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国际纺织导报 2021年第3期49卷 1-3页

作者： a.engelhardt 吴雯雯(译) 王彦(校) 纤维年代公司瑞士不详

纤维年代有限公司最新版的纺织年鉴《2020纤维年》涵盖了全球化学纤维和天然纤维产品,包括非织造布和未纺原料数据。该报告揭示了主要市场的最新动态和贸易数据。

关键词：纤维生产产业链最新动态

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全球化纤产量增长8%

国际纺织导报 2008年第7期36卷 4-4,6,8页

作者： a.engelhardt 汪玲玲（译）行兰（校）欧瑞康苏拉公司（瑞士）不详

2007年,全球化纤产量增长8%,达4410万t。其中纤维素纤维增长了9%,达370万t,而合成纤维仅增长了7.9%,为4040万t。纤维素纤维良好的增长态势很大程度上与粘胶短纤有关。合成纤维领域的增长则主要是受聚酯纤维的影响,但诸如聚酰胺、聚丙烯... 详细信息

2007年,全球化纤产量增长8%,达4410万t。其中纤维素纤维增长了9%,达370万t,而合成纤维仅增长了7.9%,为4040万t。纤维素纤维良好的增长态势很大程度上与粘胶短纤有关。合成纤维领域的增长则主要是受聚酯纤维的影响,但诸如聚酰胺、聚丙烯以及聚丙烯腈聚合物则呈下降趋势。

关键词：聚酯纤维聚酰胺纤维 PP纤维丙烯腈纤维弹性纤维纤维素纤维碳纤维全球产量

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成为更好的CEO

新理财（公司理财） 2024年第2期 82-83页

作者：亨利·恩格尔哈特不详

CEO(首席执行官)等领导要作出全面的决策,但做决策并不意味着回避员工的意见和想法。亨利·恩格尔哈特(Henry engelhardt)解释了如何在控制全局的同时征求员工意见。我曾强调过,优秀领导者的首要能力是决策能力,而要提高决策能力,就应... 详细信息

CEO(首席执行官)等领导要作出全面的决策,但做决策并不意味着回避员工的意见和想法。亨利·恩格尔哈特(Henry engelhardt)解释了如何在控制全局的同时征求员工意见。我曾强调过,优秀领导者的首要能力是决策能力,而要提高决策能力,就应该尽可能多地听取别人的意见,这就引出了领导力的第二个关键能力--善于与人打交道。那么,如何知道自己是否是个好领导?很简单,看员工是否愿意追随你。

关键词：首席执行官恩格尔哈特 CEO 提高决策能力领导力决策意见

Simulation of ductile fracture initiation in steels using a stress triaxiality-shear stress coupled model

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Acta Mechanica Sinica 2019年第3期35卷 600-614页

作者： Yazhi Zhu Michael D.engelhardt Zuanfeng Pan Department of Structural Engineering Tongji UniversityShanghai 200092China Ferguson Structural Engineering Laboratory Department of CivilArchitectural and Environmental EngineeringUniversity of Texas at AustinAustinTX 78712USA

Micromechanics-based models provide powerful tools to predict initiation of ductile fracture in steels. A new criterion is presented herein to study the process of ductile fracture when the effects of both stress triaxiality and shear stress on void growth and coalescence are considered. Finite-element analyses of two different kinds of steel, viz. ASTM A992 and AISI 1045, were carried out to monitor the history of stress and strain states and study the methodology for determining fracture initiation. Both the new model and void growth model (VGM) were calibrated for both kinds of steel and their accuracy for predicting fracture initiation evaluated. The results indicated that both models offer good accuracy for predicting fracture of A992 steel. However, use of the VGM leads to a significant deviation for 1045 steel, while the new model presents good performance for predicting fracture over a wide range of stress triaxiality while capturing the effect of shear stress on fracture initiation.

