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Hepatitis C infection and lymphoproliferative disease:Accidental comorbidities?

World Journal of Gastroenterology 2014年第43期20卷 16197-16202页

作者： Tawfik Khoury Shmuel Chen Tomer Adar e Ollech Jacob Meir Mizrahi Department of Internal Medicine Hebrew University-Hadassah Medical CenterJerusalemIL 91120Israel Institute for Gastroenterology and Liver Disease Hebrew University-Hadassah Medical CenterJerusalemIL 91120Israel

Chronic hepatitis C virus(HCV)infection has been associated with liver cancer and cirrhosis,autoimmune disorders such as thyroiditis and mixed cryoglobulinema,and alterations in immune function and chronic inflammation,both implicated in B cell lymphoproliferative diseases that may progress to non-Hodgkin lymphoma(NHL).HCV bound to B cell surface receptors can induce lymphoproliferation,leading to DNA mutations and/or lower antigen response *** findings and epidemiological reports suggest an association between HCV infection and *** performed a systematic review of the literature to clarify this potential *** searched the english-language literature utilizing Medline,embase,Paper First,Web ofScience,Google Scholar,and the Cochrane Database of Systematic Reviews,with search terms broadly defined to capture discussions of HCV and its relationship with NHL and/or lymphoproliferative *** were screened to further identify relevant studies and literature in the basic sciences.A total of 62 reports discussing the relationship between HCV,NHL,and lymphoproliferative diseases were *** studies suggest that at least a portion of NHL may be etiologically attributable to HCV,particularly in areas with high HCV *** that showed a lack of association between HCV infection and lymphoma may have been influenced by small sample size,short follow-up periods,and database *** association appears strongest with the B-cell lymphomas relative to other lymphoproliferative *** by which chronic HCV infection promotes lymphoproliferative disease remains *** is a multifactorial process involving genetic,environmental,and infectious *** most probably have a role in the lymphomagenesis but further study to clarify the association and underlying mechanisms is warranted.

关键词： Blood Hepatitis C infection Non-Hodgkin’ s lymphoma Pathogenesis Treatment

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Hypothesized summative anal physiology score correlates but poorly predicts incontinence severity

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World Journal of Gastroenterology 2017年第31期23卷 5732-5738页

作者： Christopher J Young Assad Zahid Cherry e Koh Jane M Young Department of Colorectal Surgery University of Sydney RPAH Medical Centre Discipline of Surgery University of Sydney Surgical Outcome Research Centre(SOu RCe) Royal Prince Alfred HospitalUniversity of Sydney School of Public health University of Sydney

To explore the relationship between such a construct and an existing continence score. MeTHODSA retrospective study of incontinent patients who underwent anal physiology (AP) was performed. AP results and Cleveland Clinic Continence Scores (CCCS) were extracted. An anal physiology score (APS) was developed using maximum resting pressures (MRP), anal canal length (ACL), internal and external sphincter defects and pudendal terminal motor latency. Univariate associations between each variable, APS and CCCS were assessed. Multiple regression analyses were performed. ReSULTSOf 508 (419 women) patients, 311 had both APS and CCCS measured. Average MRP was 51 mmHg (SD 23.2 mmHg) for men and 39 mmHg (19.2 mmHg) for women. Functional ACL was 1.7 cm for men and 0.7 cm for women. Univariate analyses demonstrated significant associations between CCCS and MRP (P = 0.0002), ACL (P = 0.0006) and pudendal neuropathy (P e association between APS and CCCS was significant (P ed for only 9.2% of the variability in CCCS. Multiple regression showed that the variables most useful in predicting CCCS were external sphincter defect, pudendal neuropathy and previous pelvic surgery, but only improving the scores predictive ability to 12.5%. CONCLUSIONThis study shows that the ability of AP tests to predict continence scores improves when considered collectively, but that a constructed summation model before and after multiple regression is poor at predicting the variability in continence scores.

关键词： Incontinence Anal physiology Anal canal Anal ultrasound Manometry electromyography

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Reconsidering sex differences during place learning in tungara frogs

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Current Zoology 2019年第3期65卷 317-321页

作者： Robert e.VeNTURA Yuxiang LIU Sabrina S.BURMeISTeR Department of Biology University of North Carolina Chapel Hill NC 27599 USA Department of Neuroscience University of Texas Southwestern Medical Center Dallas TX 75390 USA

In tungara frogs, female mate choice requires remembering the location and/or calls of preferred males who advertise from fixed positions within a breeding pond. A previous study found that, when solving a place discrimination task in the laboratory, female tCingara frogs were able to learn a visual cue to solve the task, whereas males were not. In that task, male performance appeared to be inhibited, in part, by their attempt to use egocentric cues. We tested whether the sex difference in place learning previously reported would generalize to other training parameters with different cues available by eliminating the potential to use egocentric cues and increasing the number of trials per day. As before, frogs were given a choice between a red or yellow door, one of which led to shelters and return to their home cage. In the current testing conditions, we detected a preference for the red door;thus, we only considered frogs rewarded to the yellow door. Training was associated with an in crease in correct choices and an in creased preference for the yellow door. However, there was no evide nee for a sex d iff ere nee in learni ng. In summary, un der the curre nt training conditions, we fou nd that the appare nt female advantage in place learning was no Ion ger evide nt. Future studies that in vestigate sex d iff ere nces in cue pref ere nee and/or ability to switch among cues will further illuminate the conditions under which sex differences in learning are manifest in tungara frogs.

