2010(€3673116), but the costs increment was not the same as in previous years. Chemotherapy and targeted therapy were responsible for most of the expenditure. Drugs placed on the national market before 1999 accounted for more than 50% of the expenditure up to 2007. From 2008, these drugs represented less than 50% of the total expenditure. Cancer drugs placed between 1999 and 2002 accounted for 25%-35% of the costs in all the years studied, while drugs placed between 2003 and 2005 accounted for less than 30%. Drugs placed between 2006 and 2010 were responsible for less than 10% of the ***:In this study, older drugs were responsible for most of the expenditure up to 2007, which is in agreement with the Karolinska study.

关键词： Cancer Costs Drugs Economy Treatment

Purification and Biochemical Characterization of Native and Pegylated Form of L-Asparaginase from Aspergillus terreus and Evaluation of Its Antiproliferative Activity

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Advances in Microbiology 2012年第2期2卷 138-145页

作者： Claudio Battiston Loureiro Kleiton Silva Borges Augusto faria Andrade Luiz Gonzaga Tone Suraia Said Departamento de Ciencias Farmaceuticas FCFRP-USPRibeirao PretoBrazil Departamento de Genetica FMRP-USPRibeirao PretoBrazil Departamento de Puericultura e Pediatria FMRP-USPRibeirao PretoBrazil

L-asparaginase is a chemotherapeutic drug used in the treatment of lymphoblastic leukemia. In the present study, the extracellular L-asparaginase produced by strain (PC-1.7A) of Aspergillus terreus was purified, characterized, and modified with polyethylene glycol. Moreover, its antiproliferative activity was evaluated. The apparent molecular weight of the enzyme was found to be 136 kDa. The optimal pH and temperature for the enzyme were 9.0℃ and 40℃, respectively. The enzyme retained 100% of the activity at 40℃ for 120 min. Pegylated L-asparaginase was more thermostable and more resistant to trypsin than native enzyme. Native L-asparaginase against human normal cells did not show cytotoxicity. However, in the leukemia cell lines RS4;11 and HL60 the antiproliferative effects of native L-asparaginase were observed after 96 and 72 h of incubation, respectively. For the first time, an L-asparaginase from fungus was evaluated as an antitumor agent in human cells lines and further investigations should be conducted to improve the knowledge about this enzyme.

关键词： Aspergillus terreus L-Asparaginase Antineoplasic Activity Leukemia

Induced Myopia among Readymade Garment (RGM) Workers

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Open Journal of Ophthalmology 2021年第2期11卷 91-98页

作者： Anisur Rahman Sharah Rahman Jamsed Faridi faria Tilat Toma Ashfia Farhin Huq Ashraful Islam Khondokar Department of Ophthalmology Dhaka Medical College Dhaka Bangladesh (Cornea & Anterior Segment) Ispahani Islamia Eye Institute and Hospital Dhaka Bangladesh Dhaka Medical College Dhaka Bangladesh Bangladesh Eye Trust Hospital Dhaka Bangladesh Department of Ophthalmology Dhaka Medical College and Hospital Dhaka Bangladesh

Background: To determine the induced refractive error among the readymade garment workers. Those who are working in the knitting section and those who are working other than the knitting and computer section. Methods: It was a prospective cross-sectional analytic study among 600 workers in 2 factories at Joydevpur, Gazipur, Bangladesh on January 2020. Group: A comprises 300 workers who were working at knitting section for a minimum of six hours a day and 5 days a week. Group: B comprises another 300 workers who were appointed for loading-unloading, care-taker, driver and security guard also. Prevalence of refractive error in two groups was compared. Results: The mean age of participants in group: A was 26.61 ± 4.99 (CI 95%, 26.04 ± 27.18) and in group: B was 28.51 ± 5.69 (95% CI 27.86 ± 29.15). Prevalence of refractive error between two groups was 52 and 28.3 respectively. The chi-square statistic is 44.9775. The p-value is Conclusion: Knitting workers at readymade garment (RGM) are more prone to develop late onset myopia than other workers in the same premises.

关键词： Myopia Readymade Garment (RGM) Near-Work Late Onset Myopia Visual Acuity

Investigation on Effect of Acid Wash with Thermocol Ball on Physical Properties of Knitted Garments

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Journal of Textile Science and Technology 2016年第2期2卷 16-21页

作者： Elias Khalil Masud Rana Jewel faria Md. Al-Amin Islam Md. Sohel Rana Department of Textile Engineering World University of Bangladesh Dhaka Bangladesh

Washing is considered as the final process of garments finishing. Acid washing is one kind of finishing treatment used for making sewn garments aesthetic, fashionable, soft, comfortable and also adding value to the final garments. This paper investigates the effect of the acid washing (with thermocol balls and potassium permanganate) on different physical properties of three knitted garments (Single Jersey 100% Cotton T-shirt, Single Jersey 95% Cotton 5% Spandex T-Shirt and 1 × 1 Rib100% Cotton T-Shirt). Typical washing procedures and techniques were followed and then physical properties were analyzed under standard condition. It is observed that fabric weight, CPI, WPI, spirality and shrinkage increase while bursting strength, stitch length absorbency decrease after washing treatment. pH of all the samples is under controlled and lies between 7 to 8. There is no change in pilling, colorfastness to wash, water and dry rubbing while a little bit decrease in wet rubbing.