关键词： Ductile fracture Void growth Stress triaxiality Shear stress ratio ASTM A992 steel AISI 1045 steel

Geomorphic predictors of riparian vegetation in small mountain watersheds

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Journal of Plant Ecology 2015年第6期8卷 593-604页

作者： Blake M.engelhardt Jeanne C.Chambers Peter J.Weisberg Department of Natural Resources and Environmental Science University of NevadaMS 1861664 Virginia StreetRenoNV 89557USA USDA Forest Service Rocky Mountain Research Station920 Valley RoadRenoNV 89512USA

Aims Hydrogeomorphic processes operating at watershed,process zone and site scales influence the distribution of riparian ***,most studies examining the relationships between hydrogeomorphic processes and riparian vegetation are conducted at site *** quantified the relative importance of watershed,process zone and site geomorphic characteristics for predicting riparian plant community types and plant species abundances in four small mountain watersheds in central Nevada,*** We mapped riparian vegetation types and identified process zones(based on dominant geomorphic process and valley fill material)within the *** sampled sites in each combination of veg-etation type and process zone(n=184 sites)and collected data on watershed scale factors,valley and stream geomorphic characteristics and on plant cover of each geomorphic *** community types were defined by cluster and indicator species analyses of plant cover data,and related to geomorphic variables using ordination analysis(nonmetric multidimensional scaling).linear mixed effects models were used to predict abundances of indicator *** Findings Variables describing position in the watershed(elevation,contrib-uting area)that are related to gradients of temperature,moisture and stream discharge were of primary importance in predicting plant community *** describing local geomorphic setting(valley width,stream gradient,channel sediments,geomor-phic surface height)were of secondary importance,but accurately described the geomorphic setting of indicator *** process zone classification did not include position in the watershed or channel characteristics and only predicted plant community types with unique geomorphic *** small mountain watersheds,predicting riparian vegetation distribution requires explicit consid-eration of scale and geomorphic context within and among water-sheds in addition to site variables.

关键词： great basin multiscale plant community analysis process zone riparian

Oral immune regulation using colitis extracted proteins for treatment of Crohn's disease: Results of a phase Ⅰ clinical trial

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World Journal of Gastroenterology 2005年第20期11卷 3105-3111页

作者： Eran Israeli Eran Goldin Oren Shibolet Athalia Klein Nilla Hemed Dean engelhardt Elazar Rabbani Yaron Ilan Gastroenterology and Liver Units Department of Medicine Hebrew University-Hadassah Medical Center Jerusalem Israel Enzo Biochem New York NY USA

AIM: To evaluate safety and possible efficacy of induction of oral immune regulation using colitis extracted proteins (CEP) in Crohn's disease (CD) subjects. METHODS: Ten CDs were treated orally with autologous CEP thrice weekly for 16 wk. Subjects were monitored for CDAI and IBDQ. Immune modulatory effect was assessed by T-lymphocyte FACS analysis, CEP-specific IFNγ ELISPOT assay and cytokine levels. RESULTS: Induction of oral immune regulation significantly ameliorated disease activity. All (10/10) subjects had clinical response (CDAI≤70) and 7/10 achieved clinical remission (CDAI≤150). Significant increase in mean IBDQ score was noted (134±9 vs 164±12). No treatment-related adverse events were noted. High levels of CEP-specific IFNγ spot forming colonies were detected in five subjects prior to treatment and in all five, a marked decrease was observed. The CD4+/CD8+ lymphocyte ratio and peripheral NKT cell numbers increased significantly, in 7/10 and in 5/10 subjects, respectively. Significant increase in serum IL-10 and IL-4 levels was observed in 7/10 subjects during treatment period. CONCLUSION: Immune regulation via oral administration of CEP is a safe and possibly effective treatment for subjects with moderate CD and may provide means of antigen-specific immune modulation.