关键词： allocentric cue egocentric cue local cue place learning tungara frog

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Wolbachia pipientis:A potential candidate for combating and eradicating dengue epidemics in Pakistan

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Asian Pacific Journal of Tropical Medicine 2015年第12期8卷 963-973页

作者： Uruj Tahir Umair Hassan Khan Muhammad Saad Zubair Bahar-e-Mustafa Department of environmental Sciences Fatima Jinnah Women University Department of Microbiology.University of Agriculture Faisalabad Department of Microbiology.Government College University Faisalabad

Dengue virus syndrome is an emerging global health challenge which is endemic in tropical countries like *** recent years dengue incidences have increased considerably in different areas of Pakistan with more sever impacts on urban and peri-urban *** review is an effort to highlight the changing epidemiology of dengue fever,role of Government of Pakistan in disease management and control using preventive and community based approaches in the ***,there is an emphasis on application of Wolbachia as novel,inexpeasive and environmentally benign candidate for control and eradication of dengue transmitting vectors.

关键词： Dengue Pakistan Antiviral agents Chemical methods

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Phylogenetic position of sponges in early metazoan evolution and bionic applications of siliceous sponge spicules

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Chinese Science Bulletin 2007年第22期52卷 3029-3040页

作者： Werner e G MULLeR WANG XiaoHong ZeNG LingSen Heinz C SCHRODeR Institut for Physiologische Chemie Abteilung Angewandte Molekularbiologie Universit&t Duesbergweg 6 D-55099 Mainz Germany National Research Center for Geoanalysis Beijing 100037 China Faculty for environmental Sciences Peking University Beijing 100871 China Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China

Sponges are the oldest and the simplest but not primitive multicellular animals. They represent the earliest evolutionary metazoan phylum still extant. It was a long and painful scientific process to posi-tion the most enigmatic and mysterious metazoan,the Porifera,into their correct phylogenetic place among the eukaryotes in general and multicellular animals in particular. As living fossils,sponges provide the best evidence for the early evolution of Metazoa. More recently,interest has been focused on the bionic applications of sponges' siliceous spicules,after the discovery of their unique structure and high fiber performance. In this review,the emergence of sponges,evolutionary novelties found in sponges,and the phylogenetic position of sponges in early metazoan evolution are highlighted. In ad-dition,the present state of knowledge on silicatein-mediated "biosilica" formation in marine sponges,including the involvement of other molecules in silica metabolism and their potential application in nanobiotechnology and medicine,is given.

关键词：海绵多细胞动物仿生学硅土

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Text Sentiment Analysis Based on Multi-Layer Bi-Directional LSTM with a Trapezoidal Structure

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Intelligent Automation & Soft Computing 2023年第7期37卷 639-654页

作者： Zhengfang He Cristina e.Dumdumaya Ivy Kim D.Machica School of Intelligent Science and engineering Yunnan Technology and Business UniversityKunming650000China College of Information and Computing University of Southeastern PhilippinesDavao CityDavao del SurPhilippines

Sentiment analysis,commonly called opinion mining or emotion artificial intelligence(AI),employs biometrics,computational linguistics,nat-ural language processing,and text analysis to systematically identify,extract,measure,and investigate affective states and subjective *** analy-sis algorithms include emotion lexicon,traditional machine learning,and deep *** the text sentiment analysis algorithm based on a neural network,multi-layer Bi-directional long short-term memory(LSTM)is widely used,but the parameter amount of this model is too ***,this paper proposes a Bi-directional LSTM with a trapezoidal structure *** design of the trapezoidal structure is derived from classic neural networks,such as LeNet-5 and *** classic models have trapezoidal-like structures,and these structures have achieved success in the field of deep *** are two benefits to using the Bi-directional LSTM with a trapezoidal *** is that compared with the single-layer configuration,using the of the multi-layer structure can better extract the high-dimensional features of the *** is that using the trapezoidal structure can reduce the model’s *** paper introduces the Bi-directional LSTM with a trapezoidal structure model in detail and uses Stanford sentiment treebank 2(STS-2)for *** can be seen from the experimental results that the trapezoidal structure model and the normal structure model have similar ***,the trapezoidal structure model parameters are 35.75%less than the normal structure model.