关键词： Acid Wash Potassium Permanganate Thermocol Ball Physical Properties Knitted Garments

Derivation Method for Determining Sorbitol in Fruit Trees

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American Journal of Plant Sciences 2014年第23期5卷 3457-3463页

作者： Regina Celia.faria Simao Canesin William Deodato Isique Salatier Buzetti Juliana Aparecida de Souza University of Sao Paulo State(UNESP) Ilha Solteira CampusIlha SolteiraBrazil

The goal of this study is to describe a methodology for the analysis of D-sorbitol using benzyl alcohol as derivatizing agent and liquid chromatography equipped with a diode-array detector (HPLC-DAD). The study was performed at the University of São Paulo State (UNESP), Ilha Solteira Campus, Brazil. The axillary buds of fruit trees were collected from the UNESP Teaching and Research Farm. Benzyl alcohol was used as derivatizing agent to extract D-sorbitol from the buds. Next, the D-sorbitol underwent solid phase extraction (SPE) using C18 cartridges and was then analyzed by liquid chromatography (HPLC-DAD). The HPLC-DAD derivatization method proposed showed excellent chromatography resolution and high accuracy in the separation of D-sorbitol (derivatized) for the axillary buds of avocado, black mulberry, Japanese pear and peach and also enabled eliminating the use of hazardous derivatizing agents.

关键词： Benzyl Alcohol Polyols HPLC-DAD

On the Bump Tests of Cracked Shafts Using Acoustic Emission Techniques

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Engineering（科研） 2016年第9期8卷 572-581页

作者： Gilberto Luiz S. Pimentel-Junior Frederico B. Oliveira Marco Tulio C. faria Department of Mechanical Engineering Universidade Federal de Minas Gerais Belo Horizonte Brazil

An investigation about the application of Acoustic Emission (AE) techniques to analyze the dynamic response of different cracked shafts rendered in bump tests is presented in this work. The experimental apparatus devised for this work complies of six shafts with different transverse crack sizes and a high-frequency data acquisition system. The AE signals generated in the bump tests performed on the different cracked shafts are captured by a wideband AE transducer. Those signals are treated by using statistical moments, wavelet transforms, and frequency- and time-domain procedures. A transverse crack of predetermined depth is etched into each shaft. The experimental results show that the values of kurtosis and skewness estimated for the AE signals can be used to identify the crack size.

关键词： Acoustic Emission Cracked Rotors Bump Tests Shaft Crack

Correction to:Effects of chemical sterilization of the culture media,porous membranes and luminosity on in vitro culture of Eucalyptus grandis×Eucalyptus urophylla

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Journal of Forestry Research 2022年第5期33卷 1705-1707页

作者： Letícia Vaz Molinari Denys Matheus Santana Costa Souza Maria Lopes Martins Avelar Sérgio Bruno Fernandes Douglas Santos Gonçalves Júlio Cézar Tannure faria Dulcineia de Carvalho Gilvano Ebling Brondani Department of Forestry Sciences Federal University of LavrasLavrasMinas GeraisBrazil

Correction to:***://***/10.1007/s11676-020-01240-5 In the original publication of the article,there were errors in the fig 3 and fig *** corrected Figs.3 and 6 are given below:The original article has been corrected.

关键词： corrected porous media

The potential of Hoplias malabaricus(Characiformes:Erythrinidae),a Neotropical carnivore,for aquaculture

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Aquaculture and Fisheries 2019年第3期4卷 89-97页

作者： Marcos Daniel Renó faria Aderbal Cavalcante-Neto Ivan Bezerra Allaman Aline Dal’Olio Gomes Renata Guimarães Moreira Eric M.Hallerman Alexandre Wagner Silva Hilsdorf Unit of Biotechnology University of Mogi das CruzesMogi das CruzesSP08780-970Brazil Department of Exact Sciences and Technology State University of Santa CruzIlhéusBA45662-900Brazil Department of Physiology Bioscience InstituteUniversity of São PauloSão PauloSP05508-020Brazil Department of Fish and Wildlife Conservation Virginia Polytechnic Institute and State UniversityBlacksburgVA 23061-0321USA

We describe key production-related traits of trahira(Hoplias malabaricus),an aquaculture candidate species,in a semi-intensive fish farming *** quantified growth from hatch through grow-out at two stocking densities and evaluated fillet protein,lipids and fatty-acid *** made 2430 observations of growth and morphometrics on 270 juvenile fish allocated to four fish ponds,two at 5 fish/m^(2)(90 animals)and two at 10 fish/m^(2)(180 animals)through 11 *** fish reached an average length of 27.5 cm(±0.38)and 27.0 cm(±0.24),and weight of 263.0 g(±10.54)and 246.7 g(±6.89),respectively,at the low and high *** was no significant difference in weight(P>0.05)between the densities for any of the parameters assessed,and hence the same growth curve applied to both densities(A=292.9;B=28.1;and K=0.65).Standard length,however,differed significantly(P<0.05)between densities,with K=0.35 at the low and K=0.29 at the high *** both stocking densities,total lipids increased throughout the trial,while protein content *** acid(C18:0)increased throughout the experimental period,while docosahexaenoic acid and the n3/n6 profile decreased,with no differences among stocking *** malabaricus may prove a viable aquaculture species in Neotropical regions,where development of native species may contribute to sustainable aquaculture production.

关键词： Farming Growth models Native species Trahira Fatty acids

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广播电视在IP与MPEG世界中的标准化

广播与电视技术 2015年第A2期40卷 89-92页

作者： Gérard faria TeamCast公司

尽管美国高级电视制式委员会（ATSC）各成员在诸多议题上仍未达成一致,但他们在将数字电视融入互联网时代的技术层面上已经做了大量富有成效的工作。

关键词： MPEG 广播电视标准化世界互联网时代电视制式数字电视多议题