关键词： Crohn's disease Colitis extracted proteins

适用于湿砂造型的低排放添加剂——铸造厂提高铸件表面质量和生产率并减少排放和消耗的新举措

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特种铸造及有色合金 2017年第7期37卷 810-812页

作者： Thomas engelhardt 科莱恩欧洲中东和非洲地区(EMEA)应用开发部

为了改善湿砂造型的生态环境,科莱恩公司推出了一种低排放添加剂技术,可让铸造厂的湿砂系统的BTEX排放量降低到80%,并且可以优化生产效率,使铸件表面粗糙度降低。探讨了当前膨润土湿砂减排的主要技术,以期对这项技术的潜力进行评估,并... 详细信息

为了改善湿砂造型的生态环境,科莱恩公司推出了一种低排放添加剂技术,可让铸造厂的湿砂系统的BTEX排放量降低到80%,并且可以优化生产效率,使铸件表面粗糙度降低。探讨了当前膨润土湿砂减排的主要技术,以期对这项技术的潜力进行评估,并为铸造厂和相关产业所需的可持续性改进做出贡献。概述了新技术的原理,并解释了公司创新研发的新的检测方法,用于测量和比较在实际铸造工艺条件下此新技术与加光亮碳形成剂的湿型砂的芳烃排放物的比较。最后,展示了低排放添加剂新技术在欧洲铸造厂实际应用中取得的成果。

关键词：湿砂造型添加剂低排放

Deepening trochleoplasty combined with balanced medial patellofemoral ligament reconstruction for an adequate graft tensioning

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World Journal of Orthopedics 2017年第12期8卷 935-945页

作者： Lars V von engelhardt Pia Weskamp Matthias Lahner Gunter Spahn Joerg Jerosch Faculty of Health University of Witten/Herdecke Depart-ment of Orthopedics Trauma Surgery and Sports MedicineJohanna Etienne Hospital Joint Center Hilden and Ruhr-University Bochum Center of Trauma and Orthopedic Surgery Jena University Hospital

AIM To evaluate our modified deepening trochleoplasty com-bined with a balanced medial patellofemoral ligament(MPFL) reconstruction for soft tissue alignement. METHODS Thirty-three knees with with recurrent patellar dislocations and a trochlear dysplasia in 30 patients(m/f = 12/21, mean age 24 ± 9 years) underwent a combination of a modified deepening trochleoplasty and a balanced MPFL reconstruction for a medial soft tissue alignement. After a mean follow-up period of 29 ± 23 mo, patients' return to sports, possible complications as well as the clinical outcomes using the Kujala, International Knee Documentation Committee(IKDC) and Lysholm scoring were evaluated. Moreover, patients' satisfaction with the general outcome, the cosmetic outcome, the pre-and postoperative pain and a potential avoidance behaviour were assessed with additional standardized questionnaires which also included different visual analog scales. RESULTS There were no signs of a persistent instability. The Kujala score improved from a mean of 64 ± 16 points to 94 ± 9 points, the Lysholm score improved from a mean of 63 ± 17 to 95 ± 6 points and the IKDC score from 58 ± 11 to 85 ± 12 points, P < 0.0001, respectively. The assessment of pain using a visual analog scale showed a significant pain reduction from a mean of 4.8 ± 2.0 to 1.3 ± 3.4 points(P < 0.0001). Two of 26 cases(92%) who were engaged in regular physical activity before surgery did not return to full sporting activities. One patient felt that his sport was too risky for his knee and reported an ongoing avoidance behaviour. The other patient preferred to wait for surgery of her contralateral knee. Of the eight patients who were not engaged in sporting activities before surgery, three started regular sporting activities after surgery. In 31 of the 33 cases(94%), the patients were very satisfied with the clinical outcome of the surgery. Regarding the cosmetic results, no patients felt impaired in their self-confidence and in their clothi

关键词： Trochlea dysplasia Medial-patellofemoral ligament Patellofemoral instability Patella dislocation Trochleoplasty

Twenty-first century climate change and submerged aquatic vegetation in a temperate estuary:the case of Chesapeake Bay