关键词： Text sentiment Bi-directional LSTM Trapezoidal structure

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Impact of climate factors on contact rate of vector-borne diseases： Case study of malaria

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International Journal of Biomathematics 2017年第1期10卷 77-97页

作者： ezekiel Dangbe Antoine Perasso Damakoa Irepran David Bekol1e The University Institute of Technology University of Ngaoundere UMR6249 Chrono-environment Laboratory University of Franche-Comte The Faculty of Sciences University of Ngaoundere P. O. Boz 454 Ngaoundere Cameroon

Climate change influences more and more of our activities. These changes led to envi- ronmental changes which has in turn affected the spatial and temporal distribution of the incidence of vector-borne diseases. To establish the impact of climate on contact rate of vector-borne diseases, we examine the variation of prevalence of diseases according to season. In this paper, the goal is to establish that the basic reproductive number R0 depends on the duration of transmission period and the date of the first conta- mination case that was declared （to） in the specific ease of malaria. We described the dynamics of transmission of malaria by using non-autonomous differential equations. We analyzed the stability of endemic equilibrium （ee） and disease-free equilibrium （DFe）. We prove that the persistence of disease depends on minimum and maximum values of contact rate of vector-borne diseases.

关键词： SIR models vector-borne disease impact of climate factors malaria.

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高比例风电系统中日前发电计划的旋转备用容量优化方法

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电气自动化 2022年第4期44卷 26-28,33页

作者：伯利曼华南理工大学广东广州510641

针对高比例风电场旋转备用容量运行稳定性差、发电计划输电效率低等问题,设计了一种旋转备用容量优化模型。采用高压直流技术制订出最优发电计划,使风电场输送电能达到最大化;利用引力搜索优化算法分析整个风电系统运行过程,根据用户满... 详细信息

针对高比例风电场旋转备用容量运行稳定性差、发电计划输电效率低等问题,设计了一种旋转备用容量优化模型。采用高压直流技术制订出最优发电计划,使风电场输送电能达到最大化;利用引力搜索优化算法分析整个风电系统运行过程,根据用户满意度的反馈筛选出最优方案,增加风电场输电效益。试验结果表明:输电效率在85%以上;设计稳定范围为40~60 Hz,输电效率最高达到90%,大大提高了优化能力。

关键词：高比例风电系统旋转备用容量优化模型电压保护策略高压直流优化方案 GSA优化算法

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A Lexically Based Proposal of Argument Structure Meaningi

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外国语 2005年第1期28卷 3-13页

作者： Adele e.Goldberg Devin Casenhiser Nitya Sethuraman Princeton University Princeton UniversityIndiana UniversityUSA

Children conservatively produce syntactic patterns on a verb-by-verb basis (Akhtar and Tomasello, 1997;Baker, 1979; Bates and MacWhinney, 1987; Bowerman, 1982; Braine, 1976; Brooks and Tomasello, 1999;Gropen et al., 1989; Ingram and Thompson, 1996; Lieven et al., 1997; MacWhinney, 1982; Olguin and Tomasello, 1993; Schlesinger, 1982; Tomasello, 1992). Ultimately, however,

关键词：构词法副词词汇语法

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A methodology for rearranging transit stops for enhancing transit users generalized travel time

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Journal of Traffic and Transportation engineering(english edition) 2017年第1期4卷 14-30页

作者： Mohammad Nurul Hassan Yaser e.Hawas Roadway Transportation and Traffic Safety Research CentreUnited Arab Emirates UniversityAl AinUnited Arab Emirates Department of Civil and environmental engineering United Arab Emirates UniversityAI AinUnited Arab Emirates

This study develops a methodology to consohdate transit stops. It develops a mathematical model and a program which takes stop consolidation decision（s） according to users gener- alized travel time savings and desired accessibility. The model iterates until the users generalized travel time savings are maximized. The study tests this mathematical model in different hypothetical scenarios. Six factors （distance between stops, passenger activity, average cruising speed, maximum walking distance, service frequency, and percentage of decreased passengers） with multiple levels were set to build the scenarios. Three responses {percentage of consolidated stops, percentages of travel time and operating time savings） were observed. The findings showed that the distance between the stops the passenger ac- tivity, and the probable demand change （or the percentage of decreased passengers） are the most influential factors. The frequency of service was found to be influential as well. The average cruising speed has very little influence on the response variables. Finally, the model is tested on two routes （route 900 and 930） ofAl Ain City public bus service. It shows that 22 and 32 out of 98 and 126 stops can be consolidated in route 900 and 930 respectively. This can save considerable amounts of users travel and operating times. In monetary values, the savings are about $329,827 and $491,094 per year for routes 900 and 930, respectively.

关键词： Public transit Stop consolidation Transit users travel time Transit operating time Trip time

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