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Ecosystem Health and Sustainability 2017年第7期3卷 14-34页

作者： Thomas M.Arnold Richard C.Zimmerman Katharina A.M.engelhardt J.Court Stevenson Departments of Biology and Environmental Studies Dickinson CollegeCarlislePAUSA Department of Ocean Earth and Atmospheric SciencesOld Dominion UniversityNorfolkVAUSA Appalachian Laboratory University of Maryland Center for Environmental ScienceFrostburgMDUSA Horn Point Laboratory University of Maryland Center for Environmental ScienceCambridgeMDUSA

Introduction:The Chesapeake Bay was once renowned for expansive meadows of submerged aquatic vegetation(SAV).However,only 10%of the original meadows *** restoration effortswill be complicated by accelerating climate change,including physiological stressors such as a predicted mean temperature increase of 2-6℃and a 50-160%increase in CO_(2)***:As the Chesapeake Bay begins to exhibit characteristics of a subtropical estuary,summer heat waves will become more frequent and *** alone would eventually eliminate eelgrass(Zostera marina)from the *** will favor native heat-tolerant species such as widgeon grass(Ruppia maritima)while facilitating colonization by non-native seagrasses(e.g.,Halodule spp.).Intensifying human activity will also fuel coastal zone acidification and the resulting high CO_(2)/low pH conditions may benefit SAV via a“CO_(2)fertilization effect.”Discussion:Acidification is known to offset the effects of thermal stress and may have similar effects in estuaries,assuming water clarity is sufficient to support CO_(2)-stimulated photosynthesis and plants are not overgrown by ***,coastal zone acidification is variable,driven mostly by local biological processes that may or may not always counterbalance the effects of regional *** precarious equipoise between two forces-thermal stress and acidification-will be critically important because it may ultimately determine the fate of cool-water plants such as Zostera marina in the Chesapeake ***:The combined impacts of warming,coastal zone acidification,water clarity,and overgrowth of competing algae will determine the fate of SAV communities in rapidly changing temperate estuaries.

关键词： Submerged aquatic vegetation climate temperature coastal acidification Chesapeake Bay

Tumor-intrinsic metabolic reprogramming and how it drives resistance to anti-PD-1/PD-L1 treatment

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Cancer Drug Resistance 2023年第3期6卷 611-641页

作者： Kyra Laubach Tolga Turan Rebecca Mathew Julie Wilsbacher John engelhardt Josue Samayoa Computational Oncology AbbVieSouth San FranciscoCA 94080USA Immuno-Oncology AbbVieSouth San FranciscoCA 94080USA Immuno-Oncology AbbVieLake CountyIL 60064USA

The development of immune checkpoint blockade (ICB) therapies has been instrumental in advancing the field of immunotherapy. Despite the prominence of these treatments, many patients exhibit primary or acquired resistance, rendering them ineffective. For example, anti-programmed cell death protein 1 (anti-PD-1)/anti-programmed cell death ligand 1 (anti-PD-L1) treatments are widely utilized across a range of cancer indications, but the response rate is only 10%-30%. As such, it is necessary for researchers to identify targets and develop drugs that can be used in combination with existing ICB therapies to overcome resistance. The intersection of cancer, metabolism, and the immune system has gained considerable traction in recent years as a way to comprehensively study the mechanisms that drive oncogenesis, immune evasion, and immunotherapy resistance. As a result, new research is continuously emerging in support of targeting metabolic pathways as an adjuvant to ICB to boost patient response and overcome resistance. Due to the plethora of studies in recent years highlighting this notion, this review will integrate the relevant articles that demonstrate how tumor-derived alterations in energy, amino acid, and lipid metabolism dysregulate anti-tumor immune responses and drive resistance to anti-PD-1/PD-L1 therapy.

关键词： Immunotherapy resistance tumor-immune microenvironment immune checkpoint blockade energy metabolism amino acid metabolism lipid metabolism